Author results

4NP4
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CLOSTRIDIUM DIFFICILE TOXIN B CROP DOMAIN IN COMPLEX WITH FAB DOMAINS OF NEUTRALIZING ANTIBODY BEZLOTOXUMAB
分子名称:Toxin B, bezlotoxumab heavy chain, bezlotoxumab light chain
著者Orth, P., Xiao, L., Hernandez, L.D., Reichert, P., Sheth, P., Beaumont, M., Murgolo, N., Ermakov, G., DiNunzio, E., Racine, F., Karczewski, J., Secore, S., Ingram, R.N., Mayhood, T., Strickland, C., Therien, A.G.
登録日2013-11-20
公開日2014-05-21
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography.
J.Biol.Chem., 289, 2014
1R55
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN ADAM 33
分子名称:ADAM 33, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
著者Orth, P., Reichert, P., Wang, W., Prosise, W.W., Yarosh-Tomaine, T., Hammond, G., Xiao, L., Mirza, U.A., Zou, J., Strickland, C., Taremi, S.S., Le, H.V., Madison, V.
登録日2003-10-09
公開日2004-10-12
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Crystal structre of the catalytic domain of human ADAM33
J.Mol.Biol., 335, 2004
5EGM
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DEVELOPMENT OF A NOVEL TRICYCLIC CLASS OF POTENT AND SELECTIVE FIXA INHIBITORS
分子名称:Coagulation factor IX, SODIUM ION, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ...
著者Meng, D., Andre, P., Bateman, T.J., Berger, R., Chen, Y., Desai, K., Dewnani, S., Ellsworth, K., Feng, D., Geissler, W.M., Guo, L., Hruza, A., Jian, T., Li, H., Parker, D.L., Reichert, P., Sherer, E.C., Smith, C.J., Sonatore, L.M., Tschirret-Guth, R., Wu, J., Xu, J., Zhang, T., Campeau, L., Orr, R., Poirier, M., McCabe-Dunn, j., Araki, K., Nishimura, T., Sakurada, I., Hirabayashi, T., Wood, H.B.
登録日2015-10-27
公開日2015-11-18
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.841 Å)
主引用文献Development of a novel tricyclic class of potent and selective FIXa inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
3D85
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CRYSTAL STRUCTURE OF IL-23 IN COMPLEX WITH NEUTRALIZING FAB
分子名称:FAB of antibody 7G10, light chain, heavy chain, ...
著者Beyer, B.M., Ingram, R., Ramanathan, L., Reichert, P., Le, H., Madison, V.
登録日2008-05-22
公開日2008-09-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody
J.Mol.Biol., 382, 2008
3D87
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CRYSTAL STRUCTURE OF INTERLEUKIN-23
分子名称:Interleukin-23 subunit p19, Interleukin-12 subunit p40, PHOSPHATE ION, ...
著者Beyer, B.M., Ingram, R., Ramanathan, L., Reichert, P., Le, H., Madison, V.
登録日2008-05-22
公開日2008-09-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody
J.Mol.Biol., 382, 2008
4ZAE
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DEVELOPMENT OF A NOVEL CLASS OF POTENT AND SELECTIVE FIXA INHIBITORS
分子名称:Coagulation factor IX, 2,6-dichloro-N-[(2R)-2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide, SODIUM ION, ...
著者Hruza, A., Reichert, P.
登録日2015-04-13
公開日2015-06-03
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Development of a novel class of potent and selective FIXa inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
2INT
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4
分子名称:INTERLEUKIN-4
著者Walter, M.R., Cook, W.J., Zhao, B.G., Cameron Junior, R., Ealick, S.E., Walter Junior, R.L., Reichert, P., Nagabhushan, T.L., Trotta, P.P., Bugg, C.E.
登録日1993-07-22
公開日1994-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structure of recombinant human interleukin-4.
J.Biol.Chem., 267, 1992
4YZU
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RAPID DEVELOPMENT OF TWO FACTOR IXA INHIBITORS FROM HIT TO LEAD
分子名称:Coagulation factor IX, N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide, SODIUM ION, ...
著者Hruza, A., Reichert, P.
登録日2015-03-25
公開日2015-05-20
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献Rapid development of two factor IXa inhibitors from hit to lead.
Bioorg.Med.Chem.Lett., 25, 2015
4Z0K
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RAPID DEVELOPMENT OF TWO FACTOR IXA INHIBITORS FROM HIT TO LEAD
分子名称:Coagulation factor IX, N-[(2R)-10-hydroxy-2,7-dimethyl-1,2,3,4-tetrahydropyrido[1,2-b]indazol-2-yl]-4-(4H-1,2,4-triazol-4-yl)benzamide, SODIUM ION, ...
著者Hruza, A., Reichert, P.
登録日2015-03-26
公開日2015-05-20
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献Rapid development of two factor IXa inhibitors from hit to lead.
Bioorg.Med.Chem.Lett., 25, 2015
5DK3
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CRYSTAL STRUCTURE OF PEMBROLIZUMAB, A FULL LENGTH IGG4 ANTIBODY
分子名称:Light Chain, Heavy Chain, SULFATE ION, ...
著者Scapin, G., Prosise, W., Reichert, P.
登録日2015-09-02
公開日2015-11-18
最終更新日2016-08-03
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab.
Nat.Struct.Mol.Biol., 22, 2015
5TNO
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DISCOVERY OF NOVEL AMINOBENZISOXAZOLE DERIVATIVES AS ORALLY AVAILABLE FACTOR IXA INHIBITORS
分子名称:Coagulation factor IX, UNKNOWN LIGAND, SODIUM ION, ...
著者Sakurada, I., Endo, T., Hikita, K., Hirabayashi, T., Hosaka, Y., Kato, Y., Maeda, Y., Matsumoto, S., Mizuno, T., Nagasue, H., Nishimura, T., Shimada, S., Shinozaki, M., Taguchi, K., Takeuchi, K., Yokoyama, T., Hruza, A., Reichert, P., Zhang, T., Wood, H.B., Nakao, K., Furusako, S.
登録日2016-10-14
公開日2017-04-26
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5TNT
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DISCOVERY OF NOVEL AMINOBENZISOXAZOLE DERIVATIVES AS ORALLY AVAILABLE FACTOR IXA INHIBITORS
分子名称:Coagulation factor IX, N-[(1S,4S,7R)-2-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)-2-azabicyclo[2.2.1]heptan-7-yl]-2-chloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide, SODIUM ION, ...
著者Sakurada, I., Endo, T., Hikita, K., Hirabayashi, T., Hosaka, Y., Kato, Y., Maeda, Y., Matsumoto, S., Mizuno, T., Nagasue, A., Nishimura, T., Shimada, S., Shinozaki, M., Taguchi, K., Takeuchi, K., Yokoyama, T., Hruza, A., Reichert, P., Zhang, T., Wood, H.B., Nakao, K., Furusako, S.
登録日2016-10-14
公開日2017-04-26
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
1R54
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN ADAM33
分子名称:ADAM 33, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
著者Orth, P., Reicher, P., Wang, W., Prosise, W.W., Yarosh-Tomaine, T., Hammond, G., Xiao, L., Mirza, U.A., Zou, J., Strickland, C., Taremi, S.S.
登録日2003-10-09
公開日2004-10-12
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structre of the catalytic domain of human ADAM33
J.Mol.Biol., 335, 2004
5HMH
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HDM2 IN COMPLEX WITH A 3,3-DISUBSTITUTED PIPERIDINE
分子名称:E3 ubiquitin-protein ligase Mdm2, 4-[2-(4-{[(2R,3S)-2-propyl-1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}-3-{[5-(trifluoromethyl)thiophen-3-yl]oxy}piperidin-3-yl]carbonyl}piperazin-1-yl)phenoxy]butanoic acid, SULFATE ION
著者Scapin, G.
登録日2016-01-16
公開日2016-04-06
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.
Acs Med.Chem.Lett., 7, 2016
5HMI
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HDM2 IN COMPLEX WITH A 3,3-DISUBSTITUTED PIPERIDINE
分子名称:E3 ubiquitin-protein ligase Mdm2, {4-[2-(2-hydroxyethoxy)phenyl]piperazin-1-yl}[(2R,3S)-2-propyl-1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}-3-{[5-(trifluoromethyl)thiophen-3-yl]oxy}piperidin-3-yl]methanone, SULFATE ION
著者Scapin, G.
登録日2016-01-16
公開日2016-04-06
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.
Acs Med.Chem.Lett., 7, 2016
5HMK
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HDM2 IN COMPLEX WITH A 3,3-DISUBSTITUTED PIPERIDINE
分子名称:E3 ubiquitin-protein ligase Mdm2, {4-[2-(2-hydroxyethoxy)phenyl]piperazin-1-yl}[(2R,3S)-2-propyl-3-[4-(trifluoromethyl)phenoxy]-1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-3-yl]methanone
著者Scapin, G.
登録日2016-01-16
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.
Acs Med.Chem.Lett., 7, 2016
1CU1
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CRYSTAL STRUCTURE OF AN ENZYME COMPLEX FROM HEPATITIS C VIRUS
分子名称:PROTEIN (PROTEASE/HELICASE NS3), ZINC ION, PHOSPHATE ION
著者Yao, N., Weber, P.C.
登録日1999-08-20
公開日2000-08-23
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase.
Structure Fold.Des., 7, 1999
1RH2
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RECOMBINANT HUMAN INTERFERON-ALPHA 2B
分子名称:INTERFERON-ALPHA 2B, ZINC ION
著者Walter, M.R.
登録日1996-11-07
公開日1997-11-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography.
Structure, 4, 1996
3EQC
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X-RAY STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK1) IN A TERNARY COMPLEX WITH COMPOUND 1, ATP-GS AND MG2P
分子名称:Dual specificity mitogen-activated protein kinase kinase 1, 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
著者Fischmann, T.O.
登録日2008-09-30
公開日2009-02-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
Biochemistry, 48, 2009
3EQD
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X-RAY STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK1) IN A BINARY COMPLEX WITH ATP-GS AND MG2P
分子名称:Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
著者Fischmann, T.O.
登録日2008-09-30
公開日2009-02-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
Biochemistry, 48, 2009
3EQF
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X-RAY STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK1) IN A BINARY COMPLEX WITH K252A AND MG2P
分子名称:Dual specificity mitogen-activated protein kinase kinase 1, K-252A, MAGNESIUM ION, ...
著者Fischmann, T.O.
登録日2008-09-30
公開日2009-02-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
Biochemistry, 48, 2009
3EQG
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X-RAY STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK1) IN A TERNARY COMPLEX WITH PD, ADP AND MG2P
分子名称:Dual specificity mitogen-activated protein kinase kinase 1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Fischmann, T.O.
登録日2008-09-30
公開日2009-02-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
Biochemistry, 48, 2009
3EQH
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X-RAY STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK1) IN A TERNARY COMPLEX WITH U0126, ADP AND MG2P
分子名称:Dual specificity mitogen-activated protein kinase kinase 1, (2Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile, ADENOSINE-5'-DIPHOSPHATE, ...
著者Fischmann, T.O.
登録日2008-09-30
公開日2009-02-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
Biochemistry, 48, 2009
3EQI
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X-RAY STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK1) IN A BINARY COMPLEX WITH ADP AND MG2P
分子名称:Dual specificity mitogen-activated protein kinase kinase 1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Fischmann, T.O.
登録日2008-09-30
公開日2009-02-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
Biochemistry, 48, 2009
3NOS
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HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH ARGININE SUBSTRATE
分子名称:ENDOTHELIAL NITRIC-OXIDE SYNTHASE, ZINC ION, N-OMEGA-HYDROXY-L-ARGININE, ...
著者Fischmann, T.O., Weber, P.C.
登録日1999-02-03
公開日2000-02-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.
Nat.Struct.Biol., 6, 1999
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