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3CF6
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BU of 3cf6 by Molmil
Structure of Epac2 in complex with cyclic-AMP and Rap
Descriptor: 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, Rap guanine nucleotide exchange factor (GEF) 4, Ras-related protein Rap-1b, ...
Authors:Rehmann, H, Arias-Palomo, E, Hadders, M.A, Schwede, F, Llorca, O, Bos, J.L.
Deposit date:2008-03-02
Release date:2008-07-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B
Nature, 455, 2008
2BYV
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BU of 2byv by Molmil
Structure of the cAMP responsive exchange factor Epac2 in its auto- inhibited state
Descriptor: RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4
Authors:Rehmann, H, Wittinghofer, A, Bos, J.L.
Deposit date:2005-08-08
Release date:2006-02-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the Cyclic-AMP Responsive Exchange Factor Epac2 in its Auto-Inhibited State
Nature, 439, 2006
1O7F
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BU of 1o7f by Molmil
CRYSTAL STRUCTURE OF THE REGULATORY DOMAIN OF EPAC2
Descriptor: CAMP-DEPENDENT RAP1 GUANINE-NUCLEOTIDE EXCHANGE FACTOR
Authors:Rehmann, H, Prakash, B, Wolf, E, Rueppel, A, De Rooij, J, Bos, J.L, Wittinghofer, A.
Deposit date:2002-11-04
Release date:2002-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and Regulation of the Camp-Binding Domains of Epac2
Nat.Struct.Biol., 10, 2002
4MGI
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BU of 4mgi by Molmil
Selective activation of Epac1 and Epac2
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ...
Authors:Rehmann, H.
Deposit date:2013-08-28
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4MGY
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BU of 4mgy by Molmil
Selective activation of Epac1 and Epac2
Descriptor: (2S,4aR,6R,7R,7aR)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-methoxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-ol 2-oxide, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ...
Authors:Rehmann, H.
Deposit date:2013-08-29
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4MH0
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BU of 4mh0 by Molmil
Selective activation of Epac1 and Epac2
Descriptor: (2S,4aR,6R,7R,7aS)-6-{6-amino-8-[(4-fluorobenzyl)sulfanyl]-9H-purin-9-yl}-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ...
Authors:Rehmann, H.
Deposit date:2013-08-29
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4MGK
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BU of 4mgk by Molmil
Selective activation of Epac1 and Epac2
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ...
Authors:Rehmann, H.
Deposit date:2013-08-28
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4MGZ
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BU of 4mgz by Molmil
Selective activation of Epac1 and Epac2
Descriptor: (2S,4aR,6R,7R,7aS)-6-[6-amino-8-(benzylsulfanyl)-9H-purin-9-yl]-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ...
Authors:Rehmann, H.
Deposit date:2013-08-29
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4JGW
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BU of 4jgw by Molmil
The conformation of a docking site for SH3 domains is pre-selected in the Guanine Nucleotide Exchange Factor Rlf
Descriptor: Ral guanine nucleotide dissociation stimulator-like 2
Authors:Rehmann, H, Popovic, M, Jakobi, A.J.
Deposit date:2013-03-04
Release date:2013-09-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containing proteins via a binding site with a preselected conformation.
J.Struct.Biol., 183, 2013
5CM8
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BU of 5cm8 by Molmil
Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small G-protein Ral
Descriptor: Ral guanine nucleotide dissociation stimulator-like 2, Ras-related protein Ral-a
Authors:Popovic, M, Schouten, A, Rehmann, H.
Deposit date:2015-07-16
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity.
J.Struct.Biol., 193, 2016
5CM9
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BU of 5cm9 by Molmil
Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small G-protein Ral
Descriptor: Ral guanine nucleotide dissociation stimulator-like 2, Ras-related protein Ral-a
Authors:Popovic, M, Schouten, A, Rehmann, H.
Deposit date:2015-07-16
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity.
J.Struct.Biol., 193, 2016
1C1Y
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BU of 1c1y by Molmil
CRYSTAL STRUCTURE OF RAP.GMPPNP IN COMPLEX WITH THE RAS-BINDING-DOMAIN OF C-RAF1 KINASE (RAFRBD).
Descriptor: CALCIUM ION, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Nassar, N.
Deposit date:1999-07-22
Release date:1999-08-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue.
Nature, 375, 1995
4NVP
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BU of 4nvp by Molmil
Structure of the cyclic nucleotide-binding domain of HCN4 channel complexed with 7-CH-cAMP
Descriptor: (2S,4aR,6R,7R,7aS)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Authors:Alfieri, A, Moroni, A.
Deposit date:2013-12-05
Release date:2014-03-19
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels.
Acs Chem.Biol., 9, 2014

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