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3CF6
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STRUCTURE OF EPAC2 IN COMPLEX WITH CYCLIC-AMP AND RAP
Descriptor:Rap guanine nucleotide exchange factor (GEF) 4, Ras-related protein Rap-1b, 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, ...
Authors:Rehmann, H., Arias-Palomo, E., Hadders, M.A., Schwede, F., Llorca, O., Bos, J.L.
Deposit date:2008-03-02
Release date:2008-07-29
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B
Nature, 455, 2008
2BYV
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STRUCTURE OF THE CAMP RESPONSIVE EXCHANGE FACTOR EPAC2 IN ITS AUTO- INHIBITED STATE
Descriptor:RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4
Authors:Rehmann, H., Wittinghofer, A., Bos, J.L.
Deposit date:2005-08-08
Release date:2006-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the Cyclic-AMP Responsive Exchange Factor Epac2 in its Auto-Inhibited State
Nature, 439, 2006
1O7F
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CRYSTAL STRUCTURE OF THE REGULATORY DOMAIN OF EPAC2
Descriptor:CAMP-DEPENDENT RAP1 GUANINE-NUCLEOTIDE EXCHANGE FACTOR
Authors:Rehmann, H., Prakash, B., Wolf, E., Rueppel, A., De Rooij, J., Bos, J.L., Wittinghofer, A.
Deposit date:2002-11-04
Release date:2002-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and Regulation of the Camp-Binding Domains of Epac2
Nat.Struct.Biol., 10, 2002
4MGI
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SELECTIVE ACTIVATION OF EPAC1 AND EPAC2
Descriptor:Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ...
Authors:Rehmann, H.
Deposit date:2013-08-28
Release date:2014-09-03
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4MGK
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SELECTIVE ACTIVATION OF EPAC1 AND EPAC2
Descriptor:Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ...
Authors:Rehmann, H.
Deposit date:2013-08-28
Release date:2014-09-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4MGY
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SELECTIVE ACTIVATION OF EPAC1 AND EPAC2
Descriptor:Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, (2S,4aR,6R,7R,7aR)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-methoxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-ol 2-oxide, ...
Authors:Rehmann, H.
Deposit date:2013-08-29
Release date:2014-09-03
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4MGZ
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SELECTIVE ACTIVATION OF EPAC1 AND EPAC2
Descriptor:Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, (2S,4aR,6R,7R,7aS)-6-[6-amino-8-(benzylsulfanyl)-9H-purin-9-yl]-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide, ...
Authors:Rehmann, H.
Deposit date:2013-08-29
Release date:2014-09-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4MH0
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SELECTIVE ACTIVATION OF EPAC1 AND EPAC2
Descriptor:Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, (2S,4aR,6R,7R,7aS)-6-{6-amino-8-[(4-fluorobenzyl)sulfanyl]-9H-purin-9-yl}-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide, ...
Authors:Rehmann, H.
Deposit date:2013-08-29
Release date:2014-09-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4JGW
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THE CONFORMATION OF A DOCKING SITE FOR SH3 DOMAINS IS PRE-SELECTED IN THE GUANINE NUCLEOTIDE EXCHANGE FACTOR RLF
Descriptor:Ral guanine nucleotide dissociation stimulator-like 2
Authors:Rehmann, H., Popovic, M., Jakobi, A.J.
Deposit date:2013-03-04
Release date:2013-09-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containing proteins via a binding site with a preselected conformation.
J.Struct.Biol., 183, 2013
5CM8
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STRUCTURAL BASIS FOR THE SELECTIVITY OF GUANINE NUCLEOTIDE EXCHANGE FACTORS FOR THE SMALL G-PROTEIN RAL
Descriptor:Ral guanine nucleotide dissociation stimulator-like 2, Ras-related protein Ral-a
Authors:Popovic, M., Schouten, A., Rehmann, H.
Deposit date:2015-07-16
Release date:2016-01-13
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity.
J.Struct.Biol., 193, 2016
5CM9
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STRUCTURAL BASIS FOR THE SELECTIVITY OF GUANINE NUCLEOTIDE EXCHANGE FACTORS FOR THE SMALL G-PROTEIN RAL
Descriptor:Ral guanine nucleotide dissociation stimulator-like 2, Ras-related protein Ral-a
Authors:Popovic, M., Schouten, A., Rehmann, H.
Deposit date:2015-07-16
Release date:2016-01-13
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity.
J.Struct.Biol., 193, 2016
4NVP
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STRUCTURE OF THE CYCLIC NUCLEOTIDE-BINDING DOMAIN OF HCN4 CHANNEL COMPLEXED WITH 7-CH-CAMP
Descriptor:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, (2S,4aR,6R,7R,7aS)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide
Authors:Alfieri, A., Moroni, A.
Deposit date:2013-12-05
Release date:2014-03-19
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels.
Acs Chem.Biol., 9, 2014
1C1Y
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CRYSTAL STRUCTURE OF RAP.GMPPNP IN COMPLEX WITH THE RAS-BINDING-DOMAIN OF C-RAF1 KINASE (RAFRBD).
Descriptor:RAS-RELATED PROTEIN RAP-1A, PROTO-ONCOGENE SERINE/THREONINE PROTEIN KINASE RAF-1, MAGNESIUM ION, ...
Authors:Nassar, N.
Deposit date:1999-07-22
Release date:1999-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue.
Nature, 375, 1995