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Structure of a Thermophilic Serpin in the Native State
Descriptor:	COG4826: Serine protease inhibitor, SULFATE ION
Authors:	Fulton, K.F, Buckle, A.M, Cabrita, L.D, Irving, J.A, Butcher, R.E, Smith, I, Reeve, S, Lesk, A.M, Bottomley, S.P, Rossjohn, J, Whisstock, J.C.
Deposit date:	2004-03-10
Release date:	2004-12-14
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (1.76 Å)
Cite:	The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition. J.Biol.Chem., 280, 2005

Candida albicans glutaminyl tRNA synthetase (GLN4) in complex with N-pyrimidinyl-beta-thiophenylacrylamide
Descriptor:	(2E)-N-(pyrimidin-2-yl)-3-(thiophen-2-yl)prop-2-enamide, ZINC ION, glutamine--tRNA ligase
Authors:	Sychantha, D, Wright, G.D.
Deposit date:	2023-10-12
Release date:	2024-03-06
Method:	X-RAY DIFFRACTION (2.73 Å)
Cite:	Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-beta-thiophenylacrylamides exerts highly selective antifungal activity. Cell Chem Biol, 2024

Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta- NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (UCP1106)
Descriptor:	4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-4-methoxy-phenyl]benzoic acid, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:	Hajian, B, Anderson, A.C.
Deposit date:	2016-04-11
Release date:	2016-08-24
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (1.814 Å)
Cite:	Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis. Plos One, 11, 2016