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3IOL
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BU of 3iol by Molmil
Crystal structure of Glucagon-Like Peptide-1 in complex with the extracellular domain of the Glucagon-Like Peptide-1 Receptor
Descriptor: Glucagon, Glucagon-like peptide 1 receptor, decyl 4-O-alpha-D-glucopyranosyl-1-thio-beta-D-glucopyranoside
Authors:Reedtz-Runge, S.
Deposit date:2009-08-14
Release date:2009-10-27
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor
J.Biol.Chem., 285, 2010
4ZGM
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BU of 4zgm by Molmil
Crystal structure of Semaglutide peptide backbone in complex with the GLP-1 receptor extracellular domain
Descriptor: 3,6,9,12,15,18-hexaoxahexacosan-1-ol, Glucagon-like peptide 1 receptor, Semaglutide peptide backbone; 8Aib,34R-GLP-1(7-37)-OH
Authors:Reedtz-Runge, S.
Deposit date:2015-04-23
Release date:2015-09-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.
J.Med.Chem., 58, 2015
5E94
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BU of 5e94 by Molmil
Antibody-bound Glucagon-like Peptide-1 receptor extracellular domain
Descriptor: Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, Glucagon-like peptide 1 receptor
Authors:Soroka, V, Schluckebier, G, Reedtz-Runge, S.
Deposit date:2015-10-14
Release date:2016-08-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insight into antibody-mediated antagonism of the Glucagon-like peptide-1 Receptor.
Sci Rep, 6, 2016
5II0
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BU of 5ii0 by Molmil
Crystal structure of the human calcitonin receptor ectodomain in complex with a truncated salmon calcitonin analogue
Descriptor: Calcitonin, Calcitonin receptor, SODIUM ION, ...
Authors:Johansson, E, Reedtz-Runge, S.
Deposit date:2016-03-01
Release date:2016-05-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Type II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography.
J.Biol.Chem., 291, 2016
6LN2
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BU of 6ln2 by Molmil
Crystal structure of full length human GLP1 receptor in complex with Fab fragment (Fab7F38)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab7F38_heavy chain, Fab7F38_light chain, ...
Authors:Wu, F, Yang, L, Hang, K, Laursen, M, Wu, L, Han, G.W, Ren, Q, Roed, N.K, Lin, G, Hanson, M, Jiang, H, Wang, M, Reedtz-Runge, S, Song, G, Stevens, R.C.
Deposit date:2019-12-28
Release date:2020-03-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Full-length human GLP-1 receptor structure without orthosteric ligands.
Nat Commun, 11, 2020
5XF1
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BU of 5xf1 by Molmil
Structure of the Full-length glucagon class B G protein-coupled receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, H, Qiao, A, Yang, D, Yang, L, Dai, A, de Graaf, C, Reedtz-Runge, S, Dharmarajan, V, Zhang, H, Han, G.W, Grant, T, Sierra, R, Weierstall, U, Nelson, G, Liu, W, Wu, Y, Ma, L, Cai, X, Lin, G, Wu, X, Geng, Z, Dong, Y, Song, G, Griffin, P, Lau, J, Cherezov, V, Yang, H, Hanson, M, Stevens, R, Jiang, H, Wang, M, Zhao, Q, Wu, B.
Deposit date:2017-04-06
Release date:2017-05-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
5XEZ
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BU of 5xez by Molmil
Structure of the Full-length glucagon class B G protein-coupled receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide, ...
Authors:Zhang, H, Qiao, A, Yang, D, Yang, L, Dai, A, de Graaf, C, Reedtz-Runge, S, Dharmarajan, V, Zhang, H, Han, G.W, Grant, T, Sierra, R, Weierstall, U, Nelson, G, Liu, W, Wu, Y, Ma, L, Cai, X, Lin, G, Wu, X, Geng, Z, Dong, Y, Song, G, Griffin, P, Lau, J, Cherezov, V, Yang, H, Hanson, M, Stevens, R, Jiang, H, Wang, M, Zhao, Q, Wu, B.
Deposit date:2017-04-06
Release date:2017-05-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
6LML
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BU of 6lml by Molmil
Cryo-EM structure of the human glucagon receptor in complex with Gi1
Descriptor: Glucagon, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Qiao, A, Han, S, Li, X, Sun, F, Zhao, Q, Wu, B.
Deposit date:2019-12-26
Release date:2020-04-01
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of Gsand Girecognition by the human glucagon receptor.
Science, 367, 2020
6LMK
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BU of 6lmk by Molmil
Cryo-EM structure of the human glucagon receptor in complex with Gs
Descriptor: Glucagon, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Qiao, A, Han, S, Tai, L, Sun, F, Zhao, Q, Wu, B.
Deposit date:2019-12-26
Release date:2020-04-01
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis of Gsand Girecognition by the human glucagon receptor.
Science, 367, 2020
7X9B
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BU of 7x9b by Molmil
Cryo-EM structure of neuropeptide Y Y2 receptor in complex with NPY and Gi
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Tang, T, Han, S, Zhao, Q, Wu, B.
Deposit date:2022-03-15
Release date:2022-05-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors.
Sci Adv, 8, 2022
7X9C
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BU of 7x9c by Molmil
Cryo-EM structure of neuropeptide Y Y4 receptor in complex with PP and Gi
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Tang, T, Han, S, Zhao, Q, Wu, B.
Deposit date:2022-03-15
Release date:2022-05-18
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors.
Sci Adv, 8, 2022
7X9A
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BU of 7x9a by Molmil
Cryo-EM structure of neuropeptide Y Y1 receptor in complex with NPY and Gi
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Tang, T, Han, S, Zhao, Q, Wu, B.
Deposit date:2022-03-15
Release date:2022-05-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors.
Sci Adv, 8, 2022
5OTV
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BU of 5otv by Molmil
Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Cyc/Thr11Hcs
Descriptor: Glucagon, Glucagon-like peptide 1 receptor
Authors:Mortensen, S.
Deposit date:2017-08-22
Release date:2018-07-04
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:alpha-Helix or beta-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4.
Biochemistry, 57, 2018
5OTU
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BU of 5otu by Molmil
Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Hcs/Thr11Hcs
Descriptor: Glucagon, Glucagon-like peptide 1 receptor
Authors:Mortensen, S.
Deposit date:2017-08-22
Release date:2018-07-04
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:alpha-Helix or beta-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4.
Biochemistry, 57, 2018
5OTT
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BU of 5ott by Molmil
Extracellular domain of GLP-1 receptor in complex with exendin-4 variant Gly2Hcs/Thr5Hcs
Descriptor: Exendin-4, Glucagon-like peptide 1 receptor
Authors:Mortensen, S.
Deposit date:2017-08-22
Release date:2018-07-04
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:alpha-Helix or beta-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4.
Biochemistry, 57, 2018
5OTX
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BU of 5otx by Molmil
Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Cys/Thr11Cys
Descriptor: Glucagon, Glucagon-like peptide 1 receptor
Authors:Mortensen, S.
Deposit date:2017-08-22
Release date:2018-07-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:alpha-Helix or beta-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4.
Biochemistry, 57, 2018
5OTW
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BU of 5otw by Molmil
Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Hcs/Thr11Cys
Descriptor: Glucagon, Glucagon-like peptide 1 receptor
Authors:Mortensen, S.
Deposit date:2017-08-22
Release date:2018-07-04
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:alpha-Helix or beta-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4.
Biochemistry, 57, 2018
5YQZ
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BU of 5yqz by Molmil
Structure of the glucagon receptor in complex with a glucagon analogue
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glucagon analogue, ...
Authors:Zhang, H, Qiao, A, Yang, L, VAN EPS, N, Frederiksen, K, Yang, D, Dai, A, Cai, X, Zhang, H, Yi, C, Can, C, He, L, Yang, H, Lau, J, Ernst, O, Hanson, M, Stevens, R, Wang, M, Seedtz-Runge, S, Jiang, H, Zhao, Q, Wu, B.
Deposit date:2017-11-08
Release date:2018-01-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the glucagon receptor in complex with a glucagon analogue.
Nature, 553, 2018
6X1A
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BU of 6x1a by Molmil
Non peptide agonist PF-06882961, bound to Glucagon-Like peptide-1 (GLP-1) Receptor
Descriptor: 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Zhang, X, Danev, R.
Deposit date:2020-05-18
Release date:2020-09-09
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 80, 2020
6X19
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BU of 6x19 by Molmil
Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor
Descriptor: 3-{(1S)-1-[5-(2,2-dimethylmorpholin-4-yl)-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl]butyl}-1,2,4-oxadiazol-5(4H)-one, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Zhang, X, Danev, R.
Deposit date:2020-05-18
Release date:2020-09-09
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 80, 2020
6X18
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BU of 6x18 by Molmil
GLP-1 peptide hormone bound to Glucagon-Like peptide-1 (GLP-1) Receptor
Descriptor: Glucagon, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Zhang, X, Danev, R.
Deposit date:2020-05-18
Release date:2020-09-09
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 80, 2020
7F8U
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BU of 7f8u by Molmil
Crystal structure of the cholecystokinin receptor CCKAR in complex with lintitript
Descriptor: 2-[2-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]indol-1-yl]ethanoic acid, Fusion protein of Cholecystokinin receptor type A and Endolysin
Authors:Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2021-07-02
Release date:2021-10-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Nat.Chem.Biol., 17, 2021
7F8W
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BU of 7f8w by Molmil
Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gq
Descriptor: Gastrin-17, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2021-07-02
Release date:2021-10-13
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Nat.Chem.Biol., 17, 2021
7F8Y
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BU of 7f8y by Molmil
Crystal structure of the cholecystokinin receptor CCKAR in complex with devazepide
Descriptor: N-[(3S)-1-methyl-2-oxidanylidene-5-phenyl-3H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide, fusion protein of Cholecystokinin receptor type A and Endolysin
Authors:Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2021-07-02
Release date:2021-10-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Nat.Chem.Biol., 17, 2021
7F8V
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BU of 7f8v by Molmil
Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gi
Descriptor: Gastrin-17, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2021-07-02
Release date:2021-10-13
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Nat.Chem.Biol., 17, 2021

 

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