Author results

1FLK
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MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3
Descriptor:TNF RECEPTOR ASSOCIATED FACTOR 3
Authors:Ni, C.-Z., Welsh, K., Leo, E., Chiou, C.-K., Wu, H., Reed, J.C., Ely, K.R.
Deposit date:2000-08-14
Release date:2000-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for CD40 signaling mediated by TRAF3.
Proc.Natl.Acad.Sci.USA, 97, 2000
1FLL
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MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3
Descriptor:TNF RECEPTOR ASSOCIATED FACTOR 3, B-CELL SURFACE ANTIGEN CD40
Authors:Ni, C.-Z., Welsh, K., Leo, E., Chiou, C.-K., Wu, H., Reed, J.C., Ely, K.R.
Deposit date:2000-08-14
Release date:2000-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Molecular basis for CD40 signaling mediated by TRAF3.
Proc.Natl.Acad.Sci.USA, 97, 2000
1I6Z
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BAG DOMAIN OF BAG1 COCHAPERONE
Descriptor:BAG-FAMILY MOLECULAR CHAPERONE REGULATOR-1
Authors:Briknarova, K., Takayama, S., Brive, L., Havert, M.L., Knee, D.A., Velasco, J., Homma, S., Cabezas, E., Stuart, J., Hoyt, D.W., Satterthwait, A.C., Llinas, M., Reed, J.C., Ely, K.R.
Deposit date:2001-03-06
Release date:2001-09-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural analysis of BAG1 cochaperone and its interactions with Hsc70 heat shock protein.
Nat.Struct.Biol., 8, 2001
1KZZ
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DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3
Descriptor:TNF receptor associated factor 3, TRAF family member-associated NF-kappa-b activator
Authors:Li, C., Ni, C.-Z., Havert, M.L., Cabezas, E., He, J., Kaiser, D., Reed, J.C., Satterthwait, A.C., Cheng, G., Ely, K.R.
Deposit date:2002-02-08
Release date:2002-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Downstream regulator TANK binds to the CD40 recognition site on TRAF3.
Structure, 10, 2002
1L0A
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DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3
Descriptor:TNF receptor associated factor 3, TRAF family member-associated NF-kappa-b activator
Authors:Li, C., Ni, C.-Z., Havert, M.L., Cabezas, E., He, J., Kaiser, D., Reed, J.C., Satterthwait, A.C., Cheng, G., Ely, K.R.
Deposit date:2002-02-08
Release date:2002-04-10
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Downstream regulator TANK binds to the CD40 recognition site on TRAF3.
Structure, 10, 2002
1OTV
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PQQC, PYRROLOQUINOLINQUINONE SYNTHASE C
Descriptor:Coenzyme PQQ synthesis protein C
Authors:Magnusson, O.T., Toyama, H., Saeki, M., Rojas, A., Reed, J.C., Adachi, O., Klinman, J.P., SChwarzenbacher, R.
Deposit date:2003-03-23
Release date:2004-05-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Quinone Biogenesis: Structure and Mechanism of PqqC, the Final Catalyst in the Production of Pyrroloquinoline Quinone.
Proc.Natl.Acad.Sci.USA, 101, 2004
1OTW
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CRYSTAL STRUCTURE OF PQQC IN COMPLEX WITH PQQ AND A PUTATIVE H2O2
Descriptor:Coenzyme PQQ synthesis protein C, PYRROLOQUINOLINE QUINONE, HYDROGEN PEROXIDE
Authors:Magnusson, O.T., Toyama, H., Saeki, M., Rojas, A., Reed, J.C., Liddington, R.C., Klinman, J.P., Schwarzenbacher, R.
Deposit date:2003-03-23
Release date:2004-05-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone.
Proc.Natl.Acad.Sci.USA, 101, 2004
1RF3
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STRUCTURALLY DISTINCT RECOGNITION MOTIFS IN LYMPHOTOXIN-B RECEPTOR AND CD40 FOR TRAF-MEDIATED SIGNALING
Descriptor:TNF receptor associated factor 3, 24-residue peptide from Lymphotoxin-B Receptor
Authors:Li, C., Norris, P.S., Ni, C.Z., Havert, M.L., Chiong, E.M., Tran, B.R., Cabezas, E., Cheng, G., Reed, J.C., Satterthwait, A.C., Ware, C.F., Ely, K.R.
Deposit date:2003-11-07
Release date:2004-07-06
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling.
J.Biol.Chem., 278, 2003
1YSG
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH "SAR BY NMR" LIGANDS
Descriptor:Apoptosis regulator Bcl-X, 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID, 5,6,7,8-TETRAHYDRONAPHTHALEN-1-OL
Authors:Oltersdorf, T., Elmore, S.W., Shoemaker, A.R., Armstrong, R.C., Augeri, D.J., Belli, B.A., Bruncko, M., Deckwerth, T.L., Dinges, J., Hajduk, P.J., Joseph, M.K., Kitada, S., Korsmeyer, S.J., Kunzer, A.R., Letai, A., Li, C., Mitten, M.J., Nettesheim, D.G., Ng, S., Nimmer, P.M., O'Connor, J.M., Oleksijew, A., Petros, A.M., Reed, J.C., Shen, W., Tahir, S.K., Thompson, C.B., Tomaselli, K.J., Wang, B., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H.
Deposit date:2005-02-08
Release date:2005-06-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Nature, 435, 2005
1YSI
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-X, N-[(4'-FLUORO-1,1'-BIPHENYL-4-YL)CARBONYL]-3-NITRO-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE
Authors:Oltersdorf, T., Elmore, S.W., Shoemaker, A.R., Armstrong, R.C., Augeri, D.J., Belli, B.A., Bruncko, M., Deckwerth, T.L., Dinges, J., Hajduk, P.J., Joseph, M.K., Kitada, S., Korsmeyer, S.J., Kunzer, A.R., Letai, A., Li, C., Mitten, M.J., Nettesheim, D.G., Ng, S., Nimmer, P.M., O'Connor, J.M., Oleksijew, A., Petros, A.M., Reed, J.C., Shen, W., Tahir, S.K., Thompson, C.B., Tomaselli, K.J., Wang, B., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H.
Deposit date:2005-02-08
Release date:2005-06-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Nature, 435, 2005
1YSN
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL COMPLEXED WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-X, 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE
Authors:Oltersdorf, T., Elmore, S.W., Shoemaker, A.R., Armstrong, R.C., Augeri, D.J., Belli, B.A., Bruncko, M., Deckwerth, T.L., Dinges, J., Hajduk, P.J., Joseph, M.K., Kitada, S., Korsmeyer, S.J., Kunzer, A.R., Letai, A., Li, C., Mitten, M.J., Nettesheim, D.G., Ng, S., Nimmer, P.M., O'Connor, J.M., Oleksijew, A., Petros, A.M., Reed, J.C., Shen, W., Tahir, S.K., Thompson, C.B., Tomaselli, K.J., Wang, B., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H.
Deposit date:2005-02-08
Release date:2005-06-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Nature, 435, 2005
1YSW
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-2 COMPLEXED WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-2, 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE
Authors:Oltersdorf, T., Elmore, S.W., Shoemaker, A.R., Armstrong, R.C., Augeri, D.J., Belli, B.A., Bruncko, M., Deckwerth, T.L., Dinges, J., Hajduk, P.J., Joseph, M.K., Kitada, S., Korsmeyer, S.J., Kunzer, A.R., Letai, A., Li, C., Mitten, M.J., Nettesheim, D.G., Ng, S., Nimmer, P.M., O'Connor, J.M., Oleksijew, A., Petros, A.M., Reed, J.C., Shen, W., Tahir, S.K., Thompson, C.B., Tomaselli, K.J., Wang, B., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H.
Deposit date:2005-02-09
Release date:2005-06-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Nature, 435, 2005
1YSX
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SOLUTION STRUCTURE OF DOMAIN 3 FROM HUMAN SERUM ALBUMIN COMPLEXED TO AN ANTI-APOPTOTIC LIGAND DIRECTED AGAINST BCL-XL AND BCL-2
Descriptor:Serum albumin, 4-({2-[(2,4-DIMETHYLPHENYL)SULFANYL]ETHYL}AMINO)-N-[(4'-FLUORO-1,1'-BIPHENYL-4-YL)CARBONYL]-3-NITROBENZENESULFONAMIDE
Authors:Oltersdorf, T., Elmore, S.W., Shoemaker, A.R., Armstrong, R.C., Augeri, D.J., Belli, B.A., Bruncko, M., Deckwerth, T.L., Dinges, J., Hajduk, P.J., Joseph, M.K., Kitada, S., Korsmeyer, S.J., Kunzer, A.R., Letai, A., Li, C., Mitten, M.J., Nettesheim, D.G., Ng, S., Nimmer, P.M., O'Connor, J.M., Oleksijew, A., Petros, A.M., Reed, J.C., Shen, W., Tahir, S.K., Thompson, C.B., Tomaselli, K.J., Wang, B., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H.
Deposit date:2005-02-09
Release date:2005-06-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Nature, 435, 2005
1ZMS
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LMP1 PROTEIN BINDS TO TRAF3 AS A STRUCTURAL CD40
Descriptor:TNF receptor associated factor 3, Latent membrane protein 1
Authors:Wu, S.D., Xie, P., Welsh, K., Li, C., Ni, C.-Z., Zhu, X., Reed, J.C., Satterthwait, A.C., Bishop, G.A., Ely, K.R.
Deposit date:2005-05-10
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:LMP1 protein from the Epstein Barr virus is a structural CD40 decoy in B lymphocytes fro binding to TRAF3
J.Biol.Chem., 39, 2005
2A25
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CRYSTAL STRUCTURE OF SIAH1 SBD BOUND TO THE PEPTIDE EKPAAVVAPITTG FROM SIP
Descriptor:Ubiquitin ligase SIAH1, Calcyclin-binding protein peptide, ZINC ION
Authors:Santelli, E., Leone, M., Li, C., Fukushima, T., Preece, N.E., Olson, A.J., Ely, K.R., Reed, J.C., Pellecchia, M., Liddington, R.C., Matsuzawa, S.
Deposit date:2005-06-21
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex
J.Biol.Chem., 280, 2005
2A26
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CRYSTAL STRUCTURE OF THE N-TERMINAL, DIMERIZATION DOMAIN OF SIAH INTERACTING PROTEIN
Descriptor:Calcyclin-binding protein, SULFATE ION, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID
Authors:Santelli, E., Leone, M., Li, C., Fukushima, T., Preece, N.E., Olson, A.J., Ely, K.R., Reed, J.C., Pellecchia, M., Liddington, R.C., Matsuzawa, S.
Deposit date:2005-06-21
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex
J.Biol.Chem., 280, 2005
1RCW
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CRYSTAL STRUCTURE OF CT610 FROM CHLAMYDIA TRACHOMATIS
Descriptor:CT610, FE (III) ION
Authors:Schwarzenbacher, R., Liddington, R.C.
Deposit date:2003-11-04
Release date:2004-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosis.
J.Biol.Chem., 279, 2004
2GKW
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KEY CONTACTS PROMOTE RECONGNITO OF BAFF-R BY TRAF3
Descriptor:TNF receptor-associated factor 3, Tumor necrosis factor receptor superfamily member 13C
Authors:Ely, K.R.
Deposit date:2006-04-03
Release date:2006-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation.
J.Immunol., 173, 2004
2I39
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CRYSTAL STRUCTURE OF VACCINIA VIRUS N1L PROTEIN
Descriptor:Protein N1, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Aoyagi, M., Aleshin, A.E., Stec, B., Liddington, R.C.
Deposit date:2006-08-17
Release date:2006-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein.
Protein Sci., 16, 2007
3H16
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CRYSTAL STRUCTURE OF A BACTERIA TIR DOMAIN, PDTIR FROM PARACOCCUS DENITRIFICANS
Descriptor:TIR protein, SULFATE ION
Authors:Chan, S.L., Low, L.Y., Santelli, E., Pascual, J.
Deposit date:2009-04-11
Release date:2009-06-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Mimicry in Innate Immunity: CRYSTAL STRUCTURE OF A BACTERIAL TIR DOMAIN.
J.Biol.Chem., 284, 2009
4EWI
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CRYSTAL STRUCTURE OF THE NLRP4 PYRIN DOMAIN
Descriptor:NACHT, LRR and PYD domains-containing protein 4, CHLORIDE ION, ...
Authors:Eibl, C., Hessenberger, M., Puehringer, S., Page, R., Diederichs, K., Peti, W.
Deposit date:2012-04-27
Release date:2012-09-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural and Functional Analysis of the NLRP4 Pyrin Domain.
Biochemistry, 51, 2012