Author results

6EZJ
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IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE
Descriptor:Imidazoleglycerol-phosphate dehydratase 2, chloroplastic, MANGANESE (II) ION, ...
Authors:Rawson, S., Bisson, C., Hurdiss, D.L., Muench, S.P.
Deposit date:2017-11-15
Release date:2018-02-07
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EZM
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IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE FROM SACCHAROMYCES CEREVISIAE
Descriptor:Imidazoleglycerol-phosphate dehydratase, MANGANESE (II) ION, [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid
Authors:Rawson, S., Bisson, C., Hurdiss, D.L., Muench, S.P.
Deposit date:2017-11-15
Release date:2018-02-07
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6XRA
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DISTINCT CONFORMATIONAL STATES OF SARS-COV-2 SPIKE PROTEIN
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, J., Cai, Y.F., Xiao, T.S., Peng, H.Q., Sterling, S.M., Walsh Jr, R.M., Rawson, S., Rits-Volloch, S., Chen, B.
Deposit date:2020-07-11
Release date:2020-07-22
Last modified:2020-08-05
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Distinct conformational states of SARS-CoV-2 spike protein.
Science, 2020
6G2J
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MOUSE MITOCHONDRIAL COMPLEX I IN THE ACTIVE STATE
Descriptor:NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial, ...
Authors:Agip, A.N.A., Blaza, J.N., Bridges, H.R., Viscomi, C., Rawson, S., Muench, S.P., Hirst, J.
Deposit date:2018-03-23
Release date:2018-06-06
Last modified:2018-08-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states.
Nat. Struct. Mol. Biol., 25, 2018
6G72
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MOUSE MITOCHONDRIAL COMPLEX I IN THE DEACTIVE STATE
Descriptor:NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial, ...
Authors:Agip, A.N.A., Blaza, J.N., Bridges, H.R., Viscomi, C., Rawson, S., Muench, S.P., Hirst, J.
Deposit date:2018-04-04
Release date:2018-06-06
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states.
Nat. Struct. Mol. Biol., 25, 2018
6NYB
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STRUCTURE OF A MAPK PATHWAY COMPLEX
Descriptor:Serine/threonine-protein kinase B-raf, Dual specificity mitogen-activated protein kinase kinase 1, 14-3-3 protein zeta, ...
Authors:Park, E., Rawson, S., Li, K., Jeon, H., Eck, M.J.
Deposit date:2019-02-11
Release date:2019-10-09
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
6Q0J
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STRUCTURE OF A MAPK PATHWAY COMPLEX
Descriptor:Serine/threonine-protein kinase B-raf, Dual specificity mitogen-activated protein kinase kinase 1, 14-3-3 protein zeta, ...
Authors:Park, E., Rawson, S., Jeon, H., Eck, M.J.
Deposit date:2019-08-01
Release date:2019-10-09
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
6Q0K
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STRUCTURE OF A MAPK PATHWAY COMPLEX
Descriptor:Serine/threonine-protein kinase B-raf, 14-3-3 protein zeta/delta
Authors:Park, E., Rawson, S., Jeon, H., Eck, M.J.
Deposit date:2019-08-01
Release date:2019-10-09
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
6Q0T
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STRUCTURE OF A MAPK PATHWAY COMPLEX
Descriptor:Serine/threonine-protein kinase B-raf, Dual specificity mitogen-activated protein kinase kinase 1, 14-3-3 protein zeta, ...
Authors:Park, E., Rawson, S., Jeon, H., Eck, M.J.
Deposit date:2019-08-02
Release date:2019-10-09
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
6V05
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CRYO-EM STRUCTURE OF A SUBSTRATE-ENGAGED BAM COMPLEX
Descriptor:Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ...
Authors:Tomasek, D., Rawson, S., Lee, J., Wzorek, J.S., Harrison, S.C., Li, Z., Kahne, D.
Deposit date:2019-11-18
Release date:2020-06-10
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structure of a nascent membrane protein as it folds on the BAM complex.
Nature, 583, 2020
6XR8
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DISTINCT CONFORMATIONAL STATES OF SARS-COV-2 SPIKE PROTEIN
Descriptor:Spike glycoprotein, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, J., Cai, Y.F., Xiao, T.S., Peng, H.Q., Sterling, S.M., Walsh Jr, R.M., Rawson, S., Volloch, S.R., Chen, B.
Deposit date:2020-07-11
Release date:2020-07-22
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Distinct conformational states of SARS-CoV-2 spike protein
Science, 2020
6FO0
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CRYOEM STRUCTURE OF BOVINE CYTOCHROME BC1 IN COMPLEX WITH THE ANTI-MALARIAL COMPOUND GSK932121
Descriptor:Cytochrome b-c1 complex subunit 1, mitochondrial, Cytochrome b-c1 complex subunit 2, ...
Authors:Johnson, R.M., Amporndanai, K., O'Neill, P.M., Fishwick, C.W.G., Jamson, A.H., Rawson, S.D., Hasnain, S.S., Antonyuk, S.V., Muench, S.P.
Deposit date:2018-02-05
Release date:2018-02-28
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:X-ray and cryo-EM structures of inhibitor-bound cytochromebc1complexes for structure-based drug discovery.
IUCrJ, 5, 2018
6FO2
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CRYOEM STRUCTURE OF BOVINE CYTOCHROME BC1 WITH NO LIGAND BOUND
Descriptor:Cytochrome b-c1 complex subunit 1, mitochondrial, Cytochrome b-c1 complex subunit 2, ...
Authors:Johnson, R.M., Amporndanai, K., O'Neill, P.M., Fishwick, C.W.G., Jamson, A.H., Rawson, S.D., Hasnain, S.S., Antonyuk, S.V., Muench, S.P.
Deposit date:2018-02-05
Release date:2018-02-28
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:X-ray and cryo-EM structures of inhibitor-bound cytochromebc1complexes for structure-based drug discovery.
IUCrJ, 5, 2018
6FO6
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CRYOEM STRUCTURE OF BOVINE CYTOCHROME BC1 IN COMPLEX WITH THE ANTI-MALARIAL INHIBITOR SCR0911
Descriptor:Cytochrome b-c1 complex subunit Rieske, mitochondrial, Cytochrome b-c1 complex subunit 1, ...
Authors:Johnson, R.M., Amporndanai, K., O'Neill, P.M., Fishwick, C.W.G., Jamson, A.H., Rawson, S.D., Hasnain, S.S., Antonyuk, S.V., Muench, S.P.
Deposit date:2018-02-06
Release date:2018-02-28
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:X-ray and cryo-EM structures of inhibitor-bound cytochromebc1complexes for structure-based drug discovery.
IUCrJ, 5, 2018
4O1M
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TOXOPLASMA GONDII ENOYL ACYL CARRIER PROTEIN REDUCTASE
Descriptor:Enoyl-acyl carrier reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Muench, S.P., Wilkinson, C., Prigge, S.T., Rice, D.W.
Deposit date:2013-12-16
Release date:2014-02-05
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target
Bioorg.Med.Chem.Lett., 24, 2014
6R4L
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CRYSTAL STRUCTURE OF S. CEREVISIA NIEMANN-PICK TYPE C PROTEIN NCR1
Descriptor:NPC intracellular cholesterol transporter 1-related protein 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ERGOSTEROL, ...
Authors:Winkler, M.B.L., Kidmose, R.T., Pedersen, B.P.
Deposit date:2019-03-22
Release date:2019-09-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.
Cell, 179, 2019
6R4M
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CRYSTAL STRUCTURE OF S. CEREVISIA NIEMANN-PICK TYPE C PROTEIN NPC2
Descriptor:Phosphatidylglycerol/phosphatidylinositol transfer protein, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Winkler, M.B.L., Kidmose, R.T., Pedersen, B.P.
Deposit date:2019-03-22
Release date:2019-09-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.
Cell, 179, 2019
6R4N
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CRYSTAL STRUCTURE OF S. CEREVISIA NIEMANN-PICK TYPE C PROTEIN NPC2 WITH ERGOSTEROL BOUND
Descriptor:Phosphatidylglycerol/phosphatidylinositol transfer protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Winkler, M.B.L., Kidmose, R.T., Pedersen, B.P.
Deposit date:2019-03-22
Release date:2019-09-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.
Cell, 179, 2019
5OKD
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CRYSTAL STRUCTURE OF BOVINE CYTOCHROME BC1 IN COMPLEX WITH INHIBITOR SCR0911.
Descriptor:Cytochrome b-c1 complex subunit 1, mitochondrial, Cytochrome b-c1 complex subunit 2, ...
Authors:Amporndanai, K., O'Neill, P.M., Hasnain, S.S., Antonyuk, S.V.
Deposit date:2017-07-25
Release date:2018-02-28
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:X-ray and cryo-EM structures of inhibitor-bound cytochromebc1complexes for structure-based drug discovery.
IUCrJ, 5, 2018
6PP9
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CRYSTAL STRUCTURE OF BRAF:MEK1 COMPLEX
Descriptor:Serine/threonine-protein kinase B-raf, Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Li, K., Gonzalez Del-Pino, G., Park, E., Eck, M.J.
Deposit date:2019-07-05
Release date:2019-10-09
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
6SLI
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STRUCTURE OF THE RAGAB PEPTIDE TRANSPORTER
Descriptor:Lipoprotein RagB, RagA protein, ALA-SER-THR-THR-GLY-GLY-ASN-SER-GLN-ARG-GLY-SER-GLY, ...
Authors:Madej, M., Ranson, N.A., White, J.B.R.
Deposit date:2019-08-19
Release date:2020-05-20
Last modified:2020-08-05
Method:X-RAY DIFFRACTION (3.38 Å)
Cite:Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis.
Nat Microbiol, 5, 2020
6SLJ
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STRUCTURE OF THE RAGAB PEPTIDE TRANSPORTER
Descriptor:RagA protein, Lipoprotein RagB, ALA-SER-THR-THR-GLY-ALA-ASN-SER-GLN-ARG-GLY-SER-GLY, ...
Authors:Madej, M., Ranson, N.A., White, J.B.R.
Deposit date:2019-08-20
Release date:2020-05-20
Last modified:2020-08-05
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis.
Nat Microbiol, 5, 2020
6SLN
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STRUCTURE OF THE RAGAB PEPTIDE TRANSPORTER
Descriptor:RagA protein, Lipoprotein RagB, GLN-THR-ALA-GLY-ALA-ASN-SER-GLN-ARG-GLY-SER-ALA-GLY, ...
Authors:Madej, M., Ranson, N.A., White, J.B.R.
Deposit date:2019-08-20
Release date:2020-05-20
Last modified:2020-08-05
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis.
Nat Microbiol, 5, 2020
6SM3
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STRUCTURE OF THE RAGAB PEPTIDE IMPORTER IN THE 'CLOSED-CLOSED' STATE
Descriptor:Lipoprotein RagB, RagA protein, GLY-GLY-ALA-THR-THR-ALA-THR-THR-THR-THR-SER-THR-SER, ...
Authors:White, J.B.R., Ranson, N.A., van den Berg, B.
Deposit date:2019-08-21
Release date:2020-05-20
Last modified:2020-08-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis.
Nat Microbiol, 5, 2020
6SML
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STRUCTURE OF THE RAGAB PEPTIDE IMPORTER IN THE 'OPEN-OPEN' STATE
Descriptor:Lipoprotein RagB, RagA protein, GLY-THR-GLY-GLY-SER-THR-GLY-THR-THR-SER-ALA-GLY, ...
Authors:White, J.B.R., Ranson, N.A., van den Berg, B.
Deposit date:2019-08-22
Release date:2020-05-20
Last modified:2020-08-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis.
Nat Microbiol, 5, 2020
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167518
PDB entries from 2020-08-12