Author results

4HKQ
  • Download 4hkq
  • View 4hkq
Molmil generated image of 4hkq
XMRV REVERSE TRANSCRIPTASE IN COMPLEX WITH RNA/DNA HYBRID
Descriptor:Reverse transcriptase/ribonuclease H p80, RNA (5'-R(*AP*AP*CP*AP*GP*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*CP*AP*U)-3'), DNA (5'-D(*TP*GP*GP*AP*AP*TP*CP*A*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*TP*CP*TP*G)-3')
Authors:Nowak, E., Potrzebowski, W., Konarev, P.V., Rausch, J.W., Bona, M.K., Svergun, D.I., Bujnicki, J.M., Le Grice, S.F.J., Nowotny, M.
Deposit date:2012-10-15
Release date:2013-02-20
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid
Nucleic Acids Res., 41, 2013
3QLH
  • Download 3qlh
  • View 3qlh
Molmil generated image of 3qlh
HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH MANICOL AT THE RNASE H ACTIVE SITE AND TMC278 (RILPIVIRINE) AT THE NNRTI BINDING POCKET
Descriptor:reverse transcriptase/ribonuclease H, (2S)-5,7-dihydroxy-9-methyl-2-(prop-1-en-2-yl)-1,2,3,4-tetrahydro-6H-benzo[7]annulen-6-one, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ...
Authors:Himmel, D.M., Wojtak, K., Bauman, J.D., Arnold, E.
Deposit date:2011-02-02
Release date:2011-12-21
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Synthesis, activity, and structural analysis of novel alpha-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.
J.Med.Chem., 54, 2011
4QAG
  • Download 4qag
  • View 4qag
Molmil generated image of 4qag
STRUCTURE OF A DIHYDROXYCOUMARIN ACTIVE-SITE INHIBITOR IN COMPLEX WITH THE RNASE H DOMAIN OF HIV-1 REVERSE TRANSCRIPTASE
Descriptor:Reverse transcriptase/ribonuclease H, MANGANESE (II) ION, (7,8-dihydroxy-2-oxo-2H-chromen-4-yl)acetic acid
Authors:Himmel, D.M., Ho, W.C., Arnold, E.
Deposit date:2014-05-04
Release date:2014-06-04
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (1.712 Å)
Cite:Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure-Activity Analysis of Inhibitor Analogs.
J.Mol.Biol., 426, 2014