Author results

1EM6
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HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH GLCNAC AND CP-526,423
Descriptor:LIVER GLYCOGEN PHOSPHORYLASE, 1-N-ACETYL-BETA-D-GLUCOSAMINE, BIS[5-CHLORO-1H-INDOL-2-YL-CARBONYL-AMINOETHYL]-ETHYLENE GLYCOL, ...
Authors:Rath, V.L., Ammirati, M., Danley, D.E., Ekstrom, J.L., Hynes, T.R., Olson, T.V., Hoover, D.J.
Deposit date:2000-03-16
Release date:2000-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Human liver glycogen phosphorylase inhibitors bind at a new allosteric site.
Chem.Biol., 7, 2000
1EXV
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HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH GLCNAC AND CP-403,700
Descriptor:LIVER GLYCOGEN PHOSPHORYLASE, 1-N-ACETYL-BETA-D-GLUCOSAMINE, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Rath, V.L., Ammirati, M., Danley, D.E., Ekstrom, J.L., Hynes, T.R., Olson, T.V., Hoover, D.J.
Deposit date:2000-05-04
Release date:2000-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Human liver glycogen phosphorylase inhibitors bind at a new allosteric site.
Chem.Biol., 7, 2000
1FA9
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HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH AMP
Descriptor:GLYCOGEN PHOSPHORYLASE, LIVER FORM, ALPHA-D-GLUCOSE, ...
Authors:Rath, V.L., Ammirati, M., LeMotte, P.K., Fennell, K.F., Mansour, M.N., Danley, D.E., Hynes, T.R., Schulte, G.K., Wasilko, D.J., Pandit, J.
Deposit date:2000-07-12
Release date:2000-08-25
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core.
Mol.Cell, 6, 2000
1FC0
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HUMAN LIVER GLYCOGEN PHOSPHORYLASE COMPLEXED WITH N-ACETYL-BETA-D-GLUCOPYRANOSYLAMINE
Descriptor:GLYCOGEN PHOSPHORYLASE, LIVER FORM, 1-N-ACETYL-BETA-D-GLUCOSAMINE, ...
Authors:Rath, V.L., Ammirati, M., LeMotte, P.K., Fennell, K.F., Mansour, M.M., Danley, D.E., Hynes, T.R., Schulte, G.K., Wasilko, D.J., Pandit, J.
Deposit date:2000-07-17
Release date:2000-08-25
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core.
Mol.Cell, 6, 2000
1QTQ
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GLUTAMINYL-TRNA SYNTHETASE COMPLEXED WITH TRNA AND AN AMINO ACID ANALOG
Descriptor:RNA (TRNA GLN II ), PROTEIN (GLUTAMINYL-TRNA SYNTHETASE), SULFATE ION, ...
Authors:Rath, V.L., Silvian, L.F., Beijer, B., Sproat, B.S., Steitz, T.A.
Deposit date:1998-01-28
Release date:1998-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:How glutaminyl-tRNA synthetase selects glutamine.
Structure, 6, 1998
1YGP
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PHOSPHORYLATED FORM OF YEAST GLYCOGEN PHOSPHORYLASE WITH PHOSPHATE BOUND IN THE ACTIVE SITE.
Descriptor:YEAST GLYCOGEN PHOSPHORYLASE, PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Lin, K., Rath, V.L., Dai, S.C., Fletterick, R.J., Hwang, P.K.
Deposit date:1996-05-30
Release date:1996-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A protein phosphorylation switch at the conserved allosteric site in GP.
Science, 273, 1996
1L5Q
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HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH CAFFEINE, N-ACETYL-BETA-D-GLUCOPYRANOSYLAMINE, AND CP-403700
Descriptor:Glycogen phosphorylase, liver form, 1-N-ACETYL-BETA-D-GLUCOSAMINE, ...
Authors:Ekstrom, J.L., Pauly, T.A., Carty, M.D., Soeller, W.C., Culp, J., Danley, D.E., Hoover, D.J., Treadway, J.L., Gibbs, E.M., Fletterick, R.J., Day, Y.S.N., Myszka, D.G., Rath, V.L.
Deposit date:2002-03-07
Release date:2002-12-04
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
Chem.Biol., 9, 2002
1L5R
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HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH RIBOFLAVIN, N-ACETYL-BETA-D-GLUCOPYRANOSYLAMINE AND CP-403,700
Descriptor:glycogen phosphorylase, liver form, 1-N-ACETYL-BETA-D-GLUCOSAMINE, ...
Authors:Ekstrom, J.L., Pauly, T.A., Carty, M.D., Soeller, W.C., Culp, J., Danley, D.E., Hoover, D.J., Treadway, J.L., Gibbs, E.M., Fletterick, R.J., Day, Y.S.N., Myszka, D.G., Rath, V.L.
Deposit date:2002-03-07
Release date:2002-12-04
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
Chem.Biol., 9, 2002
1L5S
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HUMAN LIVER GLYCOGEN PHOSPHORYLASE COMPLEXED WITH URIC ACID, N-ACETYL-BETA-D-GLUCOPYRANOSYLAMINE, AND CP-403,700
Descriptor:Glycogen phosphorylase, liver form, 1-N-ACETYL-BETA-D-GLUCOSAMINE, ...
Authors:Ekstrom, J.L., Pauly, T.A., Carty, M.D., Soeller, W.C., Culp, J., Danley, D.E., Hoover, D.J., Treadway, J.L., Gibbs, E.M., Fletterick, R.J., Day, Y.S.N., Myszka, D.G., Rath, V.L.
Deposit date:2002-03-07
Release date:2002-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
Chem.Biol., 9, 2002
1L7X
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HUMAN LIVER GLYCOGEN PHOSPHORYLASE B COMPLEXED WITH CAFFEINE, N-ACETYL-BETA-D-GLUCOPYRANOSYLAMINE, AND CP-403,700
Descriptor:Glycogen phosphorylase, liver form, 1-N-ACETYL-BETA-D-GLUCOSAMINE, ...
Authors:Ekstrom, J.L., Pauly, T.A., Carty, M.D., Soeller, W.C., Culp, J., Danley, D.E., Hoover, D.J., Treadway, J.L., Gibbs, E.M., Fletterick, R.J., Day, Y.S.N., Myszka, D.G., Rath, V.L.
Deposit date:2002-03-18
Release date:2002-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
Chem.Biol., 9, 2002
1NPZ
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CRYSTAL STRUCTURES OF CATHEPSIN S INHIBITOR COMPLEXES
Descriptor:Cathepsin S, N~2~-(morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-leucinamide
Authors:Pauly, T.A., Sulea, T., Ammirati, M., Sivaraman, J., Danley, D.E., Griffor, M.C., Kamath, A.V., Wang, I.K., Laird, E.R., Seddon, A.P., Menard, R., Cygler, M., Rath, V.L.
Deposit date:2003-01-20
Release date:2003-04-15
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Specificity determinants of human cathepsin s revealed by crystal structures of complexes.
Biochemistry, 42, 2003
1NQC
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CRYSTAL STRUCTURES OF CATHEPSIN S INHIBITOR COMPLEXES
Descriptor:Cathepsin S, N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE
Authors:Pauly, T.A., Sulea, T., Ammirati, M., Sivaraman, J., Danley, D.E., Griffor, M.C., Kamath, A.V., Wang, I.K., Laird, E.R., Menard, R., Cygler, M., Rath, V.L.
Deposit date:2003-01-21
Release date:2003-04-15
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Specificity determinants of human cathepsin s revealed by crystal structures of complexes.
Biochemistry, 42, 2003
1PL6
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HUMAN SDH/NADH/INHIBITOR COMPLEX
Descriptor:Sorbitol dehydrogenase, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Pauly, T.A., Ekstrom, J.L., Beebe, D.A., Chrunyk, B., Cunningham, D., Griffor, M., Kamath, A., Lee, S.E., Madura, R., Mcguire, D., Subashi, T., Wasilko, D., Watts, P., Mylari, B.L., Oates, P.J., Adams, P.D., Rath, V.L.
Deposit date:2003-06-07
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase.
Structure, 11, 2003
1PL7
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HUMAN SORBITOL DEHYDROGENASE (APO)
Descriptor:Sorbitol dehydrogenase, ZINC ION
Authors:Pauly, T.A., Ekstrom, J.L., Beebe, D.A., Chrunyk, B., Cunningham, D., Griffor, M., Kamath, A., Lee, S.E., Madura, R., Mcguire, D., Subashi, T., Wasilko, D., Watts, P., Mylari, B.L., Oates, P.J., Adams, P.D., Rath, V.L.
Deposit date:2003-06-07
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase.
Structure, 11, 2003
1PL8
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HUMAN SDH/NAD+ COMPLEX
Descriptor:human sorbitol dehydrogenase, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Pauly, T.A., Ekstrom, J.L., Beebe, D.A., Chrunyk, B., Cunningham, D., Griffor, M., Kamath, A., Lee, S.E., Madura, R., Mcguire, D., Subashi, T., Wasilko, D., Watts, P., Mylari, B.L., Oates, P.J., Adams, P.D., Rath, V.L.
Deposit date:2003-06-07
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase.
Structure, 11, 2003
1XOI
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HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH CHLOROINDOLOYL GLYCINE AMIDE
Descriptor:Glycogen phosphorylase, liver form, 1-N-ACETYL-BETA-D-GLUCOSAMINE, ...
Authors:Wright, S.W., Rath, V.L., Gibbs, E.M., Treadway, J.L.
Deposit date:2004-10-06
Release date:2005-04-12
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.
Bioorg.Med.Chem.Lett., 15, 2005
1WUT
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ACYL UREAS AS HUMAN LIVER GLYCOGEN PHOSPHORYLASE INHIBITORS FOR THE TREATMENT OF TYPE 2 DIABETES
Descriptor:Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Klabunde, T., Wendt, K.U., Kadereit, D., Brachvogel, V., Burger, H.-J., Herling, A.W., Oikonomakos, N.G., Kosmopoulou, M.N., Schmoll, D., Sarubbi, E., von Roedern, E., Schonafinger, K., Defossa, E.
Deposit date:2004-12-08
Release date:2005-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs
Protein Sci., 14, 2005
2ATI
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GLYCOGEN PHOSPHORYLASE INHIBITORS
Descriptor:Glycogen phosphorylase, liver form, ALPHA-D-GLUCOSE, ...
Authors:Klabunde, T., Wendt, K.U., Kadereit, D., Brachvogel, V., Burger, H.J., Herling, A.W., Oikonomakos, N.G., Schmoll, D., Sarubbi, E., von Roedern, E., Schoenafinger, K., Defossa, E.
Deposit date:2005-08-25
Release date:2006-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes.
J.Med.Chem., 48, 2005
2C0Y
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THE CRYSTAL STRUCTURE OF A CYS25ALA MUTANT OF HUMAN PROCATHEPSIN S
Descriptor:PROCATHEPSIN S
Authors:Kaulmann, G., Palm, G.J., Schilling, K., Hilgenfeld, R., Wiederanders, B.
Deposit date:2005-09-08
Release date:2006-11-08
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Crystal Structure of a Cys25 -> Ala Mutant of Human Procathepsin S Elucidates Enzyme-Prosequence Interactions.
Protein Sci., 15, 2006