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6N9G
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CRYSTAL STRUCTURE OF RGS7-GBETA5 DIMER
Descriptor:Regulator of G-protein signaling 7, Guanine nucleotide-binding protein subunit beta-5
Authors:Patil, D.N., Rangarajan, E., Izard, T., Martemyanov, K.A.
Deposit date:2018-12-03
Release date:2019-01-09
Method:X-RAY DIFFRACTION (2.129 Å)
Cite:Structural organization of a major neuronal G protein regulator, the RGS7-G beta 5-R7BP complex.
Elife, 7, 2018
6MFS
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MOUSE TALIN1 RESIDUES 1-138 FUSED TO RESIDUES 169-400 IN COMPLEX WITH PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE (PIP2)
Descriptor:Talin-1 fusion, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, PHOSPHATE ION
Authors:Izard, T., Chinthalapudi, K., Rangarajan, E.S.
Deposit date:2018-09-12
Release date:2018-09-26
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The interaction of talin with the cell membrane is essential for integrin activation and focal adhesion formation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5U2B
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE PHENYLAMINO-SUBSTITUTED ESTROGEN, (8R,9S,13S,14S,17S)-13-METHYL-17-(PHENYLAMINO)-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-3-OL, WITHOUT A COACTIVATOR PEPTIDE
Descriptor:Estrogen receptor, (8~{R},9~{S},13~{S},14~{S},17~{S})-13-methyl-17-phenylazanyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol
Authors:Nwachukwu, J.C., Nowak, J., Carlson, K.E., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-11-30
Release date:2017-04-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.
Mol. Cell, 65, 2017
5U2D
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH OXABICYCLIC HEPTENE SULFONATE (OBHS)
Descriptor:Estrogen receptor, Nuclear receptor coactivator 2, cyclohexa-2,5-dien-1-yl (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate
Authors:Nwachukwu, J.C., Erumbi, R., Nowak, J., Carlson, K.E., Katzenellenbogen, J.A., Izard, T., Nettles, K.W.
Deposit date:2016-11-30
Release date:2017-04-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.
Mol. Cell, 65, 2017
5KR9
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH COUMESTROL
Descriptor:Estrogen receptor, NCOA2, Coumestrol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-07-07
Release date:2017-02-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5KRA
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH DDT AND DDE
Descriptor:Estrogen receptor, NCOA2, 1-[2,2-bis(chloranyl)-1-(4-chlorophenyl)ethenyl]-4-chloranyl-benzene, ...
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-07-07
Release date:2017-02-15
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5KRC
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH ZEARALENONE
Descriptor:Estrogen receptor, NCOA2, (3S,11E)-14,16-dihydroxy-3-methyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-07-07
Release date:2017-02-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5KRF
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE DYNAMIC WAY DERIVATIVE, 1A
Descriptor:Estrogen receptor, KHKILHRLLQDSSS Peptide, 4-[1-methyl-7-(trifluoromethyl)indazol-3-yl]benzene-1,3-diol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-07-07
Release date:2017-02-15
Method:X-RAY DIFFRACTION (2.193 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5KRH
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH 16-BENZYLIDENE ESTRONE
Descriptor:Estrogen receptor, NCOA2, (8~{R},9~{S},13~{S},14~{S},16~{E})-13-methyl-3-oxidanyl-16-(phenylmethylidene)-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-one
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-07-07
Release date:2017-02-15
Method:X-RAY DIFFRACTION (2.243 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5KRI
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH 16B-BENZYL 17B-ESTRADIOL
Descriptor:Estrogen receptor, NCOA2, (8~{R},9~{S},13~{S},14~{S},16~{R},17~{S})-13-methyl-16-(phenylmethyl)-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-07-07
Release date:2017-01-18
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.247 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5KRJ
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH AN A-NAPHTHYL SUBSTITUTED OBHS DERIVATIVE
Descriptor:Estrogen receptor, NCOA2, naphthalen-1-yl (1~{S},2~{R},4~{S})-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-07-07
Release date:2017-01-18
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5KRK
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH 4,4'-((5-BROMO-2,3-DIHYDRO-1H-INDEN-1-YLIDENE)METHYLENE)DIPHENOL
Descriptor:Estrogen receptor, NCOA2, 4-[(5-bromanyl-2,3-dihydroinden-1-ylidene)-(4-hydroxyphenyl)methyl]phenol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-07-07
Release date:2017-01-18
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.391 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5KRL
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE A-CD RING ESTROGEN, (1S,7AS)-5-(2-CHLORO-4-HYDROXYPHENYL)-7A-METHYL-2,3,3A,4,7,7A-HEXAHYDRO-1H-INDEN-1-OL
Descriptor:Estrogen receptor, NCOA2, (1~{S},3~{a}~{R},7~{a}~{S})-5-(2-chloranyl-4-oxidanyl-phenyl)-2,3,3~{a},4,7,7~{a}-hexahydro-1~{H}-inden-1-ol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-07-07
Release date:2017-01-18
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5KRM
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE A-CD RING ESTROGEN, (1S,7AS)-5-(2,5-DIFLUORO-4-HYDROXYPHENYL)-7A-METHYL-2,3,3A,4,7,7A-HEXAHYDRO-1H-INDEN-1-OL
Descriptor:Estrogen receptor, NCOA2, (1~{S},3~{a}~{R},7~{a}~{S})-5-[2,5-bis(fluoranyl)-4-oxidanyl-phenyl]-7~{a}-methyl-1,2,3,3~{a},4,7-hexahydroinden-1-ol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-07-07
Release date:2017-01-18
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5KRO
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE METHYL(PHENYL)AMINO-SUBSTITUTED ESTROGEN, (8R,9S,13S,14S,17S)-13-METHYL-17-(METHYL(PHENYL)AMINO)-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-3-OL
Descriptor:Estrogen receptor, NCOA2, (8~{R},9~{S},13~{S},14~{S},17~{S})-13-methyl-17-[methyl(phenyl)amino]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-07-07
Release date:2017-01-18
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLD
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE PHENYLAMINO-SUBSTITUTED ESTROGEN, (8R,9S,13S,14S,17S)-13-METHYL-17-(PHENYLAMINO)-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-3-OL
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, (8~{R},9~{S},13~{S},14~{S},17~{S})-13-methyl-17-phenylazanyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-11
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.375 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLF
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE CONSTRAINED WAY DERIVATIVE, 4-(2-(3-METHYLBUT-2-EN-1-YL)-7-(TRIFLUOROMETHYL)-2H-INDAZOL-3-YL)BENZENE-1,3-DIOL
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, 4-[2-(3-methylbut-2-en-1-yl)-7-(trifluoromethyl)-2H-indazol-3-yl]benzene-1,3-diol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-11
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLG
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH (E)-4,4''-DIHYDROXY-3'-((HYDROXYIMINIO)METHYL)-[1,1':2',1''-TERPHENYL]-4'-OLATE
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, 2~3~-[(E)-(hydroxyimino)methyl][1~1~,2~1~:2~2~,3~1~-terphenyl]-1~4~,2~4~,3~4~-triol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-11
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.228 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLL
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH (E)-2-CHLORO-4'-HYDROXY-4-((HYDROXYIMINIO)METHYL)-[1,1'-BIPHENYL]-3-OLATE
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, 2-chloro-4-[(E)-(hydroxyimino)methyl][1,1'-biphenyl]-3,4'-diol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-11
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.423 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLM
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH 4,4',4''-(THIOPHENE-2,3,5-TRIYL)TRIPHENOL
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, 4,4',4''-(thiene-2,3,5-triyl)triphenol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-11
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLO
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH A SQUARIC ACID-LINKED DIMERIC ESTROGEN
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, (14beta,17alpha)-21-(4-aminophenyl)-19-norpregna-1(10),2,4-trien-20-yne-3,17-diol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-11
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLP
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE OBHS-BSC ANALOG, 3-FLUOROPHENYL (1R,2R,4S)-5-(4-HYDROXYPHENYL)-6-(4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2-SULFONATE AND 3-METHYL-6-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-2-AMINE
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, 3-methyl-6-phenyl-3H-imidazo[4,5-b]pyridin-2-amine, ...
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-11
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLT
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH OCTANE-1,8-DIYL BIS(2,3-BIS(4-HYDROXYPHENYL)PENTANOATE)
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, 8-{[2,3-bis(4-hydroxyphenyl)pentanoyl]oxy}octyl (2R,3S)-2,3-bis(4-hydroxyphenyl)pentanoate
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLU
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH THE PEG-LINKED DIMERIC ESTROGEN, EE2-(EG)6-EE2-AMINE
Descriptor:Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2, (14beta,17alpha)-21-(4-aminophenyl)-19-norpregna-1(10),2,4-trien-20-yne-3,17-diol
Authors:Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.223 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
5TLV
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CRYSTAL STRUCTURE OF THE ER-ALPHA LIGAND-BINDING DOMAIN (Y537S) IN COMPLEX WITH 4,4'-(THIOPHENE-2,3-DIYL)BIS(3-FLUOROPHENOL)
Descriptor:Estrogen receptor, Nuclear receptor coactivator 2, 4,4'-(thiene-2,3-diyl)bis(3-fluorophenol)
Authors:Nwachukwu, J.C., Erumbi, R., Srinivasan, S., Bruno, N.E., Nowak, J., Izard, T., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
Deposit date:2016-10-12
Release date:2017-01-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.323 Å)
Cite:Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017