Author results

1AAL
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STRUCTURAL EFFECTS INDUCED BY MUTAGENESIS AFFECTED BY CRYSTAL PACKING FACTORS: THE STRUCTURE OF A 30-51 DISULFIDE MUTANT OF BASIC PANCREATIC TRYPSIN INHIBITOR
Descriptor:BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION
Authors:Eigenbrot, C., Randal, M., Kossiakoff, A.A.
Deposit date:1992-04-09
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural effects induced by mutagenesis affected by crystal packing factors: the structure of a 30-51 disulfide mutant of basic pancreatic trypsin inhibitor.
Proteins, 14, 1992
1AAP
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X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR
Descriptor:ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN
Authors:Hynes, T.R., Randal, M., Kennedy, L.A., Eigenbrot, C., Kossiakoff, A.A.
Deposit date:1990-09-14
Release date:1991-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
Biochemistry, 29, 1990
1BPT
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CREVICE-FORMING MUTANTS OF BPTI: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A
Descriptor:BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION
Authors:Housset, D., Wlodawer, A., Tao, F., Fuchs, J., Woodward, C.
Deposit date:1991-12-11
Release date:1993-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crevice-forming mutants in the rigid core of bovine pancreatic trypsin inhibitor: crystal structures of F22A, Y23A, N43G, and F45A.
Protein Sci., 2, 1993
1BRC
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RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN
Descriptor:TRYPSIN, AMYLOID BETA-PROTEIN PRECURSOR INHIBITOR DOMAIN (APPI)
Authors:Perona, J.J., Fletterick, R.J.
Deposit date:1992-12-17
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Relocating a negative charge in the binding pocket of trypsin.
J.Mol.Biol., 230, 1993
1BTI
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CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A
Descriptor:BOVINE PANCREATIC TRYPSIN INHIBITOR
Authors:Housset, D., Tao, F., Kim, K.-S., Fuchs, J., Woodward, C., Wlodawer, A.
Deposit date:1991-07-11
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crevice-forming mutants in the rigid core of bovine pancreatic trypsin inhibitor: crystal structures of F22A, Y23A, N43G, and F45A.
Protein Sci., 2, 1993
1CA0
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BOVINE CHYMOTRYPSIN COMPLEXED TO APPI
Descriptor:BOVINE CHYMOTRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR
Authors:Scheidig, A.J., Kossiakoff, A.A.
Deposit date:1997-01-23
Release date:1997-07-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
1CBW
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BOVINE CHYMOTRYPSIN COMPLEXED TO BPTI
Descriptor:BOVINE CHYMOTRYPSIN, BPTI, SULFATE ION
Authors:Hynes, T.R., Scheidig, A.J., Kossiakoff, A.A.
Deposit date:1996-12-22
Release date:1997-07-23
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
1D9C
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BOVINE INTERFERON-GAMMA AT 2.0 ANGSTROMS
Descriptor:INTERFERON-GAMMA
Authors:Randal, M., Kossiakoff, A.A.
Deposit date:1999-10-27
Release date:1999-11-10
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species.
Acta Crystallogr.,Sect.D, 56, 2000
1D9G
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BOVINE INTERFERON-GAMMA AT 2.9 ANGSTROMS
Descriptor:INTERFERON-GAMMA
Authors:Randal, M., Kossiakoff, A.A.
Deposit date:1999-10-27
Release date:1999-11-10
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species.
Acta Crystallogr.,Sect.D, 56, 2000
1F4B
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI THYMIDYLATE SYNTHASE
Descriptor:THYMIDYLATE SYNTHASE, SULFATE ION, GLYCEROL
Authors:Erlanson, D.A., Braisted, A.C., Raphael, D.R., Randal, M., Stroud, R.M., Gordon, E., Wells, J.A.
Deposit date:2000-06-07
Release date:2000-06-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Site-directed ligand discovery.
Proc.Natl.Acad.Sci.USA, 97, 2000
1F4C
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CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COVALENTLY MODIFIED AT C146 WITH N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL
Descriptor:THYMIDYLATE SYNTHASE, SULFATE ION, N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL, ...
Authors:Erlanson, D.A., Braisted, A.C., Raphael, D.R., Randal, M., Stroud, R.M., Gordon, E., Wells, J.A.
Deposit date:2000-06-07
Release date:2000-06-22
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Site-directed ligand discovery.
Proc.Natl.Acad.Sci.USA, 97, 2000
1F4D
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CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE C146S, L143C COVALENTLY MODIFIED AT C143 WITH N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL
Descriptor:THYMIDYLATE SYNTHASE, SULFATE ION, N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL, ...
Authors:Erlanson, D.A., Braisted, A.C., Raphael, D.R., Randal, M., Stroud, R.M., Gordon, E., Wells, J.A.
Deposit date:2000-06-07
Release date:2000-06-22
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Site-directed ligand discovery.
Proc.Natl.Acad.Sci.USA, 97, 2000
1F4E
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CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH TOSYL-D-PROLINE
Descriptor:THYMIDYLATE SYNTHASE, SULFATE ION, TOSYL-D-PROLINE, ...
Authors:Erlanson, D.A., Braisted, A.C., Raphael, D.R., Randal, M., Stroud, R.M., Gordon, E., Wells, J.A.
Deposit date:2000-06-07
Release date:2000-06-22
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Site-directed ligand discovery.
Proc.Natl.Acad.Sci.USA, 97, 2000
1F4F
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CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH SP-722
Descriptor:THYMIDYLATE SYNTHASE, SULFATE ION, 4-[[GLUTAMIC ACID]-CARBONYL]-BENZENE-SULFONYL-D-PROLINE
Authors:Erlanson, D.A., Braisted, A.C., Raphael, D.R., Randal, M., Stroud, R.M., Gordon, E., Wells, J.A.
Deposit date:2000-06-07
Release date:2000-06-22
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Site-directed ligand discovery.
Proc.Natl.Acad.Sci.USA, 97, 2000
1F4G
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CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH SP-876
Descriptor:THYMIDYLATE SYNTHASE, SULFATE ION, N-[4-[[GLUTAMIC ACID]-CARBONYL]-BENZENE-SULFONYL-D-PROLINYL]-3-AMINO-PROPANOIC ACID, ...
Authors:Erlanson, D.A., Braisted, A.C., Raphael, D.R., Randal, M., Stroud, R.M., Gordon, E., Wells, J.A.
Deposit date:2000-06-07
Release date:2000-06-22
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Site-directed ligand discovery.
Proc.Natl.Acad.Sci.USA, 97, 2000
1FAN
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CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A
Descriptor:BOVINE PANCREATIC TRYPSIN INHIBITOR
Authors:Danishefsky, A.T., Wlodawer, A., Kim, K.-S., Tao, F., Woodward, C.
Deposit date:1992-08-21
Release date:1993-10-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crevice-forming mutants in the rigid core of bovine pancreatic trypsin inhibitor: crystal structures of F22A, Y23A, N43G, and F45A.
Protein Sci., 2, 1993
1FVC
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X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING
Descriptor:IGG1-KAPPA 4D5 FV (LIGHT CHAIN), IGG1-KAPPA 4D5 FV (HEAVY CHAIN)
Authors:Eigenbrot, C., Randal, M., Kossiakoff, A.A., Presta, L.
Deposit date:1992-10-20
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
J.Mol.Biol., 229, 1993
1FVD
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X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING
Descriptor:IGG1-KAPPA 4D5 FAB (LIGHT CHAIN), IGG1-KAPPA 4D5 FAB (HEAVY CHAIN)
Authors:Eigenbrot, C., Presta, L., Randal, M., Kossiakoff, A.A.
Deposit date:1992-10-20
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
J.Mol.Biol., 229, 1993
1FVE
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X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING
Descriptor:IGG1-KAPPA 4D5 FAB (LIGHT CHAIN), IGG1-KAPPA 4D5 FAB (HEAVY CHAIN)
Authors:Eigenbrot, C., Randal, M., Presta, L., Kossiakoff, A.A.
Deposit date:1992-10-20
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
J.Mol.Biol., 229, 1993
1FYH
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1:1 COMPLEX BETWEEN AN INTERFERON GAMMA SINGLE-CHAIN VARIANT AND ITS RECEPTOR
Descriptor:Interferon gamma, Interferon gamma receptor 1, CHLORIDE ION
Authors:Randal, M., Kossiakoff, A.A.
Deposit date:2000-09-29
Release date:2000-10-11
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex.
Structure, 9, 2001
1M47
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CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-2
Descriptor:interleukin-2, SULFATE ION
Authors:Arkin, M.A., Randal, M., DeLano, W.L., Hyde, J., Luong, T.N., Oslob, J.D., Raphael, D.R., Taylor, L., Wang, J., Wells, J.A., McDowell, R.S., Wells, J.A., Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface.
Proc.Natl.Acad.Sci.USA, 100, 2003
1M48
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CRYSTAL STRUCTURE OF HUMAN IL-2 COMPLEXED WITH (R)-N-[2-[1-(AMINOIMINOMETHYL)-3-PIPERIDINYL]-1-OXOETHYL]-4-(PHENYLETHYNYL)-L-PHENYLALANINE METHYL ESTER
Descriptor:interleukin-2, 2-[3-METHYL-4-(N-METHYL-GUANIDINO)-BUTYRYLAMINO]-3-(4-PHENYLETHYNYL-PHENYL)-PROPIONIC ACID METHYL ESTER
Authors:Arkin, M.A., Randal, M., DeLano, W.L., Hyde, J., Luong, T.N., Oslob, J.D., Raphael, D.R., Taylor, L., Wang, J., McDowell, R.S., Wells, J.A., Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100, 2003
1M49
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CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-2 COMPLEXED WITH SP-1985
Descriptor:interleukin-2, 2-[2-(1-CARBAMIMIDOYL-PIPERIDIN-3-YL)-ACETYLAMINO]-3-{4-[2-(3-OXALYL-1H-INDOL-7-YL)ETHYL]-PHENYL}-PROPIONIC ACID METHYL ESTER
Authors:Arkin, M.A., Randal, M., DeLano, W.L., Hyde, J., Luong, T.N., Oslob, J.D., Raphael, D.R., Taylor, L., Wang, J., McDowell, R.S., Wells, J.A., Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100, 2003
1M4A
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CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-2 Y31C COVALENTLY MODIFIED AT C31 WITH (1H-INDOL-3-YL)-(2-MERCAPTO-ETHOXYIMINO)-ACETIC ACID
Descriptor:interleukin-2, (1H-INDOL-3-YL)-(2-MERCAPTO-ETHOXYIMINO)-ACETIC ACID, GLYCEROL
Authors:Arkin, M.A., Randal, M., DeLano, W.L., Hyde, J., Luong, T.N., Oslob, J.D., Raphael, D.R., Taylor, L., Wang, J., McDowell, R.S., Wells, J.A., Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100, 2003
1M4B
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CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-2 K43C COVALENTLY MODIFIED AT C43 WITH 2-[2-(2-CYCLOHEXYL-2-GUANIDINO-ACETYLAMINO)-ACETYLAMINO]-N-(3-MERCAPTO-PROPYL)-PROPIONAMIDE
Descriptor:interleukin-2, 2-[2-(2-CYCLOHEXYL-2-GUANIDINO-ACETYLAMINO)-ACETYLAMINO]-N-(3-MERCAPTO-PROPYL)-PROPIONAMIDE
Authors:Arkin, M.A., Randal, M., DeLano, W.L., Hyde, J., Luong, T.N., Oslob, J.D., Raphael, D.R., Taylor, L., Wang, J., McDowell, R.S., Wells, J.A., Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100, 2003
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