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4GHL
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BU of 4ghl by Molmil
Structural Basis for Marburg virus VP35 mediate immune evasion mechanisms
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Ramanan, P, Borek, D.M, Otwinowski, Z, Leung, D.W, Amarasinghe, G.K.
Deposit date:2012-08-07
Release date:2012-11-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural basis for Marburg virus VP35-mediated immune evasion mechanisms.
Proc.Natl.Acad.Sci.USA, 109, 2012
7N40
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BU of 7n40 by Molmil
Crystal structure of LIN9-RbAp48-LIN37, a MuvB subcomplex
Descriptor: Histone-binding protein RBBP4, Isoform 2 of Protein lin-9 homolog, Protein lin-37 homolog
Authors:Asthana, A, Ramanan, P, Tripathi, S.M, Rubin, S.M.
Deposit date:2021-06-02
Release date:2022-02-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes.
Nat Commun, 13, 2022
3L25
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BU of 3l25 by Molmil
Crystal structure of Zaire Ebola VP35 interferon inhibitory domain bound to 8 bp dsRNA
Descriptor: CHLORIDE ION, FORMIC ACID, GLYCEROL, ...
Authors:Leung, D.W, Prins, K.C, Borek, D.M, Farahbakhsh, M, Tufariello, J.M, Ramanan, P, Nix, J.C, Helgeson, L.A, Otwinowski, Z, Honzatko, R.B, Basler, C.F, Amarasinghe, G.K.
Deposit date:2009-12-14
Release date:2010-01-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35.
Nat.Struct.Mol.Biol., 17, 2010
3L28
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BU of 3l28 by Molmil
Crystal structure of Zaire Ebola VP35 interferon inhibitory domain K339A mutant
Descriptor: CHLORIDE ION, Polymerase cofactor VP35, SODIUM ION, ...
Authors:Leung, D.W, Prins, K.C, Borek, D.M, Farahbakhsh, M, Tufariello, J.M, Ramanan, P, Nix, J.C, Helgeson, L.A, Otwinowski, Z, Honzatko, R.B, Basler, C.F, Amarasinghe, G.K.
Deposit date:2009-12-14
Release date:2010-01-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35.
Nat.Struct.Mol.Biol., 17, 2010
3L29
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BU of 3l29 by Molmil
Crystal Structure of Zaire Ebola VP35 interferon inhibitory domain K319A/R322A mutant
Descriptor: CHLORIDE ION, Polymerase cofactor VP35
Authors:Leung, D.W, Ramanan, P, Borek, D.M, Amarasinghe, G.K.
Deposit date:2009-12-14
Release date:2010-02-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mutations abrogating VP35 interaction with double-stranded RNA render ebola virus avirulent in guinea pigs.
J.Virol., 84, 2010
3L27
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BU of 3l27 by Molmil
Crystal structure of Zaire Ebola VP35 interferon inhibitory domain R312A mutant
Descriptor: CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ...
Authors:Leung, D.W, Prins, K.C, Borek, D.M, Farahbakhsh, M, Tufariello, J.M, Ramanan, P, Nix, J.C, Helgeson, L.A, Otwinowski, Z, Honzatko, R.B, Basler, C.F, Amarasinghe, G.K.
Deposit date:2009-12-14
Release date:2010-01-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35.
Nat.Struct.Mol.Biol., 17, 2010
3L26
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BU of 3l26 by Molmil
Crystal structure of Zaire Ebola VP35 interferon inhibitory domain bound to 8 bp dsRNA
Descriptor: CHLORIDE ION, MAGNESIUM ION, Polymerase cofactor VP35, ...
Authors:Leung, D.W, Prins, K.C, Borek, D.M, Farahbakhsh, M, Tufariello, J.M, Ramanan, P, Nix, J.C, Helgeson, L.A, Otwinowski, Z, Honzatko, R.B, Basler, C.F, Amarasinghe, G.K.
Deposit date:2009-12-14
Release date:2010-01-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35.
Nat.Struct.Mol.Biol., 17, 2010
4YOO
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BU of 4yoo by Molmil
p107 pocket domain in complex with LIN52 P29A peptide
Descriptor: LIN52 peptide, Retinoblastoma-like protein 1,Retinoblastoma-like protein 1, SULFATE ION
Authors:Guiley, K.Z, Liban, T.J, Felthousen, J.G, Ramanan, P, Tripathi, S, Litovchick, L, Rubin, S.M.
Deposit date:2015-03-12
Release date:2015-05-13
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural mechanisms of DREAM complex assembly and regulation.
Genes Dev., 29, 2015
4YOZ
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BU of 4yoz by Molmil
p107 pocket domain in complex with HPV E7 peptide
Descriptor: HPV E7 peptide, Retinoblastoma-like protein 1,Retinoblastoma-like protein 1, SULFATE ION
Authors:Liban, T.J, Guiley, K.Z, Felthousen, J.G, Ramanan, P, Litovchick, L, Rubin, S.M.
Deposit date:2015-03-12
Release date:2015-06-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.245 Å)
Cite:Structural mechanisms of DREAM complex assembly and regulation.
Genes Dev., 29, 2015
4YOS
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BU of 4yos by Molmil
p107 pocket domain complexed with LIN52 peptide
Descriptor: 1,2-ETHANEDIOL, Protein lin-52 homolog, Retinoblastoma-like protein 1,Retinoblastoma-like protein 1, ...
Authors:Guiley, K.Z, Liban, T.J, Felthousen, J.G, Ramanan, P, Tripathi, S, Litovchick, L, Rubin, S.M.
Deposit date:2015-03-12
Release date:2015-05-27
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural mechanisms of DREAM complex assembly and regulation.
Genes Dev., 29, 2015
4IBG
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BU of 4ibg by Molmil
Ebola virus VP35 bound to small molecule
Descriptor: GLYCEROL, PHOSPHATE ION, Polymerase cofactor VP35, ...
Authors:Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K.
Deposit date:2012-12-08
Release date:2014-03-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.413 Å)
Cite:In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.
J.Mol.Biol., 426, 2014
4IBB
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BU of 4ibb by Molmil
Ebola virus VP35 bound to small molecule
Descriptor: Polymerase cofactor VP35, {4-[(5R)-3-hydroxy-2-oxo-4-(thiophen-2-ylcarbonyl)-5-(2,4,5-trimethylphenyl)-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetic acid
Authors:Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-12-08
Release date:2014-02-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.752 Å)
Cite:In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.
J.Mol.Biol., 426, 2014
4IBD
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BU of 4ibd by Molmil
Ebola virus VP35 bound to small molecule
Descriptor: 5-[(2R)-3-benzoyl-2-(4-bromothiophen-2-yl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-2-methylbenzoic acid, GLYCEROL, MAGNESIUM ION, ...
Authors:Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K.
Deposit date:2012-12-08
Release date:2014-03-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.
J.Mol.Biol., 426, 2014
4IBI
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BU of 4ibi by Molmil
Ebola virus VP35 bound to small molecule
Descriptor: 3-{(2S)-2-(7-chloro-1,3-benzodioxol-5-yl)-4-hydroxy-5-oxo-3-[3-(trifluoromethyl)benzoyl]-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid, Polymerase cofactor VP35
Authors:Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K.
Deposit date:2012-12-08
Release date:2014-03-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.473 Å)
Cite:In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.
J.Mol.Biol., 426, 2014
4IBJ
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BU of 4ibj by Molmil
Ebola virus VP35 bound to small molecule
Descriptor: 3-{(5S)-3-hydroxy-2-oxo-4-[3-(trifluoromethyl)benzoyl]-5-[3-(trifluoromethyl)phenyl]-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid, Polymerase cofactor VP35
Authors:Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K.
Deposit date:2012-12-08
Release date:2014-03-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.
J.Mol.Biol., 426, 2014
4IBF
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BU of 4ibf by Molmil
Ebola virus VP35 bound to small molecule
Descriptor: (4-{(2R)-2-(4-bromothiophen-2-yl)-3-[(5-chlorothiophen-2-yl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}phenyl)acetic acid, Polymerase cofactor VP35
Authors:Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-12-08
Release date:2014-03-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.291 Å)
Cite:In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.
J.Mol.Biol., 426, 2014
4IBE
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BU of 4ibe by Molmil
Ebola virus VP35 bound to small molecule
Descriptor: 5-[(2R)-3-benzoyl-2-(4-bromothiophen-2-yl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-2-chlorobenzoic acid, GLYCEROL, Polymerase cofactor VP35
Authors:Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-12-08
Release date:2014-03-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.
J.Mol.Biol., 426, 2014
4IBK
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BU of 4ibk by Molmil
Ebola virus VP35 bound to small molecule
Descriptor: 3-{(2S)-2-(7-chloro-1,3-benzodioxol-5-yl)-3-[(5-chlorothiophen-2-yl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K.
Deposit date:2012-12-08
Release date:2014-03-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.
J.Mol.Biol., 426, 2014
4IBC
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BU of 4ibc by Molmil
Ebola virus VP35 bound to small molecule
Descriptor: DIMETHYL SULFOXIDE, Polymerase cofactor VP35, {4-[(2R)-3-(2-chlorobenzoyl)-2-(2-chlorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetic acid
Authors:Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K.
Deposit date:2012-12-08
Release date:2014-03-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.745 Å)
Cite:In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.
J.Mol.Biol., 426, 2014
5VJ2
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BU of 5vj2 by Molmil
Structure of human respiratory syncytial virus non-structural protein 1 (NS1)
Descriptor: 1,4-DIETHYLENE DIOXIDE, CHLORIDE ION, GLYCEROL, ...
Authors:Leung, D.W, Borek, D.M, Amarasinghe, G.K.
Deposit date:2017-04-18
Release date:2017-07-12
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.
Nat Microbiol, 2, 2017
6DKU
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BU of 6dku by Molmil
Crystal structure of Myotis VP35 mutant of interferon inhibitory domain
Descriptor: VP35
Authors:Liu, H, Ginell, G.M, Keefe, L.J, Leung, D.W, Amarasinghe, G.K.
Deposit date:2018-05-30
Release date:2018-07-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes.
Cell Rep, 24, 2018

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PDB entries from 2024-03-27

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