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2AXB
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CRYSTAL STRUCTURE ANALYSIS OF A 2-O-[2-(METHOXY)ETHYL]-2-THIOTHYMIDINE MODIFIED OLIGODEOXYNUCLEOTIDE DUPLEX
Descriptor:5'-D(*GP*CP*GP*TP*AP*(S2M)P*AP*CP*GP*C)-3')
Authors:Diop-Frimpong, B., Prakash, T.P., Rajeev, K.G., Manoharan, M., Egli, M.
Deposit date:2005-09-04
Release date:2005-11-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines.
Nucleic Acids Res., 33, 2005
2G92
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CRYSTAL STRUCTURE ANALYSIS OF THE RNA DODECAMER CGC-(NF2)-AAUUAGCG, WITH AN INCORPORATED 2,4-DIFLUOROTOLUYL RESIDUE (NF2)
Descriptor:5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*AP*GP*CP*G)-3'
Authors:Egli, M., Li, F.
Deposit date:2006-03-04
Release date:2006-04-18
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide.
Acs Chem.Biol., 1, 2006
2Q1O
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CRYSTAL STRUCTURE ANALYSIS OF THE RNA DODECAMER CGC-NF2-AAUUGGCG, WITH AN INCORPORATED 2,4-DIFLUOROTOLUYL RESIDUE (NF2)
Descriptor:RNA (5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3')
Authors:Li, F., Pallan, P.S.
Deposit date:2007-05-25
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic Acids Res., 35, 2007
2Q1R
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CRYSTAL STRUCTURE ANALYSIS OF THE RNA DODECAMER CGCGAAUUAGCG, WITH A G-A MISMATCH.
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*AP*GP*CP*G)-3'), MAGNESIUM ION
Authors:Li, F., Pallan, P.S.
Deposit date:2007-05-25
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic Acids Res., 35, 2007
3P4A
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2'FLUORO MODIFIED RNA OCTAMER FA2U2
Descriptor:2'Fluoro modified RNA 8-MER, STRONTIUM ION, MAGNESIUM ION
Authors:Manoharan, M., Akinc, A., Pandey, R.K., Qin, J., Hadwiger, P., John, M., Mills, K., Charisse, K., Maier, M.A., Nechev, L., Greene, E.M., Pallan, P.S., Rozners, E., Rajeev, K.G., Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
5D8T
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RNA OCTAMER CONTAINING (S)-5' METHYL, 2'-F U.
Descriptor:RNA oligonucleotide containing (S)-C5'-Me-2'-FU, COBALT HEXAMMINE(III)
Authors:Harp, J.M., Egli, M.
Deposit date:2015-08-17
Release date:2016-06-29
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J.Org.Chem., 81, 2016
5DEK
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RNA OCTAMER CONTAINING DT
Descriptor:RNA oligonucleotide containing dT, COBALT HEXAMMINE(III)
Authors:Harp, J.M., Egli, M.
Deposit date:2015-08-25
Release date:2016-07-20
Method:X-RAY DIFFRACTION (1.993 Å)
Cite:Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J.Org.Chem., 81, 2016
5DER
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RNA OLIGONUCLEOTIDE CONTAINING (R)-C5'-ME-2'F U
Descriptor:RNA oligonucleotide containing (R)-C5'-Me-2'-FU
Authors:Harp, J.M., Egli, M.
Deposit date:2015-08-25
Release date:2016-06-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J.Org.Chem., 81, 2016
5V1K
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STRUCTURE OF R-GNA DODECAMER
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*(5BU)P*(8RJ)P*AP*GP*CP*G)-3')
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-02
Release date:2017-06-21
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 2017
5V1L
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STRUCTURE OF S-GNA DODECAMER
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3'), STRONTIUM ION, SPERMINE
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-02
Release date:2017-06-14
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
5V2H
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RNA OCTAMER CONTAINING GLYCOL NUCLEIC ACID, SGNT
Descriptor:RNA (5'-R(*(CBV)P*GP*AP*AP*(ZTH)P*UP*CP*G)-3'), COBALT HEXAMMINE(III), MAGNESIUM ION
Authors:Harp, J.M., Egli, M.
Deposit date:2017-03-04
Release date:2017-06-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.080013 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
5VR4
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RNA OCTAMER CONTAINING 2'-F-4'-OME U.
Descriptor:RNA (5'-R(*CP*GP*AP*AP*(UMO)P*UP*CP*G)-3'), COBALT TETRAAMMINE ION
Authors:Harp, J.M., Egli, M.
Deposit date:2017-05-10
Release date:2017-10-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.
J. Am. Chem. Soc., 139, 2017
6CXZ
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RNA OCTAMER CONTAINING 2'-F, 4'-CALPHA-ME U.
Descriptor:RNA (5'-R(*CP*GP*AP*AP*(U4M)P*UP*CP*G)-3'), CACODYLATE ION, COBALT HEXAMMINE(III)
Authors:Harp, J.M., Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY0
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RNA OCTAMER CONTAINING 2'-F, 4'-CBETA-OME U.
Descriptor:RNA (5'-R(*(CBV)P*GP*AP*AP*(UFB)P*UP*CP*G)-3')
Authors:Harp, J.M., Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY2
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RNA OCTAMER CONTAINING 2'-OME, 4'CALPHA-OME U.
Descriptor:RNA (5'-R(*(CBV)P*GP*AP*AP*(UOA)P*UP*CP*G)-3')
Authors:Harp, J.M., Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY4
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RNA OCTAMER CONTAINING 2'-OME, 4'- CBETA-OME U.
Descriptor:RNA (5'-R(*(CBV)P*GP*AP*AP*(UOB)P*UP*CP*G)-3')
Authors:Harp, J.M., Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018