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GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PENTAPEPTIDE
Descriptor:	EPIDERMAL GROWTH FACTOR RECEPTOR-DERIVED PEPTIDE, GROWTH FACTOR RECEPTOR BINDING PROTEIN, ZINC ION
Authors:	Rahuel, J.
Deposit date:	1998-03-26
Release date:	1999-03-30
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands. J.Mol.Biol., 279, 1998

1TZE

SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2)
Descriptor:	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2
Authors:	Rahuel, J, Grutter, M.G.
Deposit date:	1996-06-06
Release date:	1997-07-07
Last modified:	2011-11-16
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode. Nat.Struct.Biol., 3, 1996

2V12

Crystal Structure of Renin with Inhibitor 8
Descriptor:	N-[(2S,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-7-METHYL-2-(1-METHYLETHYL)-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE, RENIN
Authors:	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
Deposit date:	2007-05-21
Release date:	2007-07-03
Last modified:	2019-04-03
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

2V0Z

Crystal Structure of Renin with Inhibitor 10 (Aliskiren)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, ALISKIREN, RENIN
Authors:	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
Deposit date:	2007-05-21
Release date:	2007-07-03
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

2V16

Crystal Structure of Renin with Inhibitor 3
Descriptor:	METHYL (3R)-1-[(5S,6S,8R)-5-AMINO-9-BUTYLAMINO-6-HYDROXY-3,3,8-TRIMETHYL-9-OXO-NONANOYL]-3,4-DIHYDRO-2H-QUINOLINE-3-CARBOXYLATE, RENIN
Authors:	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
Deposit date:	2007-05-22
Release date:	2008-07-08
Last modified:	2019-04-03
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

2V13

Crystal Structure of Renin with Inhibitor 7
Descriptor:	N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE, RENIN
Authors:	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
Deposit date:	2007-05-21
Release date:	2008-07-08
Last modified:	2019-04-03
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

2V11

Crystal Structure of Renin with Inhibitor 6
Descriptor:	(2S,4S,5R,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL 1-BENZYL-1H-INDOLE-3-CARBOXYLATE, RENIN
Authors:	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
Deposit date:	2007-05-21
Release date:	2007-07-03
Last modified:	2019-04-03
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

2V10

Crystal Structure of Renin with Inhibitor 9
Descriptor:	(2R,4S,5S,7S)-5-AMINO-N-BUTYL-4-HYDROXY-7-[4-METHOXY-3-(3-METHOXYPROPOXY)BENZYL]-2,8-DIMETHYLNONANAMIDE, RENIN
Authors:	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
Deposit date:	2007-05-21
Release date:	2007-07-03
Last modified:	2019-04-03
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

1CJ1

GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE
Descriptor:	PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2), [1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)- ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER
Authors:	Rahuel, J.
Deposit date:	1999-04-21
Release date:	1999-12-22
Last modified:	2023-08-02
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic. J.Med.Chem., 42, 1999

1RNE

THE CRYSTAL STRUCTURE OF RECOMBINANT GLYCOSYLATED HUMAN RENIN ALONE AND IN COMPLEX WITH A TRANSITION STATE ANALOG INHIBITOR
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, RENIN, [[[3-(2-METHYL-PROPANE-2-SULFONYL)-1-BENZENYL]-2-PROPYL]-CARBONYL-HISTIDYL]-AMINO-[CYCLOHEXYLMETHYL]-[2-HYDROXY-4-ISOPROPYL]-PENTAN-5-OIC ACID BUTYLAMIDE
Authors:	Gruetter, M.G, Rahuel, J, Priestle, J.P.
Deposit date:	1991-12-12
Release date:	1993-10-31
Last modified:	2020-10-21
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor. J.Struct.Biol., 107, 1991

2JED

The crystal structure of the kinase domain of the protein kinase C theta in complex with NVP-XAA228 at 2.32A resolution.
Descriptor:	(4S)-2-METHYL-2,4-PENTANEDIOL, 3-(8-DIMETHYLAMINOMETHYL-6,7,8,9-TETRAHYDRO-PYRIDO[1,2-A]INDOL-10-YL)-4-(1-METHYL-1H-INDOL-3-YL)-PYRROLE-2,5-DIONE, PROTEIN KINASE C THETA
Authors:	Stark, W, Bitsch, F, Berner, A, Buelens, F, Graff, P, Depersin, H, Geiser, M, Knecht, R, Rahuel, J, Rummel, G, Schlaeppi, J.M, Schmitz, R, Strauss, A, Wagner, J.
Deposit date:	2007-01-16
Release date:	2008-02-05
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (2.32 Å)
Cite:	The Crystal Structure of the Kinase Domain of the Protein Kinase C Theta in Complex with Nvp-Xaa228 To be Published

1TMT

CHANGES IN INTERACTIONS IN COMPLEXES OF HIRUDIN DERIVATIVES AND HUMAN ALPHA-THROMBIN DUE TO DIFFERENT CRYSTAL FORMS
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), ...
Authors:	Priestle, J.P, Gruetter, M.G.
Deposit date:	1994-05-26
Release date:	1994-09-30
Last modified:	2022-12-21
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms. Protein Sci., 2, 1993

1TMU

Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Hirudin variant-2, ...
Authors:	Priestle, J.P, Gruetter, M.G.
Deposit date:	1994-05-26
Release date:	1994-09-30
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms. Protein Sci., 2, 1993

1SBN

REFINED CRYSTAL STRUCTURES OF SUBTILISIN NOVO IN COMPLEX WITH WILD-TYPE AND TWO MUTANT EGLINS. COMPARISON WITH OTHER SERINE PROTEINASE INHIBITOR COMPLEXES
Descriptor:	CALCIUM ION, EGLIN C, SUBTILISIN NOVO BPN'
Authors:	Gruetter, M.G, Heinz, D.W, Priestle, J.P.
Deposit date:	1991-12-20
Release date:	1994-01-31
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Refined crystal structures of subtilisin novo in complex with wild-type and two mutant eglins. Comparison with other serine proteinase inhibitor complexes. J.Mol.Biol., 217, 1991

1SIB

REFINED CRYSTAL STRUCTURES OF SUBTILISIN NOVO IN COMPLEX WITH WILD-TYPE AND TWO MUTANT EGLINS. COMPARISON WITH OTHER SERINE PROTEINASE INHIBITOR COMPLEXES
Descriptor:	CALCIUM ION, EGLIN C, SUBTILISIN NOVO BPN'
Authors:	Gruetter, M.G, Heinz, D.W, Priestle, J.P.
Deposit date:	1993-08-02
Release date:	1993-10-31
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Refined crystal structures of subtilisin novo in complex with wild-type and two mutant eglins. Comparison with other serine proteinase inhibitor complexes. J.Mol.Biol., 217, 1991

1DWE

Crystallographic analysis at 3.0-Angstroms resolution of the binding to human thrombin of four active site-directed inhibitors
Descriptor:	ALPHA-THROMBIN heavy chain, ALPHA-THROMBIN light chain, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ...
Authors:	Banner, D.W, Hadvary, P.
Deposit date:	1992-08-19
Release date:	1994-01-31
Last modified:	2013-02-27
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1DWB

CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
Descriptor:	ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), BENZAMIDINE, ...
Authors:	Banner, D.W, Hadvary, P.
Deposit date:	1992-08-19
Release date:	1994-01-31
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (3.16 Å)
Cite:	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1DWD

CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
Descriptor:	1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimidoyl-D-phenylalanyl]piperidine, ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), ...
Authors:	Banner, D.W, Hadvary, P.
Deposit date:	1992-08-19
Release date:	1994-01-31
Last modified:	2012-12-12
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1DWC

CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
Descriptor:	ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUDIN IIIA, ...
Authors:	Banner, D.W, Hadvary, P.
Deposit date:	1992-08-19
Release date:	1994-01-31
Last modified:	2012-12-12
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1TBQ

CRYSTAL STRUCTURE OF INSECT DERIVED DOUBLE DOMAIN KAZAL INHIBITOR RHODNIIN IN COMPLEX WITH THROMBIN
Descriptor:	RHODNIIN, THROMBIN
Authors:	Van De Locht, A, Lamba, D, Bode, W.
Deposit date:	1995-03-02
Release date:	1996-10-14
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin. EMBO J., 14, 1995

1TBR

CRYSTAL STRUCTURE OF INSECT DERIVED DOUBLE DOMAIN KAZAL INHIBITOR RHODNIIN IN COMPLEX WITH THROMBIN
Descriptor:	RHODNIIN, THROMBIN
Authors:	Van De Locht, A, Lamba, D, Bode, W.
Deposit date:	1995-03-03
Release date:	1996-10-14
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin. EMBO J., 14, 1995

Total results:	21
Displayed results:	21
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