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3F89
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BU of 3f89 by Molmil
NEMO CoZi domain
Descriptor: NF-kappa-B essential modulator
Authors:Rahighi, S, Ikeda, F, Kawasaki, M, Akutsu, M, Suzuki, N, Kato, R, Kensche, T, Uejima, T, Bloor, S, Komander, D, Randow, F, Wakatsuki, S, Dikic, I.
Deposit date:2008-11-11
Release date:2009-03-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
Cell(Cambridge,Mass.), 136, 2009
4XKH
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BU of 4xkh by Molmil
CRYSTAL STRUCTURE OF THE AIRAPL TANDEM UIMS IN COMPLEX WITH A LYS48-LINKED TRI-UBIQUITIN
Descriptor: AN1-type zinc finger protein 2B, Polyubiquitin-C
Authors:Rahighi, S, Kawasaki, M, Stanhill, A, Wakatsuki, S.
Deposit date:2015-01-11
Release date:2016-02-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Selective Binding of AIRAPL Tandem UIMs to Lys48-Linked Tri-Ubiquitin Chains.
Structure, 24, 2016
7TV4
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BU of 7tv4 by Molmil
Crystal structure of NEMO CoZi in complex with HOIP NZF1 and linear diubiquitin
Descriptor: E3 ubiquitin-protein ligase RNF31, NF-kappa-B essential modulator, Polyubiquitin-C, ...
Authors:Rahighi, S, Iyer, M, Oveisi, H.
Deposit date:2022-02-03
Release date:2022-08-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural basis for the simultaneous recognition of NEMO and acceptor ubiquitin by the HOIP NZF1 domain.
Sci Rep, 12, 2022
2ZVN
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BU of 2zvn by Molmil
NEMO CoZi domain incomplex with diubiquitin in P212121 space group
Descriptor: NF-kappa-B essential modulator, UBC protein
Authors:Rahighi, S, Ikeda, F, Kawasaki, M, Akutsu, M, Suzuki, N, Kato, R, Kensche, T, Uejima, T, Bloor, S, Komander, D, Randow, F, Wakatsuki, S, Dikic, I.
Deposit date:2008-11-12
Release date:2009-03-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
Cell(Cambridge,Mass.), 136, 2009
2ZVO
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BU of 2zvo by Molmil
NEMO CoZi domain in complex with diubiquitin in C2 space group
Descriptor: NF-kappa-B essential modulator, UBC protein
Authors:Rahighi, S, Ikeda, F, Kawasaki, M, Akutsu, M, Suzuki, N, Kato, R, Kensche, T, Uejima, T, Bloor, S, Komander, D, Randow, F, Wakatsuki, S, Dikic, I.
Deposit date:2008-11-12
Release date:2009-03-24
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
Cell(Cambridge,Mass.), 136, 2009
6E08
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BU of 6e08 by Molmil
Crystal structure of G6PD in complex with structural NADP
Descriptor: GLYCEROL, Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Rahighi, S, Mochly Rosen, D, Wakatsuki, S.
Deposit date:2018-07-06
Release date:2018-07-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator.
Nat Commun, 9, 2018
6E07
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BU of 6e07 by Molmil
Crystal structure of Canton G6PD in complex with structural NADP
Descriptor: GLYCEROL, Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Rahighi, S, Mochly-Rosen, D, Wakatsuki, S.
Deposit date:2018-07-06
Release date:2018-07-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator.
Nat Commun, 9, 2018
4OWF
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BU of 4owf by Molmil
Crystal structure of the NEMO CoZi in complex with HOIP NZF1 domain
Descriptor: E3 ubiquitin-protein ligase RNF31, NF-kappa-B essential modulator, ZINC ION
Authors:Rahighi, S, Fujita, H, Kawasaki, M, Kato, R, Iwai, K, Wakatsuki, S.
Deposit date:2014-01-31
Release date:2014-02-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanism Underlying I kappa B Kinase Activation Mediated by the Linear Ubiquitin Chain Assembly Complex.
Mol.Cell.Biol., 34, 2014
6N6R
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BU of 6n6r by Molmil
Crystal structure of ABIN-1 UBAN in complex with two M1-linked di-ubiquitins
Descriptor: TNFAIP3-interacting protein 1, Ubiquitin
Authors:Rahighi, S, Dikic, I, Wakatsuki, S.
Deposit date:2018-11-27
Release date:2019-07-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains.
J.Mol.Biol., 431, 2019
6N6S
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BU of 6n6s by Molmil
Crystal structure of ABIN-1 UBAN
Descriptor: TNFAIP3-interacting protein 1
Authors:Rahighi, S, Dikic, I, Wakatsuki, S.
Deposit date:2018-11-27
Release date:2019-07-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains.
J.Mol.Biol., 431, 2019
6N5M
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BU of 6n5m by Molmil
Crystal structure of ABIN-1 UBAN in complex with one M1-linked di-ubiquitin
Descriptor: Polyubiquitin-C, TNFAIP3-interacting protein 1
Authors:Rahighi, S, Dikic, I, Wakatsuki, S.
Deposit date:2018-11-22
Release date:2019-07-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains.
J.Mol.Biol., 431, 2019
2MD9
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BU of 2md9 by Molmil
Solution Structure of an Active Site Mutant Pepitdyl Carrier Protein
Descriptor: Tyrocidine synthase 3
Authors:Tufar, P, Rahighi, S, Kraas, F.I, Kirchner, D.K, Loehr, F, Henrich, E, Koepke, J, Dikic, I, Guentert, P, Marahiel, M.A, Doetsch, V.
Deposit date:2013-09-06
Release date:2014-04-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Crystal Structure of a PCP/Sfp Complex Reveals the Structural Basis for Carrier Protein Posttranslational Modification.
Chem.Biol., 21, 2014
4MRT
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BU of 4mrt by Molmil
Structure of the Phosphopantetheine Transferase Sfp in Complex with Coenzyme A and a Peptidyl Carrier Protein
Descriptor: 4'-phosphopantetheinyl transferase sfp, COENZYME A, GLYCEROL, ...
Authors:Tufar, P, Rahighi, S, Kraas, F.I, Kirchner, D.K, Loehr, F, Henrich, E, Koepke, J, Dikic, I, Guentert, P, Marahiel, M.A, Doetsch, V.
Deposit date:2013-09-17
Release date:2014-04-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of a PCP/Sfp Complex Reveals the Structural Basis for Carrier Protein Posttranslational Modification.
Chem.Biol., 21, 2014
7MCR
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BU of 7mcr by Molmil
Human Apex/Ref1 homodimer formed under oxidative condition
Descriptor: DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial, MAGNESIUM ION
Authors:Nam, Y.W, Yang, S.
Deposit date:2021-04-02
Release date:2022-04-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Development of Novel Apurinic/Aprymidinic Endonuclease/Redox-factor 1 Inhibitors for the Treatment of Human Melanoma
To Be Published
7MEV
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BU of 7mev by Molmil
Human Apex/Ref1 monomer with C138A mutation
Descriptor: DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial, GLYCEROL, ...
Authors:Nam, Y.W, Yang, S.
Deposit date:2021-04-07
Release date:2022-04-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The Development of Novel Apurinic/Aprymidinic Endonuclease/Redox-factor 1 Inhibitors for the Treatment of Human Melanoma
To Be Published
7T2U
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BU of 7t2u by Molmil
SARS-CoV2 3C-Like protease complexed with Nemo peptide
Descriptor: 3C-Like Protease, NEMO peptide
Authors:Wakatsuki, S, Mathews, I.I, Hameedi, M.A.
Deposit date:2021-12-06
Release date:2022-09-14
Last modified:2022-09-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro.
Nat Commun, 13, 2022
7T2V
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BU of 7t2v by Molmil
SARS CoV2 Mpro C145S mutant
Descriptor: 3C-Like Protease
Authors:Mathews, I.I, Hameedi, M.A, Wakatsuki, S.
Deposit date:2021-12-06
Release date:2022-09-14
Last modified:2022-09-21
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro.
Nat Commun, 13, 2022
7T2T
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BU of 7t2t by Molmil
SARS-CoV2 Mpro native form
Descriptor: 3C-like proteinase
Authors:Mathews, I.I, Hameedi, M.A, Wakatsuki, S.
Deposit date:2021-12-06
Release date:2022-09-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro.
Nat Commun, 13, 2022
6XX0
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BU of 6xx0 by Molmil
Crystal structure of NEMO in complex with Ubv-LIN
Descriptor: Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b, ...
Authors:Akutsu, M, Skenderovic, A, Garcia-Pardo, J, Maculins, T, Dikic, I.
Deposit date:2020-01-26
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms.
Cell Chem Biol, 27, 2020
6YEK
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BU of 6yek by Molmil
Crystal structure of human NEMO apo form
Descriptor: Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b
Authors:Garcia-Pardo, J, Akutsu, M, Busse, P, Skenderovic, A, Maculins, T, Dikic, I.
Deposit date:2020-03-25
Release date:2021-03-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms.
Cell Chem Biol, 27, 2020
8OY3
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BU of 8oy3 by Molmil
Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (3 picosecond pump-probe delay)
Descriptor: COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-05-03
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023
8OY5
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BU of 8oy5 by Molmil
Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (1 nanosecond pump-probe delay)
Descriptor: COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-05-03
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023
8OYC
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BU of 8oyc by Molmil
Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (100 microsecond timpeoint)
Descriptor: COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-05-03
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023
8OYA
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BU of 8oya by Molmil
Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (10 microsecond pump probe delay)
Descriptor: COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-05-03
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023
8OET
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BU of 8oet by Molmil
SFX structure of the class II photolyase complexed with a thymine dimer
Descriptor: DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, DNA (14-mer), Deoxyribodipyrimidine photo-lyase, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-03-12
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023

 

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