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2QIV
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BU of 2qiv by Molmil
Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase
Descriptor: UDP-N-acetylglucosamine acyltransferase, uridine-5'-diphosphate-3-O-(R-3-hydroxydecanoyl)-N-acetyl-D-glucosamine
Authors:Williams, A.H, Raetz, C.R.H.
Deposit date:2007-07-05
Release date:2007-10-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase
Proc.Natl.Acad.Sci.Usa, 104, 2007
2QIA
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BU of 2qia by Molmil
Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine Acyltransferase
Descriptor: UDP-N-acetylglucosamine acyltransferase, uridine-5'-diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetyl-D-glucosamine
Authors:Williams, A.H, Raetz, C.R.H.
Deposit date:2007-07-03
Release date:2007-10-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase
Proc.Natl.Acad.Sci.Usa, 104, 2007
1XXE
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BU of 1xxe by Molmil
RDC refined solution structure of the AaLpxC/TU-514 complex
Descriptor: 1,5-ANHYDRO-2-C-(CARBOXYMETHYL-N-HYDROXYAMIDE)-2-DEOXY-3-O-MYRISTOYL-D-GLUCITOL, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION
Authors:Coggins, B.E, McClerren, A.L, Jiang, L, Li, X, Rudolph, J, Hindsgaul, O, Raetz, C.R.H, Zhou, P.
Deposit date:2004-11-04
Release date:2004-11-23
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Refined Solution Structure of the LpxC-TU-514 Complex and pK(a) Analysis of an Active Site Histidine: Insights into the Mechanism and Inhibitor Design
Biochemistry, 44, 2005
1MM5
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BU of 1mm5 by Molmil
Solution NMR structure of the outer membrane enzyme PagP in OG micelles
Descriptor: CrcA protein
Authors:Hwang, P.M, Choy, W.-Y, Lo, E.I, Chen, L, Forman-Kay, J.D, Raetz, C.R.H, Prive, G.G, Bishop, R.E, Kay, L.E.
Deposit date:2002-09-03
Release date:2002-09-13
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution Structure and Dynamics of the Outer Membrane Enzyme PagP by NMR
Proc.Natl.Acad.Sci.USA, 99, 2002
1MM4
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BU of 1mm4 by Molmil
Solution NMR structure of the outer membrane enzyme PagP in DPC micelles
Descriptor: CrcA protein
Authors:Hwang, P.M, Choy, W.-Y, Lo, E.I, Chen, L, Forman-Kay, J.D, Raetz, C.R.H, Prive, G.G, Bishop, R.E, Kay, L.E.
Deposit date:2002-09-03
Release date:2002-09-13
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution Structure and Dynamics of the Outer Membrane Enzyme PagP by NMR
Proc.Natl.Acad.Sci.USA, 99, 2002
1YUC
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BU of 1yuc by Molmil
Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, Bound to Phospholipid and a Fragment of Human SHP
Descriptor: GLYCEROL, L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE, Nuclear receptor 0B2, ...
Authors:Ortlund, E.A, Yoonkwang, L, Solomon, I.H, Hager, J.M, Safi, R, Choi, Y, Guan, Z, Tripathy, A, Raetz, C.R.H, McDonnell, D.P, Moore, D.D, Redinbo, M.R.
Deposit date:2005-02-13
Release date:2005-03-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP
Nat.Struct.Mol.Biol., 12, 2005
2BLN
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BU of 2bln by Molmil
N-terminal formyltransferase domain of ArnA in complex with N-5- formyltetrahydrofolate and UMP
Descriptor: ACETATE ION, N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid, PROTEIN YFBG, ...
Authors:Williams, G.J, Breazeale, S.D, Raetz, C.R.H, Naismith, J.H.
Deposit date:2005-03-07
Release date:2005-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure and Function of Both Domains of Arna, a Dual Function Decarboxylase and a Formyltransferase, Involved in 4-Amino-4-Deoxy-L-Arabinose Biosynthesis.
J.Biol.Chem., 280, 2005
2BLL
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BU of 2bll by Molmil
Apo-structure of the C-terminal decarboxylase domain of ArnA
Descriptor: PROTEIN YFBG
Authors:Williams, G.J, Breazeale, S.D, Raetz, C.R.H, Naismith, J.H.
Deposit date:2005-03-07
Release date:2005-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and Function of Both Domains of Arna, a Dual Function Decarboxylase and a Formyltransferase, Involved in 4-Amino-4-Deoxy-L- Arabinose Biosynthesis.
J.Biol.Chem., 280, 2005
4J6E
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BU of 4j6e by Molmil
Structure of LPXI D225A Mutant
Descriptor: (2R,3R,4R,5S,6R)-2-{[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)-3-{[(3R)-3-hydroxytetradecanoyl]amino}tetrahydro-2H-pyran-4-yl (3R)-3-hydroxytetradecanoate, UDP-2,3-diacylglucosamine pyrophosphatase LpxI
Authors:Metzger IV, L.E, Lee, J.K, Finer-Moore, J.S, Raetz, C.R.H, Stroud, R.M, Center for Structures of Membrane Proteins (CSMP)
Deposit date:2013-02-11
Release date:2013-05-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:LpxI structures reveal how a lipid A precursor is synthesized.
Nat.Struct.Mol.Biol., 19, 2012
3T57
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BU of 3t57 by Molmil
Activity and Crystal Structure of Arabidopsis UDP-N-acetylglucosamine acyltransferase
Descriptor: UDP-N-acetylglucosamine O-acyltransferase domain-containing protein
Authors:Raetz, C.R.H, Joo, S.H.
Deposit date:2011-07-26
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Activity and Crystal Structure of Arabidopsis thalianaUDP-N-Acetylglucosamine Acyltransferase.
Biochemistry, 51, 2012
8T0J
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BU of 8t0j by Molmil
Salmonella Typhimurium ArnD
Descriptor: Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD
Authors:Sousa, M.C, Munoz-Escudero, D, Lee, M.
Deposit date:2023-06-01
Release date:2023-10-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structure and Function of ArnD. A Deformylase Essential for Lipid A Modification with 4-Amino-4-deoxy-l-arabinose and Polymyxin Resistance.
Biochemistry, 62, 2023
6HY2
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BU of 6hy2 by Molmil
Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase
Descriptor: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, TRP-MET-LEU-ASP-PRO-ILE-ALA-GLY-LYS-TRP-SER-ARG
Authors:Williams, A.H, Dangkulwanich, M.
Deposit date:2018-10-19
Release date:2019-01-23
Last modified:2022-03-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase.
Sci Rep, 9, 2019
2JT2
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BU of 2jt2 by Molmil
Solution Structure of the Aquifex aeolicus LpxC- CHIR-090 complex
Descriptor: N-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION
Authors:Barb, A.W, Jiang, L, Raetz, C.R.H, Zhou, P.
Deposit date:2007-07-18
Release date:2007-12-04
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding
Proc.Natl.Acad.Sci.Usa, 104, 2007
4EHY
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BU of 4ehy by Molmil
Crystal structure of LpxK from Aquifex aeolicus in complex with ADP/Mg2+ at 2.2 angstrom resolution
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, GLYCEROL, ...
Authors:Emptage, R.P, Daughtry, K.D, Pemble IV, C.W, Raetz, C.R.H.
Deposit date:2012-04-04
Release date:2012-08-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface.
Proc.Natl.Acad.Sci.USA, 109, 2012
4EHX
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BU of 4ehx by Molmil
Crystal structure of LpxK from Aquifex aeolicus at 1.9 angstrom resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ...
Authors:Emptage, R.P, Daughtry, K.D, Pemble IV, C.W, Raetz, C.R.H.
Deposit date:2012-04-04
Release date:2012-08-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface.
Proc.Natl.Acad.Sci.USA, 109, 2012
4EHW
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BU of 4ehw by Molmil
Crystal structure of LpxK from Aquifex aeolicus at 2.3 angstrom resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, Tetraacyldisaccharide 4'-kinase
Authors:Emptage, R.P, Daughtry, K.D, Pemble IV, C.W, Raetz, C.R.H.
Deposit date:2012-04-04
Release date:2012-08-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface.
Proc.Natl.Acad.Sci.USA, 109, 2012
1LXA
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BU of 1lxa by Molmil
UDP N-ACETYLGLUCOSAMINE ACYLTRANSFERASE
Descriptor: UDP N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE
Authors:Roderick, S.L.
Deposit date:1995-10-07
Release date:1995-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A left-handed parallel beta helix in the structure of UDP-N-acetylglucosamine acyltransferase.
Science, 270, 1995
5YKA
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BU of 5yka by Molmil
Crystal structure of the Kdo hydroxylase KdoO, a non-heme Fe(II) alphaketoglutarate dependent dioxygenase in complex with cobalt(II)
Descriptor: ACETATE ION, CHLORIDE ION, COBALT (II) ION, ...
Authors:Chung, H.S, Pemble, C.W, Joo, S.H, Raetz, C.R.
Deposit date:2017-10-12
Release date:2018-09-05
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.448 Å)
Cite:Biochemical and Structural Insights into an Fe(II)/ alpha-Ketoglutarate/O2-Dependent Dioxygenase, Kdo 3-Hydroxylase (KdoO).
J. Mol. Biol., 430, 2018
5YVZ
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BU of 5yvz by Molmil
Crystal structure of the Kdo hydroxylase KdoO, a non-heme Fe(II) alphaketoglutarate dependent dioxygenase in complex with alphaketoglutarate and Fe(III)
Descriptor: 2-OXOGLUTARIC ACID, ACETATE ION, FE (III) ION, ...
Authors:Chung, H.S, Pemble, C.W, Joo, S.H, Raetz, C.R.
Deposit date:2017-11-28
Release date:2018-09-05
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Biochemical and Structural Insights into an Fe(II)/ alpha-Ketoglutarate/O2-Dependent Dioxygenase, Kdo 3-Hydroxylase (KdoO).
J. Mol. Biol., 430, 2018
5YW0
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BU of 5yw0 by Molmil
Crystal structure of the Kdo hydroxylase KdoO, a non-heme Fe(II) alphaketoglutarate dependent dioxygenase in complex with succinate and Fe(III)
Descriptor: ACETATE ION, FE (III) ION, GLYCEROL, ...
Authors:Chung, H.S, Pemble, C.W, Joo, S.H, Raetz, C.R.
Deposit date:2017-11-28
Release date:2018-09-05
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Biochemical and Structural Insights into an Fe(II)/ alpha-Ketoglutarate/O2-Dependent Dioxygenase, Kdo 3-Hydroxylase (KdoO).
J. Mol. Biol., 430, 2018
3FID
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BU of 3fid by Molmil
LpxR from Salmonella typhimurium
Descriptor: GLYCEROL, PENTAETHYLENE GLYCOL MONODECYL ETHER, Putative outer membrane protein (LpxR), ...
Authors:Rutten, L, Gros, P.
Deposit date:2008-12-11
Release date:2009-02-10
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Active-site architecture and catalytic mechanism of the lipid A deacylase LpxR of Salmonella typhimurium
Proc.Natl.Acad.Sci.USA, 106, 2009
3EH0
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BU of 3eh0 by Molmil
Crystal Structure of LpxD from Escherichia coli
Descriptor: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
Authors:Bartling, C.M, Raetz, C.R.H.
Deposit date:2008-09-11
Release date:2009-08-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure and acyl chain selectivity of Escherichia coli LpxD, the N-acyltransferase of lipid A biosynthesis
Biochemistry, 48, 2009
5F42
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BU of 5f42 by Molmil
Activity and Crystal Structure of Francisella novicida UDP-N-Acetylglucosamine Acyltransferase
Descriptor: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Authors:Joo, S.H, Raetz, C.R.H.
Deposit date:2015-12-03
Release date:2016-10-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal structure and activity of Francisella novicida UDP-N-acetylglucosamine acyltransferase
Biochem.Biophys.Res.Commun., 478, 2016
6A2E
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BU of 6a2e by Molmil
Apo structure of the Kdo hydroxylase KdoO, a non-heme Fe(II) alphaketoglutarate dependent dioxygenase
Descriptor: ACETATE ION, Kdo hydroxylase, KdoO, ...
Authors:Chung, H.S, Pemble, C.W, Joo, S.H.
Deposit date:2018-06-11
Release date:2018-09-05
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.939 Å)
Cite:Biochemical and Structural Insights into an Fe(II)/ alpha-Ketoglutarate/O2-Dependent Dioxygenase, Kdo 3-Hydroxylase (KdoO).
J. Mol. Biol., 430, 2018
4IHF
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BU of 4ihf by Molmil
Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production
Descriptor: Acyl carrier protein, CHLORIDE ION, S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] (3R)-3-hydroxytetradecanethioate, ...
Authors:Masoudi, A, Raetz, C.R.H, Pemble, C.W.
Deposit date:2012-12-18
Release date:2013-11-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Chasing acyl carrier protein through a catalytic cycle of lipid A production.
Nature, 505, 2014

 

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