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1B5L
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BU of 1b5l by Molmil
OVINE INTERFERON TAU
Descriptor: INTERFERON TAU, SULFATE ION
Authors:Radhakrishnan, R, Walter, L.J, Subramaniam, P.S, Johnson, H.J, Walter, M.R.
Deposit date:1999-01-07
Release date:1999-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of ovine interferon-tau at 2.1 A resolution.
J.Mol.Biol., 286, 1999
9EST
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BU of 9est by Molmil
STRUCTURAL STUDY OF PORCINE PANCREATIC ELASTASE COMPLEXED WITH 7-AMINO-3-(2-BROMOETHOXY)-4-CHLOROISOCOUMARIN AS A NONREACTIVATABLE DOUBLY COVALENT ENZYME-INHIBITOR COMPLEX
Descriptor: (2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATE, CALCIUM ION, PORCINE PANCREATIC ELASTASE, ...
Authors:Radhakrishnan, R, Powers, J.C, Meyer Jr, E.F.
Deposit date:1991-01-14
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural study of porcine pancreatic elastase complexed with 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin as a nonreactivatable doubly covalent enzyme-inhibitor complex.
Biochemistry, 30, 1991
8EST
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BU of 8est by Molmil
REACTION OF PORCINE PANCREATIC ELASTASE WITH 7-SUBSTITUTED 3-ALKOXY-4-CHLOROISOCOUMARINS: DESIGN OF POTENT INHIBITORS USING THE CRYSTAL STRUCTURE OF THE COMPLEX FORMED WITH 4-CHLORO-3-ETHOXY-7-GUANIDINO-ISOCOUMARIN
Descriptor: CALCIUM ION, ETHYL-(2-CARBOXY-4-GUANIDINIUM-PHENYL)-CHLOROACETATE, PORCINE PANCREATIC ELASTASE, ...
Authors:Radhakrishnan, R, Powers, J.C, Meyerjunior, E.F.
Deposit date:1990-02-21
Release date:1992-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin.
Biochemistry, 29, 1990
4EST
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BU of 4est by Molmil
CRYSTAL STRUCTURE OF THE COVALENT COMPLEX FORMED BY A PEPTIDYL ALPHA,ALPHA-DIFLUORO-BETA-KETO AMIDE WITH PORCINE PANCREATIC ELASTASE AT 1.78-ANGSTROMS RESOLUTION
Descriptor: CALCIUM ION, ELASTASE, INHIBITOR ACE-ALA-PRO-VAI-DIFLUORO-N-PHENYLETHYLACETAMIDE, ...
Authors:Takahashi, L.H, Radhakrishnan, R, Rosenfieldjunior, R.E, Meyerjunior, E.F, Trainor, D.A.
Deposit date:1989-05-15
Release date:1992-04-15
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal Structure of the Covalent Complex Formed by a Peptidyl Alpha,Alpha-Difluoro-Beta-Keto Amide with Porcine Pancreatic Elastase at 1.78-Angstroms Resolution
J.Am.Chem.Soc., 111, 1989
3EST
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BU of 3est by Molmil
STRUCTURE OF NATIVE PORCINE PANCREATIC ELASTASE AT 1.65 ANGSTROMS RESOLUTION
Descriptor: CALCIUM ION, PORCINE PANCREATIC ELASTASE, SULFATE ION
Authors:Meyer, E.F, Cole, G, Radhakrishnan, R, Epp, O.
Deposit date:1987-09-17
Release date:1988-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of native porcine pancreatic elastase at 1.65 A resolutions.
Acta Crystallogr.,Sect.B, 44, 1988
1NES
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BU of 1nes by Molmil
STRUCTURE OF THE PRODUCT COMPLEX OF ACETYL-ALA-PRO-ALA WITH PORCINE PANCREATIC ELASTASE AT 1.65 ANGSTROMS RESOLUTION
Descriptor: ACETYL-ALA-PRO-ALA, CALCIUM ION, ELASTASE, ...
Authors:Meyer Junior, E.F, Radhakrishnan, R, M Cole, G, Presta, L.G.
Deposit date:1995-07-31
Release date:1996-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of the product complex of acetyl-Ala-Pro-Ala with porcine pancreatic elastase at 1.65 A resolution.
J.Mol.Biol., 189, 1986
3TSS
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BU of 3tss by Molmil
TOXIC SHOCK SYNDROME TOXIN-1 TETRAMUTANT, P2(1) CRYSTAL FORM
Descriptor: TOXIC SHOCK SYNDROME TOXIN-1
Authors:Prasad, G.S, Radhakrishnan, R, Mitchell, D.T, Earhart, C.A, Dinges, M.M, Cook, W.J, Schlivert, P.M, Ohlendorf, D.H.
Deposit date:1996-12-11
Release date:1997-12-24
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity.
Protein Sci., 6, 1997
4TSS
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BU of 4tss by Molmil
TOXIC SHOCK SYNDROME TOXIN-1: TETRAGONAL P4(1)2(1)2 CRYSTAL FORM
Descriptor: TOXIC SHOCK SYNDROME TOXIN-1, ZINC ION
Authors:Prasad, G.S, Radhakrishnan, R, Mitchell, D.T, Earhart, C.A, Dinges, M.M, Cook, W.J, Schlivert, P.M, Ohlendorf, D.H.
Deposit date:1996-12-11
Release date:1997-12-24
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity.
Protein Sci., 6, 1997
5EST
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BU of 5est by Molmil
Crystallographic analysis of the inhibition of porcine pancreatic elastase by a peptidyl boronic acid: structure of a reaction intermediate
Descriptor: CALCIUM ION, ELASTASE, N~2~-[(benzyloxy)carbonyl]-N-[(1R,2S)-1-(dihydroxyboranyl)-2-methylbutyl]-L-alaninamide, ...
Authors:Takahashi, L.H, Radhakrishnan, R, Rosenfieldjunior, R.E, Meyerjunior, E.F.
Deposit date:1989-05-15
Release date:1992-04-15
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystallographic analysis of the inhibition of porcine pancreatic elastase by a peptidyl boronic acid: structure of a reaction intermediate.
Biochemistry, 28, 1989
5TSS
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BU of 5tss by Molmil
TOXIC SHOCK SYNDROME TOXIN-1: ORTHORHOMBIC P222(1) CRYSTAL FORM
Descriptor: TOXIC SHOCK SYNDROME TOXIN-1
Authors:Prasad, G.S, Radhakrishnan, R, Mitchell, D.T, Earhart, C.A, Dinges, M.M, Cook, W.J, Schlivert, P.M, Ohlendorf, D.H.
Deposit date:1996-12-11
Release date:1997-12-24
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity.
Protein Sci., 6, 1997
1MHZ
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BU of 1mhz by Molmil
METHANE MONOOXYGENASE HYDROXYLASE
Descriptor: FE (III) ION, METHANE MONOOXYGENASE HYDROXYLASE
Authors:Elango, N, Radhakrishnan, R, Froland, W.A, Waller, B.J, Earhart, C.A, Lipscomb, J.D, Ohlendorf, D.H.
Deposit date:1996-10-21
Release date:1997-05-15
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the hydroxylase component of methane monooxygenase from Methylosinus trichosporium OB3b
Protein Sci., 6, 1997
1MHY
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BU of 1mhy by Molmil
METHANE MONOOXYGENASE HYDROXYLASE
Descriptor: FE (III) ION, METHANE MONOOXYGENASE HYDROXYLASE
Authors:Elango, N, Radhakrishnan, R, Froland, W.A, Waller, B.J, Earhart, C.A, Lipscomb, J.D, Ohlendorf, D.H.
Deposit date:1996-10-21
Release date:1997-05-15
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the hydroxylase component of methane monooxygenase from Methylosinus trichosporium OB3b
Protein Sci., 6, 1997
2TSS
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BU of 2tss by Molmil
TOXIC SHOCK SYNDROME TOXIN-1 FROM STAPHYLOCOCCUS AUREUS: ORTHORHOMBICC222(1) CRYSTAL FORM
Descriptor: TOXIC SHOCK SYNDROME TOXIN-1
Authors:Prasad, G.S, Radhakrishnan, R, Mitchell, D.T, Earhart, C.A, Dinges, M.M, Cook, W.J, Schlivert, P.M, Ohlendorf, D.H.
Deposit date:1996-12-04
Release date:1997-12-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity.
Protein Sci., 6, 1997
1INC
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BU of 1inc by Molmil
CRYSTAL STRUCTURES OF THE COMPLEX OF PORCINE PANCREATIC ELASTASE WITH TWO VALINE-DERIVED BENZOXAZINONE INHIBITORS
Descriptor: CALCIUM ION, PORCINE PANCREATIC ELASTASE, SULFATE ION, ...
Authors:Meyer, E.
Deposit date:1993-03-19
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structures of the complex of porcine pancreatic elastase with two valine-derived benzoxazinone inhibitors.
J.Mol.Biol., 198, 1987
1RH2
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BU of 1rh2 by Molmil
RECOMBINANT HUMAN INTERFERON-ALPHA 2B
Descriptor: INTERFERON-ALPHA 2B, ZINC ION
Authors:Walter, M.R.
Deposit date:1996-11-07
Release date:1997-11-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography.
Structure, 4, 1996
1BMA
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BU of 1bma by Molmil
BENZYL METHYL AMINIMIDE INHIBITOR COMPLEXED TO PORCINE PANCREATIC ELASTASE
Descriptor: (1R)-1-benzyl-1-methyl-1-(2-{[4-(1-methylethyl)phenyl]amino}-2-oxoethyl)-2-{(2S)-4-methyl-2-[(trifluoroacetyl)amino]pentanoyl}diazanium, CALCIUM ION, Chymotrypsin-like elastase family member 1, ...
Authors:Peisach, E, Casebier, D, Gallion, S.L, Furth, P, Petsko, G.A, Hogan Jr, J.C, Ringe, D.
Deposit date:1995-05-01
Release date:1995-12-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Interaction of a peptidomimetic aminimide inhibitor with elastase.
Science, 269, 1995
6EST
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BU of 6est by Molmil
INTERACTION OF THE PEPTIDE CF3-LEU-ALA-NH-C6H4-CF3(TFLA) WITH PORCINE PANCREATIC ELASTASE. X-RAY STUDIES AT 1.8 ANGSTROMS
Descriptor: CALCIUM ION, DIMETHYLFORMAMIDE, PORCINE PANCREATIC ELASTASE, ...
Authors:Prange, T, Li De Lasierra, I.
Deposit date:1990-06-15
Release date:1991-10-15
Last modified:2011-12-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Interaction of the peptide CF3-Leu-Ala-NH-C6H4-CF3 (TFLA) with porcine pancreatic elastase. X-ray studies at 1.8 A.
J.Mol.Recog., 3, 1990
7EST
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BU of 7est by Molmil
Interaction of the peptide CF3-LEU-ALA-NH-C6H4-CF3(TFLA) with porcine pancreatic elastase. X-ray studies at 1.8 Angstroms
Descriptor: CALCIUM ION, DIMETHYLFORMAMIDE, ELASTASE, ...
Authors:Li De Lasierra, I, Prange, T.
Deposit date:1990-06-15
Release date:1991-10-15
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Interaction of the peptide CF3-Leu-Ala-NH-C6H4-CF3 (TFLA) with porcine pancreatic elastase. X-ray studies at 1.8 A.
J.Mol.Recog., 3, 1990
1BTU
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BU of 1btu by Molmil
PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3S, 4R)-1-TOLUENESULPHONYL-3-ETHYL-AZETIDIN-2-ONE-4-CARBOXYLIC ACID
Descriptor: (3R)-3-ethyl-N-[(4-methylphenyl)sulfonyl]-L-aspartic acid, CALCIUM ION, ELASTASE, ...
Authors:Wilmouth, R.C, Clifton, I.J, Schofield, C.J.
Deposit date:1998-09-01
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex.
Biochemistry, 37, 1998
6TU9
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BU of 6tu9 by Molmil
The ROR1 Pseudokinase Domain Bound To Ponatinib
Descriptor: 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, Inactive tyrosine-protein kinase transmembrane receptor ROR1
Authors:Mathea, S, Preuss, F, Chatterjee, D, Niininen, W, Ungureanu, D, Shin, D, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S.
Deposit date:2020-01-04
Release date:2020-01-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.
Mol.Cell, 79, 2020
6TUA
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BU of 6tua by Molmil
The RYK Pseudokinase Domain
Descriptor: SULFATE ION, Tyrosine-protein kinase RYK
Authors:Mathea, S, Chatterjee, D, Preuss, F, Shin, D, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S.
Deposit date:2020-01-04
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.
Mol.Cell, 79, 2020
6VG3
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BU of 6vg3 by Molmil
Structure of unliganded, inactive PTK7 kinase domain
Descriptor: Inactive tyrosine-protein kinase 7
Authors:Malhotra, K, Stayrook, S.E, Sheetz, J, Lemmon, M.A.
Deposit date:2020-01-07
Release date:2020-05-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural insights into receptor tyrosine kinase pseudokinase function
Mol.Cell, 2020
4HJO
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BU of 4hjo by Molmil
Crystal structure of the inactive EGFR tyrosine kinase domain with erlotinib
Descriptor: Epidermal growth factor receptor, [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE
Authors:Park, J.H, Lemmon, M.A.
Deposit date:2012-10-13
Release date:2012-11-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain.
Biochem.J., 448, 2012
3LMG
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BU of 3lmg by Molmil
Crystal structure of the ERBB3 kinase domain in complex with AMP-PNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Receptor tyrosine-protein kinase erbB-3
Authors:Shi, F, Lemmon, M.A.
Deposit date:2010-01-30
Release date:2010-04-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation.
Proc.Natl.Acad.Sci.USA, 107, 2010
1EAS
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BU of 1eas by Molmil
NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 3. DESIGN, SYNTHESIS, X-RAY CRYSTALLOGRAPHIC ANALYSIS, AND STRUCTURE-ACTIVITY RELATIONSHIPS FOR A SERIES OF ORALLY ACTIVE 3-AMINO-6-PHENYLPYRIDIN-2-ONE TRIFLUOROMETHYL KETONES
Descriptor: 3-[[(METHYLAMINO)SULFONYL]AMINO]-2-OXO-6-PHENYL-N-[3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPHENYL]-1(2H)-PYRIDINE ACETAMIDE, PORCINE PANCREATIC ELASTASE, SODIUM ION, ...
Authors:Ceccarelli, C.
Deposit date:1994-11-22
Release date:1995-02-07
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones.
J.Med.Chem., 37, 1994

 

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