Author results

3F2U
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CRYSTAL STRUCTURE OF HUMAN CHROMOBOX HOMOLOG 1 (CBX1)
分子名称:Chromobox protein homolog 1
著者Amaya, M.F., Ravichandran, M., Tempel, W., Wernimont, A.K., Loppnau, P., Kozieradzki, I., Edwards, A.M., Arrowsmith, C.H., Weigelt, J., Bountra, C., Botchkarev, A., Min, J., Ouyang, H., Structural Genomics Consortium (SGC)
登録日2008-10-30
公開日2008-11-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of the complex of human chromobox homolog 1 (CBX1)
To be Published
4RFQ
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HUMAN METHYLTRANSFERASE-LIKE 18
分子名称:Histidine protein methyltransferase 1 homolog, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION
著者Tempel, W., Ravichandran, M., Li, Y., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Hong, B.S., Structural Genomics Consortium (SGC)
登録日2014-09-26
公開日2014-10-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Human Methyltransferase-Like 18
TO BE PUBLISHED
2OWA
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CRYSTAL STRUCTURE OF PUTATIVE GTPASE ACTIVATING PROTEIN FOR ADP RIBOSYLATION FACTOR FROM CRYPTOSPORIDIUM PARVUM (CGD5_1040)
分子名称:Arfgap-like finger domain containing protein, ZINC ION
著者Dong, A., Lew, J., Zhao, Y., Hassanali, A., Lin, L., Ravichandran, M., Wasney, G., Vedadi, M., Kozieradzki, I., Bochkarev, A., Edwards, A.M., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Hui, R., Qiu, W., Structural Genomics Consortium (SGC)
登録日2007-02-15
公開日2007-02-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of putative GTPase activating protein for ADP ribosylation factor from Cryptosporidium parvum (cgd5_1040)
To be Published
2PBF
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CRYSTAL STRUCTURE OF A PUTATIVE PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE BETA-ASPARTATE METHYLTRANSFERASE (PCMT) FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE
分子名称:Protein-L-isoaspartate O-methyltransferase beta-aspartate methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Wernimont, A.K., Hassanali, A., Lin, L., Lew, J., Zhao, Y., Ravichandran, M., Wasney, G., Vedadi, M., Kozieradzki, I., Bochkarev, A., Edwards, A.M., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Hui, R., Qiu, W., Structural Genomics Consortium (SGC)
登録日2007-03-28
公開日2007-04-10
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of a putative protein-L-isoaspartate O-methyltransferase beta-aspartate methyltransferase (PCMT) from Plasmodium falciparum in complex with S-adenosyl-L-homocysteine
To be Published
2PLW
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CRYSTAL STRUCTURE OF A RIBOSOMAL RNA METHYLTRANSFERASE, PUTATIVE, FROM PLASMODIUM FALCIPARUM (PF13_0052).
分子名称:Ribosomal RNA methyltransferase, putative, SULFATE ION, ...
著者Wernimont, A.K., Hassanali, A., Lin, L., Lew, J., Zhao, Y., Ravichandran, M., Wasney, G., Vedadi, M., Kozieradzki, I., Schapira, M., Bochkarev, A., Edwards, A.M., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Hui, R., Qiu, W., Structural Genomics Consortium (SGC)
登録日2007-04-20
公開日2007-05-08
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of a ribosomal RNA methyltransferase, putative, from Plasmodium falciparum (PF13_0052).
To be Published
2PWQ
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CRYSTAL STRUCTURE OF A PUTATIVE UBIQUITIN CONJUGATING ENZYME FROM PLASMODIUM YOELII
分子名称:Ubiquitin conjugating enzyme
著者Qiu, W., Dong, A., Hassanali, A., Lin, L., Brokx, S., Altamentova, S., Hills, T., Lew, J., Ravichandran, M., Kozieradzki, I., Zhao, Y., Schapira, M., Edwards, A.M., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Bochkarev, A., Hui, R., Structural Genomics Consortium (SGC)
登録日2007-05-11
公開日2007-05-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of a putative ubiquitin conjugating enzyme from Plasmodium yoelii.
To be Published
2QU8
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CRYSTAL STRUCTURE OF PUTATIVE NUCLEOLAR GTP-BINDING PROTEIN 1 PFF0625W FROM PLASMODIUM FALCIPARUM
分子名称:Putative nucleolar GTP-binding protein 1, GUANOSINE-5'-DIPHOSPHATE
著者Wernimont, A.K., Lew, J., Lin, Y.H., Kozieradzki, I., Zhao, Y., Ravichandran, M., Shapiro, M., Bochkarev, A., Edwards, A.M., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Hui, R., Qiu, W., Sukumar, D., Hassanali, A., Structural Genomics Consortium (SGC)
登録日2007-08-03
公開日2007-08-28
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Crystal structure of putative nucleolar GTP-binding protein 1 PFF0625w from Plasmodium falciparum.
To be Published
3E95
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CRYSTAL STRUCTURE OF THE PLASMODIUM FALCIPARUM UBIQUITIN CONJUGATING ENZYME COMPLEX, PFUBC13-PFUEV1A
分子名称:Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2, UNKNOWN ATOM OR ION
著者Wernimont, A.K., Lam, A., Ali, A., Brokx, S., Lin, Y.H., Zhao, Y., Lew, J., Ravichandran, M., Wasney, G., Vedadi, M., Kozieradzki, I., Schapira, M., Bochkarev, A., Wilkstrom, M., BOuntra, C., Arrowsmith, C.H., Edwards, A.M., Hui, R., Qiu, W., Brand, V.B., Structural Genomics Consortium (SGC)
登録日2008-08-21
公開日2008-09-30
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of the Plasmodium Falciparum ubiquitin conjugating enzyme complex, PfUBC13-PfUev1a
TO BE PUBLISHED
3JWP
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM SIR2A (PF13_0152) IN COMPLEX WITH AMP
分子名称:Transcriptional regulatory protein sir2 homologue, ADENOSINE MONOPHOSPHATE, ZINC ION, ...
著者Wernimont, A.K., Hutchinson, A., Lin, Y.H., MacKenzie, F., Senisterra, G., Allali-Hassanali, A., Vedadi, M., Ravichandran, M., Cossar, D., Kozieradzki, I., Zhao, Y., Schapira, M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Hui, R., Qiu, W., Brand, V., Structural Genomics Consortium (SGC)
登録日2009-09-18
公開日2009-10-20
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP
TO BE PUBLISHED
4QOX
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CRYSTAL STRUCTURE OF CDPK4 FROM PLASMODIUM FALCIPARUM, PF3D7_0717500
分子名称:Calcium-dependent protein kinase 4, MAGNESIUM ION, 3-(3-bromobenzyl)-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
著者Wernimont, A.K., Walker, J.R., Hutchinson, A., Seitova, A., He, H., Loppnau, P., Neculai, M., Amani, M., Lin, Y.H., Ravichandran, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Lovato, D.V., Structural Genomics Consortium (SGC)
登録日2014-06-20
公開日2014-09-03
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.748 Å)
主引用文献Crystal Structure of CDPK4 from Plasmodium Falciparum, PF3D7_0717500
TO BE PUBLISHED
4RGJ
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APO CRYSTAL STRUCTURE OF CDPK4 FROM PLASMODIUM FALCIPARUM, PF3D7_0717500
分子名称:Calcium-dependent protein kinase 4
著者Wernimont, A.K., Walker, J.R., Hutchinson, A., Seitova, A., He, H., Loppnau, P., Neculai, M., Amani, M., Lin, Y.H., Ravichandran, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Lovato, D.V., Structural Genomics Consortium (SGC)
登録日2014-09-30
公開日2014-10-29
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.303 Å)
主引用文献Apo crystal structure of CDPK4 from Plasmodium falciparum, PF3D7_0717500
To be Published
5WPB
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CRYSTAL STRUCTURE OF FRAGMENT 3-(3-(PYRIDIN-2-YLMETHOXY)QUINOXALIN-2-YL)PROPANOIC ACID BOUND IN THE UBIQUITIN BINDING POCKET OF THE HDAC6 ZINC-FINGER DOMAIN
分子名称:Histone deacetylase 6, ZINC ION, 3-{3-[(pyridin-2-yl)methoxy]quinoxalin-2-yl}propanoic acid, ...
著者Harding, R.J., Tempel, W., Ferreira de Freitas, R., Franzoni, I., Ravichandran, M., Lautens, M., Santhakumar, V., Schapira, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
登録日2017-08-04
公開日2017-08-23
最終更新日2019-02-27
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.
J. Med. Chem., 60, 2017
6CEC
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CRYSTAL STRUCTURE OF FRAGMENT 3-(3-METHOXY-2-QUINOXALINYL)PROPANOIC ACID BOUND IN THE UBIQUITIN BINDING POCKET OF THE HDAC6 ZINC-FINGER DOMAIN
分子名称:Histone deacetylase 6, ZINC ION, UNKNOWN ATOM OR ION, ...
著者Harding, R.J., Halabelian, L., Ferreira de Freitas, R., Franzoni, I., Ravichandran, M., Lautens, M., Santhakumar, V., Schapira, M., Bountra, C., Edwards, A.M., Arrowsmith, C.M., Structural Genomics Consortium (SGC)
登録日2018-02-11
公開日2018-02-28
最終更新日2018-05-30
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
J. Med. Chem., 61, 2018
6CED
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CRYSTAL STRUCTURE OF FRAGMENT 3-(3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)PROPANOIC ACID BOUND IN THE UBIQUITIN BINDING POCKET OF THE HDAC6 ZINC-FINGER DOMAIN
分子名称:Histone deacetylase 6, ZINC ION, 3-(3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid, ...
著者Harding, R.J., Halabelian, L., Ferreira de Freitas, R., Franzoni, I., Ravichandran, M., Lautens, M., Santhakumar, V., Schapira, M., Bountra, C., Edwards, A.M., Arrowsmith, C.M., Structural Genomics Consortium (SGC)
登録日2018-02-11
公開日2018-02-28
最終更新日2018-05-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
J. Med. Chem., 61, 2018
6CEE
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CRYSTAL STRUCTURE OF FRAGMENT 3-(1-METHYL-2-OXO-1,2-DIHYDROQUINOXALIN-3-YL)PROPIONIC ACID BOUND IN THE UBIQUITIN BINDING POCKET OF THE HDAC6 ZINC-FINGER DOMAIN
分子名称:Histone deacetylase 6, ZINC ION, 3-(4-methyl-3-oxo-3,4-dihydroquinoxalin-2-yl)propanoic acid, ...
著者Harding, R.J., Halabelian, L., Ferreira de Freitas, R., Franzoni, I., Ravichandran, M., Lautens, M., Santhakumar, V., Schapira, M., Bountra, C., Edwards, A.M., Arrowsmith, C.M., Structural Genomics Consortium (SGC)
登録日2018-02-11
公開日2018-02-28
最終更新日2018-05-30
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
J. Med. Chem., 61, 2018
3IU1
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CRYSTAL STRUCTURE OF HUMAN TYPE-I N-MYRISTOYLTRANSFERASE WITH BOUND MYRISTOYL-COA
分子名称:Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA
著者Qiu, W., Hutchinson, A., Wernimont, A., Lin, Y.-H., Kania, A., Ravichandran, M., Kozieradzki, I., Cossar, D., Schapira, M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Wyatt, P.G., Ferguson, M.A.J., Frearson, J.A., Brand, S.Y., Robinson, D.A., Bochkarev, A., Hui, R., Structural Genomics Consortium (SGC)
登録日2009-08-29
公開日2009-09-15
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA
To be Published
3IU2
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CRYSTAL STRUCTURE OF HUMAN TYPE-I N-MYRISTOYLTRANSFERASE WITH BOUND MYRISTOYL-COA AND INHIBITOR DDD90096
分子名称:Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA, (2R)-2-{4-hydroxy-5-methoxy-2-[3-(4-methylpiperazin-1-yl)propyl]phenyl}-3-pyridin-3-yl-1,3-thiazolidin-4-one
著者Qiu, W., Hutchinson, A., Wernimont, A., Lin, Y.-H., Kania, A., Ravichandran, M., Kozieradzki, I., Cossar, D., Schapira, M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Wyatt, P.G., Ferguson, M.A.J., Frearson, J.A., Brand, S.Y., Robinson, D.A., Bochkarev, A., Hui, R., Structural Genomics Consortium (SGC)
登録日2009-08-29
公開日2009-09-15
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096
To be Published
3IWE
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CRYSTAL STRUCTURE OF HUMAN TYPE-I N-MYRISTOYLTRANSFERASE WITH BOUND MYRISTOYL-COA AND INHIBITOR DDD85646
分子名称:Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA, 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
著者Qiu, W., Hutchinson, A., Wernimont, A., Lin, Y.-H., Kania, A., Ravichandran, M., Kozieradzki, I., Cossar, D., Schapira, M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Wyatt, P.G., Ferguson, M.A.J., Frearson, J.A., Brand, S.Y., Robinson, D.A., Bochkarev, A., Hui, R., Structural Genomics Consortium (SGC)
登録日2009-09-02
公開日2009-09-15
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD85646
To be Published
3JTK
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CRYSTAL STRUCTURE OF HUMAN TYPE-I N-MYRISTOYLTRANSFERASE WITH BOUND MYRISTOYL-COA AND INHIBITOR DDD90055
分子名称:Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA, (2R)-3-benzyl-2-(2-bromo-4-hydroxy-5-methoxyphenyl)-1,3-thiazolidin-4-one
著者Qiu, W., Hutchinson, A., Wernimont, A., Lin, Y.-H., Kania, A., Ravichandran, M., Kozieradzki, I., Cossar, D., Schapira, M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Wyatt, P.G., Ferguson, M.A.J., Frearson, J.A., Brand, S.Y., Robinson, D.A., Bochkarev, A., Hui, R., Structural Genomics Consortium (SGC)
登録日2009-09-12
公開日2009-09-22
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055
To be Published
4F7B
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STRUCTURE OF THE LYSOSOMAL DOMAIN OF LIMP-2
分子名称:Lysosome membrane protein 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Neculai, D., Ravichandran, M., Seitova, A., Neculai, M., Pizzaro, J.C., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Dhe-Paganon, D., Structural Genomics Consortium (SGC)
登録日2012-05-15
公開日2013-10-09
最終更新日2013-12-18
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36.
Nature, 504, 2013
4YY8
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CRYSTAL STRUCTURE ANALYSIS OF KELCH PROTEIN FROM PLASMODIUM FALCIPARUM
分子名称:Kelch protein, UNKNOWN ATOM OR ION, GLYCEROL
著者Jiang, D.Q., Tempel, W., Loppnau, P., Graslund, S., He, H., Ravichandran, M., Seitova, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., El Bakkouri, M., Senisterra, G., Osman, K.T., Lovato, D.V., Hui, R., Hutchinson, A., Lin, Y.H., Structural Genomics Consortium (SGC)
登録日2015-03-23
公開日2015-04-01
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Crystal Structure Analysis of Kelch protein from Plasmodium falciparum.
to be published
4ZGC
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CRYSTAL STRUCTURE ANALYSIS OF KELCH PROTEIN (WITH DISULFIDE BOND) FROM PLASMODIUM FALCIPARUM
分子名称:Kelch protein, UNKNOWN ATOM OR ION
著者Jiang, D.Q., Tempel, W., Loppnau, P., Graslund, S., He, H., Ravichandran, M., Seitova, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., El Bakkouri, M., Senisterra, G., Osman, K.T., Lovato, D.V., Hui, R., Hutchinson, A., Lin, Y.H., Structural Genomics Consortium (SGC)
登録日2015-04-22
公開日2015-06-10
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of kelch protein with disulfide bond from Plasmodium falciparum.
to be published
5B8D
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CRYSTAL STRUCTURE OF A LOW OCCUPANCY FRAGMENT CANDIDATE (N-(4-METHYL-1,3-THIAZOL-2-YL)PROPANAMIDE) BOUND ADJACENT TO THE UBIQUITIN BINDING POCKET OF THE HDAC6 ZINC-FINGER DOMAIN
分子名称:Histone deacetylase 6, ZINC ION, FORMIC ACID, ...
著者Harding, R.J., Tempel, W., Collins, P., Pearce, N., Brandao-Neto, J., Douangamath, A., Ravichandran, M., Schapira, M., Bountra, C., Edwards, A.M., von Delft, F., Santhakumar, V., Arrowsmith, C.M., Structural Genomics Consortium (SGC)
登録日2016-06-14
公開日2016-07-27
最終更新日2019-02-27
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.
J. Med. Chem., 60, 2017
5KH3
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CRYSTAL STRUCTURE OF FRAGMENT (3-(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)PROPANOIC ACID) BOUND IN THE UBIQUITIN BINDING POCKET OF THE HDAC6 ZINC-FINGER DOMAIN
分子名称:Histone deacetylase 6, ZINC ION, UNKNOWN ATOM OR ION, ...
著者Harding, R.J., Dong, A., Ravichandran, M., Ferreira de Freitas, R., Schapira, M., Bountra, C., Edwards, A.M., Santhakumar, V., Arrowsmith, C.M., Structural Genomics Consortium (SGC)
登録日2016-06-14
公開日2016-07-27
最終更新日2019-02-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.
J. Med. Chem., 60, 2017
5KH7
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CRYSTAL STRUCTURE OF FRAGMENT (3-[6-OXO-3-(3-PYRIDINYL)-1(6H)-PYRIDAZINYL]PROPANOIC ACID) BOUND IN THE UBIQUITIN BINDING POCKET OF THE HDAC6 ZINC-FINGER DOMAIN
分子名称:Histone deacetylase 6, ZINC ION, 3-(6-oxidanylidene-3-pyridin-3-yl-pyridazin-1-yl)propanoic acid, ...
著者Harding, R.J., Walker, J., Ravichandran, M., Ferreira de Freitas, R., Schapira, M., Bountra, C., Edwards, A.M., Santhakumar, V., Arrowsmith, C.M., Structural Genomics Consortium (SGC)
登録日2016-06-14
公開日2016-07-27
最終更新日2019-02-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.
J. Med. Chem., 60, 2017
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