4F42
 
 | | Neurotrophin p75NTR intracellular domain | | Descriptor: | 5-MERCAPTO-2-NITRO-BENZOIC ACID, Tumor necrosis factor receptor superfamily member 16 | | Authors: | Qu, Q, Jiang, T. | | Deposit date: | 2012-05-09 | | Release date: | 2013-05-15 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Structural insights into the allosteric activation mechanism of p75NTR
To be Published
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4F44
 | | Neurotrophin p75NTR intracellular domain | | Descriptor: | 5-MERCAPTO-2-NITRO-BENZOIC ACID, Tumor necrosis factor receptor superfamily member 16 | | Authors: | Qu, Q, Jiang, T. | | Deposit date: | 2012-05-10 | | Release date: | 2013-05-15 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural insights into the allosteric activation mechanism of p75NTR
To be Published
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6KZF
 | | Racemic X-ray Structure of Calcicludine | | Descriptor: | D-calcicludine, Kunitz-type serine protease inhibitor homolog calcicludine | | Authors: | Qu, Q, Gao, S, Liu, L. | | Deposit date: | 2019-09-24 | | Release date: | 2019-11-06 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy
Angew.Chem.Int.Ed.Engl., 59, 2020
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7SLA
 | | CryoEM structure of SGLT1 at 3.15 Angstrom resolution | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Sodium/glucose cotransporter 1, nanobody Nb1 | | Authors: | Qu, Q, Han, L, Panova, O, Feng, L, Skiniotis, G. | | Deposit date: | 2021-10-23 | | Release date: | 2021-12-15 | | Last modified: | 2022-01-26 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Structure and mechanism of the SGLT family of glucose transporters.
Nature, 601, 2022
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7SL8
 | | CryoEM structure of SGLT1 at 3.4 A resolution | | Descriptor: | CHOLESTEROL, Sodium/glucose cotransporter 1, nanobody Nb1 | | Authors: | Qu, Q, Han, L, Panova, O, Feng, L, Skiniotis, G. | | Deposit date: | 2021-10-23 | | Release date: | 2021-12-15 | | Last modified: | 2022-01-26 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure and mechanism of the SGLT family of glucose transporters.
Nature, 601, 2022
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7SL9
 | | CryoEM structure of SMCT1 | | Descriptor: | Sodium-coupled monocarboxylate transporter 1, butanoic acid, nanobody Nb2 | | Authors: | Qu, Q, Han, L, Panova, O, Feng, L, Skiniotis, G. | | Deposit date: | 2021-10-23 | | Release date: | 2021-12-15 | | Last modified: | 2022-01-26 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure and mechanism of the SGLT family of glucose transporters.
Nature, 601, 2022
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7T2G
 | | CryoEM structure of mu-opioid receptor - Gi protein complex bound to mitragynine pseudoindoxyl (MP) | | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Seven, A.B, Qu, Q, Robertson, M.J, Wang, H, Kobilka, B.K, Skiniotis, G. | | Deposit date: | 2021-12-04 | | Release date: | 2022-12-07 | | Last modified: | 2023-02-15 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Insights into distinct signaling profiles of the mu OR activated by diverse agonists.
Nat.Chem.Biol., 2022
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7T2H
 | | CryoEM structure of mu-opioid receptor - Gi protein complex bound to lofentanil (LFT) | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Seven, A.B, Qu, Q, Huang, W, Robertson, M.J, Kobilka, B.K, Skiniotis, G. | | Deposit date: | 2021-12-04 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Insights into distinct signaling profiles of the mu OR activated by diverse agonists.
Nat.Chem.Biol., 2022
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7RKN
 | | Structure of CX3CL1-US28-Gi-scFv16 in OC-state | | Descriptor: | Antibody fragment scFv16, Fractalkine, G-protein coupled receptor homolog US28, ... | | Authors: | Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. | | Deposit date: | 2021-07-22 | | Release date: | 2022-01-26 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
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7RKM
 | | Structure of CX3CL1-US28-Gi-scFv16 in C-state | | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Fractalkine, ... | | Authors: | Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. | | Deposit date: | 2021-07-22 | | Release date: | 2022-01-26 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
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7RKF
 | | Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment scFv16, Fractalkine, ... | | Authors: | Tsutsumi, N, Maeda, S, Qu, Q, Skiniotis, G, Kobilka, B.K, Garcia, K.C. | | Deposit date: | 2021-07-22 | | Release date: | 2022-01-26 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
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7V6Z
 | | Cryo-EM structure of Patched1 (V1084A mutant) in lipid nanodisc, 3.64 angstrom (reprocessed with the dataset of 7dzp) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | Authors: | Luo, Y, Zhao, Y, Qu, Q, Li, D. | | Deposit date: | 2021-08-20 | | Release date: | 2021-09-22 | | Last modified: | 2022-02-16 | | Method: | ELECTRON MICROSCOPY (3.64 Å) | | Cite: | Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae.
Structure, 29, 2021
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7V6Y
 | | Cryo-EM structure of Patched in lipid nanodisc - the wildtype, 3.5 angstrom (re-processed with dataset of 7dzq) | | Descriptor: | (2S)-2-azanyl-3-[[(2S)-3-butanoyloxy-2-dec-9-enoyloxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Luo, Y, Zhao, Y, Qu, Q, Li, D. | | Deposit date: | 2021-08-20 | | Release date: | 2021-09-22 | | Last modified: | 2022-02-16 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae.
Structure, 29, 2021
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5VAI
 | | Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein | | Descriptor: | Glucagon-like peptide 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhang, Y, Sun, B, Feng, D, Hu, H, Chu, M, Qu, Q, Tarrasch, J.T, Li, S, Kobilka, T.S, Kobilka, B.K, Skiniotis, G. | | Deposit date: | 2017-03-27 | | Release date: | 2017-05-24 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.
Nature, 546, 2017
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7SBF
 | | PZM21 bound Mu Opioid Receptor-Gi Protein Complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Huang, W, Qu, Q, Wang, H, Skiniotis, G, Kobilka, B. | | Deposit date: | 2021-09-24 | | Release date: | 2022-04-20 | | Last modified: | 2022-07-06 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure-Based Evolution of G Protein-Biased mu-Opioid Receptor Agonists.
Angew.Chem.Int.Ed.Engl., 61, 2022
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7U2L
 | | C5guano-uOR-Gi-scFv16 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Wang, H, Qu, Q, Skiniotis, G, Kobilka, B. | | Deposit date: | 2022-02-24 | | Release date: | 2022-05-04 | | Last modified: | 2023-02-08 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure-based design of bitopic ligands for the μ-opioid receptor.
Nature, 613, 2023
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8K9T
 | | Cryo-EM structure of the products-bound PGAP1(Bst1)-S327A from Chaetonium thermophilum | | Descriptor: | 2-amino-2-deoxy-alpha-D-glucopyranose, 2-azanylethyl [(2R,3S,4S,5S,6S)-3,4,5,6-tetrakis(oxidanyl)oxan-2-yl]methyl hydrogen phosphate, 2-azanylethyl [(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl] hydrogen phosphate, ... | | Authors: | Li, T, Hong, J, Qu, Q, Li, D. | | Deposit date: | 2023-08-01 | | Release date: | 2023-12-20 | | Last modified: | 2024-01-17 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis.
Nat Commun, 15, 2024
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8K9R
 | | Cryo EM structure of the products-bound PGAP1(Bst1)-H443N from Chaetomium thermophilum | | Descriptor: | 2-amino-2-deoxy-alpha-D-glucopyranose, 2-azanylethyl [(2R,3S,4S,5S,6S)-3,4,5,6-tetrakis(oxidanyl)oxan-2-yl]methyl hydrogen phosphate, 2-azanylethyl [(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl] hydrogen phosphate, ... | | Authors: | Li, T, Hong, J, Qu, Q, Li, D. | | Deposit date: | 2023-08-01 | | Release date: | 2023-12-20 | | Last modified: | 2024-01-17 | | Method: | ELECTRON MICROSCOPY (2.68 Å) | | Cite: | Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis.
Nat Commun, 15, 2024
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8K9Q
 | | Cryo-EM structure of the GPI inositol-deacylase (PGAP1/Bst1) from Chaetomium thermophilum | | Descriptor: | (2~{S})-2-azanyl-3-[[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid, CHOLESTEROL HEMISUCCINATE, GPI inositol-deacylase,fused thermostable green fluorescent protein | | Authors: | Hong, J, Li, T, Qu, Q, Li, D. | | Deposit date: | 2023-08-01 | | Release date: | 2023-12-20 | | Last modified: | 2024-01-17 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis.
Nat Commun, 15, 2024
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8IMY
 | | Cryo-EM structure of GPI-T (inactive mutant) with GPI and proULBP2, a proprotein substrate | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Li, T, Xu, Y, Qu, Q, Li, D. | | Deposit date: | 2023-03-07 | | Release date: | 2023-08-16 | | Last modified: | 2023-11-01 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis.
Nat Commun, 14, 2023
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8IMX
 | | Cryo-EM structure of GPI-T with a chimeric GPI-anchored protein | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Xu, Y, Li, T, Qu, Q, Li, D. | | Deposit date: | 2023-03-07 | | Release date: | 2023-08-16 | | Last modified: | 2023-11-01 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis.
Nat Commun, 14, 2023
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7X5A
 | | CryoEM structure of RuvA-Holliday junction complex | | Descriptor: | DNA (26-MER), Holliday junction ATP-dependent DNA helicase RuvA | | Authors: | Lin, Z, Qu, Q, Zhang, X, Zhou, Z. | | Deposit date: | 2022-03-04 | | Release date: | 2023-03-08 | | Last modified: | 2023-09-20 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Cryo-EM structure of the RuvAB-Holliday junction intermediate complex from Pseudomonas aeruginosa.
Front Plant Sci, 14, 2023
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7X5B
 | | Crystal structure of RuvB | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Holliday junction ATP-dependent DNA helicase RuvB | | Authors: | Lin, Z, Qu, Q, Zhang, X, Zhou, Z, Dai, L. | | Deposit date: | 2022-03-04 | | Release date: | 2023-03-08 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Cryo-EM structure of the RuvAB-Holliday junction intermediate complex from Pseudomonas aeruginosa.
Front Plant Sci, 14, 2023
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7X7Q
 | | CryoEM structure of RuvA-RuvB-Holliday junction complex | | Descriptor: | DNA (26-MER), DNA (40-MER), Holliday junction ATP-dependent DNA helicase RuvA, ... | | Authors: | Lin, Z, Qu, Q, Zhang, X, Zhou, Z. | | Deposit date: | 2022-03-10 | | Release date: | 2023-03-15 | | Last modified: | 2023-09-20 | | Method: | ELECTRON MICROSCOPY (7.02 Å) | | Cite: | Cryo-EM structure of the RuvAB-Holliday junction intermediate complex from Pseudomonas aeruginosa.
Front Plant Sci, 14, 2023
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7X7P
 | | CryoEM structure of dsDNA-RuvB-RuvA domain3 complex | | Descriptor: | DNA, Holliday junction ATP-dependent DNA helicase RuvA, Holliday junction ATP-dependent DNA helicase RuvB | | Authors: | Lin, Z, Qu, Q, Zhang, X, Zhou, Z. | | Deposit date: | 2022-03-10 | | Release date: | 2023-03-15 | | Last modified: | 2023-09-20 | | Method: | ELECTRON MICROSCOPY (7.02 Å) | | Cite: | Cryo-EM structure of the RuvAB-Holliday junction intermediate complex from Pseudomonas aeruginosa.
Front Plant Sci, 14, 2023
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