Author results

4E26
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BRAF IN COMPLEX WITH AN ORGANIC INHIBITOR 7898734
Descriptor:Serine/threonine-protein kinase B-raf, 5-chloro-7-[(R)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol
Authors:Qin, J., Xie, P., Ventocilla, C., Zhou, G., Vultur, A., Chen, Q., Herlyn, M., Winkler, J., Marmorstein, R.
Deposit date:2012-03-07
Release date:2012-05-09
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Identification of a Novel Family of BRAF(V600E) Inhibitors.
J.Med.Chem., 55, 2012
6MIF
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LIM5 DOMAIN OF PINCH1 PROTEIN
Descriptor:LIM and senescent cell antigen-like-containing domain protein 1, ZINC ION
Authors:Qin, J., Vaynberg, J.
Deposit date:2018-09-19
Release date:2018-10-31
Method:SOLUTION NMR
Cite:Lim5 domain of PINCH1 protein
To Be Published
3UCC
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ASYMMETRIC COMPLEX OF HUMAN NEURON SPECIFIC ENOLASE-1-PGA/PEP
Descriptor:Gamma-enolase, MAGNESIUM ION, 2-PHOSPHOGLYCERIC ACID, ...
Authors:Qin, J., Chai, G., Brewer, J., Lovelace, L., Lebioda, L.
Deposit date:2011-10-26
Release date:2012-08-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structures of asymmetric complexes of human neuron specific enolase with resolved substrate and product and an analogous complex with two inhibitors indicate subunit interaction and inhibitor cooperativity.
J.Inorg.Biochem., 111, 2012
3UCD
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ASYMMETRIC COMPLEX OF HUMAN NEURON SPECIFIC ENOLASE-2-PGA/PEP
Descriptor:Gamma-enolase, MAGNESIUM ION, 2-PHOSPHOGLYCERIC ACID, ...
Authors:Qin, J., Chai, G., Brewer, J., Lovelace, L., Lebioda, L.
Deposit date:2011-10-26
Release date:2012-08-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Structures of asymmetric complexes of human neuron specific enolase with resolved substrate and product and an analogous complex with two inhibitors indicate subunit interaction and inhibitor cooperativity.
J.Inorg.Biochem., 111, 2012
3UJE
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ASYMMETRIC COMPLEX OF HUMAN NEURON SPECIFIC ENOLASE-3-PGA/PEP
Descriptor:Gamma-enolase, MAGNESIUM ION, 2-PHOSPHOGLYCERIC ACID, ...
Authors:Qin, J., Chai, G., Brewer, J., Lovelace, L., Lebioda, L.
Deposit date:2011-11-07
Release date:2012-08-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structures of asymmetric complexes of human neuron specific enolase with resolved substrate and product and an analogous complex with two inhibitors indicate subunit interaction and inhibitor cooperativity.
J.Inorg.Biochem., 111, 2012
3UJF
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ASYMMETRIC COMPLEX OF HUMAN NEURON SPECIFIC ENOLASE-4-PGA/PEP
Descriptor:Gamma-enolase, MAGNESIUM ION, 2-PHOSPHOGLYCERIC ACID, ...
Authors:Qin, J., Chai, G., Brewer, J., Lovelace, L., Lebioda, L.
Deposit date:2011-11-07
Release date:2012-08-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of asymmetric complexes of human neuron specific enolase with resolved substrate and product and an analogous complex with two inhibitors indicate subunit interaction and inhibitor cooperativity.
J.Inorg.Biochem., 111, 2012
3UJR
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ASYMMETRIC COMPLEX OF HUMAN NEURON SPECIFIC ENOLASE-5-PGA/PEP
Descriptor:Gamma-enolase, MAGNESIUM ION, 2-PHOSPHOGLYCERIC ACID, ...
Authors:Qin, J., Chai, G., Brewer, J., Lovelace, L., Lebioda, L.
Deposit date:2011-11-08
Release date:2012-08-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structures of asymmetric complexes of human neuron specific enolase with resolved substrate and product and an analogous complex with two inhibitors indicate subunit interaction and inhibitor cooperativity.
J.Inorg.Biochem., 111, 2012
3UJS
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ASYMMETRIC COMPLEX OF HUMAN NEURON SPECIFIC ENOLASE-6-PGA/PEP
Descriptor:Gamma-enolase, MAGNESIUM ION, (2R)-3-oxo-2-(phosphonooxy)propanoic acid, ...
Authors:Qin, J., Chai, G., Brewer, J., Lovelace, L., Lebioda, L.
Deposit date:2011-11-08
Release date:2012-08-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structures of asymmetric complexes of human neuron specific enolase with resolved substrate and product and an analogous complex with two inhibitors indicate subunit interaction and inhibitor cooperativity.
J.Inorg.Biochem., 111, 2012
2AKM
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FLUORIDE INHIBITION OF ENOLASE: CRYSTAL STRUCTURE OF THE INHIBITORY COMPLEX
Descriptor:Gamma enolase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Qin, J., Chai, G., Brewer, J.M., Lovelace, L.L.
Deposit date:2005-08-03
Release date:2006-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Fluoride inhibition of enolase: crystal structure and thermodynamics
Biochemistry, 45, 2006
2AKZ
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FLUORIDE INHIBITION OF ENOLASE: CRYSTAL STRUCTURE OF THE INHIBITORY COMPLEX
Descriptor:Gamma enolase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Qin, J., Chai, G., Brewer, J.M., Lovelace, L.L.
Deposit date:2005-08-04
Release date:2006-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Fluoride inhibition of enolase: crystal structure and thermodynamics
Biochemistry, 45, 2006
2EVK
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THE STRUCTURES OF THIOLATE- AND CARBOXYLATE-LIGATED FERRIC H93G MYOGLOBIN: MODELS FOR CYTOCHROME P450 AND FOR OXYANION-BOUND HEME PROTEINS
Descriptor:Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ACETIC ACID
Authors:Qin, J., Perera, R., Lovelace, L.L., Dawson, J.H., Lebioda, L.
Deposit date:2005-10-31
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structures of thiolate- and carboxylate-ligated ferric H93G myoglobin: models for cytochrome P450 and for oxyanion-bound heme proteins.
Biochemistry, 45, 2006
2EVP
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THE STRUCTURES OF THIOLATE- AND CARBOXYLATE-LIGATED FERRIC H93G MYOGLOBIN: MODELS FOR CYTOCHROME P450 AND FOR OXYANION-BOUND HEME PROTEINS
Descriptor:Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, BETA-MERCAPTOETHANOL
Authors:Qin, J., Perera, R., Lovelace, L.L., Dawson, J.H., Lebioda, L.
Deposit date:2005-10-31
Release date:2006-03-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of Thiolate- and Carboxylate-Ligated Ferric H93G Myoglobin: Models for Cytochrome P450 and for Oxyanion-Bound Heme Proteins(,).
Biochemistry, 45, 2006
2KBX
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SOLUTION STRUCTURE OF ILK-PINCH COMPLEX
Descriptor:Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, ZINC ION
Authors:Qin, J.
Deposit date:2008-12-10
Release date:2008-12-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Cytosketal proteins
To be Published
1CQG
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HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN REF-1 (RESIDUES 59-71 OF THE P50 SUBUNIT OF NFKB), NMR, 31 STRUCTURES
Descriptor:THIOREDOXIN, REF-1 PEPTIDE
Authors:Clore, G.M., Qin, J., Gronenborn, A.M.
Deposit date:1996-04-02
Release date:1996-08-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal.
Structure, 4, 1996
1CQH
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HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN REF-1 (RESIDUES 59-71 OF THE P50 SUBUNIT OF NFKB), NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:THIOREDOXIN, REF-1 PEPTIDE
Authors:Clore, G.M., Qin, J., Gronenborn, A.M.
Deposit date:1996-04-02
Release date:1996-08-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal.
Structure, 4, 1996
4RLO
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HUMAN P70S6K1 WITH RUTHENIUM-BASED INHIBITOR EM5
Descriptor:Ribosomal protein S6 kinase beta-1, [(amino-kappaN)methanethiolato](3-fluoro-9-hydroxypyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dionato-kappa~2~N,N')(1,4,7-trithionane-kappa~3~S~1~,S~4~,S~7~)ruthenium, GLYCEROL, ...
Authors:Domsic, J.F., Barber-Rotenberg, J., Salami, J., Qin, J., Marmorstein, R.
Deposit date:2014-10-17
Release date:2015-01-21
Method:X-RAY DIFFRACTION (2.527 Å)
Cite:Development of Organometallic S6K1 Inhibitors.
J.Med.Chem., 58, 2015
4RLP
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HUMAN P70S6K1 WITH RUTHENIUM-BASED INHIBITOR FL772
Descriptor:p70S6K1, [(amino-kappaN)methanethiolato](3-fluoro-9-methoxypyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dionato-kappa~2~N,N')(N-methyl-1,4,7-trithiecan-9-amine-kappa~3~S~1~,S~4~,S~7~)ruthenium, CHLORIDE ION
Authors:Domsic, J.F., Barber-Rotenberg, J., Salami, J., Qin, J., Marmorstein, R.
Deposit date:2014-10-17
Release date:2015-01-21
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Development of Organometallic S6K1 Inhibitors.
J.Med.Chem., 58, 2015
1MDI
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HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN MUTANT HUMAN THIOREDOXIN AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN NFKB
Descriptor:THIOREDOXIN, TARGET SITE IN HUMAN NFKB
Authors:Clore, G.M., Qin, J., Gronenborn, A.M.
Deposit date:1995-02-27
Release date:1995-06-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF kappa B.
Structure, 3, 1995
1MDJ
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HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN NFKB (RESIDUES 56-68 OF THE P50 SUBUNIT OF NFKB)
Descriptor:THIOREDOXIN, TARGET SITE IN HUMAN NFKB
Authors:Clore, G.M., Qin, J., Gronenborn, A.M.
Deposit date:1995-02-27
Release date:1995-06-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF kappa B.
Structure, 3, 1995
1MDK
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HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN NFKB (RESIDUES 56-68 OF THE P50 SUBUNIT OF NFKB)
Descriptor:THIOREDOXIN, TARGET SITE IN HUMAN NFKB
Authors:Clore, G.M., Qin, J., Gronenborn, A.M.
Deposit date:1995-02-27
Release date:1995-06-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF kappa B.
Structure, 3, 1995
1TRS
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THE HIGH-RESOLUTION THREE-DIMENSIONAL SOLUTION STRUCTURES OF THE OXIDIZED AND REDUCED STATES OF HUMAN THIOREDOXIN
Descriptor:THIOREDOXIN
Authors:Clore, G.M., Qin, J., Gronenborn, A.M.
Deposit date:1994-05-10
Release date:1994-09-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The high-resolution three-dimensional solution structures of the oxidized and reduced states of human thioredoxin.
Structure, 2, 1994
1TRU
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THE HIGH-RESOLUTION THREE-DIMENSIONAL SOLUTION STRUCTURES OF THE OXIDIZED AND REDUCED STATES OF HUMAN THIOREDOXIN
Descriptor:THIOREDOXIN
Authors:Clore, G.M., Qin, J., Gronenborn, A.M.
Deposit date:1994-05-10
Release date:1994-09-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The high-resolution three-dimensional solution structures of the oxidized and reduced states of human thioredoxin.
Structure, 2, 1994
1TRV
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THE HIGH-RESOLUTION THREE-DIMENSIONAL SOLUTION STRUCTURES OF THE OXIDIZED AND REDUCED STATES OF HUMAN THIOREDOXIN
Descriptor:THIOREDOXIN
Authors:Clore, G.M., Qin, J., Gronenborn, A.M.
Deposit date:1994-05-10
Release date:1994-09-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The high-resolution three-dimensional solution structures of the oxidized and reduced states of human thioredoxin.
Structure, 2, 1994
1TRW
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THE HIGH-RESOLUTION THREE-DIMENSIONAL SOLUTION STRUCTURES OF THE OXIDIZED AND REDUCED STATES OF HUMAN THIOREDOXIN
Descriptor:THIOREDOXIN
Authors:Clore, G.M., Qin, J., Gronenborn, A.M.
Deposit date:1994-05-10
Release date:1994-09-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The high-resolution three-dimensional solution structures of the oxidized and reduced states of human thioredoxin.
Structure, 2, 1994
5EJC
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CRYSTAL STRUCTURAL OF THE TSC1-TBC1D7 COMPLEX
Descriptor:TBC1 domain family member 7, Hamartin
Authors:Wang, Z., Qin, J., Gong, W., Xu, W.
Deposit date:2015-11-01
Release date:2016-03-02
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis of the Interaction between Tuberous Sclerosis Complex 1 (TSC1) and Tre2-Bub2-Cdc16 Domain Family Member 7 (TBC1D7).
J.Biol.Chem., 291, 2016
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