4UAF
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4UAD
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4UAE
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7T38
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7T37
| Activated state of 2-APB and CBD-bound wildtype rat TRPV2 in nanodiscs | Descriptor: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2, cannabidiol | Authors: | Pumroy, R.A, Protopopova, A.D, Gallo, P.N, Moiseenkova-Bell, V.Y. | Deposit date: | 2021-12-07 | Release date: | 2022-05-04 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural insights into TRPV2 activation by small molecules. Nat Commun, 13, 2022
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7N0N
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7N0M
| Inactivated state of 2-APB-bound wildtype rat TRPV2 in nanodiscs | Descriptor: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2 | Authors: | Pumroy, R.A, Protopopova, A.D, Gallo, P.N, Moiseenkova-Bell, V.Y. | Deposit date: | 2021-05-25 | Release date: | 2022-05-04 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural insights into TRPV2 activation by small molecules. Nat Commun, 13, 2022
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6U84
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6U86
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6U8A
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6U88
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8FFL
| Wildtype rat TRPV2 in nanodiscs bound to RR | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Transient receptor potential cation channel subfamily V member 2 | Authors: | Pumroy, R.A, Protopopova, A.D, Rocereta, J.A, De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y. | Deposit date: | 2022-12-09 | Release date: | 2024-02-07 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Molecular details of ruthenium red pore block in TRPV channels. Embo Rep., 25, 2024
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8FFM
| Wildtype rat TRPV2 in nanodiscs bound to RR and 2-APB | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2, ... | Authors: | Pumroy, R.A, Protopopova, A.D, Rocereta, J.A, De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y. | Deposit date: | 2022-12-09 | Release date: | 2024-02-07 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular details of ruthenium red pore block in TRPV channels. Embo Rep., 25, 2024
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8FFQ
| Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and ruthenium red | Descriptor: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ERGOSTEROL, Transient receptor potential cation channel subfamily V member 5, ... | Authors: | De Jesus-Perez, J.J, Fluck, E.C, Pumroy, R.A, Protopopova, A.D, Rocereta, J.A, Moiseenkova-Bell, V.Y. | Deposit date: | 2022-12-09 | Release date: | 2024-02-07 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | Molecular details of ruthenium red pore block in TRPV channels. Embo Rep., 25, 2024
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8FFN
| RR-bound wildtype rabbit TRPV5 in nanodiscs | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ERGOSTEROL, Transient receptor potential cation channel subfamily V member 5, ... | Authors: | Fluck, E.C, De Jesus-Perez, J.J, Pumroy, R.A, Protopopova, A.D, Rocereta, J.A, Moiseenkova-Bell, V.Y. | Deposit date: | 2022-12-09 | Release date: | 2024-02-07 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Molecular details of ruthenium red pore block in TRPV channels. Embo Rep., 25, 2024
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7RK8
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7RK9
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5T94
| Crystal structure of Kap60 bound to yeast RCC1 (Prp20) | Descriptor: | Guanine nucleotide exchange factor SRM1, Importin subunit alpha | Authors: | Sankhala, R.S, Lokareddy, R.K, Pumroy, R.A, Cingolani, G. | Deposit date: | 2016-09-09 | Release date: | 2017-09-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.631 Å) | Cite: | Three-dimensional context rather than NLS amino acid sequence determines importin alpha subtype specificity for RCC1. Nat Commun, 8, 2017
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6DMW
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6DMR
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6DMU
| PI(4,5)P2 bound full-length rbTRPV5 | Descriptor: | Transient receptor potential cation channel subfamily V member 5, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Hughes, T.E.T, Pumroy, R.A, Moiseenkova-Bell, V.Y. | Deposit date: | 2018-06-05 | Release date: | 2018-10-24 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural insights on TRPV5 gating by endogenous modulators. Nat Commun, 9, 2018
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5TBK
| Crystal structure of human importin a3 bound to RCC1 | Descriptor: | Importin subunit alpha-3, Regulator of chromosome condensation | Authors: | Sankhala, R.S, Lokareddy, R.K, Pumroy, R.A, Cingolani, G. | Deposit date: | 2016-09-12 | Release date: | 2017-09-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Three-dimensional context rather than NLS amino acid sequence determines importin alpha subtype specificity for RCC1. Nat Commun, 8, 2017
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3TJ3
| Structure of importin a5 bound to the N-terminus of Nup50 | Descriptor: | Importin subunit alpha-1, Nuclear pore complex protein Nup50 | Authors: | Pumroy, R, Nardozzi, J.D, Hart, D.J, Root, M.J, Cingolani, G. | Deposit date: | 2011-08-23 | Release date: | 2011-11-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.702 Å) | Cite: | Nucleoporin Nup50 stabilizes closed conformation of armadillo repeat 10 in importin alpha 5. J.Biol.Chem., 287, 2012
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7K5C
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4PVZ
| Structure of yeast importin a bound to the membrane protein Nuclear Localization Signal sequence of INM protein Heh2 | Descriptor: | Importin subunit alpha, Inner nuclear membrane protein HEH2 | Authors: | Lokareddy, R.K, Hapsari, A.R, van Rheenen, M, Bhardwaj, A, Veenhoff, L.M, Cingolani, C. | Deposit date: | 2014-03-18 | Release date: | 2015-08-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2. Structure, 23, 2015
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