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CRYSTALLOGRAPHIC REFINEMENT OF INTERLEUKIN-1 BETA AT 2.0 ANGSTROMS RESOLUTION
Descriptor:	INTERLEUKIN-1 BETA
Authors:	Priestle, J.P, Schaer, H.-P, Gruetter, M.G.
Deposit date:	1990-01-02
Release date:	1990-04-15
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Crystallographic refinement of interleukin 1 beta at 2.0 A resolution. Proc.Natl.Acad.Sci.USA, 86, 1989

1TMT

CHANGES IN INTERACTIONS IN COMPLEXES OF HIRUDIN DERIVATIVES AND HUMAN ALPHA-THROMBIN DUE TO DIFFERENT CRYSTAL FORMS
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), ...
Authors:	Priestle, J.P, Gruetter, M.G.
Deposit date:	1994-05-26
Release date:	1994-09-30
Last modified:	2022-12-21
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms. Protein Sci., 2, 1993

1TMU

Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Hirudin variant-2, ...
Authors:	Priestle, J.P, Gruetter, M.G.
Deposit date:	1994-05-26
Release date:	1994-09-30
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms. Protein Sci., 2, 1993

1HII

COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR
Descriptor:	ACETYL-NH-VAL-CYCLOHEXYL-CH2[NCH2CHOH]CH2-BENZYL-VAL-NH-ACETYL, HIV-2 PROTEASE, SULFATE ION
Authors:	Priestle, J.P, Gruetter, M.G.
Deposit date:	1995-03-31
Release date:	1995-07-10
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, a novel pseudosymmetric inhibitor. Structure, 3, 1995

1HIH

COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR
Descriptor:	ACETYL-NH-VAL-CYCLOHEXYL-CH2[NCH2CHOH]CH2-BENZYL-VAL-NH-ACETYL, BETA-MERCAPTOETHANOL, HIV-1 PROTEASE
Authors:	Priestle, J.P, Gruetter, M.G.
Deposit date:	1995-03-31
Release date:	1995-07-10
Last modified:	2018-04-18
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, a novel pseudosymmetric inhibitor. Structure, 3, 1995

1AN1

LEECH-DERIVED TRYPTASE INHIBITOR/TRYPSIN COMPLEX
Descriptor:	CALCIUM ION, TRYPSIN, TRYPTASE INHIBITOR
Authors:	Priestle, J.P, Di Marco, S.
Deposit date:	1997-06-26
Release date:	1998-07-01
Last modified:	2023-08-02
Method:	X-RAY DIFFRACTION (2.03 Å)
Cite:	Structure of the complex of leech-derived tryptase inhibitor (LDTI) with trypsin and modeling of the LDTI-tryptase system. Structure, 5, 1997

2MIB

THE STRUCTURE OF MURINE INTERLEUKIN-1 BETA AT 2.8 ANGSTROMS RESOLUTION
Descriptor:	INTERLEUKIN-1 BETA
Authors:	Priestle, J.P, Van Oostrum, J, Schmitz, A, Gruetter, M.G.
Deposit date:	1993-12-06
Release date:	1994-01-31
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.84 Å)
Cite:	The structure of murine interleukin-1 beta at 2.8 A resolution. J.Struct.Biol., 107, 1991

1BX7

HIRUSTASIN FROM HIRUDO MEDICINALIS AT 1.2 ANGSTROMS
Descriptor:	HIRUSTASIN, SULFATE ION
Authors:	Uson, I, Sheldrick, G.M, De La Fortelle, E, Bricogne, G, Di Marco, S, Priestle, J.P, Gruetter, M.G, Mittl, P.R.E.
Deposit date:	1998-10-14
Release date:	1999-04-27
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (1.2 Å)
Cite:	The 1.2 A crystal structure of hirustasin reveals the intrinsic flexibility of a family of highly disulphide-bridged inhibitors. Structure Fold.Des., 7, 1999

1BX8

HIRUSTASIN FROM HIRUDO MEDICINALIS AT 1.4 ANGSTROMS
Descriptor:	HIRUSTASIN, SULFATE ION
Authors:	Uson, I, Sheldrick, G.M, De La Fortelle, E, Bricogne, G, Di Marco, S, Priestle, J.P, Gruetter, M.G, Mittl, P.R.E.
Deposit date:	1998-10-14
Release date:	1999-04-27
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	The 1.2 A crystal structure of hirustasin reveals the intrinsic flexibility of a family of highly disulphide-bridged inhibitors. Structure Fold.Des., 7, 1999

1PII

THREE-DIMENSIONAL STRUCTURE OF THE BIFUNCTIONAL ENZYME PHOSPHORIBOSYLANTHRANILATE ISOMERASE: INDOLEGLYCEROLPHOSPHATE SYNTHASE FROM ESCHERICHIA COLI REFINED AT 2.0 ANGSTROMS RESOLUTION
Descriptor:	N-(5'PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE, PHOSPHATE ION
Authors:	Wilmanns, M, Priestle, J.P, Jansonius, J.N.
Deposit date:	1991-06-21
Release date:	1994-01-31
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Three-dimensional structure of the bifunctional enzyme phosphoribosylanthranilate isomerase: indoleglycerolphosphate synthase from Escherichia coli refined at 2.0 A resolution. J.Mol.Biol., 223, 1992

1RNE

THE CRYSTAL STRUCTURE OF RECOMBINANT GLYCOSYLATED HUMAN RENIN ALONE AND IN COMPLEX WITH A TRANSITION STATE ANALOG INHIBITOR
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, RENIN, [[[3-(2-METHYL-PROPANE-2-SULFONYL)-1-BENZENYL]-2-PROPYL]-CARBONYL-HISTIDYL]-AMINO-[CYCLOHEXYLMETHYL]-[2-HYDROXY-4-ISOPROPYL]-PENTAN-5-OIC ACID BUTYLAMIDE
Authors:	Gruetter, M.G, Rahuel, J, Priestle, J.P.
Deposit date:	1991-12-12
Release date:	1993-10-31
Last modified:	2020-10-21
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor. J.Struct.Biol., 107, 1991

1SBN

REFINED CRYSTAL STRUCTURES OF SUBTILISIN NOVO IN COMPLEX WITH WILD-TYPE AND TWO MUTANT EGLINS. COMPARISON WITH OTHER SERINE PROTEINASE INHIBITOR COMPLEXES
Descriptor:	CALCIUM ION, EGLIN C, SUBTILISIN NOVO BPN'
Authors:	Gruetter, M.G, Heinz, D.W, Priestle, J.P.
Deposit date:	1991-12-20
Release date:	1994-01-31
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Refined crystal structures of subtilisin novo in complex with wild-type and two mutant eglins. Comparison with other serine proteinase inhibitor complexes. J.Mol.Biol., 217, 1991

1SIB

REFINED CRYSTAL STRUCTURES OF SUBTILISIN NOVO IN COMPLEX WITH WILD-TYPE AND TWO MUTANT EGLINS. COMPARISON WITH OTHER SERINE PROTEINASE INHIBITOR COMPLEXES
Descriptor:	CALCIUM ION, EGLIN C, SUBTILISIN NOVO BPN'
Authors:	Gruetter, M.G, Heinz, D.W, Priestle, J.P.
Deposit date:	1993-08-02
Release date:	1993-10-31
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Refined crystal structures of subtilisin novo in complex with wild-type and two mutant eglins. Comparison with other serine proteinase inhibitor complexes. J.Mol.Biol., 217, 1991

1TGK

HUMAN TRANSFORMING GROWTH FACTOR BETA 3, CRYSTALLIZED FROM PEG 4000
Descriptor:	TRANSFORMING GROWTH FACTOR BETA 3
Authors:	Mittl, P.R.E, Priestle, J.P, Gruetter, M.G.
Deposit date:	1996-07-10
Release date:	1997-03-12
Last modified:	2018-04-18
Method:	X-RAY DIFFRACTION (3.3 Å)
Cite:	The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding. Protein Sci., 5, 1996

1TGJ

HUMAN TRANSFORMING GROWTH FACTOR-BETA 3, CRYSTALLIZED FROM DIOXANE
Descriptor:	1,4-DIETHYLENE DIOXIDE, TRANSFORMING GROWTH FACTOR-BETA 3
Authors:	Mittl, P.R.E, Priestle, J.P, Gruetter, M.G.
Deposit date:	1996-07-09
Release date:	1997-01-11
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding. Protein Sci., 5, 1996

1PPD

RESTRAINED LEAST-SQUARES REFINEMENT OF THE SULFHYDRYL PROTEASE PAPAIN TO 2.0 ANGSTROMS
Descriptor:	2-HYDROXYETHYL-THIOPAPAIN, BETA-MERCAPTOETHANOL
Authors:	Jansonius, J.N.
Deposit date:	1984-11-06
Release date:	1985-01-02
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Restrained Least-Squares Refinement of the Sulfhydryl Protease Papain to 2.0 Angstroms Acta Crystallogr.,Sect.A, 40, 1984

1CP3

CRYSTAL STRUCTURE OF THE COMPLEX OF APOPAIN WITH THE TETRAPEPTIDE INHIBITOR ACE-DVAD-FMC
Descriptor:	ACETYL-ASP-VAL-ALA-ASP-FLUOROMETHYLKETONE, APOPAIN
Authors:	Mittl, P.R.E, Dimarco, S, Gruetter, M.G.
Deposit date:	1996-12-12
Release date:	1997-12-24
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone. J.Biol.Chem., 272, 1997

6RA4

Human ARGONAUTE-2 PAZ DOMAIN (214-347) IN COMPLEX WITH CGUGACUCU
Descriptor:	GLYCEROL, Protein argonaute-2, RNA (5'-R(CPGPUPGPAPCPUPCP*U)-3')
Authors:	Rondeau, J.-M, Bourgier, E.
Deposit date:	2019-04-05
Release date:	2019-05-08
Last modified:	2019-06-05
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	How to Computationally Stack the Deck for Hit-to-Lead Generation: In Silico Molecular Interaction Energy Profiling for de Novo siRNA Guide Strand Surrogate Selection. J.Chem.Inf.Model., 59, 2019

1HIA

KALLIKREIN COMPLEXED WITH HIRUSTASIN
Descriptor:	HIRUSTASIN, KALLIKREIN
Authors:	Mittl, P, Di Marco, S, Gruetter, M.
Deposit date:	1996-12-12
Release date:	1997-12-24
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	A new structural class of serine protease inhibitors revealed by the structure of the hirustasin-kallikrein complex. Structure, 5, 1997

2V12

Crystal Structure of Renin with Inhibitor 8
Descriptor:	N-[(2S,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-7-METHYL-2-(1-METHYLETHYL)-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE, RENIN
Authors:	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
Deposit date:	2007-05-21
Release date:	2007-07-03
Last modified:	2019-04-03
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

2V0Z

Crystal Structure of Renin with Inhibitor 10 (Aliskiren)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, ALISKIREN, RENIN
Authors:	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
Deposit date:	2007-05-21
Release date:	2007-07-03
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

2V16

Crystal Structure of Renin with Inhibitor 3
Descriptor:	METHYL (3R)-1-[(5S,6S,8R)-5-AMINO-9-BUTYLAMINO-6-HYDROXY-3,3,8-TRIMETHYL-9-OXO-NONANOYL]-3,4-DIHYDRO-2H-QUINOLINE-3-CARBOXYLATE, RENIN
Authors:	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
Deposit date:	2007-05-22
Release date:	2008-07-08
Last modified:	2019-04-03
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

2V13

Crystal Structure of Renin with Inhibitor 7
Descriptor:	N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE, RENIN
Authors:	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
Deposit date:	2007-05-21
Release date:	2008-07-08
Last modified:	2019-04-03
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

2V11

Crystal Structure of Renin with Inhibitor 6
Descriptor:	(2S,4S,5R,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL 1-BENZYL-1H-INDOLE-3-CARBOXYLATE, RENIN
Authors:	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
Deposit date:	2007-05-21
Release date:	2007-07-03
Last modified:	2019-04-03
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

2V10

Crystal Structure of Renin with Inhibitor 9
Descriptor:	(2R,4S,5S,7S)-5-AMINO-N-BUTYL-4-HYDROXY-7-[4-METHOXY-3-(3-METHOXYPROPOXY)BENZYL]-2,8-DIMETHYLNONANAMIDE, RENIN
Authors:	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
Deposit date:	2007-05-21
Release date:	2007-07-03
Last modified:	2019-04-03
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

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Displayed results:	25
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