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2Y0R
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BU of 2y0r by Molmil
Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2
Descriptor: MYOSIN-2 HEAVY CHAIN
Authors:Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J.
Deposit date:2010-12-07
Release date:2011-07-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V.
J.Biol.Chem., 286, 2011
2XO8
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BU of 2xo8 by Molmil
Crystal Structure of Myosin-2 in Complex with Tribromodichloropseudilin
Descriptor: 2,4-DICHLORO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL, ADP METAVANADATE, MAGNESIUM ION, ...
Authors:Preller, M, Chinthalapudi, K, Martin, R, Knoelker, H.J, Manstein, D.J.
Deposit date:2010-08-10
Release date:2011-05-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Inhibition of Myosin ATPase Activity by Halogenated Pseudilins: A Structure-Activity Study.
J.Med.Chem., 54, 2011
2Y9E
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BU of 2y9e by Molmil
Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2
Descriptor: MYOSIN-2
Authors:Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J.
Deposit date:2011-02-14
Release date:2011-07-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.397 Å)
Cite:Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V.
J.Biol.Chem., 286, 2011
2Y8I
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BU of 2y8i by Molmil
Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MYOSIN-2 HEAVY CHAIN
Authors:Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J.
Deposit date:2011-02-07
Release date:2011-07-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.132 Å)
Cite:Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V.
J.Biol.Chem., 286, 2011
6Q6F
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BU of 6q6f by Molmil
Crystal structure of IDH1 R132H in complex with HMS101
Descriptor: (2~{R})-2-[2-[(3~{R})-3-(4-fluorophenyl)pyrrolidin-1-yl]ethyl]-1,4-dimethyl-piperazine, Isocitrate dehydrogenase [NADP] cytoplasmic
Authors:Chaturvedi, A, Goparaju, R, Gupta, C, Kluenemann, T, Araujo Cruz, M.M, Kloos, A, Goerlich, K, Schottmann, R, Struys, E.A, Ganser, A, Preller, M, Heuser, M.
Deposit date:2018-12-10
Release date:2019-10-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site.
Leukemia, 34, 2020
5I4E
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BU of 5i4e by Molmil
Crystal Structure of Human Nonmuscle Myosin 2C motor domain
Descriptor: ADP ORTHOVANADATE, MAGNESIUM ION, Myosin-14,Alpha-actinin A
Authors:Chinthalapudi, K, Heissler, S.M, Preller, M, Sellers, J.R, Manstein, D.J.
Deposit date:2016-02-11
Release date:2017-09-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C.
Elife, 6, 2017
6Z7U
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BU of 6z7u by Molmil
Myosin-II motor domain complexed with blebbistatin in a new ADP-release conformation
Descriptor: (-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Ewert, W, Preller, M.
Deposit date:2020-06-01
Release date:2020-10-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural and Computational Insights into a Blebbistatin-Bound Myosin•ADP Complex with Characteristics of an ADP-Release Conformation along the Two-Step Myosin Power Stoke.
Int J Mol Sci, 21, 2020
6Z7T
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BU of 6z7t by Molmil
Nucleotide-free Myosin-II motor domain
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Ewert, W, Preller, M.
Deposit date:2020-06-01
Release date:2020-10-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural and Computational Insights into a Blebbistatin-Bound Myosin•ADP Complex with Characteristics of an ADP-Release Conformation along the Two-Step Myosin Power Stoke.
Int J Mol Sci, 21, 2020
6Z2S
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BU of 6z2s by Molmil
Crystal structure of adhibin analogue-bound myosin-2
Descriptor: 3,6-dibromo-1-(hydroxymethyl)carbazole, ACETATE ION, ADP METAVANADATE, ...
Authors:Ewert, W, Knoelker, H.-J, Tsiavaliaris, G, Preller, M.
Deposit date:2020-05-18
Release date:2021-06-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The synthetic carbazole adhibin acts as selective myosin class-IX inhibitor in lung cancer cells
To Be Published
7B1A
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BU of 7b1a by Molmil
Myosin-II-AA mutant motor domain
Descriptor: 1,2-ETHANEDIOL, ADP METAVANADATE, MAGNESIUM ION, ...
Authors:Ewert, W, Preller, M.
Deposit date:2020-11-24
Release date:2021-01-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and P i Release.
Int J Mol Sci, 22, 2020
7B19
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BU of 7b19 by Molmil
Mutant Myosin-II-GGG motor domain
Descriptor: ADP METAVANADATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Ewert, W, Preller, M.
Deposit date:2020-11-24
Release date:2021-01-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and P i Release.
Int J Mol Sci, 22, 2020
2XEL
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BU of 2xel by Molmil
Molecular Mechanism of Pentachloropseudilin Mediated Inhibition of Myosin Motor Activity
Descriptor: 2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL, ADP METAVANADATE, MAGNESIUM ION, ...
Authors:Chinthalapudi, K, Taft, M.H, Martin, R, Hartmann, F.K, Heissler, S.M, Tsiavaliaris, G, Gutzeit, H.O, Knoelker, H.J, Coluccio, L.M, Fedorov, R, Manstein, D.J.
Deposit date:2010-05-16
Release date:2011-06-15
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanism and Specificity of Pentachloropseudilin-Mediated Inhibition of Myosin Motor Activity.
J.Biol.Chem., 286, 2011

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