Author results

4OYN
  • Download 4oyn
  • View 4oyn
Molmil generated image of 4oyn
FIFTEEN MINUTES IRON LOADED HUMAN H FERRITIN
Descriptor:Ferritin heavy chain, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BICINE, ...
Authors:Pozzi, C., Di Pisa, F., Mangani, S.
Deposit date:2014-02-12
Release date:2015-09-09
Last modified:2015-12-02
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Iron binding to human heavy-chain ferritin.
Acta Crystallogr.,Sect.D, 71, 2015
4Y08
  • Download 4y08
  • View 4y08
Molmil generated image of 4y08
ONE MINUTE IRON LOADED HUMAN H FERRITIN
Descriptor:Ferritin heavy chain, FE (II) ION, CHLORIDE ION, ...
Authors:Pozzi, C., Di Pisa, F., Mangani, S.
Deposit date:2015-02-05
Release date:2015-09-23
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Iron binding to human heavy-chain ferritin.
Acta Crystallogr.,Sect.D, 71, 2015
4YKH
  • Download 4ykh
  • View 4ykh
Molmil generated image of 4ykh
THIRTY MINUTES IRON LOADED HUMAN H FERRITIN
Descriptor:Ferritin heavy chain, BICINE, FE (II) ION, ...
Authors:Pozzi, C., Di Pisa, F., Mangani, S.
Deposit date:2015-03-04
Release date:2015-09-09
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Iron binding to human heavy-chain ferritin.
Acta Crystallogr.,Sect.D, 71, 2015
4ZJK
  • Download 4zjk
  • View 4zjk
Molmil generated image of 4zjk
FIVE MINUTES IRON LOADED HUMAN H FERRITIN
Descriptor:Ferritin heavy chain, FE (II) ION, MAGNESIUM ION, ...
Authors:Pozzi, C., Di Pisa, F., Mangani, S.
Deposit date:2015-04-29
Release date:2015-09-09
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Iron binding to human heavy-chain ferritin.
Acta Crystallogr.,Sect.D, 71, 2015
5LG2
  • Download 5lg2
  • View 5lg2
Molmil generated image of 5lg2
HORSE L TYPE FERRITIN IRON LOADED FOR 60 MINUTES
Descriptor:Ferritin light chain, CADMIUM ION, FE (III) ION, ...
Authors:Pozzi, C., Di Pisa, F., Mangani, S.
Deposit date:2016-07-05
Release date:2017-02-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional ( mu (3)-oxo)Tris[( mu (2)-peroxo)] triiron(III) cluster.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5LG8
  • Download 5lg8
  • View 5lg8
Molmil generated image of 5lg8
HUMAN L-TYPE FERRITIN IRON LOADED FOR 60 MINUTES
Descriptor:Ferritin light chain, CADMIUM ION, FE (III) ION, ...
Authors:Pozzi, C., Di Pisa, F., Mangani, S.
Deposit date:2016-07-06
Release date:2017-02-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional ( mu (3)-oxo)Tris[( mu (2)-peroxo)] triiron(III) cluster.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6I9P
  • Download 6i9p
  • View 6i9p
Molmil generated image of 6i9p
IRON-FREE STATE OF RANA CATESBEIANA H' FERRITIN VARIANT H54N
Descriptor:Ferritin, middle subunit, MAGNESIUM ION, ...
Authors:Pozzi, C., Di Pisa, F., Mangani, S.
Deposit date:2018-11-24
Release date:2019-05-22
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H' ferritin.
J.Inorg.Biochem., 197, 2019
6I9T
  • Download 6i9t
  • View 6i9t
Molmil generated image of 6i9t
TWO MINUTES IRON LOADED RANA CATESBEIANA H' FERRITIN VARIANT H54N
Descriptor:Ferritin, middle subunit, FE (II) ION, ...
Authors:Pozzi, C., Di Pisa, F., Mangani, S.
Deposit date:2018-11-25
Release date:2019-05-22
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H' ferritin.
J.Inorg.Biochem., 197, 2019
6IAF
  • Download 6iaf
  • View 6iaf
Molmil generated image of 6iaf
FIFTEEN MINUTES IRON LOADED RANA CATESBEIANA H' FERRITIN VARIANT H54N
Descriptor:Ferritin, middle subunit, FE (II) ION, ...
Authors:Pozzi, C., Di Pisa, F., Mangani, S.
Deposit date:2018-11-26
Release date:2019-05-22
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H' ferritin.
J.Inorg.Biochem., 197, 2019
6IAJ
  • Download 6iaj
  • View 6iaj
Molmil generated image of 6iaj
SIXTY MINUTES IRON LOADED RANA CATESBEIANA H' FERRITIN VARIANT H54N
Descriptor:Ferritin, middle subunit, FE (II) ION, ...
Authors:Pozzi, C., Di Pisa, F., Mangani, S.
Deposit date:2018-11-26
Release date:2019-05-22
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H' ferritin.
J.Inorg.Biochem., 197, 2019
3UWL
  • Download 3uwl
  • View 3uwl
Molmil generated image of 3uwl
CRYSTAL STRUCTURE OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE (EFTS) IN COMPLEX WITH 5-FORMYL TETRAHYDROFOLATE
Descriptor:Thymidylate synthase, SULFATE ION, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ...
Authors:Pozzi, C., Catalano, A., Cortesi, D., Luciani, R., Ferrari, S., Fritz, T., Costi, M.P., Mangani, S.
Deposit date:2011-12-02
Release date:2012-08-29
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism.
Acta Crystallogr.,Sect.D, 68, 2012
5EOE
  • Download 5eoe
  • View 5eoe
Molmil generated image of 5eoe
CRYSTAL STRUCTURE OF EXTENDED-SPECTRUM BETA-LACTAMASE BEL-1 (ORTHORHOMBIC FORM)
Descriptor:Beta-lactamase, CHLORIDE ION, 1,2-ETHANEDIOL, ...
Authors:Pozzi, C., De Luca, F., Benvenuti, M., Docquier, J.D., Mangani, S.
Deposit date:2015-11-10
Release date:2016-09-21
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum beta-Lactamase and Its Complexes with Moxalactam and Imipenem.
Antimicrob.Agents Chemother., 60, 2016
5EOO
  • Download 5eoo
  • View 5eoo
Molmil generated image of 5eoo
CRYSTAL STRUCTURE OF EXTENDED-SPECTRUM BETA-LACTAMASE BEL-1 (MONOCLINIC FORM)
Descriptor:Beta-lactamase, CHLORIDE ION, TRIETHYLENE GLYCOL, ...
Authors:Pozzi, C., De Luca, F., Benvenuti, M., Docquier, J.D., Mangani, S.
Deposit date:2015-11-10
Release date:2016-09-21
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum beta-Lactamase and Its Complexes with Moxalactam and Imipenem.
Antimicrob.Agents Chemother., 60, 2016
5EPH
  • Download 5eph
  • View 5eph
Molmil generated image of 5eph
CRYSTAL STRUCTURE OF EXTENDED-SPECTRUM BETA-LACTAMASE BEL-1 IN COMPLEX WITH IMIPENEM
Descriptor:Beta-lactamase, CHLORIDE ION, Imipenem, ...
Authors:Pozzi, C., Benvenuti, M., De Luca, F., Docquier, J.D., Mangani, S.
Deposit date:2015-11-11
Release date:2016-09-21
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum beta-Lactamase and Its Complexes with Moxalactam and Imipenem.
Antimicrob.Agents Chemother., 60, 2016
5EUA
  • Download 5eua
  • View 5eua
Molmil generated image of 5eua
CRYSTAL STRUCTURE OF EXTENDED-SPECTRUM BETA-LACTAMASE BEL-1 IN COMPLEX WITH MOXALACTAM
Descriptor:Beta-lactamase, (2R)-2-[(1R)-1-{[(2R)-2-carboxy-2-(4-hydroxyphenyl)acetyl]amino}-1-methoxy-2-oxoethyl]-5-methylidene-5,6-dihydro-2H-1,3-oxazine-4-carboxylic acid, SODIUM ION
Authors:Pozzi, C., De Luca, F., Benvenuti, M., Docquier, J.D., Mangani, S.
Deposit date:2015-11-18
Release date:2016-09-21
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum beta-Lactamase and Its Complexes with Moxalactam and Imipenem.
Antimicrob.Agents Chemother., 60, 2016
6FM6
  • Download 6fm6
  • View 6fm6
Molmil generated image of 6fm6
CRYSTAL STRUCTURE OF THE CLASS C BETA-LACTAMASE TRU-1 FROM AEROMONAS ENTEROPELOGENES
Descriptor:Beta-lactamase, SULFATE ION, TRIETHYLENE GLYCOL
Authors:Pozzi, C., De Luca, F., Di Pisa, F., Benvenuti, M., Docquier, J.D., Mangani, S.
Deposit date:2018-01-30
Release date:2018-05-30
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Atomic-Resolution Structure of a Class C beta-Lactamase and Its Complex with Avibactam.
ChemMedChem, 13, 2018
6FM7
  • Download 6fm7
  • View 6fm7
Molmil generated image of 6fm7
CRYSTAL STRUCTURE OF THE CLASS C BETA-LACTAMASE TRU-1 FROM AEROMONAS ENTEROPELOGENES IN COMPLEX WITH AVIBACTAM
Descriptor:Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, SULFATE ION, ...
Authors:Pozzi, C., De Luca, F., Benvenuti, M., Di Pisa, F., Docquier, J.D., Mangani, S.
Deposit date:2018-01-30
Release date:2018-05-30
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:Atomic-Resolution Structure of a Class C beta-Lactamase and Its Complex with Avibactam.
ChemMedChem, 13, 2018
6GBX
  • Download 6gbx
  • View 6gbx
Molmil generated image of 6gbx
CRYSTAL STRUCTURE OF HUMAN GLUTAMINYL CYCLASE VARIANT Y115E-Y117E IN COMPLEX WITH SEN177
Descriptor:Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION, ...
Authors:Pozzi, C., Di Pisa, F., Benvenuti, M., Mangani, S.
Deposit date:2018-04-16
Release date:2018-09-19
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders.
J. Biol. Inorg. Chem., 23, 2018
6QXG
  • Download 6qxg
  • View 6qxg
Molmil generated image of 6qxg
CRYSTAL STRUCTURE OF HIS-TAG HUMAN THYMIDYLATE SYNTHASE (HT-HTS) IN COMPLEX WITH FDUMP
Descriptor:Thymidylate synthase, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, SULFATE ION
Authors:Pozzi, C., Mangani, M.
Deposit date:2019-03-07
Release date:2019-04-10
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural Comparison ofEnterococcus faecalisand Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities.
Molecules, 24, 2019
6QXH
  • Download 6qxh
  • View 6qxh
Molmil generated image of 6qxh
CRYSTAL STRUCTURE OF HIS-TAG HUMAN THYMIDYLATE SYNTHASE (HT-HTS) IN COMPLEX WITH DUMP
Descriptor:Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
Authors:Pozzi, C., Mangani, M.
Deposit date:2019-03-07
Release date:2019-04-10
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Comparison ofEnterococcus faecalisand Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities.
Molecules, 24, 2019
6QXS
  • Download 6qxs
  • View 6qxs
Molmil generated image of 6qxs
CRYSTAL STRUCTURE OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE (EFTS) IN COMPLEX WITH FDUMP
Descriptor:Thymidylate synthase, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Pozzi, C., Mangani, M.
Deposit date:2019-03-07
Release date:2019-04-10
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Structural Comparison ofEnterococcus faecalisand Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities.
Molecules, 24, 2019
6QYA
  • Download 6qya
  • View 6qya
Molmil generated image of 6qya
CRYSTAL STRUCTURE OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE (EFTS) IN COMPLEX WITH DUMP
Descriptor:Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 1,2-ETHANEDIOL, ...
Authors:Pozzi, C., Mangani, M.
Deposit date:2019-03-08
Release date:2019-04-10
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural Comparison ofEnterococcus faecalisand Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities.
Molecules, 24, 2019
6QYQ
  • Download 6qyq
  • View 6qyq
Molmil generated image of 6qyq
CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE (HTS) VARIANT R175C
Descriptor:Thymidylate synthase, SULFATE ION, CHLORIDE ION, ...
Authors:Pozzi, C., Mangani, M.
Deposit date:2019-03-09
Release date:2019-04-17
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors.
Molecules, 24, 2019
6R2E
  • Download 6r2e
  • View 6r2e
Molmil generated image of 6r2e
CRYSTAL STRUCTURE OF THE HUMAN THYMIDYLATE SYNTHASE (HTS) INTERFACE VARIANT Q62R
Descriptor:Thymidylate synthase, SULFATE ION, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ...
Authors:Pozzi, C., Mangani, M.
Deposit date:2019-03-16
Release date:2019-04-10
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R.
Biomolecules, 9, 2019
4P18
  • Download 4p18
  • View 4p18
Molmil generated image of 4p18
CRYSTAL STRUCTURE OF FROG M FERRITIN MUTANT D80K
Descriptor:Ferritin, middle subunit, SULFATE ION, ...
Authors:Pozzi, C., Di Pisa, F., Mangani, S., Bernacchioni, C., Ghini, V., Turano, P.
Deposit date:2014-02-25
Release date:2014-10-01
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Loop electrostatics modulates the intersubunit interactions in ferritin.
Acs Chem.Biol., 9, 2014