Author results

4M4X
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STRUCTURE AND DIMERIZATION PROPERTIES OF THE ARYL HYDROCARBON RECEPTOR (AHR) PAS-A DOMAIN
Descriptor:Aryl hydrocarbon receptor
Authors:Wu, D., Potluri, N., Kim, Y., Rastinejad, F.
Deposit date:2013-08-07
Release date:2013-09-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.551 Å)
Cite:Structure and dimerization properties of the aryl hydrocarbon receptor PAS-A domain.
Mol.Cell.Biol., 33, 2013
4ZP4
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2A:ARNT COMPLEX
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.
Deposit date:2015-05-07
Release date:2015-08-12
Last modified:2015-08-26
Method:X-RAY DIFFRACTION (2.355 Å)
Cite:Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
4ZPH
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2A:ARNT COMPLEX WITH PROFLAVINE
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, PROFLAVIN
Authors:Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.
Deposit date:2015-05-07
Release date:2015-08-12
Last modified:2015-08-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
4ZPK
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2A:ARNT COMPLEX WITH HRE DNA
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ...
Authors:Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.
Deposit date:2015-05-08
Release date:2015-08-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
4ZPR
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-1A:ARNT COMPLEX WITH HRE DNA
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 1-alpha, DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ...
Authors:Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.
Deposit date:2015-05-08
Release date:2015-08-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.902 Å)
Cite:Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
4ZQD
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2A:ARNT COMPLEX WITH THE BENZOXADIAZOLE ANTAGONIST 0X3
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
Authors:Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.
Deposit date:2015-05-09
Release date:2015-08-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
5SY5
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CRYSTAL STRUCTURE OF THE HETERODIMERIC NPAS1-ARNT COMPLEX
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Neuronal PAS domain-containing protein 1
Authors:Wu, D., Su, X., Potluri, N., Kim, Y., Rastinejad, F.
Deposit date:2016-08-10
Release date:2016-11-09
Method:X-RAY DIFFRACTION (3.201 Å)
Cite:NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
Elife, 5, 2016
5SY7
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CRYSTAL STRUCTURE OF THE HETERODIMERIC NPAS3-ARNT COMPLEX WITH HRE DNA
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Neuronal PAS domain-containing protein 3, DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ...
Authors:Wu, D., Su, X., Potluri, N., Kim, Y., Rastinejad, F.
Deposit date:2016-08-10
Release date:2016-11-09
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
Elife, 5, 2016
6E3S
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2 COMPLEX WITH ANTAGONIST PT2385
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile
Authors:Wu, D., Su, X., Lu, J., Li, S., Hood, B., Vasile, S., Potluri, N., Diao, X., Kim, Y., Khorasanizadeh, S., Rastinejad, F.
Deposit date:2018-07-15
Release date:2019-02-13
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 2019
6E3T
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2 COMPLEX WITH ANTAGONIST T1001
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, (6S)-6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole
Authors:Wu, D., Su, X., Lu, J., Li, S., Hood, B., Vasile, S., Potluri, N., Diao, X., Kim, Y., Khorasanizadeh, S., Rastinejad, F.
Deposit date:2018-07-15
Release date:2019-02-13
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 2019
6E3U
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2 COMPLEX WITH AGONIST M1001
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, 3-{[2-(pyrrolidin-1-yl)phenyl]amino}-1H-1lambda~6~,2-benzothiazole-1,1-dione
Authors:Wu, D., Su, X., Lu, J., Li, S., Hood, B., Vasile, S., Potluri, N., Diao, X., Kim, Y., Khorasanizadeh, S., Rastinejad, F.
Deposit date:2018-07-15
Release date:2019-02-13
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 2019
4IQR
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MULTI-DOMAIN ORGANIZATION OF THE HNF4ALPHA NUCLEAR RECEPTOR COMPLEX ON DNA
Descriptor:Hepatocyte nuclear factor 4-alpha, DNA (5'-D(*GP*GP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*C)-3'), ...
Authors:Chandra, V., Huang, P., Kim, Y., Rastinejad, F.
Deposit date:2013-01-13
Release date:2013-03-20
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex.
Nature, 495, 2013
5TFP
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CRYSTAL STRUCTURE OF THE SETDB2 AMINO TERMINAL DOMAIN
Descriptor:Histone-lysine N-methyltransferase SETDB2, GLYCEROL, L(+)-TARTARIC ACID
Authors:Khorasanizadeh, S., Kim, Y.
Deposit date:2016-09-26
Release date:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification of a helical dimerization domain in SETDB2 lysine methyltransferase
To Be Published
5UAN
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CRYSTAL STRUCTURE OF MULTI-DOMAIN RAR-BETA-RXR-ALPHA HETERODIMER ON DNA
Descriptor:Retinoic acid receptor RXR-alpha, Retinoic acid receptor beta, Nuclear receptor coactivator 2, ...
Authors:Chandra, V., Wu, D., Kim, Y., Rastinejad, F.
Deposit date:2016-12-19
Release date:2017-10-18
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (3.508 Å)
Cite:The quaternary architecture of RAR beta-RXR alpha heterodimer facilitates domain-domain signal transmission.
Nat Commun, 8, 2017