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1YKQ
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CRYSTAL STRUCTURE OF DIELS-ALDER RIBOZYME
Descriptor:Diels-Alder ribozyme, CADMIUM ION, MAGNESIUM ION
Authors:Serganov, A., Keiper, S., Malinina, L., Tereshko, V., Skripkin, E., Hobartner, C., Polonskaia, A., Phan, A.T., Wombacher, R., Micura, R., Dauter, Z., Jaschke, A., Patel, D.J.
Deposit date:2005-01-18
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation.
Nat.Struct.Mol.Biol., 12, 2005
1YKV
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CRYSTAL STRUCTURE OF THE DIELS-ALDER RIBOZYME COMPLEXED WITH THE PRODUCT OF THE REACTION BETWEEN N-PENTYLMALEIMIDE AND COVALENTLY ATTACHED 9-HYDROXYMETHYLANTHRACENE
Descriptor:Diels-Alder ribozyme, (3AS,9AS)-2-PENTYL-4-HYDROXYMETHYL-3A,4,9,9A-TETRAHYDRO-4,9[1',2']-BENZENO-1H-BENZ[F]ISOINDOLE-1,3(2H)-DIONE, MAGNESIUM ION
Authors:Serganov, A., Keiper, S., Malinina, L., Tereshko, V., Skripkin, E., Hobartner, C., Polonskaia, A., Phan, A.T., Wombacher, R., Micura, R., Dauter, Z., Jaschke, A., Patel, D.J.
Deposit date:2005-01-18
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation.
Nat.Struct.Mol.Biol., 12, 2005
1YLS
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CRYSTAL STRUCTURE OF SELENIUM-MODIFIED DIELS-ALDER RIBOZYME COMPLEXED WITH THE PRODUCT OF THE REACTION BETWEEN N-PENTYLMALEIMIDE AND COVALENTLY ATTACHED 9-HYDROXYMETHYLANTHRACENE
Descriptor:RNA Diels-Alder ribozyme, (3AS,9AS)-2-PENTYL-4-HYDROXYMETHYL-3A,4,9,9A-TETRAHYDRO-4,9[1',2']-BENZENO-1H-BENZ[F]ISOINDOLE-1,3(2H)-DIONE, MAGNESIUM ION
Authors:Serganov, A., Keiper, S., Malinina, L., Tereshko, V., Skripkin, E., Hobartner, C., Polonskaia, A., Phan, A.T., Wombacher, R., Micura, R., Dauter, Z., Jaschke, A., Patel, D.J.
Deposit date:2005-01-19
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation.
Nat.Struct.Mol.Biol., 12, 2005
3SKI
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CRYSTAL STRUCTURE OF THE 2'- DEOXYGUANOSINE RIBOSWITCH BOUND TO 2'-DEOXYGUANOSINE
Descriptor:RNA (68-MER), 2'-DEOXY-GUANOSINE, MAGNESIUM ION, ...
Authors:Pikovskaya, O., Polonskaia, A., Patel, D.J., Serganov, A.
Deposit date:2011-06-22
Release date:2011-08-17
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural principles of nucleoside selectivity in a 2'-deoxyguanosine riboswitch.
Nat.Chem.Biol., 7, 2011
3SKL
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CRYSTAL STRUCTURE OF THE 2'- DEOXYGUANOSINE RIBOSWITCH BOUND TO 2'-DEOXYGUANOSINE, IRIDIUM HEXAMMINE SOAK
Descriptor:RNA (66-MER), 2'-DEOXY-GUANOSINE, MAGNESIUM ION, ...
Authors:Pikovskaya, O., Polonskaia, A., Patel, D.J., Serganov, A.
Deposit date:2011-06-22
Release date:2011-08-17
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural principles of nucleoside selectivity in a 2'-deoxyguanosine riboswitch.
Nat.Chem.Biol., 7, 2011
3SKR
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CRYSTAL STRUCTURE OF THE 2'- DEOXYGUANOSINE RIBOSWITCH BOUND TO 2'- DEOXYGUANOSINE, COBALT HEXAMMINE SOAK
Descriptor:RNA (66-MER), 2'-DEOXY-GUANOSINE, COBALT HEXAMMINE(III), ...
Authors:Pikovskaya, O., Polonskaia, A., Patel, D.J., Serganov, A.
Deposit date:2011-06-23
Release date:2011-08-17
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural principles of nucleoside selectivity in a 2'-deoxyguanosine riboswitch.
Nat.Chem.Biol., 7, 2011
3SKT
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CRYSTAL STRUCTURE OF THE 2'- DEOXYGUANOSINE RIBOSWITCH BOUND TO 2'- DEOXYGUANOSINE, MANGANESE SOAK
Descriptor:RNA (66-MER), 2'-DEOXY-GUANOSINE, MANGANESE (II) ION, ...
Authors:Pikovskaya, O., Polonskaia, A., Patel, D.J., Serganov, A.
Deposit date:2011-06-23
Release date:2011-08-17
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural principles of nucleoside selectivity in a 2'-deoxyguanosine riboswitch.
Nat.Chem.Biol., 7, 2011
3SKW
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CRYSTAL STRUCTURE OF THE 2'- DEOXYGUANOSINE RIBOSWITCH BOUND TO 2'- DEOXYGUANOSINE, CESIUM SOAK
Descriptor:RNA (66-MER), 2'-DEOXY-GUANOSINE, CESIUM ION, ...
Authors:Pikovskaya, O., Polonskaia, A., Patel, D.J., Serganov, A.
Deposit date:2011-06-23
Release date:2011-08-17
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural principles of nucleoside selectivity in a 2'-deoxyguanosine riboswitch.
Nat.Chem.Biol., 7, 2011
3SKZ
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CRYSTAL STRUCTURE OF THE 2'- DEOXYGUANOSINE RIBOSWITCH BOUND TO GUANOSINE
Descriptor:RNA (68-MER), GUANOSINE, MAGNESIUM ION, ...
Authors:Pikovskaya, O., Polonskaia, A., Patel, D.J., Serganov, A.
Deposit date:2011-06-23
Release date:2011-08-17
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (2.605 Å)
Cite:Structural principles of nucleoside selectivity in a 2'-deoxyguanosine riboswitch.
Nat.Chem.Biol., 7, 2011
3SLM
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CRYSTAL STRUCTURE OF THE 2'- DEOXYGUANOSINE RIBOSWITCH BOUND TO 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE
Descriptor:RNA (68-MER), 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Pikovskaya, O., Polonskaia, A., Patel, D.J., Serganov, A.A.
Deposit date:2011-06-24
Release date:2011-08-17
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural principles of nucleoside selectivity in a 2'-deoxyguanosine riboswitch.
Nat.Chem.Biol., 7, 2011
3SLQ
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CRYSTAL STRUCTURE OF THE 2'- DEOXYGUANOSINE RIBOSWITCH BOUND TO GUANOSINE-5'-MONOPHOSPHATE
Descriptor:RNA (68-MER), GUANOSINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Pikovskaya, O., Polonskaia, A., Patel, D.J., Serganov, A.
Deposit date:2011-06-24
Release date:2011-08-17
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural principles of nucleoside selectivity in a 2'-deoxyguanosine riboswitch.
Nat.Chem.Biol., 7, 2011
5DE5
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN FMRP RGG MOTIF AND G-QUADRUPLEX RNA.
Descriptor:sc1, Fragile X mental retardation protein 1, POTASSIUM ION
Authors:Vasilyev, N., Polonskaia, A., Darnell, J.C., Darnell, R.B., Patel, D.J., Serganov, A.
Deposit date:2015-08-25
Release date:2015-09-23
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.0011 Å)
Cite:Crystal structure reveals specific recognition of a G-quadruplex RNA by a beta-turn in the RGG motif of FMRP.
Proc.Natl.Acad.Sci.USA, 112, 2015
5DE8
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN FMRP RGG MOTIF AND G-QUADRUPLEX RNA, IRIDIUM HEXAMMINE BOUND FORM.
Descriptor:sc1, Fragile X mental retardation protein 1, POTASSIUM ION, ...
Authors:Vasilyev, N., Polonskaia, A., Darnell, J.C., Darnell, R.B., Patel, D.J., Serganov, A.
Deposit date:2015-08-25
Release date:2015-09-23
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.1003 Å)
Cite:Crystal structure reveals specific recognition of a G-quadruplex RNA by a beta-turn in the RGG motif of FMRP.
Proc.Natl.Acad.Sci.USA, 112, 2015
5DEA
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN FMRP RGG MOTIF AND G-QUADRUPLEX RNA, CESIUM BOUND FORM.
Descriptor:sc1, Fragile X mental retardation protein 1, POTASSIUM ION, ...
Authors:Vasilyev, N., Polonskaia, A., Darnell, J.C., Darnell, R.B., Patel, D.J., Serganov, A.
Deposit date:2015-08-25
Release date:2015-09-23
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.7973 Å)
Cite:Crystal structure reveals specific recognition of a G-quadruplex RNA by a beta-turn in the RGG motif of FMRP.
Proc.Natl.Acad.Sci.USA, 112, 2015
2LA5
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RNA DUPLEX-QUADRUPLEX JUNCTION COMPLEX WITH FMRP RGG PEPTIDE
Descriptor:RNA (36-MER), Fragile X mental retardation 1 protein
Authors:Phan, A., Kuryavyi, V., Darnell, J., Serganov, A., Majumdar, A., Ilin, S., Darnell, R., Patel, D.
Deposit date:2011-03-03
Release date:2011-06-08
Last modified:2011-07-20
Method:SOLUTION NMR
Cite:Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction.
Nat.Struct.Mol.Biol., 18, 2011
1Y26
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A-RIBOSWITCH-ADENINE COMPLEX
Descriptor:Vibrio vulnificus A-riboswitch, MAGNESIUM ION, ADENINE
Authors:Serganov, A., Yuan, Y.R., Patel, D.J.
Deposit date:2004-11-20
Release date:2004-12-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for Discriminative Regulation of Gene Expression by Adenine- and Guanine-Sensing mRNAs
Chem.Biol., 11, 2004
1Y27
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G-RIBOSWITCH-GUANINE COMPLEX
Descriptor:Bacillus subtilis xpt, HYPOPHOSPHITE, GUANOSINE-5'-MONOPHOSPHATE
Authors:Serganov, A., Yuan, Y.R., Patel, D.J.
Deposit date:2004-11-20
Release date:2004-12-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Discriminative Regulation of Gene Expression by Adenine- and Guanine-Sensing mRNAs
Chem.Biol., 11, 2004
2GDI
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CRYSTAL STRUCTURE OF THIAMINE PYROPHOSPHATE-SPECIFIC RIBOSWITCH IN COMPLEX WITH THIAMINE PYROPHOSPHATE
Descriptor:TPP riboswitch, SODIUM ION, POTASSIUM ION, ...
Authors:Serganov, A.
Deposit date:2006-03-16
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch.
Nature, 441, 2006
2H1M
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SYNTHESIS, OXIDATION BEHAVIOR, CRYSTALLIZATION AND STRUCTURE OF 2'-METHYLSELENO GUANOSINE CONTAINING RNAS
Descriptor:5'-R(*GP*CP*AP*(XUG)P*AP*GP*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3', SULFATE ION
Authors:Serganov, A.A.
Deposit date:2006-05-16
Release date:2006-07-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Synthesis, Oxidation Behavior, Crystallization and Structure of 2'-Methylseleno Guanosine Containing RNAs.
J.Am.Chem.Soc., 128, 2006
4MQ1
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THE CRYSTAL STRUCTURE OF DYRK1A WITH A BOUND PYRIDO[2,3-D]PYRIMIDINE INHIBITOR
Descriptor:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, N-(5-{[(1R)-3-amino-1-(3-chlorophenyl)propyl]carbamoyl}-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide, PENTAETHYLENE GLYCOL, ...
Authors:Lukacs, C.M., Janson, C.A., Garvie, C., Liang, L.
Deposit date:2013-09-15
Release date:2013-12-11
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4MQ2
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THE CRYSTAL STRUCTURE OF DYRK1A WITH A BOUND PYRIDO[2,3-D]PYRIMIDINE INHIBITOR
Descriptor:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, methyl 4-chloro-3-{[(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)carbonyl]amino}benzoate, PENTAETHYLENE GLYCOL, ...
Authors:Lukacs, C.M., Janson, C.A., Garvie, C., Liang, L.
Deposit date:2013-09-15
Release date:2013-12-11
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4KJU
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CRYSTAL STRUCTURE OF XIAP-BIR2 WITH A BOUND BENZODIAZEPINONE INHIBITOR.
Descriptor:E3 ubiquitin-protein ligase XIAP, ZINC ION, N-{(3S)-5-(4-aminobenzoyl)-1-[(2-methoxynaphthalen-1-yl)methyl]-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl}-N~2~-methyl-L-alaninamide
Authors:Lukacs, C.M., Janson, C.A.
Deposit date:2013-05-03
Release date:2013-11-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain.
J.Med.Chem., 56, 2013
4KJV
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CRYSTAL STRUCTURE OF XIAP-BIR2 WITH A BOUND SPIROCYCLIC BENZOXAZEPINONE INHIBITOR.
Descriptor:E3 ubiquitin-protein ligase XIAP, ZINC ION, 6-methoxy-5-({(3S)-3-[(N-methyl-L-alanyl)amino]-4-oxo-2',3,3',4,5',6'-hexahydro-5H-spiro[1,5-benzoxazepine-2,4'-pyran]-5-yl}methyl)naphthalene-2-carboxylic acid
Authors:Lukacs, C.M., Janson, C.A.
Deposit date:2013-05-03
Release date:2013-11-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain.
J.Med.Chem., 56, 2013
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