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5VP2
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH MADUMYCIN II AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.8A RESOLUTION
Descriptor:50S ribosomal protein L2, 50S ribosomal protein L3, 50S ribosomal protein L4, 50S ribosomal protein L5, 50S ribosomal protein L6, 50S ribosomal protein L9, 50S ribosomal protein L13, 50S ribosomal protein L14, 50S ribosomal protein L15, 50S ribosomal protein L16, 50S ribosomal protein L17, 50S ribosomal protein L18, 50S ribosomal protein L19, 50S ribosomal protein L20, 50S ribosomal protein L21, 50S ribosomal protein L22, 50S ribosomal protein L23, 50S ribosomal protein L24, 50S ribosomal protein L25, 50S ribosomal protein L27, 50S ribosomal protein L28, 50S ribosomal protein L29, 50S ribosomal protein L30, 50S ribosomal protein L31, 50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, 50S ribosomal protein L35, 50S ribosomal protein L36, 30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, 30S ribosomal protein S5, 30S ribosomal protein S6, 30S ribosomal protein S7, 30S ribosomal protein S8, 30S ribosomal protein S9, 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, 30S ribosomal protein S13, 30S ribosomal protein S14 type Z, 30S ribosomal protein S15, 30S ribosomal protein S16, 30S ribosomal protein S17, 30S ribosomal protein S18, 30S ribosomal protein S19, 30S ribosomal protein S20, 30S ribosomal protein Thx/RNA Complex
Authors:Osterman, I.A., Khabibullina, N.F., Komarova, E.S., Kasatsky, P., Kartsev, V.G., Bogdanov, A.A., Dontsova, O.A., Konevega, A.L., Sergiev, P.V., Polikanov, Y.S.
Deposit date:2017-05-04
Release date:2017-06-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state.
Nucleic Acids Res., 2017
5KCR
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CRYO-EM STRUCTURE OF THE ESCHERICHIA COLI 70S RIBOSOME IN COMPLEX WITH ANTIBIOTIC AVILAMYCIN C, MRNA AND P-SITE TRNA AT 3.6A RESOLUTION
Descriptor:Ribosome
Authors:Arenz, S., Juette, M.F., Graf, M., Nguyen, F., Huter, P., Polikanov, Y.S., Blanchard, S.C., Wilson, D.N.
Deposit date:2016-06-06
Release date:2016-08-17
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.
Proc.Natl.Acad.Sci.USA, 113, 2016
5KCS
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CRYO-EM STRUCTURE OF THE ESCHERICHIA COLI 70S RIBOSOME IN COMPLEX WITH ANTIBIOTIC EVERNIMYCIN, MRNA, TETM AND P-SITE TRNA AT 3.9A RESOLUTION
Descriptor:70S ribosome
Authors:Arenz, S., Juette, M.F., Graf, M., Nguyen, F., Huter, P., Polikanov, Y.S., Blanchard, S.C., Wilson, D.N.
Deposit date:2016-06-06
Release date:2016-08-17
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.
Proc.Natl.Acad.Sci.USA, 113, 2016
5J4B
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH CISPLATIN (CO-CRYSTALLIZED) AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.6A RESOLUTION
Descriptor:70S Ribosome
Authors:Melnikov, S.V., Soll, D., Steitz, T.A., Polikanov, Y.S.
Deposit date:2016-03-31
Release date:2016-04-27
Last modified:2016-06-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.
Nucleic Acids Res., 44, 2016
5J4C
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH CISPLATIN (SOAKED) AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.8A RESOLUTION
Descriptor:Ribosome
Authors:Melnikov, S.V., Soll, D., Steitz, T.A., Polikanov, Y.S.
Deposit date:2016-03-31
Release date:2016-04-27
Last modified:2016-06-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.
Nucleic Acids Res., 44, 2016
5DOX
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH HYGROMYCIN-A AT 3.1A RESOLUTION
Descriptor:Ribosome
Authors:Polikanov, Y.S., Starosta, A.L., Juette, M.F., Altman, R.B., Terry, D.S., Lu, W., Burnett, B.J., Dinos, G., Reynolds, K., Blanchard, S.C., Steitz, T.A., Wilson, D.N.
Deposit date:2015-09-11
Release date:2015-12-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
5DOY
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH ANTIBIOTIC HYGROMYCIN A, MRNA AND THREE TRNAS IN THE A, P AND E SITES AT 2.6A RESOLUTION
Descriptor:Ribosome
Authors:Polikanov, Y.S., Starosta, A.L., Juette, M.F., Altman, R.B., Terry, D.S., Lu, W., Burnett, B.J., Dinos, G., Reynolds, K., Blanchard, S.C., Steitz, T.A., Wilson, D.N.
Deposit date:2015-09-11
Release date:2015-12-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
4Z3S
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH ANTIBIOTIC A201A, MRNA AND THREE TRNAS IN THE A, P AND E SITES AT 2.65A RESOLUTION
Descriptor:Ribosome
Authors:Polikanov, Y.S., Starosta, A.L., Juette, M.F., Altman, R.B., Terry, D.S., Lu, W., Burnett, B.J., Dinos, G., Reynolds, K., Blanchard, S.C., Steitz, T.A., Wilson, D.N.
Deposit date:2015-03-31
Release date:2015-06-03
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
4Y4O
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME WITH RRNA MODIFICATIONS AND BOUND TO PROTEIN Y (YFIA) AT 2.3A RESOLUTION
Descriptor:50S Ribosomal Protein L2, 50S Ribosomal Protein L3, 50S Ribosomal Protein L4, 50S Ribosomal Protein L5, 50S Ribosomal Protein L6, 50S Ribosomal Protein L9, 50S Ribosomal Protein L13, 50S Ribosomal Protein L14, 50S Ribosomal Protein L15, 50S Ribosomal Protein L16, 50S Ribosomal Protein L17, 50S Ribosomal Protein L18, 50S Ribosomal Protein L19, 50S Ribosomal Protein L20, 50S Ribosomal Protein L21, 50S Ribosomal Protein L22, 50S Ribosomal Protein L23, 50S Ribosomal Protein L24, 50S Ribosomal Protein L25, 50S Ribosomal Protein L27, 50S Ribosomal Protein L28, 50S Ribosomal Protein L29, 50S Ribosomal Protein L30, 50S Ribosomal Protein L31, 50S Ribosomal Protein L32, 50S Ribosomal Protein L33, 50S Ribosomal Protein L34, 50S Ribosomal Protein L35, 50S Ribosomal Protein L36, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, 30S Ribosomal Protein S4, 30S Ribosomal Protein S5, 30S Ribosomal Protein S6, 30S Ribosomal Protein S7, 30S Ribosomal Protein S8, 30S Ribosomal Protein S9, 30S Ribosomal Protein S10, 30S Ribosomal Protein S11, 30S Ribosomal Protein S12, 30S Ribosomal Protein S13, 30S Ribosomal Protein S14, 30S Ribosomal Protein S15, 30S Ribosomal Protein S16, 30S Ribosomal Protein S17, 30S Ribosomal Protein S18, 30S Ribosomal Protein S19, 30S Ribosomal Protein S20, 30S Ribosomal Protein THX, Protein Y/RNA Complex
Authors:Polikanov, Y.S., Melnikov, S.V., Soll, D., Steitz, T.A.
Deposit date:2015-02-10
Release date:2015-03-18
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.
Nat.Struct.Mol.Biol., 22, 2015
4Y4P
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME WITH RRNA MODIFICATIONS AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.5A RESOLUTION
Descriptor:50S Ribosomal Protein L2, 50S Ribosomal Protein L3, 50S Ribosomal Protein L4, 50S Ribosomal Protein L5, 50S Ribosomal Protein L6, 50S Ribosomal Protein L9, 50S Ribosomal Protein L13, 50S Ribosomal Protein L14, 50S Ribosomal Protein L15, 50S Ribosomal Protein L16, 50S Ribosomal Protein L17, 50S Ribosomal Protein L18, 50S Ribosomal Protein L19, 50S Ribosomal Protein L20, 50S Ribosomal Protein L21, 50S Ribosomal Protein L22, 50S Ribosomal Protein L23, 50S Ribosomal Protein L24, 50S Ribosomal Protein L25, 50S Ribosomal Protein L27, 50S Ribosomal Protein L28, 50S Ribosomal Protein L29, 50S Ribosomal Protein L30, 50S Ribosomal Protein L31, 50S Ribosomal Protein L32, 50S Ribosomal Protein L33, 50S Ribosomal Protein L34, 50S Ribosomal Protein L35, 50S Ribosomal Protein L36, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, 30S Ribosomal Protein S4, 30S Ribosomal Protein S5, 30S Ribosomal Protein S6, 30S Ribosomal Protein S7, 30S Ribosomal Protein S8, 30S Ribosomal Protein S9, 30S Ribosomal Protein S10, 30S Ribosomal Protein S11, 30S Ribosomal Protein S12, 30S Ribosomal Protein S13, 30S Ribosomal Protein S14, 30S Ribosomal Protein S15, 30S Ribosomal Protein S16, 30S Ribosomal Protein S17, 30S Ribosomal Protein S18, 30S Ribosomal Protein S19, 30S Ribosomal Protein S20, 30S Ribosomal Protein THX/RNA Complex
Authors:Polikanov, Y.S., Melnikov, S.V., Soll, D., Steitz, T.A.
Deposit date:2015-02-10
Release date:2015-03-18
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.
Nat.Struct.Mol.Biol., 22, 2015
4W2F
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH AMICOUMACIN, MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
Descriptor:PROTEIN/RNA Complex
Authors:Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4W2G
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PACTAMYCIN (SOAKED), MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
Descriptor:PROTEIN/RNA Complex
Authors:Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4W2H
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PACTAMYCIN (CO-CRYSTALLIZED), MRNA AND DEACYLATED TRNA IN THE P SITE
Descriptor:PROTEIN/RNA Complex
Authors:Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4W2I
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH NEGAMYCIN, MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
Descriptor:PROTEIN/RNA Complex
Authors:Polikanov, Y.S., Szal, T., Jiang, F., Gupta, P., Matsuda, R., Shiozuka, M., Steitz, T.A., Vazquez-Laslop, Nora, Mankin, A.S.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA.
Mol.Cell, 56, 2014
1VY4
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN THE PRE-ATTACK STATE OF PEPTIDE BOND FORMATION CONTAINING ACYLATED TRNA-SUBSTRATES IN THE A AND P SITES.
Descriptor:PROTEIN/RNA Complex
Authors:Polikanov, Y.S., Steitz, T.A., Innis, C.A.
Deposit date:2014-05-13
Release date:2014-08-20
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
Nat.Struct.Mol.Biol., 21, 2014
1VY5
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN THE POST-CATALYSIS STATE OF PEPTIDE BOND FORMATION CONTAINING DIPEPTYDIL-TRNA IN THE A SITE AND DEACYLATED TRNA IN THE P SITE.
Descriptor:PROTEIN/RNA Complex
Authors:Polikanov, Y.S., Steitz, T.A., Innis, C.A.
Deposit date:2014-05-13
Release date:2014-08-20
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
Nat.Struct.Mol.Biol., 21, 2014
1VY6
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN THE PRE-ATTACK STATE OF PEPTIDE BOND FORMATION CONTAINING SHORT SUBSTRATE-MIMIC CYTIDINE-PUROMYCIN IN THE A SITE AND ACYLATED TRNA IN THE P SITE.
Descriptor:PROTEIN/RNA Complex
Authors:Polikanov, Y.S., Steitz, T.A., Innis, C.A.
Deposit date:2014-05-13
Release date:2014-08-20
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
Nat.Struct.Mol.Biol., 21, 2014
1VY7
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN THE PRE-ATTACK STATE OF PEPTIDE BOND FORMATION CONTAINING SHORT SUBSTRATE-MIMIC CYTIDINE-CYTIDINE-PUROMYCIN IN THE A SITE AND ACYLATED TRNA IN THE P SITE.
Descriptor:PROTEIN/RNA Complex
Authors:Polikanov, Y.S., Steitz, T.A., Innis, C.A.
Deposit date:2014-05-13
Release date:2014-08-20
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
Nat.Struct.Mol.Biol., 21, 2014
4V9R
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CRYSTAL STRUCTURE OF ANTIBIOTIC DITYROMYCIN BOUND TO 70S RIBOSOME
Descriptor:PROTEIN/RNA Complex
Authors:Bulkley, D.P., Brandi, L., Polikanov, Y.S., Fabbretti, A., O'Connor, M., Gualerzi, C.O., Steitz, T.A.
Deposit date:2013-12-05
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Cell Rep, 6, 2014
4V9S
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CRYSTAL STRUCTURE OF ANTIBIOTIC GE82832 BOUND TO 70S RIBOSOME
Descriptor:PROTEIN/RNA Complex
Authors:Bulkley, D.P., Brandi, L., Polikanov, Y.S., Fabbretti, A., O'Connor, M., Gualerzi, C.O., Steitz, T.A.
Deposit date:2013-12-05
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Cell Rep, 6, 2014
4V8I
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CRYSTAL STRUCTURE OF YFIA BOUND TO THE 70S RIBOSOME.
Descriptor:PROTEIN/RNA Complex
Authors:Polikanov, Y.S., Blaha, G.M., Steitz, T.A.
Deposit date:2011-12-12
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:How hibernation factors RMF, HPF, and YfiA turn off protein synthesis.
Science, 336, 2012
4V8G
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CRYSTAL STRUCTURE OF RMF BOUND TO THE 70S RIBOSOME.
Descriptor:Ribosome
Authors:Polikanov, Y.S., Blaha, G.M., Steitz, T.A.
Deposit date:2011-12-11
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:How hibernation factors RMF, HPF, and YfiA turn off protein synthesis.
Science, 336, 2012
4V8H
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CRYSTAL STRUCTURE OF HPF BOUND TO THE 70S RIBOSOME.
Descriptor:PROTEIN/RNA Complex
Authors:Polikanov, Y.S., Blaha, G.M., Steitz, T.A.
Deposit date:2011-12-11
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:How Hibernation Factors RMF, HPF, and YfiA Turn Off Protein Synthesis.
Science, 336, 2012
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