Author results

1G3P
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAINS OF BACTERIOPHAGE MINOR COAT PROTEIN G3P
Descriptor:MINOR COAT PROTEIN, SULFATE ION
Authors:Lubkowski, J., Hennecke, F., Pluckthun, A., Wlodawer, A.
Deposit date:1997-12-22
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:The structural basis of phage display elucidated by the crystal structure of the N-terminal domains of g3p.
Nat.Struct.Biol., 5, 1998
1VD0
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CAPSID STABILIZING PROTEIN GPD, NMR, 20 STRUCTURES
Descriptor:Head decoration protein
Authors:Iwai, H., Forrer, P., Pluckthun, A., Guntert, P., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-03-17
Release date:2005-03-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR solution structure of the monomeric form of the bacteriophage lambda capsid stabilizing protein gpD.
J.Biomol.Nmr, 31, 2005
1H8O
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THREE-DIMENSIONAL STRUCTURE OF ANTI-AMPICILLIN SINGLE CHAIN FV FRAGMENT.
Descriptor:MUTANT AL2 6E7P9G, SULFATE ION
Authors:Burmester, J., Spinelli, S., Pugliese, L., Krebber, A., Honegger, A., Jung, S., Schimmele, B., Cambillau, C., Pluckthun, A.
Deposit date:2001-02-14
Release date:2001-08-02
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Selection, Characterization and X-Ray Structure of Anti-Ampicillin Single-Chain Fv Fragments from Phage-Displayed Murine Antibody Libraries
J.Mol.Biol., 309, 2001
1H8S
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THREE-DIMENSIONAL STRUCTURE OF ANTI-AMPICILLIN SINGLE CHAIN FV FRAGMENT COMPLEXED WITH THE HAPTEN.
Descriptor:MUTANT AL2 6E7P9G, (2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, SULFATE ION
Authors:Burmester, J., Spinelli, S., Pugliese, L., Krebber, A., Honegger, A., Jung, S., Schimmele, B., Cambillau, C., Pluckthun, A.
Deposit date:2001-02-15
Release date:2001-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selection, Characterization and X-Ray Structure of Anti-Ampicillin Single-Chain Fv Fragments from Phage-Displayed Murine Antibody Libraries
J.Mol.Biol., 309, 2001
1IHR
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CRYSTAL STRUCTURE OF THE DIMERIC C-TERMINAL DOMAIN OF TONB
Descriptor:TonB protein, BROMIDE ION
Authors:Chang, C., Mooser, A., Pluckthun, A., Wlodawer, A.
Deposit date:2001-04-20
Release date:2001-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of the dimeric C-terminal domain of TonB reveals a novel fold.
J.Biol.Chem., 276, 2001
4D49
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CRYSTAL STRUCTURE OF COMPUTATIONALLY DESIGNED ARMADILLO REPEAT PROTEINS FOR MODULAR PEPTIDE RECOGNITION.
Descriptor:ARMADILLO REPEAT PROTEIN ARM00027, POLY ARG DECAPEPTIDE, ARGININE
Authors:Reichen, C., Forzani, C., Zhou, T., Parmeggiani, F., Fleishman, S.J., Mittl, P.R.E., Madhurantakam, C., Honegger, A., Ewald, C., Zerbe, O., Baker, D., Caflisch, A., Pluckthun, A.
Deposit date:2014-10-27
Release date:2016-01-13
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.
J.Mol.Biol., 428, 2016
4D4E
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CRYSTAL STRUCTURE OF COMPUTATIONALLY DESIGNED ARMADILLO REPEAT PROTEINS FOR MODULAR PEPTIDE RECOGNITION.
Descriptor:ARMADILLO REPEAT PROTEIN ARM00016, GLYCEROL
Authors:Reichen, C., Forzani, C., Zhou, T., Parmeggiani, F., Fleishman, S.J., Mittl, P.R.E., Madhurantakam, C., Honegger, A., Ewald, C., Zerbe, O., Baker, D., Caflisch, A., Pluckthun, A.
Deposit date:2014-10-28
Release date:2016-01-13
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.
J.Mol.Biol., 428, 2016
1C12
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INSIGHT IN ODORANT PERCEPTION: THE CRYSTAL STRUCTURE AND BINDING CHARACTERISTICS OF ANTIBODY FRAGMENTS DIRECTED AGAINST THE MUSK ODORANT TRASEOLIDE
Descriptor:PROTEIN (ANTIBODY FRAGMENT FAB), TRAZEOLIDE
Authors:Langedijk, A.C., Spinelli, S., Anguille, C., Hermans, P., Nederlof, J., Butenandt, J., Honegger, A., Cambillau, C., Pluckthun, A.
Deposit date:1999-07-20
Release date:1999-08-14
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insight into odorant perception: the crystal structure and binding characteristics of antibody fragments directed against the musk odorant traseolide.
J.Mol.Biol., 292, 1999
1C5E
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BACTERIOPHAGE LAMBDA HEAD PROTEIN D
Descriptor:HEAD DECORATION PROTEIN, GLYCEROL
Authors:Yang, F., Forrer, P., Dauter, Z., Pluckthun, A., Wlodawer, A.
Deposit date:1999-11-18
Release date:2000-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Novel fold and capsid-binding properties of the lambda-phage display platform protein gpD.
Nat.Struct.Biol., 7, 2000
1H8N
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THREE-DIMENSIONAL STRUCTURE OF ANTI-AMPICILLIN SINGLE CHAIN FV FRAGMENT FROM PHAGE-DISPLAYED MURINE ANTIBODY LIBRARIES
Descriptor:MUTANT AL2 6E7S9G, GLYCEROL, SULFATE ION
Authors:Jung, S., Spinelli, S., Schimmele, B., Honegger, A., Pugliese, L., Cambillau, C., Pluckthun, A.
Deposit date:2001-02-14
Release date:2001-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The Importance of Framework Residues H6, H7 and H10 in Antibody Heavy Chains: Experimental Evidence for a New Structural Subclassification of Antibody V(H) Domains
J.Mol.Biol., 309, 2001
1I3G
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CRYSTAL STRUCTURE OF AN AMPICILLIN SINGLE CHAIN FV, FORM 1, FREE
Descriptor:ANTIBODY FV FRAGMENT, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Jung, S., Spinelli, S., Schimmele, B., Honegger, A., Pugliese, L., Cambillau, C., Pluckthun, A.
Deposit date:2001-02-15
Release date:2001-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Selection, characterization and x-ray structure of anti-ampicillin single-chain Fv fragments from phage-displayed murine antibody libraries.
J.Mol.Biol., 309, 2001
2A9M
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STRUCTURAL ANALYSIS OF A TIGHT-BINDING FLUORESCEIN-SCFV; APO FORM
Descriptor:fluorescein-scfv light chain, fluorescein-scfv heavy chain
Authors:Cambillau, C., Spinelli, S., Honegger, A., Pluckthun, A.
Deposit date:2005-07-12
Release date:2005-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A mutation designed to alter crystal packing permits structural analysis of a tight-binding fluorescein-scFv complex.
Protein Sci., 14, 2005
2A9N
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A MUTATION DESIGNED TO ALTER CRYSTAL PACKING PERMITS STRUCTURAL ANALYSIS OF A TIGHT-BINDING FLUORESCEIN-SCFV COMPLEX
Descriptor:fluorescein-scfv light chain, fluorescein-scfv heavy chain, 4-(2,7-DIFLUORO-6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)ISOPHTHALIC ACID
Authors:Cambillau, C., Spinelli, S., Honegger, A., Pluckthun, A.
Deposit date:2005-07-12
Release date:2005-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A mutation designed to alter crystal packing permits structural analysis of a tight-binding fluorescein-scFv complex.
Protein Sci., 14, 2005
2BKG
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CRYSTAL STRUCTURE OF E3_19 A DESIGNED ANKYRIN REPEAT PROTEIN
Descriptor:SYNTHETIC CONSTRUCT ANKYRIN REPEAT PROTEIN E3_19
Authors:Binz, H.K., Kohl, A., Pluckthun, A., Grutter, M.G.
Deposit date:2005-02-16
Release date:2006-06-21
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of a Consensus-Designed Ankyrin Repeat Protein: Implications for Stability
Proteins: Struct., Funct., Bioinf., 65, 2006
2BKK
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(3')-IIIA IN COMPLEX WITH THE INHIBITOR AR_3A
Descriptor:AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE, DESIGNED ANKYRIN REPEAT INHIBITOR AR_3A, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Kohl, A., Amstutz, P., Parizek, P., Binz, H.K., Briand, C., Capitani, G., Forrer, P., Pluckthun, A., Grutter, M.G.
Deposit date:2005-02-16
Release date:2005-08-09
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Allosteric Inhibition of Aminoglycoside Phosphotransferase by a Designed Ankyrin Repeat Protein
Structure, 13, 2005
3ZU7
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CRYSTAL STRUCTURE OF A DESIGNED SELECTED ANKYRIN REPEAT PROTEIN IN COMPLEX WITH THE MAP KINASE ERK2
Descriptor:MITOGEN-ACTIVATED PROTEIN KINASE 1, DESIGNED ANKYRIN REPEAT PROTEIN
Authors:Kummer, L., Mittl, P.R., Pluckthun, A.
Deposit date:2011-07-16
Release date:2012-06-27
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural and Functional Analysis of Phosphorylation-Specific Binders of the Kinase Erk from Designed Ankyrin Repeat Protein Libraries.
Proc.Natl.Acad.Sci.USA, 109, 2012
3ZUV
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CRYSTAL STRUCTURE OF A DESIGNED SELECTED ANKYRIN REPEAT PROTEIN IN COMPLEX WITH THE PHOSPHORYLATED MAP KINASE ERK2
Descriptor:MITOGEN-ACTIVATED PROTEIN KINASE 1, DESIGNED ANKYRIN REPEAT PROTEIN, SULFATE ION
Authors:Kummer, L., Mittl, P.R., Pluckthun, A.
Deposit date:2011-07-20
Release date:2012-06-27
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structural and Functional Analysis of Phosphorylation-Specific Binders of the Kinase Erk from Designed Ankyrin Repeat Protein Libraries.
Proc.Natl.Acad.Sci.USA, 109, 2012
1JPF
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CRYSTAL STRUCTURE OF THE LCMV PEPTIDIC EPITOPE GP276 IN COMPLEX WITH THE MURINE CLASS I MHC MOLECULE H-2DB
Descriptor:H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, BETA-2-MICROGLOBULIN, ...
Authors:Ciatto, C., Tissot, A.C., Tschopp, M., Capitani, G., Pecorari, F., Pluckthun, A., Grutter, M.G.
Deposit date:2001-08-02
Release date:2001-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Zooming in on the hydrophobic ridge of H-2D(b): implications for the conformational variability of bound peptides.
J.Mol.Biol., 312, 2001
1JPG
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CRYSTAL STRUCTURE OF THE LCMV PEPTIDIC EPITOPE NP396 IN COMPLEX WITH THE MURINE CLASS I MHC MOLECULE H-2DB
Descriptor:H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, BETA-2-MICROGLOBULIN, ...
Authors:Ciatto, C., Tissot, A.C., Tschopp, M., Capitani, G., Pecorari, F., Pluckthun, A., Grutter, M.G.
Deposit date:2001-08-02
Release date:2001-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Zooming in on the hydrophobic ridge of H-2D(b): implications for the conformational variability of bound peptides.
J.Mol.Biol., 312, 2001
1P4I
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CRYSTAL STRUCTURE OF SCFV AGAINST PEPTIDE GCN4
Descriptor:ANTIBODY VARIABLE LIGHT CHAIN, antibody variable heavy chain
Authors:Zahnd, C., Spinelli, S., Luginbuhl, B., Jermutus, L., Amstutz, P., Cambillau, C., Pluckthun, A.
Deposit date:2003-04-23
Release date:2004-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Directed in Vitro Evolution and Crystallographic Analysis of a Peptide-binding Single Chain Antibody Fragment (scFv) with Low Picomolar Affinity.
J.Biol.Chem., 279, 2004
2JAB
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A DESIGNED ANKYRIN REPEAT PROTEIN EVOLVED TO PICOMOLAR AFFINITY TO HER2
Descriptor:H10-2-G3
Authors:Zahnd, C., Wyler, E., Schwenk, J.M., Steiner, D., Lawrence, M.C., McKern, N.M., Pecorari, F., Ward, C.W., Joos, T.O., Pluckthun, A.
Deposit date:2006-11-27
Release date:2007-05-08
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A Designed Ankyrin Repeat Protein Evolved to Picomolar Affinity to Her2
J.Mol.Biol., 369, 2007
2XEE
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STRUCTURAL DETERMINANTS FOR IMPROVED THERMAL STABILITY OF DESIGNED ANKYRIN REPEAT PROTEINS WITH A REDESIGNED C-CAPPING MODULE.
Descriptor:NI3C DARPIN MUTANT5
Authors:Kramer, M., Wetzel, S.K., Pluckthun, A., Mittl, P., Grutter, M.
Deposit date:2010-05-14
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins with a Redesigned C-Capping Module.
J.Mol.Biol., 404, 2010
2XEH
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STRUCTURAL DETERMINANTS FOR IMPROVED THERMAL STABILITY OF DESIGNED ANKYRIN REPEAT PROTEINS WITH A REDESIGNED C-CAPPING MODULE.
Descriptor:NI3C MUT6, SULFATE ION
Authors:Kramer, M., Wetzel, S.K., Pluckthun, A., Mittl, P., Grutter, M.
Deposit date:2010-05-14
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins with a Redesigned C-Capping Module.
J.Mol.Biol., 404, 2010
2XEN
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STRUCTURAL DETERMINANTS FOR IMPROVED THERMAL STABILITY OF DESIGNED ANKYRIN REPEAT PROTEINS WITH A REDESIGNED C-CAPPING MODULE.
Descriptor:NI1C MUT4, 1,2-ETHANEDIOL, METHANOL, ...
Authors:Kramer, M., Wetzel, S.K., Pluckthun, A., Mittl, P., Grutter, M.
Deposit date:2010-05-17
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins with a Redesigned C-Capping Module.
J.Mol.Biol., 404, 2010
3HG0
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CRYSTAL STRUCTURE OF A DARPIN IN COMPLEX WITH ORF49 FROM LACTOCOCCAL PHAGE TP901-1
Descriptor:Baseplate protein, Designed Ankyrin Repeat Protein (DARPin) 20
Authors:Veesler, D., Dreier, B., Blangy, S., Lichiere, J., Tremblay, D., Moineau, S., Spinelli, S., Tegoni, M., Pluckthun, A., Campanacci, V., Cambillau, C.
Deposit date:2009-05-13
Release date:2009-09-08
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure and function of a DARPin neutralizing inhibitor of lactococcal phage TP901-1: comparison of DARPin and camelid VHH binding mode.
J.Biol.Chem., 284, 2009