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4ZEG
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BU of 4zeg by Molmil
Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Dual specificity protein kinase TTK, ...
Authors:Qiu, W, Plotnikova, O, Feher, M, Awrey, D.E, Battaile, K, Chirgadze, N.Y.
Deposit date:2015-04-20
Release date:2016-04-27
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor.
To Be Published
1N3J
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BU of 1n3j by Molmil
Structure and Substrate of a Histone H3 Lysine Methyltransferase from Paramecium Bursaria Chlorella Virus 1
Descriptor: Histone H3 Lysine Methyltransferase
Authors:Manzur, K.L, Farooq, A, Zeng, L, Plotnikova, O, Sachchidanand, Koch, A.W, Zhou, M.-M.
Deposit date:2002-10-28
Release date:2003-01-28
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3.
Nat.Struct.Biol., 10, 2003
7U28
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BU of 7u28 by Molmil
Structure of SARS-CoV-2 Mpro Lambda (G15S) in complex with Nirmatrelvir (PF-07321332)
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Greasley, S.E, Ferre, R.A, Plotnikova, O, Liu, W, Stewart, A.E.
Deposit date:2022-02-23
Release date:2022-03-09
Last modified:2022-06-15
Method:X-RAY DIFFRACTION (1.679 Å)
Cite:Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants.
J.Biol.Chem., 298, 2022
3IED
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BU of 3ied by Molmil
Crystal structure of N-terminal domain of Plasmodium falciparum Hsp90 (PF14_0417) in complex with AMPPN
Descriptor: AMP PHOSPHORAMIDATE, Heat shock protein
Authors:Pizarro, J.C, Wernimont, A.K, Lew, J, Hutchinson, A, Artz, J.D, Amaya, M.F, Plotnikova, O, Vedadi, M, Kozieradzki, I, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Botchkarev, A, Hui, R, Hills, T, Structural Genomics Consortium (SGC)
Deposit date:2009-07-22
Release date:2009-08-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structure of N-terminal domain of Plasmodium falciparum Hsp90 (PF14_0417) in complex with AMPPN
TO BE PUBLISHED
2RO1
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BU of 2ro1 by Molmil
NMR Solution Structures of Human KAP1 PHD finger-bromodomain
Descriptor: Transcription intermediary factor 1-beta, ZINC ION
Authors:Zeng, L, Yap, K.L, Ivanov, A.V, Wang, X, Mujtaba, S, Plotnikova, O, Rauscher, F.J.
Deposit date:2008-03-04
Release date:2008-05-20
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing
Nat.Struct.Mol.Biol., 15, 2008
7TLL
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BU of 7tll by Molmil
Structure of SARS-CoV-2 Mpro Omicron P132H in complex with Nirmatrelvir (PF-07321332)
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Greasley, S.E, Ferre, R.A, Plotnikova, O, Liu, W, Stewart, A.E.
Deposit date:2022-01-18
Release date:2022-01-26
Last modified:2022-06-15
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants.
J.Biol.Chem., 298, 2022
4O6L
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BU of 4o6l by Molmil
Crystal Structure of TTK kinase domain with an inhibitor: 401498 (N-[(1R)-1-(2-chlorophenyl)propyl]-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-1H-indazole-5-carboxamide)
Descriptor: Dual specificity protein kinase TTK, GLYCEROL, N-[(1R)-1-(2-chlorophenyl)propyl]-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-1H-indazole-5-carboxamide
Authors:Qiu, W, Plotnikova, O, Feher, M, Awrey, D.E, Chirgadze, N.Y.
Deposit date:2013-12-22
Release date:2014-12-24
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal Structure of TTK kinase domain with an inhibitor: 401498
TO BE PUBLISHED
1XR0
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BU of 1xr0 by Molmil
Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors
Descriptor: Basic fibroblast growth factor receptor 1, FGFR signalling adaptor SNT-1
Authors:Dhalluin, C, Yan, K.S, Plotnikova, O, Lee, K.W, Zeng, L, Kuti, M, Mujtaba, S, Goldfarb, M.P, Zhou, M.-M.
Deposit date:2004-10-13
Release date:2004-11-02
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors
Mol.Cell, 6, 2000
1Y6Z
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BU of 1y6z by Molmil
Middle domain of Plasmodium falciparum putative heat shock protein PF14_0417
Descriptor: heat shock protein, putative
Authors:Lunin, V.V, Botchkareva, E, Loppnau, P, Amani, M, Bray, J, Vedadi, M, Edwards, A, Arrowsmith, C, Sundstrom, M, Bochkarev, A, Hui, R, Plotnikova, O, Structural Genomics Consortium (SGC)
Deposit date:2004-12-07
Release date:2005-02-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
4JXF
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BU of 4jxf by Molmil
Crystal Structure of PLK4 Kinase with an inhibitor: 400631 ((1R,2S)-2-{3-[(E)-2-{4-[(DIMETHYLAMINO)METHYL]PHENYL}ETHENYL]-2H-INDAZOL-6-YL}-5'-METHOXYSPIRO[CYCLOPROPANE-1,3'-INDOL]-2'(1'H)-ONE)
Descriptor: (1R,2S)-2-{3-[(E)-2-{4-[(dimethylamino)methyl]phenyl}ethenyl]-2H-indazol-6-yl}-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one, 1,2-ETHANEDIOL, Serine/threonine-protein kinase PLK4
Authors:Qiu, W, Plotnikova, O, Feher, M, Awrey, D.E, Chirgadze, N.Y.
Deposit date:2013-03-28
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of PLK4 Kinase with an inhibitor: 400631
To be Published
4JS8
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BU of 4js8 by Molmil
Crystal structure of TTK kinase domain with an inhibitor: 401348
Descriptor: 4-(cyclohexylmethoxy)-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-2H-indazole, DI(HYDROXYETHYL)ETHER, Dual specificity protein kinase TTK, ...
Authors:Qiu, W, Plotnikov, A.N, Plotnikova, O, Feher, M, Awrey, D.E, Chirgadze, N.Y.
Deposit date:2013-03-22
Release date:2014-03-26
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structure of TTK kinase domain with an inhibitor: 401348
To be Published
2F6I
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BU of 2f6i by Molmil
Crystal structure of the ClpP protease catalytic domain from Plasmodium falciparum
Descriptor: ATP-dependent CLP protease, putative
Authors:Mulichak, A, Loppnau, P, Bray, J, Amani, M, Vedadi, M, Wasney, G, Finerty, P, Sundstrom, M, Weigelt, J, Edwards, A, Arrowsmith, C, Hui, R, Plotnikova, O, Structural Genomics Consortium (SGC)
Deposit date:2005-11-29
Release date:2005-12-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum.
J.Mol.Biol., 404, 2010
7U29
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BU of 7u29 by Molmil
Structure of SARS-CoV-2 Mpro mutant (K90R) in complex with Nirmatrelvir (PF-07321332)
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E.
Deposit date:2022-02-23
Release date:2022-03-09
Last modified:2022-06-15
Method:X-RAY DIFFRACTION (2.088 Å)
Cite:Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants.
J.Biol.Chem., 298, 2022
3PGG
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BU of 3pgg by Molmil
Crystal structure of cryptosporidium parvum u6 snrna-associated sm-like protein lsm5
Descriptor: U6 snRNA-associated Sm-like protein LSm5. SM domain
Authors:Dong, A, Gao, M, Zhao, Y, Lew, J, Wasney, G.A, Kozieradzki, I, Vedadi, M, Edwards, A, Arrowsmith, C, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Artz, J, Structural Genomics Consortium (SGC)
Deposit date:2010-11-01
Release date:2011-02-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Genome-Scale Protein Expression and Structural Biology of Plasmodium Falciparum and Related Apicomplexan Organisms.
Mol.Biochem.Parasitol., 151, 2007
3TB2
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BU of 3tb2 by Molmil
1-Cys peroxidoxin from Plasmodium Yoelli
Descriptor: 1,2-ETHANEDIOL, 1-Cys peroxiredoxin, GLYCEROL, ...
Authors:Qiu, W, Artz, J.D, Vedadi, M, Sharma, S, Houston, S, Lew, J, Wasney, G, Amani, M, Xu, X, Bray, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Hui, R, Bochkarev, A, Structural Genomics Consortium (SGC)
Deposit date:2011-08-04
Release date:2011-10-19
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
5V8O
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BU of 5v8o by Molmil
Discovery of a high affinity inhibitor of cGAS
Descriptor: 5-phenyltetrazolo[1,5-a]pyrimidin-7-ol, Cyclic GMP-AMP synthase, ZINC ION
Authors:Hall, J.
Deposit date:2017-03-22
Release date:2017-09-27
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
PLoS ONE, 12, 2017
5WOF
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BU of 5wof by Molmil
1.65 ANGSTROM STRUCTURE OF THE DYNEIN LIGHT CHAIN 1 FROM PLASMODIUM FALCIPARUM
Descriptor: Dynein light chain 1, putative
Authors:Walker, J.R, Lew, J, Amani, M, Alam, Z, Wasney, G, Boulanger, K, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Hui, R, Botchkarev, A, Vedadi, M, Structural Genomics Consortium (SGC)
Deposit date:2017-08-02
Release date:2017-08-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Genome-scale Protein Expression and Structural Biology of Plasmodium Falciparum and Related Apicomplexan Organisms.
MOL.BIOCHEM.PARASITOL., 151, 2007
6MP6
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BU of 6mp6 by Molmil
Cryo-EM structure of the human neutral amino acid transporter ASCT2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Neutral amino acid transporter B(0)
Authors:Yu, X, Han, S.
Deposit date:2018-10-05
Release date:2019-11-06
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation.
Elife, 8, 2019
6MPB
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BU of 6mpb by Molmil
Cryo-EM structure of the human neutral amino acid transporter ASCT2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMINE, Neutral amino acid transporter B(0)
Authors:Yu, X, Han, S.
Deposit date:2018-10-05
Release date:2019-11-06
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation.
Elife, 8, 2019
6NAO
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BU of 6nao by Molmil
Discovery of a high affinity inhibitor of cGAS
Descriptor: (1R,2S)-2-[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic acid, CYCLIC GMP-AMP SYNTHASE, ZINC ION
Authors:Hall, J.
Deposit date:2018-12-06
Release date:2018-12-19
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
PLoS ONE, 12, 2017
3K8S
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BU of 3k8s by Molmil
Crystal Structure of PPARg in complex with T2384
Descriptor: 2-chloro-N-{3-chloro-4-[(5-chloro-1,3-benzothiazol-2-yl)sulfanyl]phenyl}-4-(trifluoromethyl)benzenesulfonamide, Peroxisome proliferator-activated receptor gamma
Authors:Wang, Z.
Deposit date:2009-10-14
Release date:2009-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties
J.Biol.Chem., 283, 2008
1HZM
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BU of 1hzm by Molmil
STRUCTURE OF ERK2 BINDING DOMAIN OF MAPK PHOSPHATASE MKP-3: STRUCTURAL INSIGHTS INTO MKP-3 ACTIVATION BY ERK2
Descriptor: DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
Authors:Farooq, A, Zhou, M.-M.
Deposit date:2001-01-25
Release date:2002-01-25
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2.
Mol.Cell, 7, 2001
1JSP
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BU of 1jsp by Molmil
NMR Structure of CBP Bromodomain in complex with p53 peptide
Descriptor: CREB-BINDING PROTEIN, tumor protein p53
Authors:He, Y, Mujtaba, S, Zeng, L, Yan, S, Zhou, M.-M.
Deposit date:2001-08-17
Release date:2002-08-17
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
Mol.Cell, 13, 2004
1M3G
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BU of 1m3g by Molmil
SOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF MAPK PHOSPHATASE PAC-1: INSIGHTS INTO SUBSTRATE-INDUCED ENZYMATIC ACTIVATION
Descriptor: DUAL SPECIFICITY PROTEIN PHOSPHATASE 2
Authors:Farooq, A, Zhou, M.-M.
Deposit date:2002-06-27
Release date:2003-06-27
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Solution Structure of the MAPK Phosphatase PAC-1 Catalytic Domain Insights into Substrate-Induced Enzymatic Activation of MKP
Structure, 11, 2003
1TXJ
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BU of 1txj by Molmil
Crystal structure of translationally controlled tumour-associated protein (TCTP) from Plasmodium knowlesi
Descriptor: translationally controlled tumour-associated protein (TCTP) from Plasmodium knowlesi, PKN_PFE0545c
Authors:Walker, J.R, Vedadi, M, Sharma, S, Houston, S, Lew, J, Amani, M, Wasney, G, Skarina, T, Bray, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Hui, R, Structural Genomics Consortium (SGC)
Deposit date:2004-07-05
Release date:2004-07-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007

 

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