Author results

1CVS
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CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX
Descriptor:FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION
Authors:Plotnikov, A.N., Schlessinger, J., Hubbard, S.R., Mohammadi, M.
Deposit date:1999-08-24
Release date:2000-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for FGF receptor dimerization and activation.
Cell(Cambridge,Mass.), 98, 1999
1EV2
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CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)
Descriptor:PROTEIN (FIBROBLAST GROWTH FACTOR 2), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 2), SULFATE ION
Authors:Plotnikov, A.N., Hubbard, S.R., Schlessinger, J., Mohammadi, M.
Deposit date:2000-04-19
Release date:2000-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.), 101, 2000
1EVT
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CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)
Descriptor:PROTEIN (FIBROBLAST GROWTH FACTOR 1), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 1), SULFATE ION
Authors:Plotnikov, A.N., Hubbard, S.R., Schlessinger, J., Mohammadi, M.
Deposit date:2000-04-20
Release date:2000-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.), 101, 2000
1IHK
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CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9)
Descriptor:GLIA-ACTIVATING FACTOR, PHOSPHATE ION
Authors:Plotnikov, A.N., Eliseenkova, A.V., Ibrahimi, O.A., Lemmon, M.A., Mohammadi, M.
Deposit date:2001-04-19
Release date:2001-05-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition.
J.Biol.Chem., 276, 2001
4N3W
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CRYSTAL STRUCTURE OF THE BROMODOMAIN-PHD FINGER MODULE OF HUMAN TRANSCRIPTIONAL CO-ACTIVATOR CBP IN COMPLEX WITH ACETYLATED HISTONE 4 PEPTIDE (H4K20AC).
Descriptor:CREB-binding protein, Histone H4 peptide, ZINC ION
Authors:Plotnikov, A.N., Yang, S., Zhou, M.-M.
Deposit date:2013-10-07
Release date:2014-01-29
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBP.
Structure, 22, 2014
4N4F
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CRYSTAL STRUCTURE OF THE BROMODOMAIN-PHD FINGER MODULE OF HUMAN TRANSCRIPTIONAL CO-ACTIVATOR CBP IN COMPLEX WITH DI-ACETYLATED HISTONE 4 PEPTIDE (H412ACK16AC).
Descriptor:CREB-binding protein, Histone 4 Peptide, ZINC ION
Authors:Plotnikov, A.N., Zhou, J., Zhou, M.-M.
Deposit date:2013-10-08
Release date:2014-02-19
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBP.
Structure, 22, 2014
4NUC
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH MS435 INHIBITOR
Descriptor:Bromodomain-containing protein 4, 4-[(E)-(4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, 1,2-ETHANEDIOL
Authors:Plotnikov, A.N., Joshua, J., Zhou, M.-M.
Deposit date:2013-12-03
Release date:2014-04-02
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
4NUD
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH MS436 INHIBITOR
Descriptor:Bromodomain-containing protein 4, 4-[(E)-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, 1,2-ETHANEDIOL
Authors:Plotnikov, A.N., Joshua, J., Zhou, M.-M.
Deposit date:2013-12-03
Release date:2014-04-02
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
4NUE
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH MS267 INHIBITOR
Descriptor:Bromodomain-containing protein 4, 4-[(E)-(2-amino-4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, 1,2-ETHANEDIOL
Authors:Plotnikov, A.N., Joshua, J., Zhou, M.-M.
Deposit date:2013-12-03
Release date:2014-04-02
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
4QB3
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH OLINONE
Descriptor:Bromodomain-containing protein 4, N-[4-(1-oxo-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)butyl]acetamide, 1,2-ETHANEDIOL
Authors:Plotnikov, A.N., Joshua, J., Zhou, M.-M.
Deposit date:2014-05-06
Release date:2015-04-22
Method:X-RAY DIFFRACTION (0.94 Å)
Cite:Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression.
Chem.Biol., 21, 2014
5ULA
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH CYCLIC VINYLOGOUS AMIDE INHIBITOR MS402
Descriptor:Bromodomain-containing protein 4, 3-chloranyl-~{N}-(4-methoxyphenyl)-4-[(2-methyl-3-oxidanylidene-cyclopenten-1-yl)amino]benzamide
Authors:Plotnikov, A.N., Joshua, j., Zhou, M.-M.
Deposit date:2017-01-24
Release date:2017-03-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
1FQ9
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CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX
Descriptor:FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid, ...
Authors:Schlessinger, J., Plotnikov, A.N., Ibrahimi, O.A., Eliseenkova, A.V., Yeh, B.K., Yayon, A., Linhardt, R.J., Mohammadi, M.
Deposit date:2000-09-04
Release date:2000-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
Mol.Cell, 6, 2000
1II4
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CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
Descriptor:HEPARIN-BINDING GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 2
Authors:Ibrahimi, O.A., Eliseenkova, A.V., Plotnikov, A.N., Ornitz, D.M., Mohammadi, M.
Deposit date:2001-04-20
Release date:2001-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.
Proc.Natl.Acad.Sci.USA, 98, 2001
1IIL
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CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
Descriptor:HEPARIN-BINDING GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 2
Authors:Ibrahimi, O.A., Eliseenkova, A.V., Plotnikov, A.N., Ornitz, D.M., Mohammadi, M.
Deposit date:2001-04-23
Release date:2001-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.
Proc.Natl.Acad.Sci.USA, 98, 2001
1IJT
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CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 4 (FGF4)
Descriptor:fibroblast growth factor 4, SULFATE ION
Authors:Bellosta, P., Plotnikov, A.N., Eliseenkova, A.V., Basilico, C., Mohammadi, M.
Deposit date:2001-04-29
Release date:2001-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis.
Mol.Cell.Biol., 21, 2001
1NUN
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CRYSTAL STRUCTURE ANALYSIS OF THE FGF10-FGFR2B COMPLEX
Descriptor:Fibroblast growth factor-10, fibroblast growth factor receptor 2 isoform 2, SULFATE ION, ...
Authors:Yeh, B.K., Igarashi, M., Eliseenkova, A.V., Plotnikov, A.N., Sher, I., Ron, D., Aaronson, S.A., Mohammadi, M.
Deposit date:2003-01-31
Release date:2003-02-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors.
Proc.Natl.Acad.Sci.USA, 100, 2003
1ZD1
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HUMAN SULFORTRANSFERASE SULT4A1
Descriptor:Sulfotransferase 4A1, GLYCEROL
Authors:Dong, A., Dombrovski, L., Loppnau, P., Edwards, A.M., Arrowsmith, C.H., Sundstrom, M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-04-13
Release date:2005-04-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural and chemical profiling of the human cytosolic sulfotransferases.
Plos Biol., 5, 2007
1ZRH
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CRYSTAL STRUCTURE OF HUMAN HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 1 IN COMPLEX WITH PAP
Descriptor:Heparan sulfate glucosamine 3-O-sulfotransferase 1, ADENOSINE-3'-5'-DIPHOSPHATE
Authors:Dong, A., Dombrovski, L., Loppnau, P., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-05-19
Release date:2005-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP
To be Published
2A14
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CRYSTAL STRUCTURE OF HUMAN INDOLETHYLAMINE N-METHYLTRANSFERASE WITH SAH
Descriptor:indolethylamine N-methyltransferase, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Dong, A., Wu, H., Zeng, H., Loppnau, P., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-06-17
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Human Indolethylamine N-methyltransferase in complex with SAH.
To be Published
2AD1
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HUMAN SULFOTRANSFERASE SULT1C2
Descriptor:Sulfotransferase 1C2
Authors:Dong, A., Dombrovski, L., Loppnau, P., Edwards, A.M., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-07-19
Release date:2005-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and chemical profiling of the human cytosolic sulfotransferases.
Plos Biol., 5, 2007
2AVD
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CRYSTAL STRUCTURE OF HUMAN CATECHOL-O-METHYLTRANSFERASE DOMAIN CONTAINING 1
Descriptor:Catechol-O-methyltransferase, S-ADENOSYLMETHIONINE
Authors:Min, J.R., Wu, H., Zeng, H., Loppnau, P., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-08-29
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Human Catechol-O-methyltransferase domain containing 1 in complex with S-adenosyl-L-methionine
To be Published
2B25
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HUMAN PUTATIVE TRNA(1-METHYLADENOSINE)METHYLTRANSFERASE
Descriptor:hypothetical protein, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION
Authors:Tempel, W., Wu, H., Dong, A., Zeng, H., Loppnau, P., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-09-16
Release date:2005-09-27
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Human putative tRNA(1-methyladenosine)methyltransferase
To be Published
2B4Y
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CRYSTAL STRUCTURE OF HUMAN SIRTUIN HOMOLOG 5
Descriptor:NAD-dependent deacetylase sirtuin-5, ZINC ION, ADENOSINE-5-DIPHOSPHORIBOSE, ...
Authors:Min, J.R., Antoshenko, T., Dong, A., Schuetz, A., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-09-27
Release date:2006-02-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Human Sirtuin homolog 5 in complex with NAD
To be Published
2B9E
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HUMAN NSUN5 PROTEIN
Descriptor:NOL1/NOP2/Sun domain family, member 5 isoform 2, S-ADENOSYLMETHIONINE
Authors:Min, J.R., Wu, H., Zeng, H., Loppnau, P., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-10-11
Release date:2005-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Crystal Structure of Human NSUN5 protein in complex with S-adenosyl-L-methionine
To be Published
2BZG
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CRYSTAL STRUCTURE OF THIOPURINE S-METHYLTRANSFERASE.
Descriptor:THIOPURINE S-METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Battaile, K.P., Wu, H., Zeng, H., Loppnau, P., Dong, A., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-08-17
Release date:2005-08-25
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Structural Basis of Allele Variation of Human Thiopurine-S-Methyltransferase.
Proteins, 67, 2007