Author results

1IM3
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CRYSTAL STRUCTURE OF THE HUMAN CYTOMEGALOVIRUS PROTEIN US2 BOUND TO THE MHC CLASS I MOLECULE HLA-A2/TAX
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, beta-2-microglobulin, ...
Authors:Gewurz, B.E., Gaudet, R., Tortorella, D., Wang, E.W., Ploegh, H.L., Wiley, D.C.
Deposit date:2001-05-09
Release date:2001-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2.
Proc.Natl.Acad.Sci.USA, 98, 2001
1XD3
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CRYSTAL STRUCTURE OF UCHL3-UBVME COMPLEX
Descriptor:Ubiquitin Carboxyl-terminal esterase L3, UBC protein, MAGNESIUM ION, ...
Authors:Misaghi, S., Galardy, P.J., Meester, W.J.N., Ovaa, H., Ploegh, H.L., Gaudet, R.
Deposit date:2004-09-03
Release date:2004-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure of the Ubiquitin Hydrolase UCH-L3 Complexed with a Suicide Substrate
J.Biol.Chem., 280, 2005
2J7Q
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CRYSTAL STRUCTURE OF THE UBIQUITIN-SPECIFIC PROTEASE ENCODED BY MURINE CYTOMEGALOVIRUS TEGUMENT PROTEIN M48 IN COMPLEX WITH A UBQUITIN-BASED SUICIDE SUBSTRATE
Descriptor:MCMV TEGUMENT PROTEIN M48 ENCODED UBIQUITIN- SPECIFIC PROTEASE, M48USP, UBIQUITIN, ...
Authors:Schlieker, C., Weihofen, W.A., Frijns, E., Kattenhorn, L.M., Gaudet, R., Ploegh, H.L.
Deposit date:2006-10-16
Release date:2007-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes
Mol.Cell, 25, 2007
2JX5
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SOLUTION STRUCTURE OF THE UBIQUITIN DOMAIN N-TERMINAL TO THE S27A RIBOSOMAL SUBUNIT OF GIARDIA LAMBLIA
Descriptor:GlUb(S27a)
Authors:Catic, A., Sun, Z.J., Ratner, D.M., Misaghi, S., Spooner, E., Samuelson, J., Wagner, G., Ploegh, H.L.
Deposit date:2007-11-07
Release date:2007-12-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Sequence and structure evolved separately in a ribosomal ubiquitin variant
EMBO J., 26, 2007
2VE6
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CRYSTAL STRUCTURE OF A MURINE MHC CLASS I H2-DB MOLECULE IN COMPLEX WITH A PHOTOCLEAVABLE PEPTIDE
Descriptor:H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN D-B ALPHA CHAIN, BETA-2-MICROGLOBULIN, SENDAI VIRUS EPITOPE RESIDUES 324-332 MODIFIED AT P7
Authors:Grotenbreg, G.M., Roan, N.R., Guillen, E., Meijers, R., Wang, J.H., Bell, G.W., Starnbach, M.N., Ploegh, H.L.
Deposit date:2007-10-17
Release date:2008-01-22
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Discovery of Cd8+ T Cell Epitopes in Chlamydia Trachomatis Infection Through Use of Caged Class I Mhc Tetramers.
Proc.Natl.Acad.Sci.USA, 105, 2008
2WDT
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM UCHL3 IN COMPLEX WITH THE SUICIDE INHIBITOR UBVME
Descriptor:UBIQUITIN CARBOXYL-TERMINAL HYDROLASE L3, UBIQUITIN, CHLORIDE ION
Authors:Weihofen, W.A., Artavanis-Tsakonas, K., Gaudet, R., Ploegh, H.L.
Deposit date:2009-03-26
Release date:2009-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization and Structural Studies of the Plasmodium Falciparum Ubiquitin and Nedd8 Hydrolase Uchl3.
J.Biol.Chem., 285, 2010
2WE6
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM UBIQUITIN CARBOXYL- TERMINAL HYDROLASE 3 (UCHL3)
Descriptor:UBIQUITIN CARBOXYL-TERMINAL HYDROLASE L3
Authors:Weihofen, W.A., Artavanis-Tsakonas, K., Gaudet, R., Ploegh, H.L.
Deposit date:2009-03-27
Release date:2009-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Characterization and Structural Studies of the Plasmodium Falciparum Ubiquitin and Nedd8 Hydrolase Uchl3.
J.Biol.Chem., 285, 2010
5FNA
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CRYO-EM RECONSTRUCTION OF CASPASE-1 CARD
Descriptor:CASPASE-1
Authors:Li, Y., Lu, A., Schmidt, F.I., Yin, Q., Chen, S., Fu, T.M., Tong, A.B., Ploegh, H.L., Mao, Y., Wu, H.
Deposit date:2015-11-11
Release date:2016-03-30
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Molecular Basis of Caspase-1 Polymerization and its Inhibition by a Novel Capping Mechanism
Nat.Struct.Mol.Biol., 23, 2016
5H8D
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CRYSTAL STRUCTURE OF AN ASC BINDING NANOBODY
Descriptor:VHH nanobody
Authors:Lu, A., Schmidt, F.I., Ruan, J., Tang, C., Wu, H., Ploegh, H.L.
Deposit date:2015-12-23
Release date:2016-04-06
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.
J.Exp.Med., 213, 2016
5H8O
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CRYSTAL STRUCTURE OF AN ASC-BINDING NANOBODY IN COMPLEX WITH THE CARD DOMAIN OF ASC
Descriptor:VHH nanobody, Apoptosis-associated speck-like protein containing a CARD
Authors:Lu, A., Schmidt, F.I., Ruan, J., Tang, C., Wu, H., Ploegh, H.L.
Deposit date:2015-12-23
Release date:2016-04-06
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (4.206 Å)
Cite:A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.
J.Exp.Med., 213, 2016
5TJW
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INFLUENZA A VIRUS NUCLEOPROTEIN IN COMPLEX WITH INHIBITORY NANOBODY
Descriptor:Nucleoprotein, NP-specific inhibitory VHH
Authors:Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U.
Deposit date:2016-10-05
Release date:2016-12-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.231 Å)
Cite:The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment.
MBio, 7, 2016
5UK4
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VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307
Descriptor:Nucleoprotein, Anti-vesicular stomatitis virus N VHH, RNA (45-MER)
Authors:Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U.
Deposit date:2017-01-19
Release date:2017-04-19
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (3.204 Å)
Cite:Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication.
EMBO Rep., 18, 2017
5UKB
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VSV N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1004
Descriptor:Anti-vesicular stomatitis virus N VHH, Nucleocapsid, RNA (45-MER)
Authors:Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U.
Deposit date:2017-01-20
Release date:2017-04-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (5.473 Å)
Cite:Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication.
EMBO Rep., 18, 2017
2F16
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH BORTEZOMIB
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M.
Deposit date:2005-11-14
Release date:2006-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome.
Structure, 14, 2006
3H1D
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STRUCTURE OF THE HUWE1 HECT DOMAIN
Descriptor:E3 ubiquitin-protein ligase HUWE1, SULFATE ION
Authors:Partridge, J.R., Schwartz, T.U.
Deposit date:2009-04-11
Release date:2009-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:A structural element within the HUWE1 HECT domain modulates self-ubiquitination and substrate ubiquitination activities.
J.Biol.Chem., 285, 2010
4QXW
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CRYSTAL STRUCTURE OF THE HUMAN CEACAM1 MEMBRANE DISTAL AMINO TERMINAL (N)-DOMAIN
Descriptor:Carcinoembryonic antigen-related cell adhesion molecule 1, MALONIC ACID, B-OCTYLGLUCOSIDE
Authors:Huang, Y.H., Gandhi, A.K., Russell, A., Kondo, Y., Chen, Q., Petsko, G.A., Blumberg, R.S.
Deposit date:2014-07-22
Release date:2014-11-12
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Nature, 517, 2015
4TVS
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LAP1(AA356-583), H.SAPIENS, BOUND TO VHH-BS1
Descriptor:Torsin-1A-interacting protein 1, VHH Domain BS-1, SULFATE ION, ...
Authors:Sosa, B.A., Schwartz, T.U.
Deposit date:2014-06-27
Release date:2014-09-03
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:How lamina-associated polypeptide 1 (LAP1) activates Torsin.
Elife, 3, 2014
4XT1
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STRUCTURE OF A NANOBODY-BOUND VIRAL GPCR BOUND TO HUMAN CHEMOKINE CX3CL1
Descriptor:G-protein coupled receptor homolog US28, Fractalkine, nanobody 7, ...
Authors:Burg, J.S., Jude, K.M., Waghray, D., Garcia, K.C.
Deposit date:2015-01-22
Release date:2015-03-04
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (2.886 Å)
Cite:Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.
Science, 347, 2015
4XT3
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STRUCTURE OF A VIRAL GPCR BOUND TO HUMAN CHEMOKINE CX3CL1
Descriptor:G-protein coupled receptor homolog US28, Fractalkine, UNKNOWN LIGAND, ...
Authors:Burg, J.S., Jude, K.M., Waghray, D., Garcia, K.C.
Deposit date:2015-01-22
Release date:2015-03-04
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (3.801 Å)
Cite:Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.
Science, 347, 2015
4YGA
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CDPK1, FROM TOXOPLASMA GONDII, BOUND TO INHIBITORY VHH-1B7
Descriptor:Calmodulin-domain protein kinase 1, VHH-1B7, CALCIUM ION
Authors:Knockenhauer, K.E., Schwartz, T.U.
Deposit date:2015-02-26
Release date:2015-08-26
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Allosteric activation of apicomplexan calcium-dependent protein kinases.
Proc.Natl.Acad.Sci.USA, 112, 2015
5DZL
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CRYSTAL STRUCTURE OF THE PROTEIN HUMAN CEACAM1
Descriptor:Carcinoembryonic antigen-related cell adhesion molecule 1
Authors:Huang, Y.H., Russell, A., Gandhi, A.K., Kondo, Y., Chen, Q., Petsko, G.A., Blumberg, R.S.
Deposit date:2015-09-25
Release date:2015-10-07
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.4006 Å)
Cite:CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Nature, 517, 2015
5J1S
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TORSINA-LULL1 COMPLEX, H. SAPIENS, BOUND TO VHH-BS2
Descriptor:Torsin-1A, Torsin-1A-interacting protein 2, VHH domain BS-2, ...
Authors:Demircioglu, F.E., Schwartz, T.U.
Deposit date:2016-03-29
Release date:2016-08-17
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.399 Å)
Cite:Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia.
Elife, 5, 2016
5J1T
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TORSINADELTAE-LULL1 COMPLEX, H. SAPIENS, BOUND TO VHH-BS2
Descriptor:Torsin-1A, Torsin-1A-interacting protein 2, VHH domain BS-2, ...
Authors:Demircioglu, F.E., Schwartz, T.U.
Deposit date:2016-03-29
Release date:2016-08-17
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.402 Å)
Cite:Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia.
Elife, 5, 2016
5JJ6
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FIC-1 (AA134 - 508) FROM C. ELEGANS
Descriptor:Adenosine monophosphate-protein transferase FICD homolog, SULFATE ION
Authors:Cruz, V.E., Schwartz, T.U.
Deposit date:2016-04-22
Release date:2016-06-01
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.907 Å)
Cite:Fic-1 dimer
To be published
5JJ7
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FIC-1 (AA134 - 508 E274G) FROM C. ELEGANS
Descriptor:Adenosine monophosphate-protein transferase FICD homolog, SULFATE ION
Authors:Cruz, V.E., Schwartz, T.U.
Deposit date:2016-04-22
Release date:2016-06-01
Method:X-RAY DIFFRACTION (3.749 Å)
Cite:Fic-1 (aa134 - 508 E274G) from C. elegans
To be published
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