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1YS5
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BU of 1ys5 by Molmil
Solution structure of the antigenic domain of GNA1870 of Neisseria meningitidis
Descriptor: lipoprotein
Authors:Cantini, F, Savino, S, Masignani, V, Pizza, M, Scarselli, M, Swennen, E, Romagnoli, G, Veggi, D, Banci, L, Rappuoli, R.
Deposit date:2005-02-07
Release date:2006-02-07
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of the immunodominant domain of protective antigen GNA1870 of Neisseria meningitidis
J.Biol.Chem., 281, 2006
4E9L
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BU of 4e9l by Molmil
FdeC, a Novel Broadly Conserved Escherichia coli Adhesin Eliciting Protection against Urinary Tract Infections
Descriptor: Attaching and effacing protein, pathogenesis factor
Authors:Spraggon, G, Nesta, B, Alteri, C, Gomes Moriel, D, Rosini, R, Veggi, D, Smith, S, Bertoldi, I, Pastorello, I, Ferlenghi, I, Fontana, M.R, Frankel, G, Mobley, H.L.T, Rappuoli, R, Pizza, M, Serino, L, Soriana, M.
Deposit date:2012-03-21
Release date:2012-04-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:FdeC, a novel broadly conserved Escherichia coli adhesin eliciting protection against urinary tract infections.
MBio, 3, 2012
2KC0
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BU of 2kc0 by Molmil
Solution structure of the factor H binding protein
Descriptor: lipoprotein
Authors:Cantini, F, Veggi, D, Dragonetti, S, Savino, S, Scarselli, M, Romagnoli, G, Pizza, M, Banci, L, Rappuoli, R.
Deposit date:2008-12-13
Release date:2009-02-17
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution Structure of the Factor H-binding Protein, a Survival Factor and Protective Antigen of Neisseria meningitidis
J.Biol.Chem., 284, 2009
2KXI
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BU of 2kxi by Molmil
Solution NMR structure of the apoform of NarE (NMB1343)
Descriptor: Uncharacterized protein
Authors:Koehler, C, Carlier, L, Veggi, D, Soriani, M, Pizza, M, Boelens, R, Bonvin, A.M.J.J.
Deposit date:2010-05-06
Release date:2011-03-02
Last modified:2018-08-08
Method:SOLUTION NMR
Cite:Solution NMR structure of the apoform of NarE (NMB1343)
To be Published
2LFU
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BU of 2lfu by Molmil
The structure of a N. meningitides protein targeted for vaccine development
Descriptor: Gna2132
Authors:Esposito, V, Musi, V, De Chiara, C, Kelly, G, Veggi, D, Pizza, M, Pastore, A.
Deposit date:2011-07-15
Release date:2011-10-19
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of the C-terminal Domain of Neisseria Heparin Binding Antigen (NHBA), One of the Main Antigens of a Novel Vaccine against Neisseria meningitidis.
J.Biol.Chem., 286, 2011
1HTL
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BU of 1htl by Molmil
MUTATION OF A BURIED RESIDUE CAUSES LACK OF ACTIVITY BUT NO CONFORMATIONAL CHANGE: CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN MUTANT VAL 97--> LYS
Descriptor: HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B
Authors:Merritt, E.A, Hol, W.G.J.
Deposit date:1995-02-15
Release date:1995-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli.
Nat.Struct.Biol., 2, 1995
1LTG
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BU of 1ltg by Molmil
THE ARG7LYS MUTANT OF HEAT-LABILE ENTEROTOXIN EXHIBITS GREAT FLEXIBILITY OF ACTIVE SITE LOOP 47-56 OF THE A SUBUNIT
Descriptor: HEAT-LABILE ENTEROTOXIN
Authors:Van Den Akker, F, Hol, W.G.J.
Deposit date:1995-06-13
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Arg7Lys mutant of heat-labile enterotoxin exhibits great flexibility of active site loop 47-56 of the A subunit.
Biochemistry, 34, 1995
1LT4
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BU of 1lt4 by Molmil
HEAT-LABILE ENTEROTOXIN MUTANT S63K
Descriptor: HEAT-LABILE ENTEROTOXIN, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
Authors:Van Den Akker, F, Hol, W.G.J.
Deposit date:1997-04-14
Release date:1997-06-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a non-toxic mutant of heat-labile enterotoxin, which is a potent mucosal adjuvant.
Protein Sci., 6, 1997
7NRU
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BU of 7nru by Molmil
Structure of a natural chimera of meningococcal factor H binding protein belonging to NL096 strain
Descriptor: Factor H binding protein variant 1-2,3.x, SULFATE ION
Authors:Veggi, D, Malito, E, Bottomley, M.J.
Deposit date:2021-03-04
Release date:2022-06-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.21998358 Å)
Cite:Structural characterization of a cross-protective natural chimera of factor H binding protein from meningococcal serogroup B strain NL096.
Comput Struct Biotechnol J, 20, 2022
2Y7S
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BU of 2y7s by Molmil
Structure of a designed meningococcal antigen (factor H binding protein, mutant G1) inducing broad protective immunity
Descriptor: FACTOR H BINDING PROTEIN
Authors:Malito, E, Spraggon, G, Bottomley, M.J.
Deposit date:2011-02-01
Release date:2011-07-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rational Design of a Meningococcal Antigen Inducing Broad Protective Immunity.
Sci.Transl.Med, 3, 2011
4CJD
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BU of 4cjd by Molmil
Crystal structure of Neisseria meningitidis trimeric autotransporter and vaccine antigen NadA
Descriptor: IODIDE ION, NADA
Authors:Malito, E, Biancucci, M, Spraggon, G, Bottomley, M.J.
Deposit date:2013-12-19
Release date:2014-11-26
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.056 Å)
Cite:Structure of the Meningococcal Vaccine Antigen Nada and Epitope Mapping of a Bactericidal Antibody.
Proc.Natl.Acad.Sci.USA, 111, 2014
6XZW
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BU of 6xzw by Molmil
Crystal structure of the meningococcal vaccine antigen fHbp in complex with a cross-reactive human Fab.
Descriptor: 1,2-ETHANEDIOL, Fab 4B3 (heavy chain), Fab 4B3 (light chain), ...
Authors:Veggi, D, Cozzi, R.
Deposit date:2020-02-05
Release date:2020-10-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:4CMenB vaccine induces elite cross-protective human antibodies that compete with human factor H for binding to meningococcal fHbp.
Plos Pathog., 16, 2020
5UR8
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BU of 5ur8 by Molmil
Human antibody fragment (Fab) to meningococcal Factor H binding protein
Descriptor: human immunoglobulin gamma, heavy chain Fd fragment, kappa light chain
Authors:Beernink, P.T.
Deposit date:2017-02-09
Release date:2018-02-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.75500226 Å)
Cite:Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp.
Nat Commun, 9, 2018
5O14
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BU of 5o14 by Molmil
Co-crystal structure of a cross-reactive bactericidal human antibody targeting meningococcal vaccine antigen factor H binding protein
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Fab 1A12 Heavy Chain, ...
Authors:Lopez-Sagaseta, J.
Deposit date:2017-05-18
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.195 Å)
Cite:Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp.
Nat Commun, 9, 2018
2YPV
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BU of 2ypv by Molmil
Crystal structure of the Meningococcal vaccine antigen factor H binding protein in complex with a bactericidal antibody
Descriptor: 1,2-ETHANEDIOL, FAB 12C1, LIPOPROTEIN
Authors:Malito, E, Veggi, D, Bottomley, M.J.
Deposit date:2012-11-01
Release date:2013-02-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Defining a Protective Epitope on Factor H Binding Protein, a Key Meningococcal Virulence Factor and Vaccine Antigen.
Proc.Natl.Acad.Sci.USA, 110, 2013
6EUN
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BU of 6eun by Molmil
Crystal structure of Neisseria meningitidis vaccine antigen NadA variant 3
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ...
Authors:Dello Iacono, L, Liguori, A, Malito, E, Bottomley, M.J.
Deposit date:2017-10-30
Release date:2018-10-10
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:NadA3 Structures Reveal Undecad Coiled Coils and LOX1 Binding Regions Competed by Meningococcus B Vaccine-Elicited Human Antibodies.
MBio, 9, 2018
6EUP
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BU of 6eup by Molmil
Crystal structure of Neisseria meningitidis NadA variant 3 double mutant A33I-I38L
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, Adhesin A, ...
Authors:Dello Iacono, L, Liguori, A, Malito, E, Bottomley, M.J.
Deposit date:2017-10-31
Release date:2018-10-10
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:NadA3 Structures Reveal Undecad Coiled Coils and LOX1 Binding Regions Competed by Meningococcus B Vaccine-Elicited Human Antibodies.
MBio, 9, 2018
5AIQ
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BU of 5aiq by Molmil
Crystal structure of ligand-free NadR
Descriptor: TRANSCRIPTIONAL REGULATOR, MARR FAMILY
Authors:Liguori, A, Malito, E, Bottomley, M.J.
Deposit date:2015-02-16
Release date:2016-03-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.716 Å)
Cite:Molecular Basis of Ligand-Dependent Regulation of Nadr, the Transcriptional Repressor of Meningococcal Virulence Factor Nada.
Plos Pathog., 12, 2016
5AIP
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BU of 5aip by Molmil
Crystal structure of NadR in complex with 4-hydroxyphenylacetate
Descriptor: 4-HYDROXYPHENYLACETATE, TRANSCRIPTIONAL REGULATOR, MARR FAMILY
Authors:Liguori, A, Malito, E, Bottomley, M.J.
Deposit date:2015-02-16
Release date:2016-03-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular Basis of Ligand-Dependent Regulation of Nadr, the Transcriptional Repressor of Meningococcal Virulence Factor Nada.
Plos Pathog., 12, 2016

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