Author results

5T5G
  • Download 5t5g
  • View 5t5g
Molmil generated image of 5t5g
HUMAN SETD8 IN COMPLEX WITH MS2177
Descriptor:N-lysine methyltransferase KMT5A, UNKNOWN ATOM OR ION, 7-(2-aminoethoxy)-6-methoxy-2-(pyrrolidin-1-yl)-N-[5-(pyrrolidin-1-yl)pentyl]quinazolin-4-amine
Authors:Yu, W., Tempel, W., Babault, N., Ma, A., Butler, K.V., Jin, J., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2016-08-30
Release date:2016-09-28
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
J. Med. Chem., 59, 2016
5TH7
  • Download 5th7
  • View 5th7
Molmil generated image of 5th7
COMPLEX OF SETD8 WITH MS453
Descriptor:N-lysine methyltransferase KMT5A, N-(3-{[6,7-dimethoxy-2-(pyrrolidin-1-yl)quinazolin-4-yl]amino}propyl)propanamide, UNKNOWN ATOM OR ION, ...
Authors:Yu, W., Tempel, W., Babault, N., Ma, A., Butler, K.V., Jin, J., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2016-09-29
Release date:2016-11-09
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
J. Med. Chem., 59, 2016
5W1Y
  • Download 5w1y
  • View 5w1y
Molmil generated image of 5w1y
SETD8 IN COMPLEX WITH A COVALENT INHIBITOR
Descriptor:N-lysine methyltransferase KMT5A, 2-(4-methylpiperazin-1-yl)-3-(phenylsulfanyl)naphthalene-1,4-dione, UNKNOWN ATOM OR ION
Authors:Tempel, W., Yu, W., Li, Y., Blum, G., Luo, M., Pittella-Silva, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2017-06-05
Release date:2017-06-21
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:SETD8 in complex with a covalent inhibitor
to be published