Author results

2J7L
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E. COLI P PILUS CHAPERONE PAPD IN COMPLEX WITH A PILUS BIOGENESIS INHIBITOR, PILICIDE 2C
Descriptor:CHAPERONE PROTEIN PAPD, (3R)-8-CYCLOPROPYL-6-(MORPHOLIN-4-YLMETHYL)-7-(1-NAPHTHYLMETHYL)-5-OXO-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIDINE-3-CARBOXYLIC ACID
Authors:Remaut, H., Pinkner, J.S., Hultgren, S.J., Almqvist, F., Waksman, G.
Deposit date:2006-10-12
Release date:2006-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Rationally Designed Small Compounds Inhibit Pilus Biogenesis in Uropathogenic Bacteria.
Proc.Natl.Acad.Sci.USA, 103, 2006
2WMP
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STRUCTURE OF THE E. COLI CHAPERONE PAPD IN COMPLEX WITH THE PILIN DOMAIN OF THE PAPGII ADHESIN
Descriptor:CHAPERONE PROTEIN PAPD, PAPG PROTEIN
Authors:Ford, B.A., Verger, D., Elam, J.S., Dodson, K.W., Pinkner, J.S., Hultgren, S.J.
Deposit date:2009-07-02
Release date:2010-08-25
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the Papd-Papgii Pilin Complex Reveals an Open and Flexible P5 Pocket.
J.Bacteriol., 194, 2012
3ME0
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STRUCTURE OF THE E. COLI CHAPERONE PAPD IN COMPLEX WITH THE PILIN DOMAIN OF THE PAPGII ADHESIN
Descriptor:Chaperone protein papD, PapG protein
Authors:Ford, B.A., Elam, J.S., Dodson, K.W., Pinkner, J.S., Hultgren, S.J.
Deposit date:2010-03-31
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structure of the E. Coli Chaperone PapD in Complex with the Pilin Domain of the PapGII Adhesin
To be Published
3PNT
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CRYSTAL STRUCTURE OF THE STREPTOCOCCUS PYOGENES NAD+ GLYCOHYDROLASE SPN IN COMPLEX WITH IFS, THE IMMUNITY FACTOR FOR SPN
Descriptor:NAD+-glycohydrolase, Immunity factor for SPN
Authors:Smith, C.L., Stine Elam, J., Ellenberger, T., Ghosh, J., Pinkner, J.S., Hultgren, S.J., Caparon, M.G.
Deposit date:2010-11-19
Release date:2011-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis of Streptococcus pyogenes Immunity to Its NAD(+) Glycohydrolase Toxin.
Structure, 19, 2011
1J8R
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BINARY COMPLEX OF THE PAPG RECEPTOR-BINDING DOMAIN BOUND TO GBO4 RECEPTOR
Descriptor:PYELONEPHRITIC ADHESIN, N-ACETYL-D-GALACTOSAMINE, ALPHA D-GALACTOSE, ...
Authors:Dodson, K.W., Pinkner, J.S., Rose, T., Magnusson, G., Hultgren, S.J., Waksman, G., Midwest Center for Structural Genomics (MCSG)
Deposit date:2001-05-22
Release date:2001-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor.
Cell(Cambridge,Mass.), 105, 2001
1J8S
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PAPG ADHESIN RECEPTOR BINDING DOMAIN-UNBOUND FORM
Descriptor:PYELONEPHRITIC ADHESIN
Authors:Dodson, K.W., Pinkner, J.S., Rose, T., Magnusson, G., Hultgren, S.J., Waksman, G.
Deposit date:2001-05-22
Release date:2001-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor.
Cell(Cambridge,Mass.), 105, 2001
1N0L
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CRYSTAL STRUCTURE OF THE PAPD CHAPERONE (C-TERMINALLY 6X HISTIDINE-TAGGED) BOUND TO THE PAPE PILUS SUBUNIT (N-TERMINAL-DELETED) FROM UROPATHOGENIC E. COLI
Descriptor:Chaperone protein PapD, mature Fimbrial protein PapE
Authors:Sauer, F.G., Pinkner, J.S., Waksman, G., Hultgren, S.J.
Deposit date:2002-10-14
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation
Cell(Cambridge,Mass.), 111, 2002
1N12
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CRYSTAL STRUCTURE OF THE PAPE (N-TERMINAL-DELETED) PILUS SUBUNIT BOUND TO A PEPTIDE CORRESPONDING TO THE N-TERMINAL EXTENSION OF THE PAPK PILUS SUBUNIT (RESIDUES 1-11) FROM UROPATHOGENIC E. COLI
Descriptor:mature Fimbrial protein PapE, Peptide corresponding to the N-terminal extension of protein PapK
Authors:Sauer, F.G., Pinkner, J.S., Waksman, G., Hultgren, S.J.
Deposit date:2002-10-16
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation
Cell(Cambridge,Mass.), 111, 2002
1QPP
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CRYSTAL STRUCTURES OF SELF CAPPING PAPD CHAPERONE HOMODIMERS
Descriptor:PAPD CHAPERONE
Authors:Hung, D.L., Pinkner, J.S., Knight, S.D., Hultgren, S.J.
Deposit date:1999-05-28
Release date:1999-07-07
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of chaperone self-capping in P pilus biogenesis.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QPX
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CRYSTAL STRUCTURES OF SELF-CAPPING PAPD CHAPERONE HOMODIMERS
Descriptor:PAPD CHAPERONE
Authors:Hung, D.L., Pinkner, J.S., Knight, S.D., Hultgren, S.J.
Deposit date:1999-05-31
Release date:1999-07-07
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of chaperone self-capping in P pilus biogenesis.
Proc.Natl.Acad.Sci.USA, 96, 1999
2VQI
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STRUCTURE OF THE P PILUS USHER (PAPC) TRANSLOCATION PORE
Descriptor:OUTER MEMBRANE USHER PROTEIN PAPC, LAURYL DIMETHYLAMINE-N-OXIDE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE
Authors:Remaut, H., Tang, C., Henderson, N.S., Pinkner, J.S., Wang, T., Hultgren, S.J., Thanassi, D.G., Li, H., Waksman, G.
Deposit date:2008-03-16
Release date:2008-05-27
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Fiber formation across the bacterial outer membrane by the chaperone/usher pathway.
Cell, 133, 2008
2XG4
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E. COLI P PILUS CHAPERONE-SUBUNIT COMPLEX PAPD-PAPH BOUND TO PILUS BIOGENESIS INHIBITOR, PILICIDE 2C
Descriptor:CHAPERONE PROTEIN PAPD, PAP FIMBRIAL MINOR PILIN PROTEIN, (3R)-8-CYCLOPROPYL-6-(MORPHOLIN-4-YLMETHYL)-7-(1-NAPHTHYLMETHYL)-5-OXO-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIDINE-3-CARBOXYLIC ACID, ...
Authors:Remaut, H., Phan, G., Buelens, F., Chorell, E., Pinkner, J.S., Edvinsson, S., Almqvist, F., Hultgren, S.J., Waksman, G.
Deposit date:2010-05-30
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity.
J.Med.Chem., 53, 2010
2XG5
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E. COLI P PILUS CHAPERONE-SUBUNIT COMPLEX PAPD-PAPH BOUND TO PILUS BIOGENESIS INHIBITOR, PILICIDE 5D
Descriptor:CHAPERONE PROTEIN PAPD, PAP FIMBRIAL MINOR PILIN PROTEIN, GLYCEROL, ...
Authors:Remaut, H., Phan, G., Buelens, F., Chorell, E., Pinkner, J.S., Edvinsson, S., Almqvist, F., Hultgren, S.J., Waksman, G.
Deposit date:2010-05-30
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity.
J.Med.Chem., 53, 2010
4UV2
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STRUCTURE OF THE CURLI TRANSPORT LIPOPROTEIN CSGG IN A NON-LIPIDATED, PRE-PORE CONFORMATION
Descriptor:CURLI PRODUCTION TRANSPORT COMPONENT CSGG
Authors:Goyal, P., Krasteva, P.V., Gerven, N.V., Gubellini, F., Broeck, I.V.D., Troupiotis-Tsailaki, A., Jonckheere, W., Pehau-Arnaudet, G., Pinkner, J.S., Chapman, M.R., Hultgren, S.J., Howorka, S., Fronzes, R., Remaut, H.
Deposit date:2014-08-04
Release date:2014-09-24
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and Mechanistic Insights Into the Bacterial Amyloid Secretion Channel Csgg.
Nature, 516, 2014
4UV3
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STRUCTURE OF THE CURLI TRANSPORT LIPOPROTEIN CSGG IN ITS MEMBRANE- BOUND CONFORMATION
Descriptor:CURLI PRODUCTION ASSEMBLY/TRANSPORT COMPONENT CSGG
Authors:Goyal, P., Krasteva, P.V., Gerven, N.V., Gubellini, F., Broeck, I.V.D., Troupiotis-Tsailaki, A., Jonckheere, W., Pehau-Arnaudet, G., Pinkner, J.S., Chapman, M.R., Hultgren, S.J., Howorka, S., Fronzes, R., Remaut, H.
Deposit date:2014-08-04
Release date:2014-09-24
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (3.59 Å)
Cite:Structural and Mechanistic Insights Into the Bacterial Amyloid Secretion Channel Csgg.
Nature, 516, 2014
5LNE
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E. COLI F9 PILUS ADHESIN FMLH BOUND TO THE THOMSEN-FRIEDENREICH (TF) ANTIGEN
Descriptor:Putative Fml fimbrial adhesin FmlD, N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE, BETA-D-GALACTOSE, ...
Authors:Ruer, S., Conover, M.S., Kalas, V., Taganna, J., De Greve, H., Pinkner, J.S., Dodson, K.W., Hultgren, S.J., Remaut, H.
Deposit date:2016-08-04
Release date:2016-10-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.
Cell Host Microbe, 20, 2016
5LNG
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LECTIN DOMAIN OF E. COLI F9 PILUS ADHESIN FMLH
Descriptor:Putative Fml fimbrial adhesin FmlD, SULFATE ION
Authors:Ruer, S., Conover, M.S., Kalas, V., Taganna, J., De Greve, H., Pinkner, J.S., Dodson, K.W., Hultgren, S.J., Remaut, H.
Deposit date:2016-08-04
Release date:2016-10-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.
Cell Host Microbe, 20, 2016
5VQ5
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CRYSTAL STRUCTURE OF THE LECTIN DOMAIN FROM THE F17-LIKE ADHESIN, UCLD
Descriptor:Adhesin, IODIDE ION
Authors:Klein, R.D., Spaulding, C.N., Dodson, K.W., Pinkner, J.S., Hultgren, S.J., Fremont, D.
Deposit date:2017-05-08
Release date:2017-05-24
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.
Nature, 546, 2017
3QB2
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THE CRYSTAL STRUCTURE OF IMMUNITY FACTOR FOR SPN (IFS)
Descriptor:Immunity factor for SPN, SULFATE ION
Authors:Smith, C.L., Ellenberger, T.
Deposit date:2011-01-12
Release date:2011-03-16
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis of Streptococcus pyogenes Immunity to Its NAD(+) Glycohydrolase Toxin.
Structure, 19, 2011
1PDK
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PAPD-PAPK CHAPERONE-PILUS SUBUNIT COMPLEX FROM E.COLI P PILUS
Descriptor:PROTEIN (CHAPERONE PROTEIN PAPD), PROTEIN (PROTEIN PAPK)
Authors:Fuetterer, K., Sauer, F.G., Hultgren, S.J., Waksman, G.
Deposit date:1999-03-29
Release date:1999-08-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of chaperone function and pilus biogenesis.
Science, 285, 1999
2NA4
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CURLI SECRETION SPECIFICITY FACTOR CSGE W48A/F79A MUTANT
Descriptor:Curli production assembly/transport component CsgE
Authors:Shu, Q., Krezel, A.M., Frieden, C.
Deposit date:2015-12-21
Release date:2016-06-15
Last modified:2016-08-31
Method:SOLUTION NMR
Cite:Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation.
Proc.Natl.Acad.Sci.USA, 113, 2016
3MCY
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CRYSTAL STRUCTURE OF FIMH LECTIN DOMAIN BOUND TO BIPHENYL MANNOSIDE META-METHYL ESTER.
Descriptor:FimH, methyl 4'-(alpha-D-mannopyranosyloxy)biphenyl-3-carboxylate, GLYCEROL, ...
Authors:Ford, B.A., Hultgren, S.J.
Deposit date:2010-03-29
Release date:2010-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-based drug design and optimization of mannoside bacterial FimH antagonists.
J.Med.Chem., 53, 2010
3OHN
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CRYSTAL STRUCTURE OF THE FIMD TRANSLOCATION DOMAIN
Descriptor:Outer membrane usher protein FimD
Authors:Wang, T., Li, H.
Deposit date:2010-08-17
Release date:2011-06-01
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (3.011 Å)
Cite:Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate.
Nature, 474, 2011
3RFZ
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CRYSTAL STRUCTURE OF THE FIMD USHER BOUND TO ITS COGNATE FIMC:FIMH SUBSTRATE
Descriptor:Type 1 fimbrial adhesin, Outer membrane usher protein, type 1 fimbrial synthesis, ...
Authors:Phan, G., Remaut, H., Lebedev, A., Geibel, S., Waksman, G.
Deposit date:2011-04-07
Release date:2011-06-01
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate.
Nature, 474, 2011
5F2F
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CRYSTAL STRUCTURE OF PARA-BIPHENYL-2-METHYL-3', 5' DI-METHYL AMIDE MANNOSIDE BOUND TO FIMH LECTIN DOMAIN
Descriptor:Protein FimH, 5-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}1,~{N}3-dimethyl-benzene-1,3-dicarboxamide, GLYCEROL
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2015-12-01
Release date:2016-05-04
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.665 Å)
Cite:Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.
Chemmedchem, 11, 2016
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