Author results

6H8P
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JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND HISTONE H1.4(18-32)K26ME3 PEPTIDE (15-MER)
Descriptor:Lysine-specific demethylase 4A, Histone H1.4, NICKEL (II) ION, ...
Authors:Chowdhury, R., Walport, L.J., Schofield, C.J.
Deposit date:2018-08-03
Release date:2018-08-15
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.983 Å)
Cite:Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26.
FEBS Lett., 592, 2018
5LY2
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JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND MACROCYCLIC PEPTIDE INHIBITOR CP2_R6KME3 (13-MER)
Descriptor:Lysine-specific demethylase 4A, CP2_R6Kme3, NICKEL (II) ION, ...
Authors:CHOWDHURY, R., Madden, S.K., Hopkinson, R., SCHOFIELD, C.J.
Deposit date:2016-09-23
Release date:2017-04-12
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017
5LY1
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JMJD2A/ KDM4A COMPLEXED WITH NI(II) AND MACROCYCLIC PEPTIDE INHIBITOR CP2 (13-MER)
Descriptor:Lysine-specific demethylase 4A, CP2, NICKEL (II) ION, ...
Authors:King, O.N.F., Chowdhury, R., Kawamura, A., Schofield, C.J.
Deposit date:2016-09-23
Release date:2017-04-12
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017
4RG8
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STRUCTURAL AND BIOCHEMICAL STUDIES OF A MODERATELY THERMOPHILIC EXONUCLEASE I FROM METHYLOCALDUM SZEGEDIENSE
Descriptor:Exonuclease I, MAGNESIUM ION
Authors:Fei, L., Tian, S., Moysey, R., Misca, M., Barker, J.J., Smith, M.A., McEwan, P.A., Pilka, E.S., Crawley, L., Evans, T., Sun, D.
Deposit date:2014-09-29
Release date:2015-02-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural and Biochemical Studies of a Moderately Thermophilic Exonuclease I from Methylocaldum szegediense.
Plos One, 10, 2015
4Q23
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THE ROLE OF THREONINE 201 AND TYROSINE 204 IN THE HUMAN FARNESYL PYROPHOSPHATE SYNTHASE CATALYTIC MECHANISM AND THE MODE OF INHIBITION BY THE NITROGEN-CONTAINING BISPHOSPHONATES
Descriptor:Farnesyl pyrophosphate synthase, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, MAGNESIUM ION, ...
Authors:Tsoumpra, M.K., Muniz, J.R.C., Barnett, B.L., Kwaasi, A.A., Pilka, E.S., Kavanagh, K.L., Evdokimov, A., Walter, R.L., Ebetino, F.H., von Delft, F., Oppermann, U., Russell, R.G.G., Dunford, J.E.
Deposit date:2014-04-05
Release date:2015-03-18
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
To be Published
4LIV
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STRUCTURE OF YCFD, A RIBOSOMAL OXYGENASE FROM ESCHERICHIA COLI IN COMPLEX WITH COBALT AND SUCCINIC ACID.
Descriptor:50S ribosomal protein L16 arginine hydroxylase, COBALT (II) ION, SUCCINIC ACID
Authors:Brissett, N.C., Doherty, A.J.
Deposit date:2013-07-03
Release date:2014-05-14
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 509, 2014
4LIU
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STRUCTURE OF YCFD, A RIBOSOMAL OXYGENASE FROM ESCHERICHIA COLI.
Descriptor:50S ribosomal protein L16 arginine hydroxylase, TRIS(HYDROXYETHYL)AMINOMETHANE, PHOSPHATE ION
Authors:Brissett, N.C., Doherty, A.J., Fox, G.C.
Deposit date:2013-07-03
Release date:2014-05-14
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 509, 2014
4LIT
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STRUCTURE OF YCFD A RIBOSOMAL OXYGENASE FROM ESCHERICHIA COLI IN COMPLEX WITH COBALT AND 2-OXOGLUTARATE.
Descriptor:50S ribosomal protein L16 arginine hydroxylase, COBALT (II) ION, 2-OXOGLUTARIC ACID
Authors:Brissett, N.C., Doherty, A.J.
Deposit date:2013-07-03
Release date:2014-05-14
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 509, 2014
4KSF
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CRYSTAL STRUCTURE OF MALONYL-COA DECARBOXYLASE FROM AGROBACTERIUM VITIS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET RIR35
Descriptor:Malonyl-CoA decarboxylase, NICKEL (II) ION, CHLORIDE ION
Authors:Forouhar, F., Neely, H., Seetharaman, J., Sahdev, S., Xiao, R., Ciccosanti, C., Lee, D., Everett, J.K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-05-17
Release date:2013-06-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.
Structure, 21, 2013
4KSA
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CRYSTAL STRUCTURE OF MALONYL-COA DECARBOXYLASE FROM RHODOPSEUDOMONAS PALUSTRIS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET RPR127
Descriptor:Malonyl-CoA decarboxylase, MAGNESIUM ION
Authors:Forouhar, F., Neely, H., Seetharaman, J., Sahdev, S., Xiao, R., Patel, D.J., Ciccosanti, C., Wang, D., Everett, J.K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-05-17
Release date:2013-06-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.
Structure, 21, 2013
4KS9
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CRYSTAL STRUCTURE OF MALONYL-COA DECARBOXYLASE (RMET_2797) FROM CUPRIAVIDUS METALLIDURANS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET CRR76
Descriptor:Malonyl-CoA decarboxylase, MAGNESIUM ION
Authors:Forouhar, F., Tran, T.H., Lew, S., Seetharaman, J., Xiao, R., Acton, T.B., Everett, J.K., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-05-17
Release date:2013-06-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.
Structure, 21, 2013
4DYO
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CRYSTAL STRUCTURE OF HUMAN ASPARTYL AMINOPEPTIDASE (DNPEP) IN COMPLEX WITH ASPARTIC ACID HYDROXAMATE
Descriptor:Aspartyl aminopeptidase, ZINC ION, MAGNESIUM ION, ...
Authors:Chaikuad, A., Pilka, E., Vollmar, M., Krojer, T., Muniz, J.R.C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Kavanagh, K.L., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2012-02-29
Release date:2012-03-14
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.
Bmc Struct.Biol., 12, 2012
4CUG
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RHODOTHERMUS MARINUS YCFD-LIKE RIBOSOMAL PROTEIN L16 ARGINYL HYDROXYLASE IN COMPLEX SUBSTRATE FRAGMENT
Descriptor:CUPIN 4 FAMILY PROTEIN, 50S RIBOSOMAL PROTEIN L16, MANGANESE (II) ION, ...
Authors:McDonough, M.A., Sekirnik, R., Schofield, C.J.
Deposit date:2014-03-18
Release date:2014-04-16
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CSW
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RHODOTHERMUS MARINUS YCFD-LIKE RIBOSOMAL PROTEIN L16 ARGINYL HYDROXYLASE
Descriptor:CUPIN 4 FAMILY PROTEIN, CITRIC ACID, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:McDonough, M.A., Sekirnik, R., Schofield, C.J.
Deposit date:2014-03-11
Release date:2014-04-09
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.821 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CCO
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60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66 S373C) IN COMPLEX WITH MN(II), N-OXALYLGLYCINE (NOG) AND 60S RIBOSOMAL PROTEIN L8 (RPL8 G214C) PEPTIDE FRAGMENT (COMPLEX-3)
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, 60S RIBOSOMAL PROTEIN L8, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-05-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CCN
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60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66 L299C/C300S) IN COMPLEX WITH MN(II), N-OXALYLGLYCINE (NOG) AND 60S RIBOSOMAL PROTEIN L8 (RPL8 G220C) PEPTIDE FRAGMENT (COMPLEX-2)
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, 60S RIBOSOMAL PROTEIN L8, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-05-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CCM
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60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66) IN COMPLEX WITH MN(II), N-OXALYLGLYCINE (NOG) AND 60S RIBOSOMAL PROTEIN L8 (RPL8 G220C) PEPTIDE FRAGMENT (COMPLEX-1)
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, 60S RIBOSOMAL PROTEIN L8, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-05-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CCL
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X-RAY STRUCTURE OF E. COLI YCFD
Descriptor:50S RIBOSOMAL PROTEIN L16 ARGININE HYDROXYLASE, MANGANESE (II) ION, SULFATE ION
Authors:McDonough, M.A., Ho, C.H., Kershaw, N.J., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-04-30
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CCK
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60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66) IN COMPLEX WITH MN(II) AND N-OXALYLGLYCINE (NOG)
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, MANGANESE (II) ION, N-OXALYLGLYCINE, ...
Authors:Chowdhury, R., Ge, W., Clifton, I.J., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-05-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CCJ
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60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66) IN APO FORM
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, 1,2-ETHANEDIOL
Authors:Chowdhury, R., Ge, W., Clifton, I.J., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-05-14
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4BXF
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60S RIBOSOMAL PROTEIN L27A HISTIDINE HYDROXYLASE (MINA53 Y209C) IN COMPLEX WITH MN(II), 2-OXOGLUTARATE (2OG) AND 60S RIBOSOMAL PROTEIN L27A (RPL27A G37C) PEPTIDE FRAGMENT
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE MINA, 60S RIBOSOMAL PROTEIN L27A, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2013-07-10
Release date:2014-05-14
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4BU2
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60S RIBOSOMAL PROTEIN L27A HISTIDINE HYDROXYLASE (MINA53) IN COMPLEX WITH NI(II) AND 2-OXOGLUTARATE (2OG)
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE MINA, NICKEL (II) ION, 2-OXOGLUTARIC ACID, ...
Authors:Chowdhury, R., Clifton, I.J., McDonough, M.A., Ng, S.S., Pilka, E., Oppermann, U., Schofield, C.J.
Deposit date:2013-06-19
Release date:2014-05-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
3ISQ
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CRYSTAL STRUCTURE OF HUMAN 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE
Descriptor:4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION, CHLORIDE ION, ...
Authors:Pilka, E.S., Shafqat, N., Cocking, R., Bray, J.E., Krojer, T., Pike, A.C.W., von Delft, F., Yue, W.W., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U., Kavanagh, K.L., Structural Genomics Consortium (SGC)
Deposit date:2009-08-27
Release date:2009-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of human 4-Hydroxyphenylpyruvate dioxygenase
to be published
3GPC
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CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN A COMPLEX WITH COA
Descriptor:Acyl-coenzyme A synthetase ACSM2A, MAGNESIUM ION, COENZYME A
Authors:Pilka, E.S., Kochan, G.T., Yue, W.W., Bhatia, C., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2009-03-23
Release date:2009-04-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A
J.Mol.Biol., 388, 2009
3FE4
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CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE VI
Descriptor:Carbonic anhydrase 6, MAGNESIUM ION, GLYCEROL
Authors:Pilka, E.S., Kochan, G., Krysztofinska, E., Muniz, J., Yue, W.W., Roos, A.K., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-11-27
Release date:2008-12-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development
Biochem.Biophys.Res.Commun., 419, 2012