Author results

1QKM
  • Download 1qkm
  • View 1qkm
Molmil generated image of 1qkm
HUMAN OESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH PARTIAL AGONIST GENISTEIN
Descriptor:ESTROGEN RECEPTOR BETA, GENISTEIN
Authors:Pike, A.C.W., Brzozowski, A.M., Carlquist, M.
Deposit date:1999-07-27
Release date:2000-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the Ligand-Binding Domain of Oestrogen Receptor Beta in the Presence of a Partial Agonist and a Full Antagonist
Embo J., 18, 1999
1QKN
  • Download 1qkn
  • View 1qkn
Molmil generated image of 1qkn
RAT OESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH ANTAGONIST RALOXIFENE
Descriptor:ESTROGEN RECEPTOR BETA, ACETATE ION, RALOXIFENE
Authors:Pike, A.C.W., Brzozowski, A.M., Carlquist, M.
Deposit date:1999-07-27
Release date:2000-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of the Ligand-Binding Domain of Oestrogen Receptor Beta in the Presence of a Partial Agonist and a Full Antagonist
Embo J., 18, 1999
2WWY
  • Download 2wwy
  • View 2wwy
Molmil generated image of 2wwy
STRUCTURE OF HUMAN RECQ-LIKE HELICASE IN COMPLEX WITH A DNA SUBSTRATE
Descriptor:ATP-DEPENDENT DNA HELICASE Q1, DNA OLIGO (27BP), 5'-D(*DA DG DC DG DT DC DG DA DG DA DT DC DCP)-3', ...
Authors:Pike, A.C.W., Zhang, Y., Schnecke, C., Chaikuad, A., Krojer, T., Cooper, C.D.O., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2009-10-30
Release date:2009-12-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Recq1 Helicase-Driven DNA Unwinding, Annealing, and Branch Migration: Insights from DNA Complex Structures
Proc.Natl.Acad.Sci.USA, 112, 2015
1HJ1
  • Download 1hj1
  • View 1hj1
Molmil generated image of 1hj1
RAT OESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH PURE ANTIOESTROGEN ICI164,384
Descriptor:OESTROGEN RECEPTOR BETA, N-BUTYL-11-[(7R,8R,9S,13S,14S,17S)-3,17-DIHYDROXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-7-YL]-N-METHYLUNDECANAMIDE, PARA-MERCURY-BENZENESULFONIC ACID, ...
Authors:Pike, A.C.W., Brzozowski, A.M., Carlquist, M.
Deposit date:2001-01-08
Release date:2002-01-04
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Insights Into the Mode of Action of a Pure Antiestrogen
Structure, 9, 2001
2CLS
  • Download 2cls
  • View 2cls
Molmil generated image of 2cls
THE CRYSTAL STRUCTURE OF THE HUMAN RND1 GTPASE IN THE ACTIVE GTP BOUND STATE
Descriptor:RHO-RELATED GTP-BINDING PROTEIN RHO6, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Pike, A.C.W., Yang, X., Colebrook, S., Gileadi, O., Sobott, F., Bray, J., Wen Hwa, L., Marsden, B., Zhao, Y., Schoch, G., Elkins, J., Debreczeni, J.E., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Doyle, D.
Deposit date:2006-04-28
Release date:2006-05-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The Crystal Structure of the Human Rnd1 Gtpase in the Active GTP Bound State
To be Published
2IZZ
  • Download 2izz
  • View 2izz
Molmil generated image of 2izz
CRYSTAL STRUCTURE OF HUMAN PYRROLINE-5-CARBOXYLATE REDUCTASE
Descriptor:PYRROLINE-5-CARBOXYLATE REDUCTASE 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1,2-ETHANEDIOL
Authors:Pike, A.C.W., Guo, K., Kavanagh, K., Pilka, E.S., Berridge, G., Colebrook, S., Bray, J., Salah, E., Savitsky, P., Papagrigoriou, E., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U.
Deposit date:2006-07-31
Release date:2006-08-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Human Pyrroline-5-Carboxylate Reductase
To be Published
2J1L
  • Download 2j1l
  • View 2j1l
Molmil generated image of 2j1l
CRYSTAL STRUCTURE OF HUMAN RHO-RELATED GTP-BINDING PROTEIN RHOD
Descriptor:RHO-RELATED GTP-BINDING PROTEIN RHOD, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Pike, A.C.W., Johansson, C., Gileadi, C., Niesen, F.H., Sobott, F., Schoch, G., Elkins, J., Smee, C., Gorrec, F., Watt, S., Bray, J., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Doyle, D.
Deposit date:2006-08-14
Release date:2006-09-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Human Rho-Related GTP-Binding Protein Rhod
To be Published
2J51
  • Download 2j51
  • View 2j51
Molmil generated image of 2j51
CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE BOUND TO 5-AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO) -N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE- 1-CARBOTHIOAMIDE
Descriptor:STE20-LIKE SERINE/THREONINE-PROTEIN KINASE, 1,2-ETHANEDIOL, THIOCYANATE ION, ...
Authors:Pike, A.C.W., Rellos, P., Fedorov, O., Keates, T., Salah, E., Savitsky, P., Papagrigoriou, E., Turnbull, A.P., Debreczeni, J.E., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2006-09-08
Release date:2006-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2J7T
  • Download 2j7t
  • View 2j7t
Molmil generated image of 2j7t
CRYSTAL STRUCTURE OF HUMAN SERINE THREONINE KINASE-10 BOUND TO SU11274
Descriptor:SERINE/THREONINE-PROTEIN KINASE 10, CALCIUM ION, ACETATE ION, ...
Authors:Pike, A.C.W., Rellos, P., Fedorov, O., Das, S., Debreczeni, J., Sobott, F., Watt, S., Savitsky, P., Eswaran, J., Turnbull, A.P., Papagrigoriou, E., Ugochukwa, E., Gorrec, F., Umeano, C.C., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2006-10-17
Release date:2006-11-07
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2J7X
  • Download 2j7x
  • View 2j7x
Molmil generated image of 2j7x
STRUCTURE OF ESTRADIOL-BOUND ESTROGEN RECEPTOR BETA LBD IN COMPLEX WITH LXXLL MOTIF FROM NCOA5
Descriptor:ESTROGEN RECEPTOR BETA, NUCLEAR RECEPTOR COACTIVATOR 5, ESTRADIOL, ...
Authors:Pike, A.C.W., Brzozowski, A.M., Hubbard, R.E., Walton, J., Bonn, T., Thorsell, A.-G., Engstrom, O., Ljunggren, J., Gustaffson, J.-A., Carlquist, M.
Deposit date:2006-10-17
Release date:2006-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of Agonist-Bound Estrogen Receptor Beta Lbd in Complex with Lxxll Motif from Ncoa5
To be Published
2J7Y
  • Download 2j7y
  • View 2j7y
Molmil generated image of 2j7y
STRUCTURE OF 17-EPIESTRIOL-BOUND ESTROGEN RECEPTOR BETA LBD IN COMPLEX WITH LXXLL MOTIF FROM NCOA5
Descriptor:ESTROGEN RECEPTOR BETA, NUCLEAR RECEPTOR COACTIVATOR 5, (16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL, ...
Authors:Pike, A.C.W., Brzozowski, A.M., Hubbard, R.E., Walton, J., Bonn, T., Thorsell, A.-G., Engstrom, O., Ljunggren, J., Gustaffson, J.-A., Carlquist, M.
Deposit date:2006-10-17
Release date:2006-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of Agonist-Bound Estrogen Receptor Beta Lbd in Complex with Lxxll Motif from Ncoa5
To be Published
2JFL
  • Download 2jfl
  • View 2jfl
Molmil generated image of 2jfl
CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Descriptor:STE20-LIKE SERINE/THREONINE-PROTEIN KINASE, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, 1,2-ETHANEDIOL, ...
Authors:Pike, A.C.W., Rellos, P., Fedorov, O., Keates, T., Salah, E., Savitsky, P., Papagrigoriou, E., Bunkoczi, G., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2007-02-02
Release date:2007-02-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2JFM
  • Download 2jfm
  • View 2jfm
Molmil generated image of 2jfm
CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (UNLIGANDED FORM)
Descriptor:STE20-LIKE SERINE-THREONINE KINASE, 1,2-ETHANEDIOL
Authors:Pike, A.C.W., Rellos, P., Fedorov, O., Keates, T., Salah, E., Savitsky, P., Papagrigoriou, E., Bunkoczi, G., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2007-02-02
Release date:2007-02-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2JIF
  • Download 2jif
  • View 2jif
Molmil generated image of 2jif
STRUCTURE OF HUMAN SHORT-BRANCHED CHAIN ACYL-COA DEHYDROGENASE (ACADSB)
Descriptor:SHORT/BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, FLAVIN-ADENINE DINUCLEOTIDE, COENZYME A PERSULFIDE, ...
Authors:Pike, A.C.W., Hozjan, V., Smee, C., Niesen, F.H., Kavanagh, K.L., Umeano, C., Turnbull, A.P., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C.H., Sundstrom, M., Oppermann, U.
Deposit date:2007-02-28
Release date:2007-04-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Human Short-Branched Chain Acyl-Coa Dehydrogenase
To be Published
2UV2
  • Download 2uv2
  • View 2uv2
Molmil generated image of 2uv2
CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE BOUND TO 4-(4-(5- CYCLOPROPYL-1H-PYRAZOL-3-YLAMINO)-QUINAZOLIN-2-YLAMINO)-PHENYL)- ACETONITRILE
Descriptor:STE20-LIKE SERINE-THREONINE KINASE, 1,2-ETHANEDIOL, THIOCYANATE ION, ...
Authors:Pike, A.C.W., Rellos, P., Fedorov, O., Keates, T., Salah, E., Savitsky, P., Papagrigoriou, E., Bunkoczi, G., Debreczeni, J.E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2007-03-08
Release date:2007-03-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2UXW
  • Download 2uxw
  • View 2uxw
Molmil generated image of 2uxw
CRYSTAL STRUCTURE OF HUMAN VERY LONG CHAIN ACYL-COA DEHYDROGENASE (ACADVL)
Descriptor:VERY-LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Pike, A.C.W., Hozjan, V., Smee, C., Berridge, G., Burgess, N., Salah, E., Bunkoczi, G., Uppenberg, J., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U.
Deposit date:2007-03-30
Release date:2007-05-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal Structure of Human Very Long Chain Acyl- Coa Dehydrogenase (Acadvl)
To be Published
2UZP
  • Download 2uzp
  • View 2uzp
Molmil generated image of 2uzp
CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN PROTEIN KINASE C GAMMA.
Descriptor:PROTEIN KINASE C GAMMA TYPE, PYRIDOXAL-5'-PHOSPHATE, COBALT (II) ION, ...
Authors:Pike, A.C.W., Amos, A., Johansson, C., Sobott, F., Savitsky, P., Berridge, G., Fedorov, O., Umeano, C., Gorrec, F., Bunkoczi, G., Debreczeni, J., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2007-04-30
Release date:2007-05-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of C2 Domain of Protein Kinase C Gamma
To be Published
2V1X
  • Download 2v1x
  • View 2v1x
Molmil generated image of 2v1x
CRYSTAL STRUCTURE OF HUMAN RECQ-LIKE DNA HELICASE
Descriptor:ATP-DEPENDENT DNA HELICASE Q1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Pike, A.C.W., Shrestha, B., Burgess-Brown, N., King, O., Ugochukwu, E., Watt, S., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Gileadi, O.
Deposit date:2007-05-30
Release date:2007-07-03
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the Human Recq1 Helicase Reveals a Putative Strand-Separation Pin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2VIG
  • Download 2vig
  • View 2vig
Molmil generated image of 2vig
CRYSTAL STRUCTURE OF HUMAN SHORT-CHAIN ACYL COA DEHYDROGENASE
Descriptor:SHORT-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE,, FLAVIN-ADENINE DINUCLEOTIDE, 1,2-ETHANEDIOL, ...
Authors:Pike, A.C.W., Pantic, N., Parizotto, E., Gileadi, O., Ugochukwu, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A., Oppermann, U.
Deposit date:2007-11-30
Release date:2007-12-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Human Short-Chain Acyl Coa Dehydrogenase
To be Published
2VN8
  • Download 2vn8
  • View 2vn8
Molmil generated image of 2vn8
CRYSTAL STRUCTURE OF HUMAN RETICULON 4 INTERACTING PROTEIN 1 IN COMPLEX WITH NADPH
Descriptor:RETICULON-4-INTERACTING PROTEIN 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SODIUM ION, ...
Authors:Pike, A.C.W., Guo, K., Elkins, J., Ugochukwu, E., Roos, A.K., Filippakopoulos, P., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Oppermann, U.
Deposit date:2008-01-31
Release date:2008-03-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Human Reticulon 4 Interacting Protein 1 in Complex with Nadph
To be Published
2VSV
  • Download 2vsv
  • View 2vsv
Molmil generated image of 2vsv
CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN RHOPHILIN-2
Descriptor:RHOPHILIN-2
Authors:Pike, A.C.W., Kochan, G., Sun, Z., Shafqat, N., Pilka, E.S., Roos, A., Elkins, J., Burgess-Brown, N., Murray, J.W., von Delft, F., Wikstrom, M., Edwards, A., Arrowsmith, C.H., Bountra, C., Oppermann, U.
Deposit date:2008-04-29
Release date:2008-07-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal Structure of the Pdz Domain of Human Rhophilin-2
To be Published
2X57
  • Download 2x57
  • View 2x57
Molmil generated image of 2x57
CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2
Descriptor:VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2
Authors:Pike, A.C.W., Barr, A.J., Quigley, A., Burgess Brown, N., de Riso, A., Bullock, A., Berridge, G., Muniz, J.R.C., Chaikaud, A., Vollmar, M., Krojer, T., Ugochukwu, E., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Carpenter, E.P.
Deposit date:2010-02-05
Release date:2010-03-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the Extracellular Domain of Human Vasoactive Intestinal Polypeptide Receptor 2
To be Published
2X7G
  • Download 2x7g
  • View 2x7g
Molmil generated image of 2x7g
STRUCTURE OF HUMAN SERINE-ARGININE-RICH PROTEIN-SPECIFIC KINASE 2 (SRPK2) BOUND TO PURVALANOL B
Descriptor:UNCHARACTERIZED PROTEIN SRPK2, PURVALANOL B, SULFATE ION, ...
Authors:Pike, A.C.W., Savitsky, P., Fedorov, O., Krojer, T., Ugochukwu, E., von Delft, F., Gileadi, O., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S.
Deposit date:2010-02-26
Release date:2010-04-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Human Serine-Arginine-Rich Protein- Specific Kinase 2 (Srpk2) Bound to Purvalanol B
To be Published
2XDG
  • Download 2xdg
  • View 2xdg
Molmil generated image of 2xdg
CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN GROWTH HORMONE RELEASING HORMONE RECEPTOR.
Descriptor:GROWTH HORMONE-RELEASING HORMONE RECEPTOR, MAGNESIUM ION, 1,2-ETHANEDIOL
Authors:Pike, A.C.W., Quigley, A., Barr, A.J., Burgess Brown, N., Shrestha, L., Yang, J., Chaikuad, A., Vollmar, M., Muniz, J.R.C., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Carpenter, E.P.
Deposit date:2010-04-30
Release date:2010-06-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of the Extracellular Domain of Human Growth Hormone Releasing Hormone Receptor.
To be Published
4BW5
  • Download 4bw5
  • View 4bw5
Molmil generated image of 4bw5
CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1)
Descriptor:POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, CADMIUM ION, ...
Authors:Pike, A.C.W., Dong, Y.Y., Dong, L., Quigley, A., Shrestha, L., Mukhopadhyay, S., Strain-Damerell, C., Goubin, S., Grieben, M., Shintre, C.A., Mackenzie, A., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N., Carpenter, E.P.
Deposit date:2013-06-30
Release date:2013-07-31
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:K2P Channel Gating Mechanisms Revealed by Structures of Trek-2 and a Complex with Prozac
Science, 347, 2015
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan