1QKM | |
1QKN | |
2WWY | | STRUCTURE OF HUMAN RECQ-LIKE HELICASE IN COMPLEX WITH A DNA SUBSTRATE | | Descriptor: | ATP-DEPENDENT DNA HELICASE Q1, DNA OLIGO (27BP), 5'-D(*DA DG DC DG DT DC DG DA DG DA DT DC DCP)-3', ... | | Authors: | Pike, A.C.W., Zhang, Y., Schnecke, C., Chaikuad, A., Krojer, T., Cooper, C.D.O., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Gileadi, O. | | Deposit date: | 2009-10-30 | | Release date: | 2009-12-29 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Recq1 Helicase-Driven DNA Unwinding, Annealing, and Branch Migration: Insights from DNA Complex Structures
Proc.Natl.Acad.Sci.USA, 112, 2015
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1HJ1 | | RAT OESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH PURE ANTIOESTROGEN ICI164,384 | | Descriptor: | OESTROGEN RECEPTOR BETA, N-BUTYL-11-[(7R,8R,9S,13S,14S,17S)-3,17-DIHYDROXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-7-YL]-N-METHYLUNDECANAMIDE, PARA-MERCURY-BENZENESULFONIC ACID, ... | | Authors: | Pike, A.C.W., Brzozowski, A.M., Carlquist, M. | | Deposit date: | 2001-01-08 | | Release date: | 2002-01-04 | | Last modified: | 2018-10-24 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Insights Into the Mode of Action of a Pure Antiestrogen
Structure, 9, 2001
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2CLS | | THE CRYSTAL STRUCTURE OF THE HUMAN RND1 GTPASE IN THE ACTIVE GTP BOUND STATE | | Descriptor: | RHO-RELATED GTP-BINDING PROTEIN RHO6, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | Authors: | Pike, A.C.W., Yang, X., Colebrook, S., Gileadi, O., Sobott, F., Bray, J., Wen Hwa, L., Marsden, B., Zhao, Y., Schoch, G., Elkins, J., Debreczeni, J.E., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Doyle, D. | | Deposit date: | 2006-04-28 | | Release date: | 2006-05-04 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | The Crystal Structure of the Human Rnd1 Gtpase in the Active GTP Bound State
To be Published
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2IZZ | | CRYSTAL STRUCTURE OF HUMAN PYRROLINE-5-CARBOXYLATE REDUCTASE | | Descriptor: | PYRROLINE-5-CARBOXYLATE REDUCTASE 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1,2-ETHANEDIOL | | Authors: | Pike, A.C.W., Guo, K., Kavanagh, K., Pilka, E.S., Berridge, G., Colebrook, S., Bray, J., Salah, E., Savitsky, P., Papagrigoriou, E., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U. | | Deposit date: | 2006-07-31 | | Release date: | 2006-08-01 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal Structure of Human Pyrroline-5-Carboxylate Reductase
To be Published
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2J1L | | CRYSTAL STRUCTURE OF HUMAN RHO-RELATED GTP-BINDING PROTEIN RHOD | | Descriptor: | RHO-RELATED GTP-BINDING PROTEIN RHOD, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Pike, A.C.W., Johansson, C., Gileadi, C., Niesen, F.H., Sobott, F., Schoch, G., Elkins, J., Smee, C., Gorrec, F., Watt, S., Bray, J., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Doyle, D. | | Deposit date: | 2006-08-14 | | Release date: | 2006-09-18 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of Human Rho-Related GTP-Binding Protein Rhod
To be Published
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2J51 | | CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE BOUND TO 5-AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO) -N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE- 1-CARBOTHIOAMIDE | | Descriptor: | STE20-LIKE SERINE/THREONINE-PROTEIN KINASE, 1,2-ETHANEDIOL, THIOCYANATE ION, ... | | Authors: | Pike, A.C.W., Rellos, P., Fedorov, O., Keates, T., Salah, E., Savitsky, P., Papagrigoriou, E., Turnbull, A.P., Debreczeni, J.E., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S. | | Deposit date: | 2006-09-08 | | Release date: | 2006-10-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
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2J7T | | CRYSTAL STRUCTURE OF HUMAN SERINE THREONINE KINASE-10 BOUND TO SU11274 | | Descriptor: | SERINE/THREONINE-PROTEIN KINASE 10, CALCIUM ION, ACETATE ION, ... | | Authors: | Pike, A.C.W., Rellos, P., Fedorov, O., Das, S., Debreczeni, J., Sobott, F., Watt, S., Savitsky, P., Eswaran, J., Turnbull, A.P., Papagrigoriou, E., Ugochukwa, E., Gorrec, F., Umeano, C.C., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S. | | Deposit date: | 2006-10-17 | | Release date: | 2006-11-07 | | Last modified: | 2018-06-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
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2J7X | | STRUCTURE OF ESTRADIOL-BOUND ESTROGEN RECEPTOR BETA LBD IN COMPLEX WITH LXXLL MOTIF FROM NCOA5 | | Descriptor: | ESTROGEN RECEPTOR BETA, NUCLEAR RECEPTOR COACTIVATOR 5, ESTRADIOL, ... | | Authors: | Pike, A.C.W., Brzozowski, A.M., Hubbard, R.E., Walton, J., Bonn, T., Thorsell, A.-G., Engstrom, O., Ljunggren, J., Gustaffson, J.-A., Carlquist, M. | | Deposit date: | 2006-10-17 | | Release date: | 2006-11-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of Agonist-Bound Estrogen Receptor Beta Lbd in Complex with Lxxll Motif from Ncoa5
To be Published
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2J7Y | | STRUCTURE OF 17-EPIESTRIOL-BOUND ESTROGEN RECEPTOR BETA LBD IN COMPLEX WITH LXXLL MOTIF FROM NCOA5 | | Descriptor: | ESTROGEN RECEPTOR BETA, NUCLEAR RECEPTOR COACTIVATOR 5, (16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL, ... | | Authors: | Pike, A.C.W., Brzozowski, A.M., Hubbard, R.E., Walton, J., Bonn, T., Thorsell, A.-G., Engstrom, O., Ljunggren, J., Gustaffson, J.-A., Carlquist, M. | | Deposit date: | 2006-10-17 | | Release date: | 2006-11-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure of Agonist-Bound Estrogen Receptor Beta Lbd in Complex with Lxxll Motif from Ncoa5
To be Published
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2JFL | | CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE | | Descriptor: | STE20-LIKE SERINE/THREONINE-PROTEIN KINASE, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, 1,2-ETHANEDIOL, ... | | Authors: | Pike, A.C.W., Rellos, P., Fedorov, O., Keates, T., Salah, E., Savitsky, P., Papagrigoriou, E., Bunkoczi, G., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S. | | Deposit date: | 2007-02-02 | | Release date: | 2007-02-27 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
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2JFM | | CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (UNLIGANDED FORM) | | Descriptor: | STE20-LIKE SERINE-THREONINE KINASE, 1,2-ETHANEDIOL | | Authors: | Pike, A.C.W., Rellos, P., Fedorov, O., Keates, T., Salah, E., Savitsky, P., Papagrigoriou, E., Bunkoczi, G., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S. | | Deposit date: | 2007-02-02 | | Release date: | 2007-02-27 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
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2JIF | | STRUCTURE OF HUMAN SHORT-BRANCHED CHAIN ACYL-COA DEHYDROGENASE (ACADSB) | | Descriptor: | SHORT/BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, FLAVIN-ADENINE DINUCLEOTIDE, COENZYME A PERSULFIDE, ... | | Authors: | Pike, A.C.W., Hozjan, V., Smee, C., Niesen, F.H., Kavanagh, K.L., Umeano, C., Turnbull, A.P., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C.H., Sundstrom, M., Oppermann, U. | | Deposit date: | 2007-02-28 | | Release date: | 2007-04-03 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of Human Short-Branched Chain Acyl-Coa Dehydrogenase
To be Published
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2UV2 | | CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE BOUND TO 4-(4-(5- CYCLOPROPYL-1H-PYRAZOL-3-YLAMINO)-QUINAZOLIN-2-YLAMINO)-PHENYL)- ACETONITRILE | | Descriptor: | STE20-LIKE SERINE-THREONINE KINASE, 1,2-ETHANEDIOL, THIOCYANATE ION, ... | | Authors: | Pike, A.C.W., Rellos, P., Fedorov, O., Keates, T., Salah, E., Savitsky, P., Papagrigoriou, E., Bunkoczi, G., Debreczeni, J.E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S. | | Deposit date: | 2007-03-08 | | Release date: | 2007-03-20 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
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2UXW | | CRYSTAL STRUCTURE OF HUMAN VERY LONG CHAIN ACYL-COA DEHYDROGENASE (ACADVL) | | Descriptor: | VERY-LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Pike, A.C.W., Hozjan, V., Smee, C., Berridge, G., Burgess, N., Salah, E., Bunkoczi, G., Uppenberg, J., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U. | | Deposit date: | 2007-03-30 | | Release date: | 2007-05-01 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Crystal Structure of Human Very Long Chain Acyl- Coa Dehydrogenase (Acadvl)
To be Published
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2UZP | | CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN PROTEIN KINASE C GAMMA. | | Descriptor: | PROTEIN KINASE C GAMMA TYPE, PYRIDOXAL-5'-PHOSPHATE, COBALT (II) ION, ... | | Authors: | Pike, A.C.W., Amos, A., Johansson, C., Sobott, F., Savitsky, P., Berridge, G., Fedorov, O., Umeano, C., Gorrec, F., Bunkoczi, G., Debreczeni, J., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S. | | Deposit date: | 2007-04-30 | | Release date: | 2007-05-29 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of C2 Domain of Protein Kinase C Gamma
To be Published
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2V1X | | CRYSTAL STRUCTURE OF HUMAN RECQ-LIKE DNA HELICASE | | Descriptor: | ATP-DEPENDENT DNA HELICASE Q1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Pike, A.C.W., Shrestha, B., Burgess-Brown, N., King, O., Ugochukwu, E., Watt, S., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Gileadi, O. | | Deposit date: | 2007-05-30 | | Release date: | 2007-07-03 | | Last modified: | 2015-01-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of the Human Recq1 Helicase Reveals a Putative Strand-Separation Pin.
Proc.Natl.Acad.Sci.USA, 106, 2009
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2VIG | | CRYSTAL STRUCTURE OF HUMAN SHORT-CHAIN ACYL COA DEHYDROGENASE | | Descriptor: | SHORT-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE,, FLAVIN-ADENINE DINUCLEOTIDE, 1,2-ETHANEDIOL, ... | | Authors: | Pike, A.C.W., Pantic, N., Parizotto, E., Gileadi, O., Ugochukwu, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A., Oppermann, U. | | Deposit date: | 2007-11-30 | | Release date: | 2007-12-25 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structure of Human Short-Chain Acyl Coa Dehydrogenase
To be Published
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2VN8 | | CRYSTAL STRUCTURE OF HUMAN RETICULON 4 INTERACTING PROTEIN 1 IN COMPLEX WITH NADPH | | Descriptor: | RETICULON-4-INTERACTING PROTEIN 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SODIUM ION, ... | | Authors: | Pike, A.C.W., Guo, K., Elkins, J., Ugochukwu, E., Roos, A.K., Filippakopoulos, P., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Oppermann, U. | | Deposit date: | 2008-01-31 | | Release date: | 2008-03-18 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of Human Reticulon 4 Interacting Protein 1 in Complex with Nadph
To be Published
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2VSV | | CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN RHOPHILIN-2 | | Descriptor: | RHOPHILIN-2 | | Authors: | Pike, A.C.W., Kochan, G., Sun, Z., Shafqat, N., Pilka, E.S., Roos, A., Elkins, J., Burgess-Brown, N., Murray, J.W., von Delft, F., Wikstrom, M., Edwards, A., Arrowsmith, C.H., Bountra, C., Oppermann, U. | | Deposit date: | 2008-04-29 | | Release date: | 2008-07-15 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Crystal Structure of the Pdz Domain of Human Rhophilin-2
To be Published
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2X57 | | CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2 | | Descriptor: | VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2 | | Authors: | Pike, A.C.W., Barr, A.J., Quigley, A., Burgess Brown, N., de Riso, A., Bullock, A., Berridge, G., Muniz, J.R.C., Chaikaud, A., Vollmar, M., Krojer, T., Ugochukwu, E., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Carpenter, E.P. | | Deposit date: | 2010-02-05 | | Release date: | 2010-03-09 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of the Extracellular Domain of Human Vasoactive Intestinal Polypeptide Receptor 2
To be Published
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2X7G | | STRUCTURE OF HUMAN SERINE-ARGININE-RICH PROTEIN-SPECIFIC KINASE 2 (SRPK2) BOUND TO PURVALANOL B | | Descriptor: | UNCHARACTERIZED PROTEIN SRPK2, PURVALANOL B, SULFATE ION, ... | | Authors: | Pike, A.C.W., Savitsky, P., Fedorov, O., Krojer, T., Ugochukwu, E., von Delft, F., Gileadi, O., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S. | | Deposit date: | 2010-02-26 | | Release date: | 2010-04-14 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of Human Serine-Arginine-Rich Protein- Specific Kinase 2 (Srpk2) Bound to Purvalanol B
To be Published
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2XDG | | CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN GROWTH HORMONE RELEASING HORMONE RECEPTOR. | | Descriptor: | GROWTH HORMONE-RELEASING HORMONE RECEPTOR, MAGNESIUM ION, 1,2-ETHANEDIOL | | Authors: | Pike, A.C.W., Quigley, A., Barr, A.J., Burgess Brown, N., Shrestha, L., Yang, J., Chaikuad, A., Vollmar, M., Muniz, J.R.C., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Carpenter, E.P. | | Deposit date: | 2010-04-30 | | Release date: | 2010-06-16 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal Structure of the Extracellular Domain of Human Growth Hormone Releasing Hormone Receptor.
To be Published
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4BW5 | | CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1) | | Descriptor: | POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, CADMIUM ION, ... | | Authors: | Pike, A.C.W., Dong, Y.Y., Dong, L., Quigley, A., Shrestha, L., Mukhopadhyay, S., Strain-Damerell, C., Goubin, S., Grieben, M., Shintre, C.A., Mackenzie, A., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N., Carpenter, E.P. | | Deposit date: | 2013-06-30 | | Release date: | 2013-07-31 | | Last modified: | 2019-03-06 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | K2P Channel Gating Mechanisms Revealed by Structures of Trek-2 and a Complex with Prozac
Science, 347, 2015
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