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3KQ6
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BU of 3kq6 by Molmil
Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:Wan, Z.L, Hu, S.Q, Whittaker, L, Phillips, N.B, Whittake, J, Ismail-Beigi, F, Weiss, M.A.
Deposit date:2009-11-17
Release date:2010-02-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
3V19
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BU of 3v19 by Molmil
Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3V1G
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BU of 3v1g by Molmil
Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
1KLS
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BU of 1kls by Molmil
NMR Structure of the ZFY-6T[Y10L] Zinc Finger
Descriptor: ZINC FINGER Y-CHROMOSOMAL PROTEIN, ZINC ION
Authors:Lachenmann, M.J, Ladbury, J.E, Phillips, N.B, Narayana, N, Qian, X, Weiss, M.A.
Deposit date:2001-12-12
Release date:2002-03-13
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:The hidden thermodynamics of a zinc finger.
J.Mol.Biol., 316, 2002
1KLR
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BU of 1klr by Molmil
NMR Structure of the ZFY-6T[Y10F] Zinc Finger
Descriptor: ZINC FINGER Y-CHROMOSOMAL PROTEIN, ZINC ION
Authors:Lachenmann, M.J, Ladbury, J.E, Phillips, N.B, Narayana, N, Qian, X, Weiss, M.A.
Deposit date:2001-12-12
Release date:2002-03-13
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:The hidden thermodynamics of a zinc finger.
J.Mol.Biol., 316, 2002
2GYP
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BU of 2gyp by Molmil
Diabetes mellitus due to a frustrated Schellman motif in HNF-1a
Descriptor: Hepatocyte nuclear factor 1-alpha
Authors:Narayana, N, Phillips, N.B, Hua, Q.X, Jia, W, Weiss, M.A.
Deposit date:2006-05-09
Release date:2007-03-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Diabetes mellitus due to misfolding of a beta-cell transcription factor: stereospecific frustration of a Schellman motif in HNF-1alpha.
J.Mol.Biol., 362, 2006
6X4X
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BU of 6x4x by Molmil
B24Y DKP insulin
Descriptor: Insulin, Insulin chain A
Authors:Weiss, M.A, Yang, Y.
Deposit date:2020-05-24
Release date:2020-08-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Evolution of insulin at the edge of foldability and its medical implications.
Proc.Natl.Acad.Sci.USA, 117, 2020
5WDM
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BU of 5wdm by Molmil
An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein
Descriptor: Single-chain insulin analog
Authors:Yee, V.C, Aldabbagh, K, Peng, Y.
Deposit date:2017-07-05
Release date:2017-11-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein.
J. Biol. Chem., 293, 2018
4IUZ
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BU of 4iuz by Molmil
High resolution crystal structure of racemic ester insulin
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Insulin A chain, ...
Authors:Avital-Shmilovici, M, Mandal, K, Gates, Z.P, Phillips, N, Weiss, M.A, Kent, S.B.H.
Deposit date:2013-01-22
Release date:2013-02-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography.
J.Am.Chem.Soc., 135, 2013
5WBT
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BU of 5wbt by Molmil
Solution Structure and Dynamics of an Ultra-Stable Single-Chain Insulin Analog STUDIES OF AN ENGINEERED MONOMER AND IMPLICATIONS FOR RECEPTOR BINDING
Descriptor: Insulin
Authors:Glidden, M.D, Yang, Y, Wickramasinghe, N.P, Weiss, M.A.
Deposit date:2017-06-29
Release date:2017-11-15
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding.
J. Biol. Chem., 293, 2018
3FQ9
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BU of 3fq9 by Molmil
Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications
Descriptor: Insulin, ZINC ION
Authors:Zhao, M, Wan, Z.L, Whittaker, L, Xu, B, Phillips, N, Katsoyannis, P, Whittaker, J, Weiss, M.A.
Deposit date:2009-01-07
Release date:2009-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
J.Biol.Chem., 284, 2009
1LPV
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BU of 1lpv by Molmil
DROSOPHILA MELANOGASTER DOUBLESEX (DSX), NMR, 18 STRUCTURES
Descriptor: Doublesex protein, ZINC ION
Authors:Zhu, L, Wilken, J, Phillips, N, Narendra, U, Chan, G, Stratton, S, Kent, S, Weiss, M.A.
Deposit date:2002-05-08
Release date:2002-10-02
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers.
Genes Dev., 14, 2000
5EMS
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BU of 5ems by Molmil
Crystal Structure of an iodinated insulin analog
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Lawrence, M.C, Pandyarajan, V, Wan, Z, Weiss, M.A.
Deposit date:2015-11-06
Release date:2016-11-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.
J. Biol. Chem., 291, 2016
2MLI
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BU of 2mli by Molmil
NMR structure of B25-(alpha, beta)-dehydro-phenylalanine insulin
Descriptor: Insulin
Authors:Yang, Y, Weiss, M.
Deposit date:2014-02-27
Release date:2014-08-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
2LWZ
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BU of 2lwz by Molmil
NMR Structures of Single-chain Insulin
Descriptor: SINGLE-CHAIN INSULIN
Authors:Weiss, M.A, Yang, Y.
Deposit date:2012-08-09
Release date:2013-08-28
Method:SOLUTION NMR
Cite:Dynamic repair of an amyloidogenic protein: Insulin fibrillation is blocked by tethering a nascent alpha-helix
To be Published
1ZV1
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BU of 1zv1 by Molmil
Crystal structure of the dimerization domain of doublesex protein from D. melanogaster
Descriptor: Doublesex protein
Authors:Weiss, M.A, Bayrer, J.R, Wan, Z, Li, B, Phillips, N.B.
Deposit date:2005-06-01
Release date:2005-08-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold: implications for sex-specific gene regulation
J.Biol.Chem., 280, 2005
2MPI
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BU of 2mpi by Molmil
Solution structure of B24G insulin
Descriptor: insulin chain A, insulin chain B
Authors:Yang, Y, Wickramasinghe, N.P, Hua, Q, Weiss, M.A.
Deposit date:2014-05-19
Release date:2014-12-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NIB
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BU of 4nib by Molmil
Crystal structure of human insulin mutant B20 D-ala, B23 D-ala
Descriptor: Insulin A chain, Insulin B chain
Authors:Menting, J.G, Lawrence, M.C.
Deposit date:2013-11-05
Release date:2014-08-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4OGA
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BU of 4oga by Molmil
Insulin in complex with Site 1 of the human insulin receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
Authors:Lawrence, M.C, Menting, J.G.
Deposit date:2014-01-15
Release date:2014-08-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4P65
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BU of 4p65 by Molmil
Crystal structure of an cyclohexylalanine substituted insulin analog.
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Pandyarajan, V, Wan, Z, Weiss, M.A.
Deposit date:2014-03-21
Release date:2014-10-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN.
J.Biol.Chem., 289, 2014
2JZQ
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BU of 2jzq by Molmil
Design of an Active Ultra-Stable Single-Chain Insulin Analog 20 Structures
Descriptor: Insulin
Authors:Hua, Q.X, Nakarawa, S, Jia, W.H, Huang, K, Philips, N.F, Hu, S.Q, Weiss, M.A.
Deposit date:2008-01-11
Release date:2008-02-26
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
J.Biol.Chem., 283, 2008
3BXQ
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BU of 3bxq by Molmil
The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition
Descriptor: ZINC ION, insulin A chain, insulin B chain
Authors:Wan, Z.L, Huang, K, Hu, S.Q, Whittaker, J, Weiss, M.A.
Deposit date:2008-01-14
Release date:2008-05-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition.
J.Biol.Chem., 283, 2008

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