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1EV5
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CRYSTAL STRUCTURE ANALYSIS OF ALA167 MUTANT OF ESCHERICHIA COLI
分子名称:THYMIDYLATE SYNTHASE, SULFATE ION
著者Phan, J., Mahdavian, E., Nivens, M.C., Minor, W., Berger, S., Spencer, H.T., Dunlap, R.B., Lebioda, L.
登録日2000-04-19
公開日2000-05-03
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Catalytic cysteine of thymidylate synthase is activated upon substrate binding.
Biochemistry, 39, 2000
1EV8
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CRYSTAL STRUCTURE ANALYSIS OF CYS167 MUTANT OF ESCHERICHIA COLI
分子名称:THYMIDYLATE SYNTHASE
著者Phan, J., Mahdavian, E., Nivens, M.C., Minor, W., Berger, S., Spencer, H.T., Dunlap, R.B., Lebioda, L.
登録日2000-04-19
公開日2000-05-03
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Catalytic cysteine of thymidylate synthase is activated upon substrate binding.
Biochemistry, 39, 2000
1EVF
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CRYSTAL STRUCTURE ANALYSIS OF CYS167 MUTANT OF ESCHERICHIA COLI
分子名称:THYMIDYLATE SYNTHASE, SULFATE ION
著者Phan, J., Mahdavian, E., Nivens, M.C., Minor, W., Berger, S., Spencer, H.T., Dunlap, R.B., Lebioda, L.
登録日2000-04-19
公開日2000-05-03
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Catalytic cysteine of thymidylate synthase is activated upon substrate binding.
Biochemistry, 39, 2000
1EVG
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CRYSTAL STRUCTURE ANALYSIS OF CYS167 MUTANT OF ESCHERICHIA COLI WITH UNMODIFIED CATALYTIC CYSTEINE
分子名称:THYMIDYLATE SYNTHASE, SULFATE ION
著者Phan, J., Mahdavian, E., Nivens, M.C., Minor, W., Berger, S., Spencer, H.T., Dunlap, R.B., Lebioda, L.
登録日2000-04-19
公開日2000-05-03
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Catalytic cysteine of thymidylate synthase is activated upon substrate binding.
Biochemistry, 39, 2000
1HVY
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HUMAN THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP AND RALTITREXED, AN ANTIFOLATE DRUG, IS IN THE CLOSED CONFORMATION
分子名称:THYMIDYLATE SYNTHASE, TOMUDEX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ...
著者Phan, J., Koli, S., Minor, W., Dunlap, R.B., Berger, S.H., Lebioda, L.
登録日2001-01-08
公開日2001-01-31
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug
Biochemistry, 40, 2001
1HW3
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STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS
分子名称:THYMIDYLATE SYNTHASE, SULFATE ION, 1,2-ETHANEDIOL
著者Phan, J., Steadman, J.D., Koli, S., Ding, W.C., Minor, W., Dunlap, R.B., Berger, S.H., Lebioda, L.
登録日2001-01-09
公開日2001-01-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.
J.Biol.Chem., 276, 2001
1HW4
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STRUCTURE OF THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS
分子名称:THYMIDYLATE SYNTHASE, SULFATE ION, 1,2-ETHANEDIOL
著者Phan, J., Steadman, J.D., Koli, S., Ding, W.C., Minor, W., Dunlap, R.B., Berger, S.H., Lebioda, L.
登録日2001-01-09
公開日2001-01-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.
J.Biol.Chem., 276, 2001
1LVB
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CATALYTICALLY INACTIVE TOBACCO ETCH VIRUS PROTEASE COMPLEXED WITH SUBSTRATE
分子名称:CATALYTIC DOMAIN OF THE NUCLEAR INCLUSION PROTEIN A (NIA), OLIGOPEPTIDE SUBSTRATE FOR THE PROTEASE, GLYCEROL
著者Phan, J., Zdanov, A., Evdokimov, A.G., Tropea, J.E., Peters III, H.K., Kapust, R.B., Li, M., Wlodawer, A., Waugh, D.S.
登録日2002-05-28
公開日2002-11-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for the substrate specificity of tobacco etch virus protease.
J.Biol.Chem., 277, 2002
1LVM
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CATALYTICALLY ACTIVE TOBACCO ETCH VIRUS PROTEASE COMPLEXED WITH PRODUCT
分子名称:CATALYTIC DOMAIN OF THE NUCLEAR INCLUSION PROTEIN A (NIA), OLIGOPEPTIDE SUBSTRATE FOR THE PROTEASE
著者Phan, J., Zdanov, A., Evdokimov, A.G., Tropea, J.E., Peters III, H.K., Kapust, R.B., Li, M., Wlodawer, A., Waugh, D.S.
登録日2002-05-28
公開日2002-11-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for the substrate specificity of tobacco etch virus protease.
J.Biol.Chem., 277, 2002
1QZ0
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CRYSTAL STRUCTURE OF THE YERSINIA PESTIS PHOSPHATASE YOPH IN COMPLEX WITH A PHOSPHOTYROSYL MIMETIC-CONTAINING HEXAPEPTIDE
分子名称:Protein-tyrosine phosphatase yopH, ASP-ALA-ASP-GLU-FTY-LEU-NH2
著者Phan, J., Lee, K., Cherry, S., Tropea, J.E., Burke Jr, T.R., Waugh, D.S.
登録日2003-09-15
公開日2003-11-25
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献High-Resolution Structure of the Yersinia pestis Protein Tyrosine Phosphatase YopH in Complex with a Phosphotyrosyl Mimetic-Containing Hexapeptide
Biochemistry, 42, 2003
1TTW
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CRYSTAL STRUCTURE OF THE YERSINIA PESTIS TYPE III SECRETION CHAPERONE SYCH IN COMPLEX WITH A STABLE FRAGMENT OF YSCM2
分子名称:secretion chaperone, YscM2
著者Phan, J., Tropea, J.E., Waugh, D.S.
登録日2004-06-23
公開日2004-08-31
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Structure of the Yersinia pestis type III secretion chaperone SycH in complex with a stable fragment of YscM2.
Acta Crystallogr.,Sect.D, 60, 2004
1ZW0
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CRYSTAL STRUCTURE OF THE YERSINIA TYPE III SECRETION PROTEIN YSCE
分子名称:type III secretion protein
著者Phan, J., Austin, B.P., Waugh, D.S.
登録日2005-06-03
公開日2005-08-23
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of the Yersinia type III secretion protein YscE
Protein Sci., 14, 2005
2AOA
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CRYSTAL STRUCTURES OF A HIGH-AFFINITY MACROCYCLIC PEPTIDE MIMETIC IN COMPLEX WITH THE GRB2 SH2 DOMAIN
分子名称:Growth factor receptor-bound protein 2, 2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL
著者Phan, J., Shi, Z.D., Burke, T.R., Waugh, D.S.
登録日2005-08-12
公開日2005-10-04
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain.
J.Mol.Biol., 353, 2005
2AOB
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CRYSTAL STRUCTURES OF A HIGH-AFFINITY MACROCYCLIC PEPTIDE MIMETIC IN COMPLEX WITH THE GRB2 SH2 DOMAIN
分子名称:Growth factor receptor-bound protein 2, 2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID
著者Phan, J., Shi, Z.D., Burke, T.R., Waugh, D.S.
登録日2005-08-12
公開日2005-10-04
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain.
J.Mol.Biol., 353, 2005
2P4D
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STRUCTURE-ASSISTED DISCOVERY OF VARIOLA MAJOR H1 PHOSPHATASE INHIBITORS
分子名称:Dual specificity protein phosphatase
著者Phan, J., Tropea, J.E., Waugh, D.S.
登録日2007-03-12
公開日2007-05-29
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure-assisted discovery of variola major H1 phosphatase inhibitors
Acta Crystallogr.,Sect.D, D63, 2007
6BVI
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Abbott, J., Fesik, S.W.
登録日2017-12-13
公開日2018-10-24
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (1.746 Å)
主引用文献Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
J. Med. Chem., 61, 2018
6BVK
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Abbott, J., Fesik, S.W.
登録日2017-12-13
公開日2018-10-24
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (1.799 Å)
主引用文献Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
J. Med. Chem., 61, 2018
6BVL
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRAS, Son of sevenless homolog 1, GTPase HRas, ...
著者Phan, J., Abbott, J., Fesik, S.W.
登録日2017-12-13
公開日2018-10-24
最終更新日2019-05-29
実験手法X-RAY DIFFRACTION (1.748 Å)
主引用文献Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
J. Med. Chem., 61, 2018
6BVM
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Abbott, J., Fesik, S.W.
登録日2017-12-13
公開日2018-10-24
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (1.796 Å)
主引用文献Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
J. Med. Chem., 61, 2018
6D55
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
6D56
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
6D59
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
6D5E
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
6D5G
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
6D5H
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RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR
分子名称:GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Phan, J., Hodges, T., Fesik, S.W.
登録日2018-04-19
公開日2018-09-19
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018