Author results

4OZF
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JR5.1 PROTEIN COMPLEX
Descriptor:HLA class II histocompatibility antigen, DQ alpha 1 chain, DQ beta 1 chain, ...
Authors:Petersen, J., Reid, H.H., Rossjohn, J.
Deposit date:2014-02-15
Release date:2014-04-16
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease.
Nat.Struct.Mol.Biol., 21, 2014
4OZG
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D2 PROTEIN COMPLEX
Descriptor:HLA class II histocompatibility antigen, DQ alpha 1 chain, DQ beta 1 chain, ...
Authors:Petersen, J., Reid, H.H., Rossjohn, J.
Deposit date:2014-02-16
Release date:2014-04-16
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease.
Nat.Struct.Mol.Biol., 21, 2014
4OZH
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S16 PROTEIN COMPLEX
Descriptor:HLA class II histocompatibility antigen, DQ alpha 1 chain, DQ beta 1 chain, ...
Authors:Petersen, J., Reid, H.H., Rossjohn, J.
Deposit date:2014-02-16
Release date:2014-04-16
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease.
Nat.Struct.Mol.Biol., 21, 2014
4OZI
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S2 PROTEIN COMPLEX
Descriptor:HLA class II histocompatibility antigen, DQ alpha 1 chain, DQ beta 1 chain, ...
Authors:Petersen, J., Reid, H.H., Rossjohn, J.
Deposit date:2014-02-16
Release date:2014-04-16
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease.
Nat.Struct.Mol.Biol., 21, 2014
1UIS
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THE 2.0 CRYSTAL STRUCTURE OF EQFP611, A FAR-RED FLUORESCENT PROTEIN FROM THE SEA ANEMONE ENTACMAEA QUADRICOLOR
Descriptor:red fluorescent protein FP611, CALCIUM ION, ACETIC ACID
Authors:Petersen, J., Wilmann, P.G., Beddoe, T., Oakley, A.J., Devenish, R.J., Prescott, M., Rossjohn, J.
Deposit date:2003-07-21
Release date:2003-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2.0A crystal structure of eqFP611, a far-red fluorescent protein from the sea anemone Entacmaea quadricolor
J.Biol.Chem., 278, 2003
3FQN
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PHOSPHORYLATION OF SELF-PEPTIDES ALTERS HUMAN LEUKOCYTE ANTIGEN CLASS I-RESTRICTED ANTIGEN PRESENTATION AND GENERATES TUMOR SPECIFIC EPITOPES
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Petersen, J., Rossjohn, J.
Deposit date:2009-01-07
Release date:2009-03-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
Proc.Natl.Acad.Sci.Usa, 106, 2009
3FQR
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PHOSPHORYLATION OF SELF-PEPTIDES ALTERS HUMAN LEUKOCYTE ANTIGEN CLASS I-RESTRICTED ANTIGEN PRESENTATION AND GENERATES TUMOR SPECIFIC EPITOPES
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Petersen, J., Rossjohn, J.
Deposit date:2009-01-07
Release date:2009-03-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
Proc.Natl.Acad.Sci.Usa, 106, 2009
3FQT
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PHOSPHORYLATION OF SELF-PEPTIDES ALTERS HUMAN LEUKOCYTE ANTIGEN CLASS I-RESTRICTED ANTIGEN PRESENTATION AND GENERATES TUMOR SPECIFIC EPITOPES
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Petersen, J., Rossjohn, J.
Deposit date:2009-01-07
Release date:2009-03-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
Proc.Natl.Acad.Sci.Usa, 106, 2009
3FQU
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PHOSPHORYLATION OF SELF-PEPTIDES ALTERS HUMAN LEUKOCYTE ANTIGEN CLASS I-RESTRICTED ANTIGEN PRESENTATION AND GENERATES TUMOR SPECIFIC EPITOPES
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Petersen, J., Rossjohn, J.
Deposit date:2009-01-07
Release date:2009-03-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
Proc.Natl.Acad.Sci.Usa, 106, 2009
3FQW
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PHOSPHORYLATION OF SELF-PEPTIDES ALTERS HUMAN LEUKOCYTE ANTIGEN CLASS I-RESTRICTED ANTIGEN PRESENTATION AND GENERATES TUMOR SPECIFIC EPITOPES
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Petersen, J., Rossjohn, J.
Deposit date:2009-01-07
Release date:2009-03-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.927 Å)
Cite:Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
Proc.Natl.Acad.Sci.Usa, 106, 2009
3FQX
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PHOSPHORYLATION OF SELF-PEPTIDES ALTERS HUMAN LEUKOCYTE ANTIGEN CLASS I-RESTRICTED ANTIGEN PRESENTATION AND GENERATES TUMOR SPECIFIC EPITOPES
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Petersen, J., Rossjohn, J.
Deposit date:2009-01-07
Release date:2009-03-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
Proc.Natl.Acad.Sci.Usa, 106, 2009
4Z7U
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S13 COMPLEX
Descriptor:MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, T-CELL RECEPTOR, ...
Authors:Petersen, J., Rossjohn, J., Reid, H.H., Koning, F.
Deposit date:2015-04-08
Release date:2015-06-03
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Determinants of Gliadin-Specific T Cell Selection in Celiac Disease.
J Immunol., 194, 2015
4Z7V
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L3-12 COMPLEX
Descriptor:MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, T-CELL RECEPTOR, ...
Authors:Petersen, J., Rossjohn, J., Reid, H.H., Koning, F.
Deposit date:2015-04-08
Release date:2015-06-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Determinants of Gliadin-Specific T Cell Selection in Celiac Disease.
J Immunol., 194, 2015
4Z7W
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T316 COMPLEX
Descriptor:MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, T-CELL RECEPTOR, ...
Authors:Petersen, J., Rossjohn, J., Reid, H.H., Koning, F.
Deposit date:2015-04-08
Release date:2015-06-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Determinants of Gliadin-Specific T Cell Selection in Celiac Disease.
J Immunol., 194, 2015
5KS9
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BEL502-DQ8-GLIA-ALPHA1 COMPLEX
Descriptor:HLA class II histocompatibility antigen, DQ alpha 1 chain, DQ beta 1 chain, ...
Authors:Petersen, J., Rossjohn, J., Reid, H.H.
Deposit date:2016-07-08
Release date:2016-09-21
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution.
Structure, 24, 2016
5KSA
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BEL602-DQ8.5-GLIA-GAMMA1 COMPLEX
Descriptor:HLA class II histocompatibility antigen, DQ alpha 1 chain, DQ beta 1 chain, ...
Authors:Petersen, J., Rossjohn, J., Reid, H.H.
Deposit date:2016-07-08
Release date:2016-09-21
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution.
Structure, 24, 2016
5KSB
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T15-DQ8.5-GLIA-GAMMA1 COMPLEX
Descriptor:HLA class II histocompatibility antigen, DQ alpha 1 chain, DQ beta 1 chain, ...
Authors:Petersen, J., Rossjohn, J., Reid, H.H.
Deposit date:2016-07-08
Release date:2016-09-21
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution.
Structure, 24, 2016
6GQ7
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PI3KG IN COMPLEX WITH INH
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 3-methyl-1-(oxan-4-yl)-8-pyridin-3-yl-imidazo[4,5-c]quinolin-2-one
Authors:Petersen, J.
Deposit date:2018-06-07
Release date:2018-06-20
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:PI3Kg IN COMPLEX WITH INH
To Be Published
3VCL
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CRYSTAL STRUCTURE OF HLA-B7 WITH THE HCMV PP65 PEPTIDE RPHERNGFTVL
Descriptor:HLA class I histocompatibility antigen, B-7 alpha chain, Beta-2-microglobulin, ...
Authors:Petersen, J., Rossjohn, J.
Deposit date:2012-01-04
Release date:2012-11-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The impact of a large and frequent deletion in the human TCR beta locus on antiviral immunity
J.Immunol., 188, 2012
5NCY
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MPI3KD IN COMPLEX WITH INH1
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 1,2-ETHANEDIOL, SULFATE ION, ...
Authors:Petersen, J.
Deposit date:2017-03-06
Release date:2017-06-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design and Synthesis of Soluble and Cell-Permeable PI3K delta Inhibitors for Long-Acting Inhaled Administration.
J. Med. Chem., 60, 2017
5NCZ
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MPI3KD IN COMPLEX WITH INH1
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 1,2-ETHANEDIOL, 4-azanyl-6-[[(1~{S})-1-[6-[3-[(dimethylamino)methyl]phenyl]-3-methyl-5-oxidanylidene-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile
Authors:Petersen, J.
Deposit date:2017-03-06
Release date:2017-06-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Design and Synthesis of Soluble and Cell-Permeable PI3K delta Inhibitors for Long-Acting Inhaled Administration.
J. Med. Chem., 60, 2017
5V4M
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STRUCTURE OF HLA-DR15 WITH BOUND ALPHA3(135-145) PEPTIDE
Descriptor:HLA-DRA1, alpha3(135-145)-HLA-DRB1*15:01, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Petersen, J., Rossjohn, J.
Deposit date:2017-03-10
Release date:2017-05-03
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
Nature, 545, 2017
5V4N
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STRUCTURE OF HLA-DR1 WITH BOUND ALPHA3(135-145) PEPTIDE
Descriptor:HLA-DRA1, alpha3(135-145)-HLA-DRB1*01:01, N-ACETYL-D-GLUCOSAMINE
Authors:Petersen, J., Rossjohn, J.
Deposit date:2017-03-10
Release date:2017-05-03
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (3.405 Å)
Cite:Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
Nature, 545, 2017
6FTN
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MPI3KD IN COMPLEX WITH AZ2
Descriptor:Phosphor inositol 3 kinase, ~{N}-[5-[2-[(1~{S})-1-cyclopropylethyl]-7-methyl-1-oxidanylidene-3~{H}-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]ethanamide
Authors:Petersen, J.
Deposit date:2018-02-22
Release date:2018-06-20
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-gamma Inhibitors.
J. Med. Chem., 61, 2018
6GY0
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MPI3KD IN COMPLEX WITH AZ3
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, ~{N}-[4-methyl-5-(1-oxidanylidene-7-sulfamoyl-isoindol-5-yl)-1,3-thiazol-2-yl]ethanamide
Authors:Petersen, J.
Deposit date:2018-06-27
Release date:2019-02-06
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A class of highly selective inhibitors bind to an active state of PI3K gamma.
Nat. Chem. Biol., 2019
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