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5ANM
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CRYSTAL STRUCTURE OF IGE FC IN COMPLEX WITH A NEUTRALIZING ANTIBODY
Descriptor:IMMUNOGLOBULIN G, IG EPSILON CHAIN C REGION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Cohen, E.S., Dobson, C.L., Kack, H., Wang, B., Sims, D.A., Lloyd, C.O., England, E., Rees, D.G., Guo, H., Karagiannis, S.N., O'Brien, S., Persdotter, S., Ekdahl, H., Butler, R., Keyes, F., Oakley, S., Carlsson, M., Briend, E., Wilkinson, T., Anderson, I.K., Monk, P.D., vonWachenfeldt, K., Eriksson, P.O., Gould, H.J., Vaughan, T.J., May, R.D.
Deposit date:2015-09-07
Release date:2015-09-30
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A Novel Ige-Neutralizing Antibody for the Treatment of Severe Uncontrolled Asthma.
Mabs, 6, 2015
2VCQ
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COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 1.95A.
Descriptor:GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole
Authors:Hohwy, M., Spadola, L., Lundquist, B., von Wachenfeldt, K., Persdotter, S., Hawtin, P., Dahmen, J., Groth-Clausen, I., Folmer, R.H.A., Edman, K.
Deposit date:2007-09-26
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
2VCW
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COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 1.95A.
Descriptor:GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Authors:Hohwy, M., Spadola, L., Lundquist, B., von Wachenfeldt, K., Persdotter, S., Hawtin, P., Dahmen, J., Groth-Clausen, I., Folmer, R.H.A., Edman, K.
Deposit date:2007-09-27
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
2VCX
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COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 2.1A.
Descriptor:GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, MAGNESIUM ION, GLUTATHIONE, ...
Authors:Hohwy, M., Spadola, L., Lundquist, B., von Wachenfeldt, K., Persdotter, S., Hawtin, P., Dahmen, J., Groth-Clausen, I., Folmer, R.H.A., Edman, K.
Deposit date:2007-09-27
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
2VCZ
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COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 1.95A.
Descriptor:GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 3-(4-nitrophenyl)-1H-pyrazole
Authors:Hohwy, M., Spadola, L., Lundquist, B., von Wachenfeldt, K., Persdotter, S., Hawtin, P., Dahmen, J., Groth-Clausen, I., Folmer, R.H.A., Edman, K.
Deposit date:2007-09-28
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
2VD0
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COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 2.2A.
Descriptor:GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid, ...
Authors:Hohwy, M., Spadola, L., Lundquist, B., von Wachenfeldt, K., Persdotter, S., Hawtin, P., Dahmen, J., Groth-Clausen, I., Folmer, R.H.A., Edman, K.
Deposit date:2007-09-28
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
2VD1
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COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 2.25A.
Descriptor:GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid, ...
Authors:Hohwy, M., Spadola, L., Lundquist, B., von Wachenfeldt, K., Persdotter, S., Hawtin, P., Dahmen, J., Groth-Clausen, I., Folmer, R.H.A., Edman, K.
Deposit date:2007-09-28
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008