Author results

1BRA
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RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN
Descriptor:TRYPSIN, CALCIUM ION, BENZAMIDINE
Authors:Perona, J.J., Mcgrath, M.E., Fletterick, R.J.
Deposit date:1992-12-17
Release date:1994-04-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Relocating a negative charge in the binding pocket of trypsin.
J.Mol.Biol., 230, 1993
1BRB
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CRYSTAL STRUCTURES OF RAT ANIONIC TRYPSIN COMPLEXED WITH THE PROTEIN INHIBITORS APPI AND BPTI
Descriptor:TRYPSIN, PANCREATIC TRYPSIN INHIBITOR
Authors:Perona, J.J., Fletterick, R.J.
Deposit date:1992-12-17
Release date:1994-07-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI.
J.Mol.Biol., 230, 1993
1BRC
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RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN
Descriptor:TRYPSIN, AMYLOID BETA-PROTEIN PRECURSOR INHIBITOR DOMAIN (APPI)
Authors:Perona, J.J., Fletterick, R.J.
Deposit date:1992-12-17
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Relocating a negative charge in the binding pocket of trypsin.
J.Mol.Biol., 230, 1993
1GTS
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STRUCTURAL BASIS FOR TRANSFER RNA AMINOACEYLATION BY ESCHERICHIA COLI GLUTAMINYL-TRNA SYNTHETASE
Descriptor:TRNAGLN, PROTEIN (GLUTAMINYL-TRNA SYNTHETASE (E.C.6.1.1.18)), ADENOSINE MONOPHOSPHATE
Authors:Perona, J.J., Steitz, T.A., Rould, M.A.
Deposit date:1993-09-15
Release date:1995-02-07
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.
Biochemistry, 32, 1993
1AZ0
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ECORV ENDONUCLEASE/DNA COMPLEX
Descriptor:DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3'), PROTEIN (TYPE II RESTRICTION ENZYME ECORV), CALCIUM ION
Authors:Perona, J.J., Martin, A.M.
Deposit date:1997-11-24
Release date:1998-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational transitions and structural deformability of EcoRV endonuclease revealed by crystallographic analysis.
J.Mol.Biol., 273, 1997
1AZZ
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FIDDLER CRAB COLLAGENASE COMPLEXED TO ECOTIN
Descriptor:COLLAGENASE, ECOTIN
Authors:Perona, J.J., Fletterick, R.J.
Deposit date:1997-11-24
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix.
Biochemistry, 36, 1997
1BSS
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ECORV-T93A/DNA/CA2+
Descriptor:5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3', ECORV ENDONUCLEASE, CALCIUM ION
Authors:Perona, J.J., Horton, N.C.
Deposit date:1998-08-30
Release date:1998-09-02
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Metal ion-mediated substrate-assisted catalysis in type II restriction endonucleases
Proc.Natl.Acad.Sci.USA, 95, 1998
1BSU
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STRUCTURAL AND ENERGETIC ORIGINS OF INDIRECT READOUT IN SITE-SPECIFIC DNA CLEAVAGE BY A RESTRICTION ENDONUCLEASE
Descriptor:DNA (5'-D(P*AP*AP*GP*AP*(5CM)P*IP*TP*CP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*GP*AP*(5CM)P*IP*TP*CP*TP*T)-3'), ENDONUCLEASE ECORV (3.1.21.4), ...
Authors:Perona, J.J., Martin, A.M.
Deposit date:1998-08-30
Release date:1998-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and energetic origins of indirect readout in site-specific DNA cleavage by a restriction endonuclease.
Nat.Struct.Biol., 6, 1999
1BUA
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STRUCTURAL AND ENERGETIC ORIGINS OF INDIRECT READOUT IN SITE-SPECIFIC DNA CLEAVAGE BY A RESTRICTION ENDONUCLEASE
Descriptor:DNA (5'-D(*AP*AP*AP*GP*AP*CP*IP*TP*CP*TP*T)-3'), ENDONUCLEASE ECORV
Authors:Perona, J.J., Martin, A.M.
Deposit date:1998-09-03
Release date:1998-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural and energetic origins of indirect readout in site-specific DNA cleavage by a restriction endonuclease.
Nat.Struct.Biol., 6, 1999
4JXX
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CRYSTAL STRUCTURE OF E COLI E. COLI GLUTAMINYL-TRNA SYNTHETASE BOUND TO TRNA(GLN)(CUG) AND ATP FROM NOVEL CRYOSTABILIZATION CONDITIONS
Descriptor:Glutamine--tRNA ligase, RNA (71-MER), ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Perona, J.J., Rodriguez-Hernandez, A.
Deposit date:2013-03-28
Release date:2013-05-01
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Mechanistic Basis for Enhanced Translational Efficiency by 2-Thiouridine at the tRNA Anticodon Wobble Position.
J.Mol.Biol., 425, 2013
4JXZ
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STRUCTURE OF E. COLI GLUTAMINYL-TRNA SYNTHETASE BOUND TO ATP AND A TRNA(GLN) ACCEPTOR CONTAINING A UUG ANTICODON
Descriptor:Glutamine--tRNA ligase, RNA (71-MER), ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Perona, J.J., Rodriguez-Hernandez, A.
Deposit date:2013-03-28
Release date:2013-05-01
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and Mechanistic Basis for Enhanced Translational Efficiency by 2-Thiouridine at the tRNA Anticodon Wobble Position.
J.Mol.Biol., 425, 2013
4JYZ
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CRYSTAL STRUCTURE OF E. COLI GLUTAMINYL-TRNA SYNTHETASE BOUND TO ATP AND NATIVE TRNA(GLN) CONTAINING THE CMNM5S2U34 ANTICODON WOBBLE BASE
Descriptor:Glutamine--tRNA ligase, RNA (72-MER), ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Perona, J.J., Rodriguez-Hernandez, A.
Deposit date:2013-04-01
Release date:2013-05-29
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Mechanistic Basis for Enhanced Translational Efficiency by 2-Thiouridine at the tRNA Anticodon Wobble Position.
J.Mol.Biol., 425, 2013
2B0D
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ECORV RESTRICTION ENDONUCLEASE/GAATTC/CA2+
Descriptor:5'-D(*AP*AP*AP*GP*AP*AP*TP*TP*CP*TP*T)-3', Type II restriction enzyme EcoRV, CALCIUM ION
Authors:Hiller, D.A., Rodriguez, A.M., Perona, J.J.
Deposit date:2005-09-13
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Non-cognate Enzyme-DNA Complex: Structural and Kinetic Analysis of EcoRV Endonuclease Bound to the EcoRI Recognition Site GAATTC
J.Mol.Biol., 354, 2005
2B0E
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ECORV RESTRICTION ENDONUCLEASE/GAAUTC/CA2+
Descriptor:5'-D(*AP*AP*AP*GP*AP*AP*(DU)P*TP*CP*TP*T)-3', Type II restriction enzyme EcoRV, CALCIUM ION
Authors:Hiller, D.A., Rodriguez, A.M., Perona, J.J.
Deposit date:2005-09-13
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Non-cognate Enzyme-DNA Complex: Structural and Kinetic Analysis of EcoRV Endonuclease Bound to the EcoRI Recognition Site GAATTC
J.Mol.Biol., 354, 2005
1GSG
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STRUCTURE OF E.COLI GLUTAMINYL-TRNA SYNTHETASE COMPLEXED WITH TRNAGLN AND ATP AT 2.8 ANGSTROMS RESOLUTION
Descriptor:TRNAGLN, GLUTAMINYL-TRNA SYNTHETASE
Authors:Rould, M.A., Perona, J.J., Soell, D., Steitz, T.A.
Deposit date:1990-04-03
Release date:1992-02-24
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of E. coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP at 2.8 A resolution.
Science, 246, 1989
1LI5
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CRYSTAL STRUCTURE OF CYSTEINYL-TRNA SYNTHETASE
Descriptor:CYSTEINYL-TRNA SYNTHETASE, ZINC ION
Authors:Newberry, K.J., Hou, Y.-M., Perona, J.J.
Deposit date:2002-04-17
Release date:2002-04-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural origins of amino acid selection without editing by cysteinyl-tRNA synthetase
EMBO J., 21, 2002
1LI7
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CRYSTAL STRUCTURE OF CYSTEINYL-TRNA SYNTHETASE WITH CYSTEINE SUBSTRATE BOUND
Descriptor:CYSTEINYL-TRNA SYNTHETASE, ZINC ION, CYSTEINE
Authors:Newberry, K.J., Hou, Y.-M., Perona, J.J.
Deposit date:2002-04-17
Release date:2002-04-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural origins of amino acid selection without editing by cysteinyl-tRNA synthetase
EMBO J., 21, 2002
2GE5
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ECORV RESTRICTION ENDONUCLEASE C-TERMINAL DELETION MUTANT/GATATC/CA2+
Descriptor:5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3', Type II restriction enzyme EcoRV, CALCIUM ION
Authors:Hiller, D.A., Perona, J.J.
Deposit date:2006-03-17
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Positively Charged C-Terminal Subdomains of EcoRV Endonuclease: Contributions to DNA Binding, Bending, and Cleavage.
Biochemistry, 45, 2006
2RD2
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GLUTAMINYL-TRNA SYNTHETASE MUTANT C229R WITH BOUND ANALOG 5'-O-[N-(L-GLUTAMINYL)-SULFAMOYL]ADENOSINE
Descriptor:Glutamine tRNA, Glutaminyl-tRNA synthetase, SULFATE ION, ...
Authors:Bullock, T.L., Perona, J.J.
Deposit date:2007-09-20
Release date:2008-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A rationally engineered misacylating aminoacyl-tRNA synthetase.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2RE8
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GLUTAMINYL-TRNA SYNTHETASE MUTANT C229R WITH BOUND ANALOG 5'-O-[N-(L-GLUTAMYL)-SULFAMOYL]ADENOSINE
Descriptor:Glutamine tRNA, Glutaminyl-tRNA synthetase, SULFATE ION, ...
Authors:Bullock, T.L., Perona, J.J.
Deposit date:2007-09-25
Release date:2008-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A rationally engineered misacylating aminoacyl-tRNA synthetase.
Proc.Natl.Acad.Sci.Usa, 105, 2008
1EO3
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INHIBITION OF ECORV ENDONUCLEASE BY DEOXYRIBO-3'-S-PHOSPHOROTHIOLATES: A HIGH RESOLUTION X-RAY CRYSTALLOGRAPHIC STUDY
Descriptor:DNA (5'-D(*CP*AP*AP*GP*AP*(TSP)P*AP*TP*CP*TP*T)-3'), TYPE II RESTRICTION ENZYME ECORV, MAGNESIUM ION, ...
Authors:Horton, N.C., Connolly, B.A., Perona, J.J.
Deposit date:2000-03-21
Release date:2000-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibition of EcoRV Endonuclease by Deoxyribo-3'-S-phosphorothiolates: A High-Resolution X-ray Crystallographic Study
J.Am.Chem.Soc., 122, 2000
1EO4
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ECORV BOUND TO MN2+ AND COGNATE DNA CONTAINING A 3'S SUBSTITION AT THE CLEAVAGE SITE
Descriptor:DNA (5'-D(*CP*AP*AP*GP*AP*(TSP)P*AP*TP*CP*TP*T)-3'), TYPE II RESTRICTION ENZYME ECORV, MANGANESE (II) ION, ...
Authors:Horton, N.C., Connolly, B.A., Perona, J.J.
Deposit date:2000-03-21
Release date:2000-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibition of EcoRV Endonuclease by Deoxyribo-3'-S-phosphorothiolates: A High-Resolution X-ray Crystallographic Study
J.Am.Chem.Soc., 122, 2000
1EON
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ECORV BOUND TO 3'-S-PHOSPHOROTHIOLATE DNA AND CA2+
Descriptor:DNA (5'-D(*AP*AP*AP*GP*AP*(TSP)P*AP*TP*CP*TP*T)-3'), DNA (5'-D(*CP*AP*AP*GP*AP*(TSP)P*AP*TP*CP*TP*T)-3'), TYPE II RESTRICTION ENZYME ECORV, ...
Authors:Horton, N.C., Connolly, B.A., Perona, J.J.
Deposit date:2000-03-23
Release date:2000-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Inhibition of EcoRV Endonuclease by Deoxyribo-3'-S-phosphorothiolates: A High-Resolution X-ray Crystallographic Study
J.Am.Chem.Soc., 122, 2000
1EOO
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ECORV BOUND TO COGNATE DNA
Descriptor:DNA (5'-D(*GP*AP*AP*GP*AP*TP*AP*TP*CP*TP*TP*C)-3'), TYPE II RESTRICTION ENZYME ECORV
Authors:Horton, N.C., Perona, J.J.
Deposit date:2000-03-23
Release date:2000-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Crystallographic snapshots along a protein-induced DNA-bending pathway.
Proc.Natl.Acad.Sci.USA, 97, 2000
1EOP
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ECORV BOUND TO COGNATE DNA
Descriptor:DNA (5'-D(*GP*AP*AP*GP*AP*TP*AP*TP*CP*TP*TP*C)-3'), TYPE II RESTRICTION ENZYME ECORV
Authors:Horton, N.C., Perona, J.J.
Deposit date:2000-03-23
Release date:2000-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystallographic snapshots along a protein-induced DNA-bending pathway.
Proc.Natl.Acad.Sci.USA, 97, 2000
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