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5DO2
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COMPLEX STRUCTURE OF MERS-RBD BOUND WITH 4C2 ANTIBODY
Descriptor:S protein, 4C2 heavy chain, 4C2 light chain, ...
Authors:Li, Y., Wan, Y., Liu, P., Zhao, J., Lu, G., Qi, J., Wang, Q., Lu, X., Wu, Y., Liu, W., Yuen, K.Y., Perlman, S., Gao, G.F., Yan, J.
Deposit date:2015-09-10
Release date:2015-10-14
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (2.409 Å)
Cite:A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein.
Cell Res., 25, 2015
4PV8
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CRYSTAL STRUCTURE OF H2KB-Q600F COMPLEX
Descriptor:H-2 class I histocompatibility antigen, K-B alpha chain, Beta-2-microglobulin, ...
Authors:Twist, K.-A., Rossjohn, J., Gras, S.
Deposit date:2014-03-15
Release date:2014-04-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes.
J.Immunol., 192, 2014
4PV9
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CRYSTAL STRUCTURE OF H2KB-Q600V COMPLEX
Descriptor:H-2 class I histocompatibility antigen, K-B alpha chain, Beta-2-microglobulin, ...
Authors:Twist, K.-A., Rossjohn, J., Gras, S.
Deposit date:2014-03-15
Release date:2014-04-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes.
J.Immunol., 192, 2014
5WKJ
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2.05 A RESOLUTION STRUCTURE OF MERS 3CL PROTEASE IN COMPLEX WITH INHIBITOR GC376
Descriptor:Orf1a protein, CALCIUM ION, (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, ...
Authors:Lovell, S., Battaile, K.P., Mehzabeen, N., Kankanamalage, A.C.G., Kim, Y., Rathnayake, A.D., Chang, K.O., Groutas, W.C.
Deposit date:2017-07-25
Release date:2018-04-04
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.
Eur J Med Chem, 150, 2018
5WKK
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1.55 A RESOLUTION STRUCTURE OF MERS 3CL PROTEASE IN COMPLEX WITH INHIBITOR GC813
Descriptor:Orf1a protein, TETRAETHYLENE GLYCOL, MAGNESIUM ION, ...
Authors:Lovell, S., Battaile, K.P., Mehzabeen, N., Kankanamalage, A.C.G., Kim, Y., Rathnayake, A.D., Chang, K.O., Groutas, W.C.
Deposit date:2017-07-25
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.
Eur J Med Chem, 150, 2018
5WKL
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1.85 A RESOLUTION STRUCTURE OF MERS 3CL PROTEASE IN COMPLEX WITH PIPERIDINE-BASED PEPTIDOMIMETIC INHIBITOR 17
Descriptor:Orf1a protein, (1R,2S)-2-{[N-({[4-benzyl-1-(tert-butoxycarbonyl)piperidin-4-yl]oxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1S,2S)-2-{[N-({[4-benzyl-1-(tert-butoxycarbonyl)piperidin-4-yl]oxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid
Authors:Lovell, S., Battaile, K.P., Mehzabeen, N., Kankanamalage, A.C.G., Kim, Y., Rathnayake, A.D., Chang, K.O., Groutas, W.C.
Deposit date:2017-07-25
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.
Eur J Med Chem, 150, 2018
5WKM
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2.25 A RESOLUTION STRUCTURE OF MERS 3CL PROTEASE IN COMPLEX WITH PIPERIDINE-BASED PEPTIDOMIMETIC INHIBITOR 21
Descriptor:Orf1a protein, (1S,2S)-2-{[N-({[1-(tert-butoxycarbonyl)-4-ethylpiperidin-4-yl]oxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1R,2S)-2-{[N-({[1-(tert-butoxycarbonyl)-4-ethylpiperidin-4-yl]oxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid
Authors:Lovell, S., Battaile, K.P., Mehzabeen, N., Kankanamalage, A.C.G., Kim, Y., Rathnayake, A.D., Chang, K.O., Groutas, W.C.
Deposit date:2017-07-25
Release date:2018-04-04
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.
Eur J Med Chem, 150, 2018
2ZOK
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CRYSTAL STRUCTURE OF H-2DB IN COMPLEX WITH JHMV EPITOPE S510
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Theodossis, A., Dunstone, M.A., Rossjohn, J.
Deposit date:2008-05-22
Release date:2008-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and biological basis of CTL escape in coronavirus-infected mice
J.Immunol., 180, 2008
2ZOL
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CRYSTAL STRUCTURE OF H-2DB IN COMPLEX WITH THE W513S VARIANT OF JHMV EPITOPE S510
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Theodossis, A., Dunstone, M.A., Rossjohn, J.
Deposit date:2008-05-22
Release date:2008-06-10
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and biological basis of CTL escape in coronavirus-infected mice
J.Immunol., 180, 2008
2ZSV
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CRYSTAL STRUCTURE OF H-2KB IN COMPLEX WITH JHMV EPITOPE S598
Descriptor:H-2 class I histocompatibility antigen, K-B alpha chain, Beta-2-microglobulin, ...
Authors:Theodossis, A., Dunstone, M.A., Rossjohn, J.
Deposit date:2008-09-18
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant.
Plos Pathog., 4, 2008
2ZSW
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CRYSTAL STRUCTURE OF H-2KB IN COMPLEX WITH THE Q600Y VARIANT OF JHMV EPITOPE S598
Descriptor:H-2 class I histocompatibility antigen, K-B alpha chain, Beta-2-microglobulin, ...
Authors:Theodossis, A., Dunstone, M.A., Rossjohn, J.
Deposit date:2008-09-18
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant.
Plos Pathog., 4, 2008
4J3K
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STRUCTURE OF THE N-TERMINAL DOMIAN OF HUMAN CORONAVIRUS OC43 NUCLEOCAPSID PROTEIN
Descriptor:Nucleoprotein, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Chen, I.J., Lin, S.Y., Hou, M.H.
Deposit date:2013-02-05
Release date:2013-05-08
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure-based exploration of the important role of Arg106 in the RNA-binding domain of human coronavirus OC43 nucleocapsid protein
Biochim.Biophys.Acta, 1834, 2013
4KXJ
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CRYSTAL STRUCTURE OF HCOV-OC43 N-NTD COMPLEXED WITH PJ34
Descriptor:Nucleoprotein, N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE
Authors:Lin, S.Y., Hou, M.H.
Deposit date:2013-05-27
Release date:2014-05-28
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target
J.Med.Chem., 57, 2014
4LI4
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CRYSTAL STRUCTURE OF HCOV-OC43 N-NTD COMPLEXED WITH AMP
Descriptor:Nucleoprotein, ADENOSINE MONOPHOSPHATE
Authors:Lin, S.Y., Liu, C.L., Hou, M.H.
Deposit date:2013-07-02
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target
J.Med.Chem., 57, 2014
4LM7
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CRYSTAL STRUCTURE OF HCOV-OC43 N-NTD COMPLEXED WITH UMP
Descriptor:Nucleoprotein, URIDINE-5'-MONOPHOSPHATE
Authors:Lin, S.Y., Liu, C.L., Hou, M.H.
Deposit date:2013-07-10
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target
J.Med.Chem., 57, 2014
4LM9
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CRYSTAL STRUCTURE OF HCOV-OC43 N-NTD COMPLEXED WITH GMP
Descriptor:Nucleoprotein, GUANOSINE-5'-MONOPHOSPHATE
Authors:Lin, S.Y., Liu, C.L., Hou, M.H.
Deposit date:2013-07-10
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target
J.Med.Chem., 57, 2014
4LMC
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CRYSTAL STRUCTURE OF HCOV-OC43 N-NTD COMPLEXED WITH CMP
Descriptor:Nucleoprotein, CYTIDINE-5'-MONOPHOSPHATE
Authors:Lin, S.Y., Liu, C.L., Hou, M.H.
Deposit date:2013-07-10
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.742 Å)
Cite:Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target
J.Med.Chem., 57, 2014
4PG2
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THE CRYSTAL STRUCTURE OF H-2DB WITH A S-GLUTATHIONYLATED PEPTIDE
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Theodossis, A., Rossjohn, J.
Deposit date:2014-05-01
Release date:2014-09-10
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The cellular redox environment alters antigen presentation.
J.Biol.Chem., 289, 2014