3FKU
 
 | | Crystal structure of influenza hemagglutinin (H5) in complex with a broadly neutralizing antibody F10 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, Neutralizing antibody F10, ... | | Authors: | Hwang, W.C, Santelli, E, Stec, B, Wei, G, Cadwell, G, Bankston, L.A, Sui, J, Perez, S, Aird, D, Chen, L.M, Ali, M, Murakami, A, Yammanuru, A, Han, T, Cox, N, Donis, R.O, Liddington, R.C, Marasco, W.A. | | Deposit date: | 2008-12-17 | | Release date: | 2009-02-24 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses.
Nat.Struct.Mol.Biol., 16, 2009
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1UOJ
 | | CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN 1 IN THE CALCIUM-FREE STATE | | Descriptor: | PA-I GALACTOPHILIC LECTIN, SULFATE ION | | Authors: | Cioci, G, Mitchell, E, Gautier, C, Wimmerova, M, Perez, S, Gilboa-Garber, N, Imberty, A. | | Deposit date: | 2003-09-19 | | Release date: | 2003-12-04 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Basis of Calcium and Galactose Recognition by the Lectin Pa-Il of Pseudomonas Aeruginosa
FEBS Lett., 555, 2003
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1OKO
 | | Crystal structure of Pseudomonas Aeruginosa Lectin 1 complexed with galactose at 1.6 A resolution | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, PA-I GALACTOPHILIC LECTIN, ... | | Authors: | Cioci, G, Mitchell, E, Gautier, C, Wimmerova, M, Perez, S, Gilboa-Garber, N, Imberty, A. | | Deposit date: | 2003-07-28 | | Release date: | 2003-12-04 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural Basis of Calcium and Galactose Recognition by the Lectin Pa-Il of Pseudomonas Aeruginosa
FEBS Lett., 555, 2003
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2C25
 | | 1.8A Crystal Structure of Psathyrella velutina lectin in complex with N-acetylneuraminic acid | | Descriptor: | CALCIUM ION, N-acetyl-alpha-neuraminic acid, PSATHYRELLA VELUTINA LECTIN PVL, ... | | Authors: | Cioci, G, Mitchell, E.P, Chazalet, V, Gautier, C, Oscarson, S, Debray, H, Perez, S, Imberty, A. | | Deposit date: | 2005-09-26 | | Release date: | 2006-01-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Beta-Propeller Crystal Structure of Psathyrella Velutina Lectin: An Integrin-Like Fungal Protein Interacting with Monosaccharides and Calcium.
J.Mol.Biol., 357, 2006
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2BWM
 | | 1.8A CRYSTAL STRUCTURE OF of Psathyrella velutina LECTIN IN COMPLEX WITH METHYL 2-ACETAMIDO-1,2-DIDEOXY-1-SELENO-BETA-D-GLUCOPYRANOSIDE | | Descriptor: | CALCIUM ION, GLYCEROL, PSATHYRELLA VELUTINA LECTIN PVL, ... | | Authors: | Cioci, G, Mitchell, E.P, Chazalet, V, Gautier, C, Oscarson, S, Debray, H, Perez, S, Imberty, A. | | Deposit date: | 2005-07-15 | | Release date: | 2006-01-23 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Beta-Propeller Crystal Structure of Psathyrella Velutina Lectin: An Integrin-Like Fungal Protein Interacting with Monosaccharides and Calcium.
J.Mol.Biol., 357, 2006
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2C4D
 | | 2.6A Crystal Structure of Psathyrella velutina Lectin in Complex with N-acetylglucosamine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, PSATHYRELLA VELUTINA LECTIN PVL, ... | | Authors: | Cioci, G, Mitchell, E.P, Chazalet, V, Gautier, C, Oscarson, S, Debray, H, Perez, S, Imberty, A. | | Deposit date: | 2005-10-18 | | Release date: | 2006-01-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Beta-Propeller Crystal Structure of Psathyrella Velutina Lectin: An Integrin-Like Fungal Protein Interacting with Monosaccharides and Calcium.
J.Mol.Biol., 357, 2006
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2BWR
 | | Crystal Structure of Psathyrella Velutina Lectin at 1.5A Resolution | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Cioci, G, Mitchell, E.P, Chazalet, V, Gautier, C, Oscarson, S, Debray, H, Perez, S, Imberty, A. | | Deposit date: | 2005-07-18 | | Release date: | 2006-01-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Beta-Propeller Crystal Structure of Psathyrella Velutina Lectin: An Integrin-Like Fungal Protein Interacting with Monosaccharides and Calcium.
J.Mol.Biol., 357, 2006
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1DBN
 | | MAACKIA AMURENSIS LEUKOAGGLUTININ (LECTIN) WITH SIALYLLACTOSE | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, MANGANESE (II) ION, ... | | Authors: | Imberty, A, Gautier, C, Lescar, J, Loris, R. | | Deposit date: | 1999-11-03 | | Release date: | 2000-06-14 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | An unusual carbohydrate binding site revealed by the structures of two Maackia amurensis lectins complexed with sialic acid-containing oligosaccharides.
J.Biol.Chem., 275, 2000
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6W0Z
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6W0X
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6W0W
 | | Structure of KHK in complex with compound 3 | | Descriptor: | 6-[(3~{R},4~{S})-3,4-bis(oxidanyl)pyrrolidin-1-yl]-2-[(2~{S},3~{R})-2-methyl-3-oxidanyl-azetidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile, Ketohexokinase, SULFATE ION | | Authors: | Jasti, J. | | Deposit date: | 2020-03-03 | | Release date: | 2020-09-23 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
J.Med.Chem., 63, 2020
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6W0Y
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6W0N
 | | Structure of KHK in complex with compound 2 | | Descriptor: | 6-[(3~{S},4~{R})-3,4-bis(oxidanyl)pyrrolidin-1-yl]-2-[(3~{S})-3-methyl-3-oxidanyl-pyrrolidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile, CITRIC ACID, Ketohexokinase, ... | | Authors: | Jasti, J. | | Deposit date: | 2020-03-02 | | Release date: | 2020-09-23 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
J.Med.Chem., 63, 2020
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1UZV
 | | High affinity fucose binding of Pseudomonas aeruginosa lectin II: 1.0 A crystal structure of the complex | | Descriptor: | CALCIUM ION, PSEUDOMONAS AERUGINOSA LECTIN II, SULFATE ION, ... | | Authors: | Mitchell, E, Sabin, C.D, Snajdrova, L, Budova, M, Perret, S, Gautier, C, Gilboa-Garber, N, Koca, J, Wimmerova, M, Imberty, A. | | Deposit date: | 2004-03-17 | | Release date: | 2004-12-08 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | High Affinity Fucose Binding of Pseudomonas Aeruginosa Lectin Pa-Iil: 1.0 A Resolution Crystal Structure of the Complex Combined with Thermodynamics and Computational Chemistry Approaches.
Proteins, 58, 2005
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5WBP
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5WBM
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5WBR
 | | Structure of human Ketohexokinase complexed with hits from fragment screening | | Descriptor: | 6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-[(3S)-3-(hydroxymethyl)piperidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile, CITRIC ACID, GLYCEROL, ... | | Authors: | Pandit, J. | | Deposit date: | 2017-06-29 | | Release date: | 2017-09-13 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
J. Med. Chem., 60, 2017
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5WBQ
 | | Structure of human Ketohexokinase complexed with hits from fragment screening | | Descriptor: | 2-ethyl-7-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile, CHLORIDE ION, Ketohexokinase, ... | | Authors: | Pandit, J. | | Deposit date: | 2017-06-29 | | Release date: | 2017-09-13 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
J. Med. Chem., 60, 2017
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5WBO
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5WBZ
 | | Structure of human Ketohexokinase complexed with hits from fragment screening | | Descriptor: | 6-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile, CITRIC ACID, Ketohexokinase, ... | | Authors: | Pandit, J. | | Deposit date: | 2017-06-29 | | Release date: | 2017-09-13 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
J. Med. Chem., 60, 2017
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7Q6A
 | | Crystal structure of Chaetomium thermophilum C30S Ahp1 in post-reaction state | | Descriptor: | GLYCEROL, SULFATE ION, Thioredoxin domain-containing protein | | Authors: | Ravichandran, K.E, Wilk, P, Grudnik, P, Glatt, S. | | Deposit date: | 2021-11-05 | | Release date: | 2022-08-24 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.
Embo J., 41, 2022
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7Q69
 | | Crystal structure of Chaetomium thermophilum C30S Ahp1 in the pre-reaction state | | Descriptor: | GLYCEROL, SULFATE ION, Thioredoxin domain-containing protein | | Authors: | Ravichandran, K.E, Wilk, P, Grudnik, P, Glatt, S. | | Deposit date: | 2021-11-05 | | Release date: | 2022-08-24 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.
Embo J., 41, 2022
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7Q5N
 | | Crystal structure of Chaetomium thermophilum Ahp1-Urm1 complex | | Descriptor: | Thioredoxin domain-containing protein, Ubiquitin-related modifier 1, ZINC ION | | Authors: | Ravichandran, K.E, Wilk, P, Grudnik, P, Glatt, S. | | Deposit date: | 2021-11-04 | | Release date: | 2022-08-24 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.
Embo J., 41, 2022
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7Q68
 | | Crystal structure of Chaetomium thermophilum wild-type Ahp1 | | Descriptor: | GLYCEROL, SULFATE ION, Thioredoxin domain-containing protein | | Authors: | Ravichandran, K.E, Wilk, P, Grudnik, P, Glatt, S. | | Deposit date: | 2021-11-05 | | Release date: | 2022-08-31 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.
Embo J., 41, 2022
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1LEM
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