Author results

6BQG
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CRYSTAL STRUCTURE OF 5-HT2C IN COMPLEX WITH ERGOTAMINE
Descriptor:5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, Ergotamine, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajse, L.F., Huang, X.P., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., Liu, Z.
Deposit date:2017-11-27
Release date:2018-02-14
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell, 172, 2018
6BQH
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CRYSTAL STRUCTURE OF 5-HT2C IN COMPLEX WITH RITANSERIN
Descriptor:5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajse, L.F., Huang, X.P., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., Liu, Z.
Deposit date:2017-11-27
Release date:2018-02-14
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell, 172, 2018
2L5P
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SOLUTION NMR STRUCTURE OF PROTEIN LIPOCALIN 12 FROM RAT EPIDIDYMIS
Descriptor:Lipocalin 12
Authors:Peng, Y., Lin, D.
Deposit date:2010-11-03
Release date:2011-04-13
Last modified:2011-09-14
Method:SOLUTION NMR
Cite:Solution structure of the protein lipocalin 12 from rat epididymis
Proteins, 79, 2011
3BGD
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THIOPURINE S-METHYLTRANSFERASE
Descriptor:Thiopurine S-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 9H-purine-6-thiol
Authors:Peng, Y., Yee, V.C.
Deposit date:2007-11-26
Release date:2008-06-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis of Substrate Recognition in Thiopurine S-Methyltransferase
Biochemistry, 47 (23), 6216 6225, 2008. 10.1021/bi800102x, 2008
3BGI
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THIOPURINE S-METHYLTRANSFERASE
Descriptor:Thiopurine S-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Peng, Y., Yee, V.C.
Deposit date:2007-11-26
Release date:2008-06-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Substrate Recognition in Thiopurine S-Methyltransferase
Biochemistry, 47 (23), 6216 6225, 2008. 10.1021/bi800102x, 2008
3ROD
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METHYLTRANSFERASE
Descriptor:Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, NICOTINAMIDE
Authors:Peng, Y., Yee, V.C.
Deposit date:2011-04-25
Release date:2011-09-07
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structural basis of substrate recognition in human nicotinamide N-methyltransferase.
Biochemistry, 50, 2011
4LA1
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CRYSTAL STRUCTURE OF SJTGR (THIOREDOXIN GLUTATHIONE REDUCTASE FROM SCHISTOSOMA JAPONICUMI)COMPLEX WITH FAD
Descriptor:Thioredoxin glutathione reductase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Peng, Y., Wu, Q., Huang, F., Chen, J., Li, X., Zhou, X., Fan, X.
Deposit date:2013-06-18
Release date:2014-07-30
Method:X-RAY DIFFRACTION (2.348 Å)
Cite:Crystal structure of SjTGR complex with FAD
To be Published
4QPO
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MECHANISTIC BASIS OF PLASMID-SPECIFIC DNA BINDING OF THE F PLASMID REGULATORY PROTEIN, TRAM
Descriptor:Relaxosome protein TraM, PHOSPHATE ION
Authors:Peng, Y., Lu, J., Wong, J., Edwards, R.A., Frost, L.S., Glover, J.N.M.
Deposit date:2014-06-24
Release date:2014-09-03
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Mechanistic Basis of Plasmid-Specific DNA Binding of the F Plasmid Regulatory Protein, TraM.
J.Mol.Biol., 426, 2014
4QPQ
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MECHANISTIC BASIS OF PLASMID-SPECIFIC DNA BINDING OF THE F PLASMID REGULATORY PROTEIN, TRAM
Descriptor:Relaxosome protein TraM, sbmA DNA1, sbmA DNA2
Authors:Peng, Y., Lu, J., Wong, J., Edwards, R.A., Frost, L.S., Glover, J.N.M.
Deposit date:2014-06-24
Release date:2014-09-24
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (3.106 Å)
Cite:Mechanistic Basis of Plasmid-Specific DNA Binding of the F Plasmid Regulatory Protein, TraM.
J.Mol.Biol., 426, 2014
1Z9M
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CRYSTAL STRUCTURE OF NECTIN-LIKE MOLECULE-1 PROTEIN DOMAIN 1
Descriptor:GAPA225
Authors:Dong, X., Xu, F., Gong, Y., Gao, J., Lin, P., Chen, T., Peng, Y., Qiang, B., Yuan, J., Peng, X., Rao, Z.
Deposit date:2005-04-03
Release date:2006-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the V Domain of Human Nectin-like Molecule-1/Syncam3/Tsll1/Igsf4b, a Neural Tissue-specific Immunoglobulin-like Cell-Cell Adhesion Molecule
J.Biol.Chem., 281, 2006
4AGH
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STRUCTURAL FEATURES OF SSDNA BINDING PROTEIN MOSUB1 FROM MAGNAPORTHE ORYZAE
Descriptor:MOSUB1, TRANSCRIPTION COFACTOR
Authors:Huang, J., Zhao, Y., Huang, D., liu, J., Peng, Y.
Deposit date:2012-01-27
Release date:2012-08-29
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (1.787 Å)
Cite:Structural Features of the Single-Stranded DNA-Binding Protein Mosub1 from Magnaporthe Oryzae.
Acta Crystallogr.,Sect.D, 68, 2012
4UX5
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STRUCTURE OF DNA COMPLEX OF PCG2
Descriptor:TRANSCRIPTION FACTOR MBP1, 5'-D(*CP*AP*AP*TP*GP*AP*CP*GP*CP*GP*TP*AP*AP*GP)-3', 5'-D(*CP*TP*TP*AP*CP*GP*CP*GP*TP*CP*AP*TP*TP*GP)-3'
Authors:Liu, J., Huang, J., Zhao, Y., Liu, H., Wang, D., Yang, J., Zhao, W., Taylor, I.A., Peng, Y.
Deposit date:2014-08-19
Release date:2015-01-14
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of DNA Recognition by Pcg2 Reveals a Novel DNA Binding Mode for Winged Helix-Turn-Helix Domains.
Nucleic Acids Res., 43, 2015
4I8B
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CRYSTAL STRUCTURE OF THIOREDOXIN FROM SCHISTOSOMA JAPONICUM
Descriptor:Thioredoxin
Authors:Wu, Q., Peng, Y., Zhao, J., Li, X., Fan, X., Zhou, X., Chen, J., Luo, Z., Shi, D.
Deposit date:2012-12-03
Release date:2013-12-04
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Expression, characterization and crystal structure of thioredoxin from Schistosoma japonicum.
Parasitology, 142, 2015
5WDM
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AN ULTRA-STABLE SINGLE-CHAIN INSULIN ANALOG RESISTS THERMAL INACTIVATION AND EXHIBITS BIOLOGICAL SIGNALING DURATION EQUIVALENT TO THE NATIVE PROTEIN
Descriptor:Single-chain insulin analog
Authors:Yee, V.C., Aldabbagh, K., Peng, Y.
Deposit date:2017-07-05
Release date:2017-11-15
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein.
J. Biol. Chem., 293, 2018
3LQS
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COMPLEX STRUCTURE OF D-AMINO ACID AMINOTRANSFERASE AND 4-AMINO-4,5-DIHYDRO-THIOPHENECARBOXYLIC ACID (ADTA)
Descriptor:D-alanine aminotransferase, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ACETIC ACID
Authors:Lepore, B.W., Liu, D., Peng, Y., Fu, M., Yasuda, C., Manning, J.M., Silverman, R.B., Ringe, D.
Deposit date:2010-02-10
Release date:2010-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Chiral discrimination among aminotransferases: inactivation by 4-amino-4,5-dihydrothiophenecarboxylic acid.
Biochemistry, 49, 2010
3MAP
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CRYSTAL STRUCTURE OF HOMODIMERIC R132H MUTANT OF HUMAN CYTOSOLIC NADP(+)-DEPENDENT ISOCITRATE DEHYDROGENASE IN COMPLEX WITH NADP AND ISOCITRATE
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOCITRIC ACID
Authors:Yang, B., Peng, Y., Ding, J.
Deposit date:2010-03-24
Release date:2010-11-10
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H.
Cell Res., 20, 2010
3MAR
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CRYSTAL STRUCTURE OF HOMODIMERIC R132H MUTANT OF HUMAN CYTOSOLIC NADP(+)-DEPENDENT ISOCITRATE DEHYDROGENASE IN COMPLEX WITH NADP
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Yang, B., Peng, Y., Ding, J.
Deposit date:2010-03-24
Release date:2010-11-10
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H.
Cell Res., 20, 2010
3MAS
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CRYSTAL STRUCTURE OF HETERODIMERIC R132H MUTANT OF HUMAN CYTOSOLIC NADP(+)-DEPENDENT ISOCITRATE DEHYDROGENASE IN COMPLEX WITH NADP AND ISOCITRATE
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOCITRIC ACID
Authors:Yang, B., Peng, Y., Ding, J.
Deposit date:2010-03-24
Release date:2010-11-10
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H.
Cell Res., 20, 2010
3RPN
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CRYSTAL STRUCTURE OF HUMAN KAPPA CLASS GLUTATHIONE TRANSFERASE IN COMPLEX WITH S-HEXYLGLUTATHIONE
Descriptor:Glutathione S-transferase kappa 1, S-HEXYLGLUTATHIONE
Authors:Wang, B., Peng, Y., Zhang, T., Ding, J.
Deposit date:2011-04-27
Release date:2011-07-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures and kinetic studies of human Kappa class glutathione transferase provide insights into the catalytic mechanism.
Biochem.J., 439, 2011
3RPP
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CRYSTAL STRUCTURE OF HUMAN KAPPA CLASS GLUTATHIONE TRANSFERASE IN APO FORM
Descriptor:Glutathione S-transferase kappa 1
Authors:Wang, B., Peng, Y., Zhang, T., Ding, J.
Deposit date:2011-04-27
Release date:2011-07-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures and kinetic studies of human Kappa class glutathione transferase provide insights into the catalytic mechanism.
Biochem.J., 439, 2011
4KNB
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C-MET IN COMPLEX WITH OSI LIGAND
Descriptor:Hepatocyte growth factor receptor, 7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine, GAMMA-BUTYROLACTONE
Authors:Wang, J., Steinig, A.G., Li, A.H., Chen, X., Dong, H., Ferraro, C., Jin, M., Kadalbajoo, M., Kleinberg, A., Stolz, K.M., Tavares-Greco, P.A., Wang, T., Albertella, M.R., Peng, Y., Crew, L., Kahler, J.
Deposit date:2013-05-09
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.
Bioorg.Med.Chem.Lett., 23, 2013
5ADO
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CRYSTAL STRUCTURE OF THE PARAOXON-MODIFIED A.17 ANTIBODY FAB FRAGMENT - LIGHT CHAIN S35R MUTANT
Descriptor:FAB A.17, DIETHYL PHOSPHONATE
Authors:Chatziefthimiou, S.D., Smirnov, I.V., Golovin, A.V., Stepanova, A.V., Peng, Y., Zolotareva, O.I., Belogurov, A.A., Ponomarenko, N.A., Blackburn, G.M., Gabibov, A.A., Lerner, R., Wilmanns, M.
Deposit date:2015-08-21
Release date:2016-11-09
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Robotic Qm/Mm-Driven Maturation of Antibody Combining Sites.
Sci.Adv., 2, 2016
5ADP
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CRYSTAL STRUCTURE OF THE A.17 ANTIBODY FAB FRAGMENT - LIGHT CHAIN S35R MUTANT
Descriptor:FAB A.17
Authors:Chatziefthimiou, S.D., Smirnov, I.V., Golovin, A.V., Stepanova, A.V., Peng, Y., Zolotareva, O.I., Belogurov, A.A., Ponomarenko, N.A., Blackburn, G.M., Gabibov, A.A., Lerner, R., Wilmanns, M.
Deposit date:2015-08-21
Release date:2016-11-09
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Robotic Qm/Mm-Driven Maturation of Antibody Combining Sites.
Sci.Adv., 2, 2016
5GRE
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CRYSTAL STRUCTURE OF THE ALPHA GAMMA HETERODIMER OF HUMAN IDH3 IN COMPLEX WITH MG(2+), CITRATE AND ADP
Descriptor:Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit gamma, ...
Authors:Ma, T., Peng, Y., Ding, J.
Deposit date:2016-08-11
Release date:2017-02-15
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.
Sci Rep, 7, 2017
5GRH
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CRYSTAL STRUCTURE OF THE ALPHA GAMMA HETERODIMER OF HUMAN IDH3 IN COMPLEX WITH MG(2+)
Descriptor:Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit gamma, ...
Authors:Ma, T., Peng, Y.
Deposit date:2016-08-11
Release date:2017-02-15
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.
Sci Rep, 7, 2017
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