Author results

1E0O
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CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX
Descriptor:FIBROBLAST GROWTH FACTOR 1, FIBROBLAST GROWTH FACTOR RECEPTOR 2, NICKEL (II) ION, ...
Authors:Pellegrini, L., Burke, D.F., von Delft, F., Mulloy, B., Blundell, T.L.
Deposit date:2000-04-03
Release date:2000-10-23
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Ligand and Heparin
Nature, 407, 2000
1N0W
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CRYSTAL STRUCTURE OF A RAD51-BRCA2 BRC REPEAT COMPLEX
Descriptor:DNA repair protein RAD51 homolog 1, Breast cancer type 2 susceptibility protein, peptide linker, ...
Authors:Pellegrini, L., Yu, D.S., Lo, T., Anand, S., Lee, M., Blundell, T.L., Venkitaraman, A.R.
Deposit date:2002-10-15
Release date:2002-11-27
Last modified:2016-05-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
Nature, 420, 2002
1SRS
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SERUM RESPONSE FACTOR (SRF) CORE COMPLEXED WITH SPECIFIC SRE DNA
Descriptor:DNA (5'-D(*CP*CP*(5IU)P*TP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*CP*CP*AP*TP*G)-3'), DNA (5'-D(*CP*CP*AP*TP*GP*GP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*A P*AP*G)-3'), PROTEIN (SERUM RESPONSE FACTOR (SRF))
Authors:Pellegrini, L., Tan, S., Richmond, T.J.
Deposit date:1995-07-28
Release date:1995-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of serum response factor core bound to DNA.
Nature, 376, 1995
2ILR
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CRYSTAL STRUCTURE OF HUMAN FANCONI ANEMIA PROTEIN E C-TERMINAL DOMAIN
Descriptor:Fanconi anemia group E protein
Authors:Pellegrini, L., Nookala, R.K.
Deposit date:2006-10-03
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into Fanconi Anaemia from the structure of human FANCE
Nucleic Acids Res., 35, 2007
5NWL
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CRYSTAL STRUCTURE OF A HUMAN RAD51-ATP FILAMENT.
Descriptor:DNA repair protein RAD51 homolog 1, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Pellegrini, L., Moschetti, T.
Deposit date:2017-05-06
Release date:2018-03-07
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (3.93 Å)
Cite:Two distinct conformational states define the interaction of human RAD51-ATP with single-stranded DNA.
EMBO J., 37, 2018
5OF3
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CRYSTAL STRUCTURE OF THE HETEROTRIMERIC PRISLX PRIMASE FROM S. SOLFATARICUS.
Descriptor:DNA primase small subunit PriS, DNA primase large subunit PriL, Uncharacterized protein, ...
Authors:Pellegrini, L., Holzer, S.
Deposit date:2017-07-10
Release date:2017-11-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.906 Å)
Cite:Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster.
Nat Commun, 8, 2017
5OFN
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CRYSTAL STRUCTURE OF THE HETEROTRIMERIC PRISLX PRIMASE FROM S. SOLFATARICUS.
Descriptor:DNA primase small subunit PriS, DNA primase large subunit PriL,PriL-X fusion protein, ZINC ION
Authors:Pellegrini, L., Holzer, S.
Deposit date:2017-07-11
Release date:2017-11-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster.
Nat Commun, 8, 2017
5OGS
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CRYSTAL STRUCTURE OF HUMAN AND-1 SEPB DOMAIN
Descriptor:WD repeat and HMG-box DNA-binding protein 1, MALONATE ION
Authors:Pellegrini, L., Simon, A.C.
Deposit date:2017-07-13
Release date:2017-11-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:The human CTF4-orthologue AND-1 interacts with DNA polymerase alpha /primase via its unique C-terminal HMG box.
Open Biol, 7, 2017
5NXQ
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CRYSTAL STRUCTURE OF THE CARBOXY-TERMINAL DOMAIN OF YEAST CTF4 BOUND TO A STAPLED SLD5 CIP
Descriptor:DNA polymerase alpha-binding protein, MET-ASP-ILE-UA1-ILE-ASP-ASP-ILE-LEU-UA2-GLU-LEU-ASP-LYS-GLU, GLYCEROL
Authors:Wu, Y., Pellegrini, L.
Deposit date:2017-05-10
Release date:2017-08-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.413 Å)
Cite:Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.
Angew. Chem. Int. Ed. Engl., 56, 2017
5HOG
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CRYSTAL STRUCTURE OF THE CARBOXY-TERMINAL DOMAIN OF YEAST CTF4 BOUND TO DNA2.
Descriptor:DNA polymerase alpha-binding protein, Dna2p
Authors:Simon, A.C., Pellegrini, L.
Deposit date:2016-01-19
Release date:2016-06-22
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (3.092 Å)
Cite:Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase.
Mol.Cell, 63, 2016
5HOI
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CRYSTAL STRUCTURE OF THE CARBOXY-TERMINAL DOMAIN OF YEAST CTF4 BOUND TO TOF2.
Descriptor:DNA polymerase alpha-binding protein, Topoisomerase 1-associated factor 2
Authors:Simon, A.C., Pellegrini, L.
Deposit date:2016-01-19
Release date:2016-06-22
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase.
Mol.Cell, 63, 2016
3LGB
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CRYSTAL STRUCTURE OF THE FE-S DOMAIN OF THE YEAST DNA PRIMASE
Descriptor:DNA primase large subunit, IRON/SULFUR CLUSTER, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Sauguet, L., Pellegrini, L.
Deposit date:2010-01-20
Release date:2010-04-21
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Shared Active Site Architecture between the Large Subunit of Eukaryotic Primase and DNA Photolyase
PLOS ONE, 5, 2010
4C8H
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CRYSTAL STRUCTURE OF THE C-TERMINAL REGION OF YEAST CTF4, SELENOMETHIONINE PROTEIN.
Descriptor:CTF4
Authors:Simon, A.C., Pellegrini, L.
Deposit date:2013-10-01
Release date:2014-04-30
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (2.691 Å)
Cite:A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase Alpha in the Eukaryotic Replisome
Nature, 510, 2014
4C8S
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CRYSTAL STRUCTURE OF THE C-TERMINAL REGION OF YEAST CTF4
Descriptor:DNA POLYMERASE ALPHA-BINDING PROTEIN
Authors:Simon, A.C., Pellegrini, L.
Deposit date:2013-10-01
Release date:2014-04-30
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase a in the Eukaryotic Replisome
Nature, 510, 2014
4C93
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CRYSTAL STRUCTURE OF THE CARBOXY-TERMINAL DOMAIN OF YEAST CTF4 BOUND TO POL ALPHA.
Descriptor:DNA POLYMERASE ALPHA-BINDING PROTEIN, DNA POLYMERASE ALPHA CATALYTIC SUBUNIT A
Authors:Simon, A.C., Pellegrini, L.
Deposit date:2013-10-02
Release date:2014-04-30
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (2.694 Å)
Cite:A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase a in the Eukaryotic Replisome
Nature, 510, 2014
4C95
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CRYSTAL STRUCTURE OF THE CARBOXY-TERMINAL DOMAIN OF YEAST CTF4 BOUND TO SLD5
Descriptor:DNA POLYMERASE ALPHA-BINDING PROTEIN, DNA REPLICATION COMPLEX GINS PROTEIN SLD5
Authors:Simon, A.C., Pellegrini, L.
Deposit date:2013-10-02
Release date:2014-04-30
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (2.694 Å)
Cite:A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase a in the Eukaryotic Replisome
Nature, 510, 2014
1IK9
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CRYSTAL STRUCTURE OF A XRCC4-DNA LIGASE IV COMPLEX
Descriptor:DNA REPAIR PROTEIN XRCC4, DNA LIGASE IV
Authors:Sibanda, B.L., Critchlow, S.E., Begun, J., Pei, X.Y., Jackson, S.P., Blundell, T.L., Pellegrini, L.
Deposit date:2001-05-03
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of an Xrcc4-DNA ligase IV complex.
Nat.Struct.Biol., 8, 2001
1PWA
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CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 19
Descriptor:Fibroblast growth factor-19, SULFATE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Harmer, N.J., Pellegrini, L., Chirgadze, D., Fernandez-Recio, J., Blundell, T.L.
Deposit date:2003-07-01
Release date:2004-01-27
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity.
Biochemistry, 43, 2004
1Z56
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CO-CRYSTAL STRUCTURE OF LIF1P-LIG4P
Descriptor:Ligase interacting factor 1, DNA ligase IV
Authors:Dore, A.S., Furnham, N., Davies, O.R., Sibanda, B.L., Chirgadze, D.Y., Jackson, S.P., Pellegrini, L., Blundell, T.L.
Deposit date:2005-03-17
Release date:2006-01-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.92 Å)
Cite:Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.
DNA REPAIR, 5, 2006
1ZT2
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HETERODIMERIC STRUCTURE OF THE CORE PRIMASE.
Descriptor:DNA primase small subunit, DNA primase large subunit, ZINC ION, ...
Authors:Lao-Sirieix, S.H., Nookala, R.K., Roversi, P., Bell, S.D., Pellegrini, L.
Deposit date:2005-05-26
Release date:2005-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Structure of the heterodimeric core primase.
Nat.Struct.Mol.Biol., 12, 2005
2YGK
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CRYSTAL STRUCTURE OF THE NURA NUCLEASE FROM SULFOLOBUS SOLFATARICUS
Descriptor:NURA, MANGANESE (II) ION
Authors:Rzechorzek, N.J., Blackwood, J.K., Abrams, A.S., Maman, J.D., Robinson, N.P., Pellegrini, L.
Deposit date:2011-04-18
Release date:2011-12-14
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Functional Insights Into DNA-End Processing by the Archaeal Hera Helicase-Nura Nuclease Complex.
Nucleic Acids Res., 40, 2012
3C1D
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X-RAY CRYSTAL STRUCTURE OF RECX
Descriptor:Regulatory protein recX
Authors:Ragone, S., Maman, J.D., Furnham, N., Pellegrini, L.
Deposit date:2008-01-23
Release date:2008-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for inhibition of homologous recombination by the RecX protein.
Embo J., 27, 2008
3FLO
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CRYSTAL STRUCTURE OF THE CARBOXYL-TERMINAL DOMAIN OF YEAST DNA POLYMERASE ALPHA IN COMPLEX WITH ITS B SUBUNIT
Descriptor:DNA polymerase alpha subunit B, DNA polymerase alpha catalytic subunit A, SULFATE ION, ...
Authors:Klinge, S.N., Pellegrini, L.
Deposit date:2008-12-19
Release date:2009-06-09
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:3D architecture of DNA Pol alpha reveals the functional core of multi-subunit replicative polymerases
Embo J., 28, 2009
4B08
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YEAST DNA POLYMERASE ALPHA, SELENOMETHIONINE PROTEIN
Descriptor:DNA POLYMERASE ALPHA CATALYTIC SUBUNIT A
Authors:Perera, R.L., Torella, R., Klinge, S., Kilkenny, M.L., Maman, J.D., Pellegrini, L.
Deposit date:2012-06-29
Release date:2013-02-27
Last modified:2013-05-01
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Mechanism for Priming DNA Synthesis by Yeast DNA Polymerase Alpha
Elife, 2, 2013
4BPU
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CRYSTAL STRUCTURE OF HUMAN PRIMASE IN HETERODIMERIC FORM, COMPRISING PRIS AND TRUNCATED PRIL LACKING THE C-TERMINAL FE-S DOMAIN.
Descriptor:DNA PRIMASE SMALL SUBUNIT, DNA PRIMASE LARGE SUBUNIT, ZINC ION, ...
Authors:Kilkenny, M.L., Perera, R.L., Pellegrini, L.
Deposit date:2013-05-28
Release date:2013-09-25
Last modified:2013-10-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
Proc.Natl.Acad.Sci.USA, 110, 2013
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