Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
6GGS
DownloadVisualize
BU of 6ggs by Molmil
Structure of RIP2 CARD filament
Descriptor: Receptor-interacting serine/threonine-protein kinase 2
Authors:Pellegrini, E, Cusack, S, Desfosses, A, Schoehn, G, Malet, H, Gutsche, I, Sachse, C, Hons, M.
Deposit date:2018-05-03
Release date:2018-10-17
Method:ELECTRON MICROSCOPY (3.94 Å)
Cite:RIP2 filament formation is required for NOD2 dependent NF-kappa B signalling.
Nat Commun, 9, 2018
6GFJ
DownloadVisualize
BU of 6gfj by Molmil
Structure of RIP2 CARD domain fused to crystallisable MBP tag
Descriptor: Sugar ABC transporter substrate-binding protein,Receptor-interacting serine/threonine-protein kinase 2, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Pellegrini, E, Cusack, S.
Deposit date:2018-04-30
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:RIP2 filament formation is required for NOD2 dependent NF-kappa B signalling.
Nat Commun, 9, 2018
5NG2
DownloadVisualize
BU of 5ng2 by Molmil
Structure of RIP2K(D146N) with bound Staurosporine
Descriptor: PHOSPHATE ION, Receptor-interacting serine/threonine-protein kinase 2, STAUROSPORINE
Authors:Pellegrini, E, Cusack, S.
Deposit date:2017-03-16
Release date:2017-06-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.
PLoS ONE, 12, 2017
5NG0
DownloadVisualize
BU of 5ng0 by Molmil
Structure of RIP2K(L294F) with bound AMPPCP
Descriptor: COBALT (II) ION, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Pellegrini, E, Cusack, S.
Deposit date:2017-03-16
Release date:2017-06-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.
PLoS ONE, 12, 2017
5NG3
DownloadVisualize
BU of 5ng3 by Molmil
Structure of inactive kinase RIP2K(K47R)
Descriptor: Receptor-interacting serine/threonine-protein kinase 2, SULFATE ION
Authors:Pellegrini, E, Cusack, S.
Deposit date:2017-03-16
Release date:2017-06-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.
PLoS ONE, 12, 2017
5C4M
DownloadVisualize
BU of 5c4m by Molmil
RhoA GDP with novel switch II conformation
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA
Authors:Pellegrini, E, Bowler, M.W.
Deposit date:2015-06-18
Release date:2016-06-29
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:RhoA GDP with novel switch II conformation
To Be Published
5ETA
DownloadVisualize
BU of 5eta by Molmil
Structure of MAPK14 with bound the KIM domain of the Toxoplasma protein GRA24
Descriptor: Mitogen-activated protein kinase 14, Putative transmembrane protein
Authors:Pellegrini, E, Palencia, A, Braun, L, Kapp, U, Bougdour, A, Belrhali, H, Bowler, M.W, Hakimi, M.
Deposit date:2015-11-17
Release date:2016-10-26
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist.
Structure, 25, 2017
5ETF
DownloadVisualize
BU of 5etf by Molmil
Structure of dead kinase MAPK14 with bound the KIM domain of MKK6
Descriptor: Dual specificity mitogen-activated protein kinase kinase 6, Mitogen-activated protein kinase 14
Authors:Pellegrini, E, Palencia, A, Braun, L, Kapp, U, Bougdour, A, Belrhali, H, Bowler, M.W, Hakimi, M.
Deposit date:2015-11-17
Release date:2016-10-26
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist.
Structure, 25, 2017
8AZA
DownloadVisualize
BU of 8aza by Molmil
Structure of RIP2K dimer bound to the XIAP BIR2 domain
Descriptor: E3 ubiquitin-protein ligase XIAP, Receptor-interacting serine/threonine-protein kinase 2, ZINC ION
Authors:Pellegrini, E, Cusack, S.
Deposit date:2022-09-05
Release date:2022-10-26
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface.
Life Sci Alliance, 6, 2023
5ETI
DownloadVisualize
BU of 5eti by Molmil
Structure of dead kinase MAPK14
Descriptor: Mitogen-activated protein kinase 14
Authors:Pellegrini, E, Bowler, M.W.
Deposit date:2015-11-17
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Architecture of the MKK6-p38 alpha complex defines the basis of MAPK specificity and activation.
Science, 381, 2023
5M70
DownloadVisualize
BU of 5m70 by Molmil
Crystal Structure of human RhoGAP mutated in its arginin finger (R85A) in complex with RhoA.GDP.AlF4- human
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rho GTPase-activating protein 1, ...
Authors:Pellegrini, E, Bowler, M.W.
Deposit date:2016-10-26
Release date:2017-05-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Assessing the Influence of Mutation on GTPase Transition States by Using X-ray Crystallography, (19) F NMR, and DFT Approaches.
Angew. Chem. Int. Ed. Engl., 56, 2017
5M6X
DownloadVisualize
BU of 5m6x by Molmil
Crystal Structure of human RhoGAP mutated in its arginine finger (R85A) in complex with RhoA.GDP.MgF3- human
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rho GTPase-activating protein 1, ...
Authors:Pellegrini, E, Bowler, M.W.
Deposit date:2016-10-26
Release date:2017-05-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Assessing the Influence of Mutation on GTPase Transition States by Using X-ray Crystallography, (19) F NMR, and DFT Approaches.
Angew. Chem. Int. Ed. Engl., 56, 2017
3ZI4
DownloadVisualize
BU of 3zi4 by Molmil
The structure of Beta-phosphoglucomutase Inhibited With Glucose-6-phosphate and Scandium Tetrafluoride
Descriptor: 6-O-phosphono-beta-D-glucopyranose, BETA-PHOSPHOGLUCOMUTASE, MAGNESIUM ION, ...
Authors:Pellegrini, E, Bowler, M.W.
Deposit date:2013-01-03
Release date:2014-01-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Metal Fluorides: Multi-Functional Tools for the Study of Phosphoryl Transfer Enzymes
To be Published
4C4T
DownloadVisualize
BU of 4c4t by Molmil
Structure of beta-phosphoglucomutase in complex with a phosphonate analogue of beta-glucose-1-phosphate and aluminium tetrafluoride
Descriptor: (1R)-1,5-anhydro-1-[(S)-fluoro(phosphono)methyl]-D-glucitol, BETA-PHOSPHOGLUCOMUTASE, MAGNESIUM ION, ...
Authors:Pellegrini, E, Bowler, M.W.
Deposit date:2013-09-09
Release date:2014-07-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Alpha-Fluorophosphonates Reveal How a Phosphomutase Conserves Transition State Conformation Over Hexose Recognition in its Two-Step Reaction.
Proc.Natl.Acad.Sci.USA, 111, 2014
4C4R
DownloadVisualize
BU of 4c4r by Molmil
Structure of beta-phosphoglucomutase in complex with a phosphonate analogue of beta-glucose-1-phosphate and magnesium trifluoride
Descriptor: (1R)-1,5-anhydro-1-(phosphonomethyl)-D-glucitol, BETA-PHOSPHOGLUCOMUTASE, MAGNESIUM ION, ...
Authors:Pellegrini, E, Bowler, M.W.
Deposit date:2013-09-09
Release date:2014-07-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Alpha-Fluorophosphonates Reveal How a Phosphomutase Conserves Transition State Conformation Over Hexose Recognition in its Two-Step Reaction.
Proc.Natl.Acad.Sci.USA, 111, 2014
4C4S
DownloadVisualize
BU of 4c4s by Molmil
Structure of beta-phosphoglucomutase in complex with an alpha- fluorophosphonate analogue of beta-glucose-1-phosphate and magnesium trifluoride
Descriptor: (1R)-1,5-anhydro-1-[(S)-fluoro(phosphono)methyl]-D-glucitol, BETA-PHOSPHOGLUCOMUTASE, MAGNESIUM ION, ...
Authors:Pellegrini, E, Bowler, M.W.
Deposit date:2013-09-09
Release date:2014-07-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Alpha-Fluorophosphonates Reveal How a Phosphomutase Conserves Transition State Conformation Over Hexose Recognition in its Two-Step Reaction.
Proc.Natl.Acad.Sci.USA, 111, 2014
8A8M
DownloadVisualize
BU of 8a8m by Molmil
Structure of the MAPK p38alpha in complex with its activating MAP2K MKK6
Descriptor: Dual specificity mitogen-activated protein kinase kinase 6, MAGNESIUM ION, Mitogen-activated protein kinase 14, ...
Authors:Bowler, M.W, Juyoux, P, Pellegrini, E.
Deposit date:2022-06-23
Release date:2022-07-13
Last modified:2023-09-27
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Architecture of the MKK6-p38 alpha complex defines the basis of MAPK specificity and activation.
Science, 381, 2023
8PNT
DownloadVisualize
BU of 8pnt by Molmil
Structure of the human nuclear cap-binding complex bound to PHAX and m7G-capped RNA
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ...
Authors:Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J.
Deposit date:2023-07-01
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex.
Cell Rep, 43, 2024
8PMP
DownloadVisualize
BU of 8pmp by Molmil
Structure of the human nuclear cap-binding complex bound to ARS2[147-871] and m7GTP
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ...
Authors:Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J.
Deposit date:2023-06-29
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex.
Cell Rep, 43, 2024
8BY6
DownloadVisualize
BU of 8by6 by Molmil
Structure of the human nuclear cap-binding complex bound to NCBP3(560-620) and cap-analogue m7GpppG
Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ...
Authors:Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J.
Deposit date:2022-12-12
Release date:2024-01-24
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.19 Å)
Cite:Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex.
Cell Rep, 43, 2024
5ETC
DownloadVisualize
BU of 5etc by Molmil
Structure of inactive MAPK14 with ordered Activation Loop
Descriptor: Mitogen-activated protein kinase 14, SULFATE ION
Authors:Kapp, U, Pellegrini, E, Bowler, M.W.
Deposit date:2015-11-17
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.422 Å)
Cite:Architecture of the MKK6-p38 alpha complex defines the basis of MAPK specificity and activation.
Science, 381, 2023
2WF7
DownloadVisualize
BU of 2wf7 by Molmil
Structure of Beta-Phosphoglucomutase inhibited with Glucose-6- phosphonate and Aluminium tetrafluoride
Descriptor: 6,7-dideoxy-7-phosphono-beta-D-gluco-heptopyranose, BETA-PHOSPHOGLUCOMUTASE, MAGNESIUM ION, ...
Authors:Bowler, M.W, Baxter, N.J, Webster, C.E, Pollard, S, Alizadeh, T, Hounslow, A.M, Cliff, M.J, Bermel, W, Williams, N.H, Hollfelder, F, Blackburn, G.M, Waltho, J.P.
Deposit date:2009-04-03
Release date:2010-05-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Alpha-Fluorophosphonates Reveal How a Phosphomutase Conserves Transition State Conformation Over Hexose Recognition in its Two-Step Reaction.
Proc.Natl.Acad.Sci.USA, 111, 2014
6R3V
DownloadVisualize
BU of 6r3v by Molmil
Crystal Structure of RhoA-GDP-Pi in Complex with RhoGAP
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Jin, Y.
Deposit date:2019-03-21
Release date:2019-05-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A GAP-GTPase-GDP-PiIntermediate Crystal Structure Analyzed by DFT Shows GTP Hydrolysis Involves Serial Proton Transfers.
Chemistry, 25, 2019

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon