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3EQY
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BU of 3eqy by Molmil
Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor
Descriptor: 12-mer peptide inhibitor, GUANIDINE, Mdm4 protein, ...
Authors:Pazgier, M, Lu, W.
Deposit date:2008-10-01
Release date:2009-03-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Proc.Natl.Acad.Sci.USA, 106, 2009
3EQS
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BU of 3eqs by Molmil
Crystal structure of human MDM2 in complex with a 12-mer peptide inhibitor
Descriptor: 12-mer peptide inhibitor, E3 ubiquitin-protein ligase Mdm2, GUANIDINE
Authors:Pazgier, M, Lu, W.
Deposit date:2008-10-01
Release date:2009-03-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Proc.Natl.Acad.Sci.USA, 106, 2009
4EYC
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BU of 4eyc by Molmil
Crystal structure of the cathelin-like domain of human cathelicidin LL-37 (hCLD)
Descriptor: Cathelicidin antimicrobial peptide
Authors:Pazgier, M, Pozharski, E, Toth, E, Lu, W.
Deposit date:2012-05-01
Release date:2013-02-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Analysis of the Pro-Domain of Human Cathelicidin, LL-37.
Biochemistry, 52, 2013
5UML
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BU of 5uml by Molmil
CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH 12-MER PEPTIDE INHIBITOR M3
Descriptor: PEPTIDE INHIBITOR M3, Protein Mdm4
Authors:Pazgier, M, Gohain, N, Tolbert, W.D.
Deposit date:2017-01-27
Release date:2018-01-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for p53 activation
To Be Published
5UMM
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BU of 5umm by Molmil
CRYSTAL STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH 12-MER PEPTIDE INHIBITOR M3
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, PEPTIDE INHIBITOR M3
Authors:Pazgier, M, Gohain, N, Tolbert, W.D.
Deposit date:2017-01-27
Release date:2018-01-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for p53 activation
To Be Published
4RBX
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BU of 4rbx by Molmil
Crystal structure of human alpha-defensin 5, HD5 (Glu21Arg mutant)
Descriptor: Defensin-5, SULFATE ION
Authors:Pazgier, M, Gohain, N, Tolbert, W.D.
Deposit date:2014-09-13
Release date:2015-07-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Design of a potent antibiotic peptide based on the active region of human defensin 5.
J.Med.Chem., 58, 2015
4RXZ
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BU of 4rxz by Molmil
Crystal Structure of MDMX phosporylated Tyr99 in complex with a 12-mer peptide
Descriptor: 12-MER PEPTIDE INHIBITOR, Protein Mdm4
Authors:Pazgier, M, Gohain, N, Tolbert, W.D.
Deposit date:2014-12-12
Release date:2015-07-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural basis of how stress-induced MDMX phosphorylation activates p53.
Oncogene, 35, 2016
3QTE
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BU of 3qte by Molmil
Crystal structure of human alpha-defensin 6 (H27W mutant)
Descriptor: CHLORIDE ION, Defensin-6, GLYCEROL
Authors:Pazgier, M, Lu, W.
Deposit date:2011-02-22
Release date:2012-01-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Human alpha-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets.
Science, 337, 2012
4E82
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BU of 4e82 by Molmil
Crystal structure of monomeric variant of human alpha-defensin 5, HD5 (Glu21EMe mutant)
Descriptor: Defensin-5
Authors:Pazgier, M.
Deposit date:2012-03-19
Release date:2012-05-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Functional determinants of human enteric {alpha}-defensin HD5: crucial role for hydrophobicity at dimer interface.
J.Biol.Chem., 287, 2012
4E83
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BU of 4e83 by Molmil
Crystal structure of human alpha-defensin 5, HD5 (Leu29NLe mutant)
Descriptor: CHLORIDE ION, Defensin-5
Authors:Pazgier, M.
Deposit date:2012-03-19
Release date:2012-05-16
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Functional determinants of human enteric {alpha}-defensin HD5: crucial role for hydrophobicity at dimer interface.
J.Biol.Chem., 287, 2012
4RBW
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BU of 4rbw by Molmil
Crystal structure of human alpha-defensin 5, HD5 (Thr7Arg Glu21Arg mutant)
Descriptor: CHLORIDE ION, Defensin-5, SULFATE ION
Authors:Pazgier, M, Gohain, N, Tolbert, W.D.
Deposit date:2014-09-13
Release date:2015-07-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Design of a potent antibiotic peptide based on the active region of human defensin 5.
J.Med.Chem., 58, 2015
2NLF
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BU of 2nlf by Molmil
Human beta-defensin-1 (Mutant Leu13Glu)
Descriptor: Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLD
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BU of 2nld by Molmil
Human beta-defensin-1 (Mutant Gln11Ala)
Descriptor: ACETATE ION, Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLB
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BU of 2nlb by Molmil
Human beta-defensin-1 (Mutant Asn4Ala)
Descriptor: Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLG
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BU of 2nlg by Molmil
Human beta-defensin-1 (Mutant Lys22Glu)
Descriptor: Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLQ
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BU of 2nlq by Molmil
Human beta-defensin-1 (Mutant Lys31Ala)
Descriptor: Beta-defensin 1, GLYCEROL, GLYCINE, ...
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLE
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BU of 2nle by Molmil
Human beta-defensin-1 (Mutant Gln11Ala)
Descriptor: ACETATE ION, Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLC
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BU of 2nlc by Molmil
Human beta-defensin-1 (mutant Ser8Ala)
Descriptor: ACETATE ION, Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLH
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BU of 2nlh by Molmil
Human beta-defensin-1 (Mutant GLN24ALA)
Descriptor: ACETATE ION, Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLP
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BU of 2nlp by Molmil
Human beta-defensin-1 (Mutant Gln24Glu)
Descriptor: Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLS
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BU of 2nls by Molmil
Human beta-defensin-1 (Mutant Gln24Ala)
Descriptor: Beta-defensin 1
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
3H6C
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BU of 3h6c by Molmil
Crystal structure of human alpha-defensin 1 (Mutant Gln22Ala)
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Neutrophil defensin 1
Authors:Pazgier, M, Lu, W.
Deposit date:2009-04-23
Release date:2010-03-09
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3I5W
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BU of 3i5w by Molmil
Crystal structure of human alpha-defensin 5 (mutant R13H)
Descriptor: CHLORIDE ION, CITRATE ANION, Defensin-5
Authors:Pazgier, M, Lu, W.
Deposit date:2009-07-06
Release date:2009-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5
Febs Lett., 583, 2009
3IWY
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BU of 3iwy by Molmil
Crystal structure of human MDM2 complexed with D-peptide (12 residues)
Descriptor: D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2
Authors:Pazgier, M, Lu, W.
Deposit date:2009-09-03
Release date:2010-04-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms.
Proc.Natl.Acad.Sci.USA, 398, 2010
3IUX
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BU of 3iux by Molmil
Crystal structure of human MDM2 in complex with a potent miniature protein inhibitor (18-residues)
Descriptor: ACETATE ION, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ...
Authors:Pazgier, M, Lu, W.
Deposit date:2009-08-31
Release date:2009-10-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Apamin as a template for structure-based rational design of potent peptide activators of p53.
Angew.Chem.Int.Ed.Engl., 48, 2009

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