Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
2HN2
DownloadVisualize
BU of 2hn2 by Molmil
Crystal structure of the CorA Mg2+ transporter homologue from T. maritima in complex with divalent cations
Descriptor: CALCIUM ION, Magnesium transport protein corA
Authors:Payandeh, J, Pai, E.F.
Deposit date:2006-07-11
Release date:2006-08-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:A structural basis for Mg(2+) homeostasis and the CorA translocation cycle.
Embo J., 25, 2006
2HN1
DownloadVisualize
BU of 2hn1 by Molmil
Crystal structure of a CorA soluble domain from A. fulgidus in complex with Co2+
Descriptor: COBALT (II) ION, Magnesium and cobalt transporter
Authors:Payandeh, J, Pai, E.F.
Deposit date:2006-07-11
Release date:2006-08-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A structural basis for Mg(2+) homeostasis and the CorA translocation cycle.
Embo J., 25, 2006
4EKW
DownloadVisualize
BU of 4ekw by Molmil
Crystal structure of the NavAb voltage-gated sodium channel (wild-type, 3.2 A)
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein, PHOSPHATE ION
Authors:Payandeh, J, Gamal El-Din, T.M, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2012-04-10
Release date:2012-05-16
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Crystal structure of a voltage-gated sodium channel in two potentially inactivated states.
Nature, 486, 2012
3RVZ
DownloadVisualize
BU of 3rvz by Molmil
Crystal structure of the NavAb voltage-gated sodium channel (Ile217Cys, 2.8 A)
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein
Authors:Payandeh, J, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2011-05-06
Release date:2011-07-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of a voltage-gated sodium channel.
Nature, 475, 2011
3RW0
DownloadVisualize
BU of 3rw0 by Molmil
Crystal structure of the NavAb voltage-gated sodium channel (Met221Cys, 2.95 A)
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein
Authors:Payandeh, J, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2011-05-06
Release date:2011-07-13
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:The crystal structure of a voltage-gated sodium channel.
Nature, 475, 2011
3RVY
DownloadVisualize
BU of 3rvy by Molmil
Crystal structure of the NavAb voltage-gated sodium channel (Ile217Cys, 2.7 A)
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein
Authors:Payandeh, J, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2011-05-06
Release date:2011-07-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure of a voltage-gated sodium channel.
Nature, 475, 2011
2F6U
DownloadVisualize
BU of 2f6u by Molmil
Crystal Structure of (S)-3-O-Geranylgeranylglyceryl Phosphate Synthase complexed with citrate
Descriptor: (S)-3-O-Geranylgeranylglyceryl Phosphate Synthase, CITRIC ACID
Authors:Payandeh, J.
Deposit date:2005-11-29
Release date:2006-01-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The crystal structure of (S)-3-O-geranylgeranylglyceryl phosphate synthase reveals an ancient fold for an ancient enzyme
J.Biol.Chem., 281, 2006
5BO1
DownloadVisualize
BU of 5bo1 by Molmil
Crystal structure of a human Jag1 fragment in complex with an anti-Jag1 Fab
Descriptor: Fab heavy chain, Fab light chain, GLYCEROL, ...
Authors:Payandeh, J, de Leon-Boenig, G.
Deposit date:2015-05-26
Release date:2015-11-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung.
Nature, 528, 2015
7SEL
DownloadVisualize
BU of 7sel by Molmil
E. coli MsbA in complex with LPS and inhibitor G7090 (compound 3)
Descriptor: (2E)-3-{7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1-methylnaphthalen-2-yl}prop-2-enoic acid, (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, ATP-dependent lipid A-core flippase
Authors:Payandeh, J, Koth, C.M, Verma, V.A.
Deposit date:2021-09-30
Release date:2022-03-09
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (2.978 Å)
Cite:Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity.
J.Med.Chem., 65, 2022
6XLP
DownloadVisualize
BU of 6xlp by Molmil
Structure of the essential inner membrane lipopolysaccharide-PbgA complex
Descriptor: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-deoxy-3-O-[(1R,3R)-1,3-dihydroxytetradecyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-1-O-phosphono-alpha-D-glucopyranose-(6-1)-[3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-6)]1,5-anhydro-2-deoxy-2-{[(1S,3R)-1-hydroxy-3-(pentanoyloxy)undecyl]amino}-4-O-phosphono-D-glucitol, ...
Authors:Payandeh, J, Clairefeuille, T.
Deposit date:2020-06-29
Release date:2020-08-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the essential inner membrane lipopolysaccharide-PbgA complex.
Nature, 584, 2020
7JWP
DownloadVisualize
BU of 7jwp by Molmil
Fab CJ11 in complex IL-18 peptide liberated by Caspase cleavage
Descriptor: Fab CJ11 Heavy chain, Fab CJ11 Light chain, IL-18 peptide
Authors:Payandeh, J, Ho, H.
Deposit date:2020-08-26
Release date:2021-03-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function.
Proc.Natl.Acad.Sci.USA, 118, 2021
7JWQ
DownloadVisualize
BU of 7jwq by Molmil
Fab CJ11 in complex IL-1beta peptide liberated by Caspase cleavage
Descriptor: Fab CJ11 Heavy chain, Fab CJ11 Light chain, IL-1beta peptide
Authors:Payandeh, J, Ho, H.
Deposit date:2020-08-26
Release date:2021-03-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function.
Proc.Natl.Acad.Sci.USA, 118, 2021
7U8G
DownloadVisualize
BU of 7u8g by Molmil
Cryo-EM structure of the core human NADPH oxidase NOX2
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 7G5 - heavy chain, ...
Authors:Noreng, S, Ota, N, Sun, Y, Masureel, M, Payandeh, J, Yi, T, Koerber, J.T.
Deposit date:2022-03-08
Release date:2022-10-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the core human NADPH oxidase NOX2.
Nat Commun, 13, 2022
8F0Q
DownloadVisualize
BU of 8f0q by Molmil
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the acylsulfonamide inhibitor GDC-0310
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-cyclopropyl-4-({1-[(1S)-1-(3,5-dichlorophenyl)ethyl]piperidin-4-yl}methoxy)-2-fluoro-N-(methanesulfonyl)benzamide, ...
Authors:Kschonsak, M, Jao, C.C, Arthur, C.P, Rohou, A.L, Bergeron, P, Ortwine, D, McKerall, S.J, Hackos, D.H, Deng, L, Chen, J, Sutherlin, D, Dragovich, P.S, Volgraf, M, Wright, M.R, Payandeh, J, Ciferri, C, Tellis, J.C.
Deposit date:2022-11-03
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Elife, 12, 2023
8F0P
DownloadVisualize
BU of 8f0p by Molmil
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-1305
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
Authors:Kschonsak, M, Jao, C.C, Arthur, C.P, Rohou, A.L, Bergeron, P, Ortwine, D, McKerall, S.J, Hackos, D.H, Deng, L, Chen, J, Sutherlin, D, Dragovich, P.S, Volgraf, M, Wright, M.R, Payandeh, J, Ciferri, C, Tellis, J.C.
Deposit date:2022-11-03
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Elife, 12, 2023
8F0S
DownloadVisualize
BU of 8f0s by Molmil
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-9296
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kschonsak, M, Jao, C.C, Arthur, C.P, Rohou, A.L, Bergeron, P, Ortwine, D, McKerall, S.J, Hackos, D.H, Deng, L, Chen, J, Sutherlin, D, Dragovich, P.S, Volgraf, M, Wright, M.R, Payandeh, J, Ciferri, C, Tellis, J.C.
Deposit date:2022-11-03
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Elife, 12, 2023
8F0R
DownloadVisualize
BU of 8f0r by Molmil
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the arylsulfonamide inhibitor GNE-3565
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-4-({(1S,2S,4S)-2-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]cyclohexyl}amino)-2-fluoro-N-(pyrimidin-4-yl)benzene-1-sulfonamide, ...
Authors:Kschonsak, M, Jao, C.C, Arthur, C.P, Rohou, A.L, Bergeron, P, Ortwine, D, McKerall, S.J, Hackos, D.H, Deng, L, Chen, J, Sutherlin, D, Dragovich, P.S, Volgraf, M, Wright, M.R, Payandeh, J, Ciferri, C, Tellis, J.C.
Deposit date:2022-11-03
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Elife, 12, 2023
5EK0
DownloadVisualize
BU of 5ek0 by Molmil
Human Nav1.7-VSD4-NavAb in complex with GX-936.
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide, Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha
Authors:Ahuja, S, Mukund, S, Starovasnik, M.A, Koth, C.M, Payandeh, J.
Deposit date:2015-11-03
Release date:2015-12-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.53 Å)
Cite:Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.
Science, 350, 2015
6BPP
DownloadVisualize
BU of 6bpp by Molmil
E. coli MsbA in complex with LPS and inhibitor G092
Descriptor: (2E)-3-{6-[(1S)-1-(3-amino-2,6-dichlorophenyl)ethoxy]-4-cyclopropylquinolin-3-yl}prop-2-enoic acid, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 3-HYDROXY-TETRADECANOIC ACID, ...
Authors:Ho, H, Koth, C.M, Payandeh, J.
Deposit date:2017-11-24
Release date:2018-05-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Structural basis for dual-mode inhibition of the ABC transporter MsbA.
Nature, 557, 2018
6BPL
DownloadVisualize
BU of 6bpl by Molmil
E. coli MsbA in complex with LPS and inhibitor G907
Descriptor: (2E)-3-{6-[(1S)-1-(2-chloro-6-cyclopropylphenyl)ethoxy]-4-cyclopropylquinolin-3-yl}prop-2-enoic acid, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-amino-2-deoxy-alpha-D-glucopyranose, ...
Authors:Ho, H, Koth, C.M, Payandeh, J.
Deposit date:2017-11-23
Release date:2018-05-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.908 Å)
Cite:Structural basis for dual-mode inhibition of the ABC transporter MsbA.
Nature, 557, 2018
7TJ8
DownloadVisualize
BU of 7tj8 by Molmil
Cryo-EM structure of the human Nax channel in complex with beta3 solved in nanodiscs
Descriptor: (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Noland, C.L, Kschonsak, M, Ciferri, C, Payandeh, J.
Deposit date:2022-01-14
Release date:2022-03-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure-guided unlocking of Na X reveals a non-selective tetrodotoxin-sensitive cation channel.
Nat Commun, 13, 2022
7TJ9
DownloadVisualize
BU of 7tj9 by Molmil
Cryo-EM structure of the human Nax channel in complex with beta3 solved in GDN
Descriptor: (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Noland, C.L, Kschonsak, M, Ciferri, C, Payandeh, J.
Deposit date:2022-01-14
Release date:2022-03-30
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure-guided unlocking of Na X reveals a non-selective tetrodotoxin-sensitive cation channel.
Nat Commun, 13, 2022
6XIW
DownloadVisualize
BU of 6xiw by Molmil
Cryo-EM structure of the sodium leak channel NALCN-FAM155A complex
Descriptor: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kschonsak, M, Chua, H.C, Noland, C.L, Weidling, C, Clairfeuille, T, Bahlke, O.O, Ameen, A.O, Li, Z.R, Arthur, C.P, Ciferri, C, Pless, S.A, Payandeh, J.
Deposit date:2020-06-22
Release date:2020-07-29
Last modified:2020-11-25
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure of the human sodium leak channel NALCN.
Nature, 587, 2020
6N4Q
DownloadVisualize
BU of 6n4q by Molmil
CryoEM structure of Nav1.7 VSD2 (actived state) in complex with the gating modifier toxin ProTx2
Descriptor: Beta/omega-theraphotoxin-Tp2a, Fab heavy chain, Fab light chain, ...
Authors:Xu, H, Rohou, A, Arthur, C.P, Estevez, A, Ciferri, C, Payandeh, J, Koth, C.M.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Cell, 176, 2019
6N4I
DownloadVisualize
BU of 6n4i by Molmil
Structural basis of Nav1.7 inhibition by a gating-modifier spider toxin
Descriptor: Beta/omega-theraphotoxin-Tp2a, Nav1.7 VSD2-NavAb channel chimera protein, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
Authors:Xu, H, Koth, C.M, Payandeh, J.
Deposit date:2018-11-19
Release date:2019-01-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.541 Å)
Cite:Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Cell, 176, 2019

 

123>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon