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1B0X
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BU of 1b0x by Molmil
THE CRYSTAL STRUCTURE OF AN EPH RECEPTOR SAM DOMAIN REVEALS A MECHANISM FOR MODULAR DIMERIZATION.
Descriptor: PROTEIN (EPHA4 RECEPTOR TYROSINE KINASE)
Authors:Stapleton, D, Balan, I, Pawson, T, Sicheri, F.
Deposit date:1998-11-14
Release date:1999-05-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization.
Nat.Struct.Biol., 6, 1999
1BY1
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BU of 1by1 by Molmil
DBL homology domain from beta-PIX
Descriptor: PROTEIN (PIX)
Authors:Aghazadeh, B, Zhu, K, Kubiseski, T.J, Liu, G.A, Pawson, T, Zheng, Y, Rosen, M.K.
Deposit date:1998-10-22
Release date:1999-10-24
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structure and Mutagenesis of the Dbl Homology Domain
Nat.Struct.Biol., 5, 1998
1Z1V
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BU of 1z1v by Molmil
NMR structure of the Saccharomyces cerevisiae Ste50 SAM domain
Descriptor: STE50 protein
Authors:Kwan, J.J, Warner, N, Maini, J, Pawson, T, Donaldson, L.W.
Deposit date:2005-03-06
Release date:2006-02-14
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Saccharomyces cerevisiae Ste50 binds the MAPKKK Ste11 through a head-to-tail SAM domain interaction.
J.Mol.Biol., 356, 2006
1DDM
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BU of 1ddm by Molmil
SOLUTION STRUCTURE OF THE NUMB PTB DOMAIN COMPLEXED TO A NAK PEPTIDE
Descriptor: NUMB ASSOCIATE KINASE, NUMB PROTEIN
Authors:Zwahlen, C, Li, S.C, Kay, L.E, Pawson, T, Forman-Kay, J.D.
Deposit date:1999-11-11
Release date:2000-04-10
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb.
EMBO J., 19, 2000
1H3H
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BU of 1h3h by Molmil
Structural Basis for Specific Recognition of an RxxK-containing SLP-76 peptide by the Gads C-terminal SH3 domain
Descriptor: GRB2-RELATED ADAPTOR PROTEIN 2, LYMPHOCYTE CYTOSOLIC PROTEIN 2
Authors:Liu, Q, Berry, D, Nash, P, Pawson, T, McGlade, C.J, Li, S.S.
Deposit date:2002-09-03
Release date:2003-03-06
Last modified:2013-07-24
Method:SOLUTION NMR
Cite:Structural Basis for Specific Binding of the Gads SH3 Domain to an Rxxk Motif-Containing Slp-76 Peptide: A Novel Mode of Peptide Recognition
Mol.Cell, 11, 2003
1F1W
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BU of 1f1w by Molmil
SRC SH2 THREF1TRP MUTANT COMPLEXED WITH THE PHOSPHOPEPTIDE S(PTR)VNVQN
Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, S(PTR)VNVQN PHOSPHOPEPTIDE
Authors:Kimber, M.S, Nachman, J, Cunningham, A.M, Gish, G.D, Pawson, T, Pai, E.F.
Deposit date:2000-05-20
Release date:2000-07-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for specificity switching of the Src SH2 domain.
Mol.Cell, 5, 2000
1F2F
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BU of 1f2f by Molmil
SRC SH2 THREF1TRP MUTANT
Descriptor: PHOSPHATE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Kimber, M.S, Nachman, J, Cunningham, A.M, Gish, G.D, Pawson, T, Pai, E.F.
Deposit date:2000-05-24
Release date:2000-07-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for specificity switching of the Src SH2 domain.
Mol.Cell, 5, 2000
1JU5
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BU of 1ju5 by Molmil
Ternary complex of an Crk SH2 domain, Crk-derived phophopeptide, and Abl SH3 domain by NMR spectroscopy
Descriptor: Abl, Crk
Authors:Donaldson, L.W, Pawson, T, Kay, L.E, Forman-Kay, J.D.
Deposit date:2001-08-23
Release date:2002-11-06
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide
Proc.Natl.Acad.Sci.USA, 99, 2002
1JPA
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BU of 1jpa by Molmil
Crystal Structure of unphosphorylated EphB2 receptor tyrosine kinase and juxtamembrane region
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, neural kinase, Nuk=Eph/Elk/Eck family receptor-like tyrosine kinase
Authors:Wybenga-Groot, L.E, Pawson, T, Sicheri, F.
Deposit date:2001-08-01
Release date:2001-10-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region.
Cell(Cambridge,Mass.), 106, 2001
1KA7
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BU of 1ka7 by Molmil
SAP/SH2D1A bound to peptide n-Y-c
Descriptor: SH2 DOMAIN PROTEIN 1A, peptide n-Y-c
Authors:Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C.
Deposit date:2001-10-31
Release date:2001-11-07
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
EMBO J., 21, 2002
1KA6
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BU of 1ka6 by Molmil
SAP/SH2D1A bound to peptide n-pY
Descriptor: SH2 DOMAIN PROTEIN 1A, peptide n-pY
Authors:Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C.
Deposit date:2001-10-31
Release date:2001-11-07
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
EMBO J., 21, 2002
2HEN
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BU of 2hen by Molmil
Crystal Structure of the EphB2 Receptor Kinase domain in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Ephrin type-B receptor 2, MAGNESIUM ION
Authors:Wybenga-Groot, L.E, Sicheri, F, Pawson, T.
Deposit date:2006-06-21
Release date:2007-02-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases
EMBO J., 25, 2006
2HEL
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BU of 2hel by Molmil
Crystal structure of a mutant EphA4 kinase domain (Y742A)
Descriptor: Eph receptor A4
Authors:Wybenga-Groot, L.E, Sicheri, F, Pawson, T.
Deposit date:2006-06-21
Release date:2007-02-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases.
EMBO J., 25, 2006
2JFA
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BU of 2jfa by Molmil
ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH AN AFFINITY-SELECTED COREPRESSOR PEPTIDE
Descriptor: COREPRESSOR PEPTIDE, ESTROGEN RECEPTOR, RALOXIFENE, ...
Authors:Heldring, N, Pawson, T, McDonnell, D, Treuter, E, Gustafsson, J.A, Pike, A.C.W.
Deposit date:2007-01-29
Release date:2007-02-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Insights Into Corepressor Recognition by Antagonist-Bound Estrogen Receptors.
J.Biol.Chem., 282, 2007
2JF9
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BU of 2jf9 by Molmil
ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH A TAMOXIFEN-SPECIFIC PEPTIDE ANTAGONIST
Descriptor: 1,2-ETHANEDIOL, 4-HYDROXYTAMOXIFEN, AB5 PEPTIDE, ...
Authors:Heldring, N, Pawson, T, McDonnell, D, Treuter, E, Gustafsson, J.A, Pike, A.C.W.
Deposit date:2007-01-29
Release date:2007-02-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Insights Into Corepressor Recognition by Antagonist-Bound Estrogen Receptors.
J.Biol.Chem., 282, 2007
2KIS
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BU of 2kis by Molmil
Solution structure of CA150 FF1 domain and FF1-FF2 interdomain linker
Descriptor: Transcription elongation regulator 1
Authors:Murphy, J.M, Hansen, D, Wiesner, S, Muhandiram, D, Borg, M, Smith, M.J, Sicheri, F, Kay, L.E, Forman-Kay, J.D, Pawson, T.
Deposit date:2009-05-08
Release date:2009-09-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays.
J.Mol.Biol., 393, 2009
2NMB
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BU of 2nmb by Molmil
DNUMB PTB DOMAIN COMPLEXED WITH A PHOSPHOTYROSINE PEPTIDE, NMR, ENSEMBLE OF STRUCTURES.
Descriptor: PROTEIN (GPPY PEPTIDE), PROTEIN (NUMB PROTEIN)
Authors:Li, S.-C, Zwahlen, C, Vincent, S.J.F, McGlade, C.J, Pawson, T, Forman-Kay, J.D.
Deposit date:1998-10-29
Release date:1998-11-04
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity.
Nat.Struct.Biol., 5, 1998
2PLE
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BU of 2ple by Molmil
NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE
Descriptor: PHOSPHOLIPASE C GAMMA-1, C-TERMINAL SH2 DOMAIN, PHOSPHOPEPTIDE FROM PDGF
Authors:Pascal, S.M, Singer, A.U, Gish, G, Yamazaki, T, Shoelson, S.E, Pawson, T, Kay, L.E, Forman-Kay, J.D.
Deposit date:1994-08-19
Release date:1995-01-26
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide.
Cell(Cambridge,Mass.), 77, 1994
2PLD
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BU of 2pld by Molmil
NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE
Descriptor: PHOSPHOLIPASE C GAMMA-1, C-TERMINAL SH2 DOMAIN, PHOSPHOPEPTIDE FROM PDGF
Authors:Pascal, S.M, Singer, A.U, Gish, G, Yamazaki, T, Shoelson, S.E, Pawson, T, Kay, L.E, Forman-Kay, J.D.
Deposit date:1994-08-19
Release date:1995-01-26
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide.
Cell(Cambridge,Mass.), 77, 1994
2P0F
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BU of 2p0f by Molmil
ArhGAP9 PH domain in complex with Ins(1,3,5)P3
Descriptor: PHOSPHATE ION, Rho GTPase-activating protein 9
Authors:Ceccarelli, D.F.J, Blasutig, I, Goudreault, M, Ruston, J, Pawson, T, Sicheri, F.
Deposit date:2007-02-28
Release date:2007-03-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Non-canonical Interaction of Phosphoinositides with Pleckstrin Homology Domains of Tiam1 and ArhGAP9.
J.Biol.Chem., 282, 2007
2P0H
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BU of 2p0h by Molmil
ArhGAP9 PH domain in complex with Ins(1,3,4)P3
Descriptor: (1S,3S,4S)-1,3,4-TRIPHOSPHO-MYO-INOSITOL, Rho GTPase-activating protein 9
Authors:Ceccarelli, D.F.J, Blasutig, I, Goudreault, M, Ruston, J, Pawson, T, Sicheri, F.
Deposit date:2007-02-28
Release date:2007-03-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Non-canonical Interaction of Phosphoinositides with Pleckstrin Homology Domains of Tiam1 and ArhGAP9.
J.Biol.Chem., 282, 2007
2P0D
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BU of 2p0d by Molmil
ArhGAP9 PH domain in complex with Ins(1,4,5)P3
Descriptor: D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Rho GTPase-activating protein 9
Authors:Ceccarelli, D.F.J, Blasutig, I, Goudreault, M, Ruston, J, Pawson, T, Sicheri, F.
Deposit date:2007-02-28
Release date:2007-03-27
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.811 Å)
Cite:Non-canonical Interaction of Phosphoinositides with Pleckstrin Homology Domains of Tiam1 and ArhGAP9.
J.Biol.Chem., 282, 2007
2QNJ
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BU of 2qnj by Molmil
Kinase and Ubiquitin-associated domains of MARK3/Par-1
Descriptor: MAP/microtubule affinity-regulating kinase 3
Authors:Murphy, J.M, Ceccarelli, D.F.J, Sicheri, F, Pawson, T.
Deposit date:2007-07-18
Release date:2007-09-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain
Proc.Natl.Acad.Sci.Usa, 104, 2007
3V7D
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BU of 3v7d by Molmil
Crystal Structure of ScSkp1-ScCdc4-pSic1 peptide complex
Descriptor: Cell division control protein 4, Protein SIC1, Suppressor of kinetochore protein 1
Authors:Tang, X, Orlicky, S, Mittag, T, Csizmok, V, Pawson, T, Forman-Kay, J, Sicheri, F, Tyers, M.
Deposit date:2011-12-20
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4LG6
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BU of 4lg6 by Molmil
Crystal structure of ANKRA2-CCDC8 complex
Descriptor: Ankyrin repeat family A protein 2, Coiled-coil domain-containing protein 8, UNKNOWN ATOM OR ION
Authors:Xu, C, Bian, C, Tempel, W, Mackenzie, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2013-06-27
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ankyrin Repeats of ANKRA2 Recognize a PxLPxL Motif on the 3M Syndrome Protein CCDC8.
Structure, 23, 2015

 

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