Author results

1SHG
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CRYSTAL STRUCTURE OF A SRC-HOMOLOGY 3 (SH3) DOMAIN
Descriptor:ALPHA-SPECTRIN SH3 DOMAIN
Authors:Noble, M., Pauptit, R., Musacchio, A., Saraste, M., Wierenga, R.K.
Deposit date:1993-05-19
Release date:1993-10-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a Src-homology 3 (SH3) domain.
Nature, 359, 1992
1UZU
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GLYCOGEN PHOSPHORYLASE B IN COMPLEX WITH INDIRUBIN-5'-SULPHONATE
Descriptor:GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Kosmopoulou, M.N., Leonidas, D.D., Chrysina, E.D., Bischler, N., Eisenbrand, G., Sakarellos, C.E., Pauptit, R., Oikonomakos, N.G.
Deposit date:2004-03-16
Release date:2004-05-27
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex.
Eur. J. Biochem., 271, 2004
2IEG
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CRYSTAL STRUCTURE OF RABBIT MUSCLE GLYCOGEN PHOSPHORYLASE IN COMPLEX WITH 3,4-DIHYDRO-2-QUINOLONE
Descriptor:Glycogen phosphorylase, muscle form, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, ...
Authors:Birch, A.M., Kenny, P.W., Oikonomakos, N.G., Otterbein, L., Schofield, P., Whittamore, P.R.O., Whalley, D.P., Rowsell, S., Pauptit, R., Pannifer, A., Breed, J., Minshull, C.
Deposit date:2006-09-19
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
2IEI
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CRYSTAL STRUCTURE OF RABBIT MUSCLE GLYCOGEN PHOSPHORYLASE IN COMPLEX WITH 3,4-DIHYDRO-2-QUINOLONE
Descriptor:Glycogen phosphorylase, muscle form, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, ...
Authors:Birch, A.M., Kenny, P.W., Oikonomakos, N.G., Otterbein, L., Schofield, P., Whittamore, P.R.O., Whalley, D.P., Rowsell, S., Pauptit, R., Pannifer, A., Breed, J., Minshull, C.
Deposit date:2006-09-19
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
4A9Y
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P38ALPHA MAP KINASE BOUND TO CMPD 8
Descriptor:MITOGEN-ACTIVATED PROTEIN KINASE 14, N-(3-{[7-METHOXY-6-(2-PYRROLIDIN-1-YLETHOXY)QUINAZOLIN-4-YL]AMINO}-4-METHYLPHENYL)-2-MORPHOLIN-4-YLISONICOTINAMIDE
Authors:Gerhardt, S., Hargreaves, D.
Deposit date:2011-11-29
Release date:2012-05-16
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases
Bioorg.Med.Chem.Lett., 22, 2012
4AA0
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P38ALPHA MAP KINASE BOUND TO CMPD 2
Descriptor:MITOGEN-ACTIVATED PROTEIN KINASE 14, N-[4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxidanylidene-quinazolin-3-yl]phenyl]-2-morpholin-4-yl-pyridine-4-carboxamide
Authors:Gerhardt, S., Hargreaves, D.
Deposit date:2011-11-30
Release date:2012-05-16
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases
Bioorg.Med.Chem.Lett., 22, 2012
4AA4
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P38ALPHA MAP KINASE BOUND TO CMPD 22
Descriptor:MITOGEN-ACTIVATED PROTEIN KINASE 14, N-[4-METHYL-3-[6-(4-METHYLPIPERAZIN-1-YL)-4-OXIDANYLIDENE-QUINAZOLIN-3-YL]PHENYL]FURAN-3-CARBOXAMIDE
Authors:Gerhardt, S., Hargreaves, D.
Deposit date:2011-11-30
Release date:2012-05-16
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases
Bioorg.Med.Chem.Lett., 22, 2012
4AA5
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P38ALPHA MAP KINASE BOUND TO CMPD 33
Descriptor:MITOGEN-ACTIVATED PROTEIN KINASE 14, N-CYCLOPROPYL-4-METHYL-3-[6-(4-METHYLPIPERAZIN-1-YL)-4-OXIDANYLIDENE-QUINAZOLIN-3-YL]BENZAMIDE
Authors:Gerhardt, S., Hargreaves, D.
Deposit date:2011-11-30
Release date:2012-05-16
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases
Bioorg.Med.Chem.Lett., 22, 2012
4AAC
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P38ALPHA MAP KINASE BOUND TO CMPD 29
Descriptor:MITOGEN-ACTIVATED PROTEIN KINASE 14, N-isoxazol-3-yl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxo-quinazolin-3-yl]benzamide, CHLORIDE ION
Authors:Gerhardt, S., Hargreaves, D.
Deposit date:2011-12-01
Release date:2012-05-16
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases
Bioorg.Med.Chem.Lett., 22, 2012
1ABO
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CRYSTAL STRUCTURE OF THE COMPLEX OF THE ABL TYROSINE KINASE SH3 DOMAIN WITH 3BP-1 SYNTHETIC PEPTIDE
Descriptor:ABL TYROSINE KINASE, 3BP-1 SYNTHETIC PEPTIDE, 10 RESIDUES, ...
Authors:Musacchio, A., Wilmanns, M., Saraste, M.
Deposit date:1995-05-19
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.
Nat.Struct.Biol., 1, 1994
1ABQ
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CRYSTAL STRUCTURE OF THE UNLIGANDED ABL TYROSINE KINASE SH3 DOMAIN
Descriptor:ABL TYROSINE KINASE SRC-HOMOLOGY 3 (SH3) DOMAIN
Authors:Musacchio, A., Wilmanns, M., Saraste, M.
Deposit date:1995-05-19
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.
Nat.Struct.Biol., 1, 1994
1AWO
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THE SOLUTION NMR STRUCTURE OF ABL SH3 AND ITS RELATIONSHIP TO SH2 IN THE SH(32) CONSTRUCT, 20 STRUCTURES
Descriptor:ABL TYROSINE KINASE
Authors:Cowburn, D.
Deposit date:1997-10-03
Release date:1998-01-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct.
Structure, 3, 1995
1AEY
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ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, SOLUTION NMR, 15 STRUCTURES
Descriptor:ALPHA-SPECTRIN
Authors:Blanco, F.J., Ortiz, A.R., Serrano, L.
Deposit date:1997-03-02
Release date:1997-05-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:1H and 15N NMR assignment and solution structure of the SH3 domain of spectrin: comparison of unrefined and refined structure sets with the crystal structure.
J.Biomol.NMR, 9, 1997
1BK2
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A-SPECTRIN SH3 DOMAIN D48G MUTANT
Descriptor:A-SPECTRIN
Authors:Martinez, J.C., Pisabarro, M.T., Serrano, L.
Deposit date:1998-07-14
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Obligatory steps in protein folding and the conformational diversity of the transition state.
Nat.Struct.Biol., 5, 1998
1E6G
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A-SPECTRIN SH3 DOMAIN A11V, V23L, M25I, V53I, V58L MUTANT
Descriptor:SPECTRIN ALPHA CHAIN, SULFATE ION
Authors:Vega, M.C., Serrano, L.
Deposit date:2000-08-15
Release date:2002-05-23
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational Strain in the Hydrophobic Core and its Implications for Protein Folding and Design
Nat.Struct.Biol., 9, 2002
1E6H
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A-SPECTRIN SH3 DOMAIN A11V, M25I, V44I, V58L MUTANTS
Descriptor:SPECTRIN ALPHA CHAIN
Authors:Vega, M.C., Serrano, L.
Deposit date:2000-08-17
Release date:2002-05-23
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Conformational Strain in the Hydrophobic Core and its Implications for Protein Folding and Design
Nat.Struct.Biol., 9, 2002
1E7O
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A-SPECTRIN SH3 DOMAIN A11V, V23L, M25V, V44I, V58L MUTATIONS
Descriptor:SPECTRIN ALPHA CHAIN, GLYCEROL
Authors:Vega, M.C., Serrano, L.
Deposit date:2000-08-31
Release date:2003-05-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A Thermodynamic and Kinetic Analysis of the Folding Pathway of an SH3 Domain Entropically Stabilised by a Redesigned Hydrophobic Core
J.Mol.Biol., 328, 2003
1H8K
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A-SPECTRIN SH3 DOMAIN A11V, V23L, M25V, V53I, V58L MUTANT
Descriptor:SPECTRIN ALPHA CHAIN
Authors:Vega, M.C., Serrano, L.
Deposit date:2001-02-09
Release date:2002-05-23
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Conformational Strain in the Hydrophobic Core and its Implications for Protein Folding and Design
Nat.Struct.Biol., 9, 2002
1HD3
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A-SPECTRIN SH3 DOMAIN F52Y MUTANT
Descriptor:SPECTRIN ALPHA CHAIN, SULFATE ION, GLYCEROL
Authors:Vega, M.C., Viguera, A.R., Serrano, L.
Deposit date:2000-11-06
Release date:2001-11-01
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Unspecific Hydrophobic Stabilization of Folding Transition States
Proc.Natl.Acad.Sci.USA, 99, 2002
1UUE
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A-SPECTRIN SH3 DOMAIN (V44T, D48G MUTANT)
Descriptor:SPECTRIN ALPHA CHAIN
Authors:Vega, M.C., Fernandez, A., Wilmanns, M., Serrano, L.
Deposit date:2003-12-18
Release date:2004-02-19
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Solvation in Protein Folding Analysis: Combination of Theoretical and Experimental Approaches
Proc.Natl.Acad.Sci.USA, 101, 2004
2CDT
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ALPHA-SPECTRIN SH3 DOMAIN A56S MUTANT
Descriptor:SPECTRIN ALPHA CHAIN
Authors:Casares, S., Camara-Artigas, A., Vega, M.C., Lopez-Mayorga, O., Conejero-Lara, F.
Deposit date:2006-01-27
Release date:2007-02-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Cooperative Propagation of Local Stability Changes from Low-Stability and High-Stability Regions in a SH3 Domain.
Proteins: Struct., Funct., Bioinf., 67, 2007
1Z62
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INDIRUBIN-3'-AMINOOXY-ACETATE INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR AND THE ALLOSTERIC SITE. BROAD SPECIFICITIES OF THE TWO SITES
Descriptor:Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Kosmopoulou, M.N., Leonidas, D.D., Chrysina, E.D., Eisenbrand, G., Oikonomakos, N.G.
Deposit date:2005-03-21
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Indirubin-3'-Aminooxy-Acetate Inhibits Glycogen Phosphorylase by Binding at the Inhibitor and the Allosteric Site. Broad Specificities of the Two Sites
LETT.DRUG DES.DISCOVERY, 2, 2005